A provisional screening instrument for four common mental disorders in adult primary care patients.

OBJECTIVE: To develop an adult self-report instrument for provisional diagnosis of four common mental disorders in primary care patients. METHODS: Primary care patients were evaluated during routine clinic visits with a self-report screening tool comprised of 85 DSM-IV symptom-based candidate questions. Patients with a physician-assessed provisional diagnosis for generalized anxiety disorder (GAD), major depressive episode (MDE), past/present mania, and adult attention-deficit/hyperactivity disorder (ADHD), or none of these, completed additional self-report clinical questionnaires, and then were interviewed on the telephone by a trained rater for a SCID/ACDS diagnosis. Responses to the symptom-based candidate questions were used to calculate sensitivity and specificity for a SCID/ACDS diagnosis (GAD, N = 24; MDE, N = 89; Mania, N = 24; ADHD, N = 65) and to select the optimal four questions for each diagnosis to be included in the instrument. RESULTS: Analyses resulted in a 17-item instrument for provisional differential diagnosis of GAD, MDE, past/present mania, and ADHD. Comparison of limited symptom-based versus full DSM-IV criteria-based diagnosis showed minimal differences for relative diagnostic accuracy. Sensitivities and specificities, respectively, were 83% and 75% for GAD, 80% and 80% for MDE, 83% and 82% for mania, and 82%and 73% for ADHD. CONCLUSIONS: Based on this preliminary work, the Provisional Diagnostic Instrument-4 is a brief, easily scored, self-report instrument that may assist primary care physicians to identify potential cases of GAD, MDE, past/present mania, and ADHD.

Quality of medical care for people with and without comorbid mental illness and substance misuse: systematic review of comparative studies.

BACKGROUND: There has been long-standing concern about the quality of medical care offered to people with mental illness. AIMS: To investigate whether the quality of medical care received by people with mental health conditions, including substance misuse, differs from the care received by people who have no comparable mental disorder. METHOD: A systematic review of studies that examined the quality of medical care in those with and without mental illness was conducted using robust critical appraisal techniques. RESULTS: Of 31 valid studies, 27 examined receipt of medical care in those with and without mental illness and 10 examined medical care in those with and without substance use disorder (or dual diagnosis). Nineteen of 27 and 10 of 10, respectively, suggested inferior quality of care in at least one domain. Twelve studies found no appreciable differences in care or failed to detect a difference in at least one key area. Several studies showed an increase in healthcare utilisation but without any increase in quality. Three studies found superior care for individuals with mental illness in specific subdomains. There was inadequate information concerning patient satisfaction and structural differences in healthcare delivery. There was also inadequate separation of delivery of care from uptake in care on which to base causal explanations. CONCLUSIONS: Despite similar or more frequent medical contacts, there are often disparities in the physical healthcare delivered to those with psychiatric illness although the magnitude of this effect varies considerably.

Suboptimal depression screening following cancer diagnosis.

OBJECTIVE: To describe the proportion of veterans with cancer screened for depression as compared to the general population (GenPop) of veterans. METHODS: Data were abstracted from electronic medical records (2000-2004) at a Midwestern Veterans Health Administration (VHA) facility and from the VHA External Peer Review Program (EPRP). Depression screening was assessed in the 12-month period following cancer diagnosis or in the 12-month period prior to EPRP medical record abstraction. Statistical analysis included multivariate logistic regression. RESULTS: Annual depression screening among veterans with cancer improved from 42% in 2000 to 81% in 2003. Screening was 9-31% lower and 11-50% lower among veterans with cancer at the Midwestern facility, as compared to the GenPop of veterans nationwide and at the Midwestern facility, respectively. Of subjects with cancer at the Midwestern facility, 19% screened positive. Advanced disease [odds ratio (OR)=0.51; 95% confidence interval (CI(95)): 0.38-0.68] and respiratory cancers (OR=0.55; CI(95): 0.38-0.80) were associated with lower odds of screening receipt. CONCLUSIONS: Screening for depression among veterans with cancer improved 39% but is considerably lower than the proportion of GenPop veterans screened nationally and at the local facility. Targeted interventions to improve screening in patients with cancer are required based on evidence that screening translates into increased provider recognition and treatment of depression.

Acetylcholinesterase activity in veterans of the first Gulf War.

BACKGROUND: Factors affecting acetylcholine-mediated neurotransmission have been proposed as possible explanations for physical and mental health symptoms among veterans of the 1990-1991 Gulf War. This study was designed to examine relationships of deployment to the Gulf, as well as symptoms after military service, with postdeployment activity of acetylcholinesterase (AChE) and related enzymes. METHODS: The patient population included 488 veterans, originally from Iowa at enlistment, who served in the US military during August 1990 to July 1991. Demographic, military, and clinical characteristics were obtained from a population-based cohort study (in 1995-1996) and from a nested case-control study (in 1999-2002). Stored serum samples (from the 1999-2002 assessment) were analyzed for activity of AChE and related enzymes. These two data sources were merged, and multiple linear regression models estimated the association of deployment, stress (anxiety) or mood disorders, and symptoms compatible with Gulf War veterans' illnesses (GWVIs), with enzyme activity. RESULTS: Seventy-four percent (n = 361) of veterans had been deployed to the Gulf. At the time of evaluation, 23% (n = 113) of participants reported anxiety and 15% (n = 71) reported mood disorders; 49% (n = 171 of 347 eligible veterans) had symptoms of GWVIs, and the median AChE activity was 839 units. AChE activity was similar for compared groups across all categories, including an adjusted difference of -27 units (p = .50) for deployed versus nondeployed veterans and 87 units (p = .13) for veterans with versus without symptoms of GWVIs. CONCLUSIONS: Neither deployment to the Gulf nor symptoms compatible with GWVIs are associated with long-term serum AChE activity.

Nonadherence to depression treatment guidelines among veterans with diabetes mellitus.

OBJECTIVE: To assess the adequacy of antidepressant dosage and duration among veterans with and without diabetes mellitus (DM), as well as provider-level and patient-level predictors of depression care quality, based on Veterans Health Administration (VHA) evidence-based clinical practice guidelines. STUDY DESIGN: Retrospective (1997-2005) cohort study of administrative, clinical, and pharmacy data from a midwestern VHA facility. METHODS: The sample included 2332 subjects (773 with DM) who had a new episode of depression, received antidepressant therapy, and had neither schizophrenia nor bipolar disorder. Antidepressant dosage and duration were evaluated in the acute and continuation phases. Dosage was adequate if the treatment dosage met the minimum therapeutic dosage specified in VHA guidelines. Treatment duration was adequate if the medication possession ratio was at least 80%. Multivariate logistic regression analysis was used to calculate odds ratios (ORs), adjusted for demographic, clinical, and healthcare utilization characteristics. RESULTS: Most subjects received an adequate dosage during the acute (88%) and continuation (58%) phases. Subjects with DM were 1.51-fold more likely to receive adequate dosage during the acute phase but were similarly likely (OR, 1.15) to receive adequate dosage during the continuation phase. Few subjects (<10%) received adequate treatment duration. Diabetes mellitus was not associated with less adequate duration during the acute phase (OR, 1.14). Few factors were identified as significant predictors of both antidepressant dosage and duration. CONCLUSIONS: Diabetes mellitus did not adversely affect depression care quality. Adequate antidepressant dosages were prescribed, but treatment duration fell short of guideline recommendations. Strategies to more effectively manage depression treatment are needed.

Specific phobia of illness in the community.

This study evaluated the prevalence, risk factors and morbidity associated with specific phobia of illness. Subjects were from a random, community telephone survey of 500 persons age 40 to 65 who lived in Johnson County, Iowa, USA. Forty-three subjects reported that illness fears substantially bothered them personally or affected their medical care, work, or social life. Twenty-one of these subjects could be contacted and agreed to a semistructured interview designed to diagnose specific phobia of illness and screen for other common psychiatric disorders. Based on the interview, 10 subjects met the criteria for specific phobia of illness, 10 for major depressive disorder, 5 for obsessive-compulsive disorder, 5 for generalized anxiety disorder, 4 for hypochondriasis, 4 for panic disorder and 4 for specific phobia other than illness. Assuming subjects not interviewed were similar to subjects who were, the community prevalence of specific phobia of illness is 4.0%. Among the 10 subjects with specific phobia of illness, 7 had prior negative experiences with illness and 8 had comorbid Axis I disorders. The phobia interfered with medical care as well as social functioning for many subjects. These results suggest a prevalence rate and risk factors that will be useful for additional studies of illness phobia.

Provision of psychosocial care for cancer patients: service delivery in urban and rural settings.

Although common, psychosocial distress is frequently under diagnosed and untreated in the US health care system. Previous research shows that cancer patients have unmet psychosocial needs, and provision of psychosocial care frequently falls to primary care providers who may lack the resources to adequately deal with complex psychosocial issues. We conducted 25 in-depth key informant interviews with health care professionals working within medical facilities that provide care to cancer patients. Cancer care centers included in the sample were located within both rural and urban communities in a midwestern state, and included providers of both inpatient and outpatient services. Interview questions addressed the assessment of psychosocial needs, availability of psychosocial care, perceptions of the effectiveness of psychosocial services, and perceptions of organizational processes to manage psychosocial needs among their patients. Respondents were also queried regarding recommendations for improving psychosocial care for patients with cancer. Assessment of psychosocial need in most settings was often subjective, not performed, or completed without access to an accepted standardized assessment tool, and clinical pathways to direct psychosocial care were often lacking. Because of the lack of systematic assessment, access to psychosocial care was frequently dependent on the subjective judgment of busy clinicians. This study shows the clear need for organizational and practice redesign initiatives in both rural and urban settings to improve the delivery of psychosocial services to cancer patients. A number of possible system improvements were identified, including the use of allied health providers, standardized screening, and information technology to increase the ease and efficiency of psychosocial assessment.

Volume of home- and community-based Medicaid waiver services and risk of hospital admissions.

OBJECTIVES: To evaluate whether type and volume of Medicaid Home- and Community-Based Services (HCBS) waiver program are associated with risk of hospitalization and whether this association changes over time. DESIGN: Prospective. SETTING: Indiana Medicaid claims data from June 2001 to December 2004. PARTICIPANTS: Medicaid recipients (N=1,354) who enrolled in the Aged and Disabled waiver program between January 2002 and June 2004. MEASUREMENTS: Time to hospital admission since enrollment in the HCBS waiver program, adjusted for demographics, comorbidities, prior use of health services, and volume of HCBS received, including attendant care, homemaking, and home-delivered meals. RESULTS: A greater volume of attendant care, homemaking services, and home-delivered meals was associated with a lower risk of hospitalization. This effect diminished over time for attendant care and homemaking. The risk of hospitalization for subjects receiving 5 hours of attendant care per month was 54% (hazard ratio (HR)=0.46, 95% confidence interval (CI)=0.38-0.57) lower during the first month of enrollment and 20% lower by Month 10 (HR=0.80, 95% CI=0.73-0.88) than for those receiving no attendant care. CONCLUSION: Greater volume of HCBS services was associated with lower risk of hospitalization. The findings highlight the potential importance of assessing and monitoring the volume of HCBS patients receive.

Depression screening disparities among veterans with diabetes compared with the general veteran population.

OBJECTIVE: We sought to describe the proportion of veterans with diabetes screened for depression compared with the general population of veterans. RESEARCH DESIGN AND METHODS: Electronic medical records (fiscal years 2001-2004) from a Midwestern Veterans Health Administration (VHA) facility and VHA External Peer Review Program (EPRP) data were used for the study. Facility-level data included inpatient and outpatient encounters, which included depression screen results. EPRP data were facility-level summary data, which detailed the proportion of general population veterans nationwide and patients at the Midwestern facility who were screened for depression. Logistic regression tested for associations between depression screen receipt and screening positive and demographic/clinical characteristics among patients with diabetes. RESULTS: Depression screening among those with diabetes improved from 62% in fiscal year 2001 to 83% in 2004. Screening was 9-23% lower and 11-22% lower in patients with diabetes compared with the general population of veterans nationwide and patients at the Midwestern facility, respectively. Seventeen percent of subjects with diabetes screened positive, which is two times higher than in the general population. Women (odds ratio 0.45 [95% CI 0.35-0.60]) and subjects with unknown A1C (0.40 [0.34-0.46]) were less likely to be screened for depression. A >or=50% service-connected disability rating was inversely associated with screening (0.84 [0.72-0.99]) but positively associated with screening positive for depression (1.56 [1.33-1.82]). CONCLUSIONS: Screening for depression among veterans with diabetes improved 21% but is considerably lower than the proportion of general population veterans screened nationally and at the facility of interest. Targeted interventions to improve screening in patients with diabetes are required based on evidence that screening translates into increased provider recognition and treatment of depression.

Beyond the traditional prognostic indicators: the impact of primary care utilization on cancer survival.

PURPOSE: To our knowledge to date, the effect of primary care utilization on health outcomes in cancer patients has not been described. The objective of this study was to investigate the impact of primary care utilization within 6 months of cancer diagnosis on survival in patients with lung cancer. PATIENTS AND METHODS: We used electronic medical record data (1997 to 2005) to identify male veterans with incident lung cancers (N = 323). Primary care utilization was assessed in the 6 months after cancer diagnosis. Patients were observed from cancer diagnosis to death or to last date of health care utilization (ie, censoring date). Univariate and multivariate Cox proportional hazards models tested whether primary care utilization was associated with improved survival. Multivariate analyses adjusted for demographic and clinical characteristics. RESULTS: During an average follow-up of 16.6 months, 259 patients died. In multivariate analysis, the risk of death was 36% (hazard ratio [HR], 0.64; 95% CI, 0.45 to 0.90), 56% (HR, 0.44; 95% CI, 0.29 to 0.65), and 57% (HR, 0.43; 05% CI, 0.29 to 0.64) lower for patients who had one, two, or at least three primary care visits, respectively, in the first 6 months after cancer diagnosis as compared with those without primary care utilization. The median survival duration (P < .0001, log-rank test) was 3.68, 7.52, 13.88, and 13.75 months for patients with no, one, two, or at least three primary care visits, respectively. CONCLUSION: Primary care utilization in the early phase of cancer treatment has a marked effect that results in a reduced mortality risk in patients with incident lung cancer. Additional research is required to determine how and why primary care utilization is an important prognostic indicator of prolonged survival in patients with lung cancer.

The Indiana Chronic Disease Management Program.

The Indiana Chronic Disease Management Program (ICDMP) is intended to improve the quality and cost-effectiveness of care for Medicaid members with congestive heart failure (chronic heart failure), diabetes, asthma, and other conditions. The ICDMP is being assembled by Indiana Medicaid primarily from state and local resources and has seven components: (1) identification of eligible participants to create regional registries, (2) risk stratification of eligible participants, (3) nurse care management for high-risk participants, (4) telephonic intervention for all participants, (5) an Internet-based information system, (6) quality improvement collaboratives for primary care practices, and (7) program evaluation. The evaluation involves a randomized controlled trial in two inner-city group practices, as well as a statewide observational design. This article describes the ICDMP, highlights challenges, and discusses approaches to its evaluation.

Posttraumatic stress disorder and self-reported physical health status among U.S. Military personnel serving during the Gulf War period: a population-based study.

The objective of this study was to investigate the relation between posttraumatic stress disorder (PTSD) and perceived physical health. Participants included 3,682 Gulf War veterans and control subjects of the same era who completed a telephone survey about their health status. PTSD was assessed using the PTSD Checklist-Military Version. Veterans screening positive for PTSD reported significantly more physical health symptoms and medical conditions than did veterans without PTSD. They were also more likely to rate their health status as fair or poor and to report lower levels of health-related quality of life. The results of this study are consistent with studies of other combat veterans and provide further support for an association between PTSD and adverse physical health outcomes. Stressful or traumatic life events, such as those encountered during a rapid military deployment and conflict, are associated with a variety of adverse health effects. These health effects may manifest themselves in both psychological and physical outcomes. Health care providers must be attentive to recognize and evaluate both of these dimensions.