[Myasthenia gravis associated with nivolumab]. / Miastenia grave asociada a nivolumab.

TITLE: Miastenia grave asociada a nivolumab.

[Ki-1+ large-cell anaplastic lymphoma with a leukemic appearance. Study of a case]. / Linfoma anaplásico de célula grande Ki-1 (+) con expresión leucémica. Estudio de un caso.

Ki-1 anaplastic large cell lymphoma is a well-described subtype of non-Hodgkin's lymphoma with distinctive characteristics from the cytological, immunohistochemical and clinical points of view. One of the clinical behavior characteristic is that it rarely evolves into a leukaemic phase. We report the case of a 72-year-old man in which the appearance of tumor cells in peripheral blood was one of the most revealing information. The patient showed B-symptoms, bicytopenia and bone marrow involvement, together with hepatosplenomegaly and right axilar adenopathy, which after biopsied lead to Ki-1 anaplastic large cell lymphoma's diagnosis (stage IV-B). As far as the treatment and evolution are concerned, we choose a polychemotherapy (ACOP-B) because of the patient's age. Up to now clinical and analitical course is excellent and the patient is now in remission.