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1.
Sulfonyl-morpholino-pyrimidines: SAR and development of a novel class of selective mTOR kinase inhibitor.
Bioorg Med Chem Lett;
22(12): 4163-8, 2012 Jun 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-22607682
2.
Discovery of a Series of 7-Azaindoles as Potent and Highly Selective CDK9 Inhibitors for Transient Target Engagement.
J Med Chem;
64(20): 15189-15213, 2021 10 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-34647738
3.
Discovery of AZD4573, a Potent and Selective Inhibitor of CDK9 That Enables Short Duration of Target Engagement for the Treatment of Hematological Malignancies.
J Med Chem;
63(24): 15564-15590, 2020 12 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-33306391
4.
Discovery of a Series of 3-Cinnoline Carboxamides as Orally Bioavailable, Highly Potent, and Selective ATM Inhibitors.
ACS Med Chem Lett;
9(8): 809-814, 2018 Aug 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-30128072
5.
The Identification of Potent, Selective, and Orally Available Inhibitors of Ataxia Telangiectasia Mutated (ATM) Kinase: The Discovery of AZD0156 (8-{6-[3-(Dimethylamino)propoxy]pyridin-3-yl}-3-methyl-1-(tetrahydro-2 H-pyran-4-yl)-1,3-dihydro-2 H-imidazo[4,5- c]quinolin-2-one).
J Med Chem;
61(9): 3823-3841, 2018 05 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-29683659
6.
Discovery of Novel 3-Quinoline Carboxamides as Potent, Selective, and Orally Bioavailable Inhibitors of Ataxia Telangiectasia Mutated (ATM) Kinase.
J Med Chem;
59(13): 6281-92, 2016 07 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-27259031
7.
Pyrimidinone nicotinamide mimetics as selective tankyrase and wnt pathway inhibitors suitable for in vivo pharmacology.
ACS Med Chem Lett;
6(3): 254-9, 2015 Mar 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-25815142
8.
Synthesis of functionalized cyanopyrazoles via magnesium bases.
Org Lett;
16(23): 6120-3, 2014 Dec 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-25393394
9.
Correction to Discovery of Novel 3-Quinoline Carboxamides as Potent, Selective, and Orally Bioavailable Inhibitors of Ataxia Telangiectasia Mutated (ATM) Kinase.
J Med Chem;
61(14): 6398, 2018 07 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-29969258
10.
Synthesis and asymmetric hydrogenation of (3E)-1-benzyl-3-[(2-oxopyridin-1(2H)-yl)methylidene]piperidine-2,6-dione.
Chem Commun (Camb);
48(98): 11978-80, 2012 Dec 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-23128555
11.
Rapid generation of a high quality lead for transforming growth factor-beta (TGF-beta) type I receptor (ALK5).
J Med Chem;
52(23): 7901-5, 2009 Dec 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-19736928
12.
Neutral 5-substituted 4-anilinoquinazolines as potent, orally active inhibitors of erbB2 receptor tyrosine kinase.
Bioorg Med Chem Lett;
17(22): 6326-9, 2007 Nov 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-17869514
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