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1.

A Genetic Map of the Response to DNA Damage in Human Cells.

Olivieri, Michele; Cho, Tiffany; Álvarez-Quilón, Alejandro; Li, Kejiao; Schellenberg, Matthew J; Zimmermann, Michal; Hustedt, Nicole; Rossi, Silvia Emma; Adam, Salomé; Melo, Henrique; Heijink, Anne Margriet; Sastre-Moreno, Guillermo; Moatti, Nathalie; Szilard, Rachel K; McEwan, Andrea; Ling, Alexanda K; Serrano-Benitez, Almudena; Ubhi, Tajinder; Feng, Sumin; Pawling, Judy; Delgado-Sainz, Irene; Ferguson, Michael W; Dennis, James W; Brown, Grant W; Cortés-Ledesma, Felipe; Williams, R Scott; Martin, Alberto; Xu, Dongyi; Durocher, Daniel.

Cell; 182(2): 481-496.e21, 2020 07 23.

Artículo en Inglés | MEDLINE | ID: mdl-32649862

2.

NFATC2IP is a mediator of SUMO-dependent genome integrity.

Cho, Tiffany; Hoeg, Lisa; Setiaputra, Dheva; Durocher, Daniel.

Genes Dev; 38(5-6): 233-252, 2024 Apr 17.

Artículo en Inglés | MEDLINE | ID: mdl-38503515

3.

Genome-scale mapping of DNA damage suppressors through phenotypic CRISPR-Cas9 screens.

Zhao, Yichao; Tabet, Daniel; Rubio Contreras, Diana; Lao, Linjiang; Kousholt, Arne Nedergaard; Weile, Jochen; Melo, Henrique; Hoeg, Lisa; Feng, Sumin; Coté, Atina G; Lin, Zhen-Yuan; Setiaputra, Dheva; Jonkers, Jos; Gingras, Anne-Claude; Gómez Herreros, Fernando; Roth, Frederick P; Durocher, Daniel.

Mol Cell; 83(15): 2792-2809.e9, 2023 08 03.

Artículo en Inglés | MEDLINE | ID: mdl-37478847

4.

High-Resolution CRISPR Screens Reveal Fitness Genes and Genotype-Specific Cancer Liabilities.

Hart, Traver; Chandrashekhar, Megha; Aregger, Michael; Steinhart, Zachary; Brown, Kevin R; MacLeod, Graham; Mis, Monika; Zimmermann, Michal; Fradet-Turcotte, Amelie; Sun, Song; Mero, Patricia; Dirks, Peter; Sidhu, Sachdev; Roth, Frederick P; Rissland, Olivia S; Durocher, Daniel; Angers, Stephane; Moffat, Jason.

Cell; 163(6): 1515-26, 2015 Dec 03.

Artículo en Inglés | MEDLINE | ID: mdl-26627737

5.

RIF1 acts in DNA repair through phosphopeptide recognition of 53BP1.

Setiaputra, Dheva; Escribano-Díaz, Cristina; Reinert, Julia K; Sadana, Pooja; Zong, Dali; Callen, Elsa; Sifri, Chérine; Seebacher, Jan; Nussenzweig, André; Thomä, Nicolas H; Durocher, Daniel.

Mol Cell; 82(7): 1359-1371.e9, 2022 04 07.

Artículo en Inglés | MEDLINE | ID: mdl-35216668

6.

CCNE1 amplification is synthetic lethal with PKMYT1 kinase inhibition.

Gallo, David; Young, Jordan T F; Fourtounis, Jimmy; Martino, Giovanni; Álvarez-Quilón, Alejandro; Bernier, Cynthia; Duffy, Nicole M; Papp, Robert; Roulston, Anne; Stocco, Rino; Szychowski, Janek; Veloso, Artur; Alam, Hunain; Baruah, Prasamit S; Fortin, Alexanne Bonneau; Bowlan, Julian; Chaudhary, Natasha; Desjardins, Jessica; Dietrich, Evelyne; Fournier, Sara; Fugère-Desjardins, Chloe; Goullet de Rugy, Theo; Leclaire, Marie-Eve; Liu, Bingcan; Bhaskaran, Vivek; Mamane, Yael; Melo, Henrique; Nicolas, Olivier; Singhania, Akul; Szilard, Rachel K; Tkác, Ján; Yin, Shou Yun; Morris, Stephen J; Zinda, Michael; Marshall, C Gary; Durocher, Daniel.

Nature; 604(7907): 749-756, 2022 04.

Artículo en Inglés | MEDLINE | ID: mdl-35444283

7.

Endogenous DNA 3' Blocks Are Vulnerabilities for BRCA1 and BRCA2 Deficiency and Are Reversed by the APE2 Nuclease.

Álvarez-Quilón, Alejandro; Wojtaszek, Jessica L; Mathieu, Marie-Claude; Patel, Tejas; Appel, C Denise; Hustedt, Nicole; Rossi, Silvia Emma; Wallace, Bret D; Setiaputra, Dheva; Adam, Salomé; Ohashi, Yota; Melo, Henrique; Cho, Tiffany; Gervais, Christian; Muñoz, Ivan M; Grazzini, Eric; Young, Jordan T F; Rouse, John; Zinda, Michael; Williams, R Scott; Durocher, Daniel.

Mol Cell; 78(6): 1152-1165.e8, 2020 06 18.

Artículo en Inglés | MEDLINE | ID: mdl-32516598

8.

FAM72A antagonizes UNG2 to promote mutagenic repair during antibody maturation.

Feng, Yuqing; Li, Conglei; Stewart, Jessica A; Barbulescu, Philip; Seija Desivo, Noé; Álvarez-Quilón, Alejandro; Pezo, Rossanna C; Perera, Madusha L W; Chan, Katherine; Tong, Amy Hin Yan; Mohamad-Ramshan, Rukshana; Berru, Maribel; Nakib, Diana; Li, Gavin; Kardar, Gholam Ali; Carlyle, James R; Moffat, Jason; Durocher, Daniel; Di Noia, Javier M; Bhagwat, Ashok S; Martin, Alberto.

Nature; 600(7888): 324-328, 2021 12.

Artículo en Inglés | MEDLINE | ID: mdl-34819670

9.

BRCA1 Haploinsufficiency Is Masked by RNF168-Mediated Chromatin Ubiquitylation.

Zong, Dali; Adam, Salomé; Wang, Yifan; Sasanuma, Hiroyuki; Callén, Elsa; Murga, Matilde; Day, Amanda; Kruhlak, Michael J; Wong, Nancy; Munro, Meagan; Ray Chaudhuri, Arnab; Karim, Baktiar; Xia, Bing; Takeda, Shunichi; Johnson, Neil; Durocher, Daniel; Nussenzweig, André.

Mol Cell; 73(6): 1267-1281.e7, 2019 03 21.

Artículo en Inglés | MEDLINE | ID: mdl-30704900

10.

Control of homologous recombination by the HROB-MCM8-MCM9 pathway.

Hustedt, Nicole; Saito, Yuichiro; Zimmermann, Michal; Álvarez-Quilón, Alejandro; Setiaputra, Dheva; Adam, Salomé; McEwan, Andrea; Yuan, Jing Yi; Olivieri, Michele; Zhao, Yichao; Kanemaki, Masato T; Jurisicova, Andrea; Durocher, Daniel.

Genes Dev; 33(19-20): 1397-1415, 2019 10 01.

Artículo en Inglés | MEDLINE | ID: mdl-31467087

11.

An allosteric inhibitor of the human Cdc34 ubiquitin-conjugating enzyme.

Ceccarelli, Derek F; Tang, Xiaojing; Pelletier, Benoit; Orlicky, Stephen; Xie, Weilin; Plantevin, Veronique; Neculai, Dante; Chou, Yang-Chieh; Ogunjimi, Abiodun; Al-Hakim, Abdallah; Varelas, Xaralabos; Koszela, Joanna; Wasney, Gregory A; Vedadi, Masoud; Dhe-Paganon, Sirano; Cox, Sarah; Xu, Shuichan; Lopez-Girona, Antonia; Mercurio, Frank; Wrana, Jeff; Durocher, Daniel; Meloche, Sylvain; Webb, David R; Tyers, Mike; Sicheri, Frank.

Cell; 145(7): 1075-87, 2011 Jun 24.

Artículo en Inglés | MEDLINE | ID: mdl-21683433

12.

Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.

Lü, YiQing; Cho, Tiffany; Mukherjee, Saptaparna; Suarez, Carmen Florencia; Gonzalez-Foutel, Nicolas S; Malik, Ahmad; Martinez, Sebastien; Dervovic, Dzana; Oh, Robin Hyunseo; Langille, Ellen; Al-Zahrani, Khalid N; Hoeg, Lisa; Lin, Zhen Yuan; Tsai, Ricky; Mbamalu, Geraldine; Rotter, Varda; Ashton-Prolla, Patricia; Moffat, Jason; Chemes, Lucia Beatriz; Gingras, Anne-Claude; Oren, Moshe; Durocher, Daniel; Schramek, Daniel.

Mol Syst Biol; 2024 Apr 05.

Artículo en Inglés | MEDLINE | ID: mdl-38580884

13.

An AlphaFold2 map of the 53BP1 pathway identifies a direct SHLD3-RIF1 interaction critical for shieldin activity.

Sifri, Chérine; Hoeg, Lisa; Durocher, Daniel; Setiaputra, Dheva.

EMBO Rep; 24(8): e56834, 2023 08 03.

Artículo en Inglés | MEDLINE | ID: mdl-37306046

14.

Push back to respond better: regulatory inhibition of the DNA double-strand break response.

Panier, Stephanie; Durocher, Daniel.

Nat Rev Mol Cell Biol; 14(10): 661-72, 2013 Oct.

Artículo en Inglés | MEDLINE | ID: mdl-24002223

15.

ZMYM3 regulates BRCA1 localization at damaged chromatin to promote DNA repair.

Leung, Justin W C; Makharashvili, Nodar; Agarwal, Poonam; Chiu, Li-Ya; Pourpre, Renaud; Cammarata, Michael B; Cannon, Joe R; Sherker, Alana; Durocher, Daniel; Brodbelt, Jennifer S; Paull, Tanya T; Miller, Kyle M.

Genes Dev; 31(3): 260-274, 2017 02 01.

Artículo en Inglés | MEDLINE | ID: mdl-28242625

16.

RNF168 binds and amplifies ubiquitin conjugates on damaged chromosomes to allow accumulation of repair proteins.

Doil, Carsten; Mailand, Niels; Bekker-Jensen, Simon; Menard, Patrice; Larsen, Dorthe Helena; Pepperkok, Rainer; Ellenberg, Jan; Panier, Stephanie; Durocher, Daniel; Bartek, Jiri; Lukas, Jiri; Lukas, Claudia.

Cell; 136(3): 435-46, 2009 Feb 06.

Artículo en Inglés | MEDLINE | ID: mdl-19203579

17.

The RIDDLE syndrome protein mediates a ubiquitin-dependent signaling cascade at sites of DNA damage.

Stewart, Grant S; Panier, Stephanie; Townsend, Kelly; Al-Hakim, Abdallah K; Kolas, Nadine K; Miller, Edward S; Nakada, Shinichiro; Ylanko, Jarkko; Olivarius, Signe; Mendez, Megan; Oldreive, Ceri; Wildenhain, Jan; Tagliaferro, Andrea; Pelletier, Laurence; Taubenheim, Nadine; Durandy, Anne; Byrd, Philip J; Stankovic, Tatjana; Taylor, A Malcolm R; Durocher, Daniel.

Cell; 136(3): 420-34, 2009 Feb 06.

Artículo en Inglés | MEDLINE | ID: mdl-19203578

18.

A mitotic glue for shattered chromosomes.

Xue, Yibo; Durocher, Daniel.

Nature; 618(7967): 909-910, 2023 Jun.

Artículo en Inglés | MEDLINE | ID: mdl-37316590

19.

53BP1-RIF1-shieldin counteracts DSB resection through CST- and Polα-dependent fill-in.

Mirman, Zachary; Lottersberger, Francisca; Takai, Hiroyuki; Kibe, Tatsuya; Gong, Yi; Takai, Kaori; Bianchi, Alessandro; Zimmermann, Michal; Durocher, Daniel; de Lange, Titia.

Nature; 560(7716): 112-116, 2018 08.

Artículo en Inglés | MEDLINE | ID: mdl-30022158

20.

CRISPR screens identify genomic ribonucleotides as a source of PARP-trapping lesions.

Zimmermann, Michal; Murina, Olga; Reijns, Martin A M; Agathanggelou, Angelo; Challis, Rachel; Tarnauskaite, Zygimante; Muir, Morwenna; Fluteau, Adeline; Aregger, Michael; McEwan, Andrea; Yuan, Wei; Clarke, Matthew; Lambros, Maryou B; Paneesha, Shankara; Moss, Paul; Chandrashekhar, Megha; Angers, Stephane; Moffat, Jason; Brunton, Valerie G; Hart, Traver; de Bono, Johann; Stankovic, Tatjana; Jackson, Andrew P; Durocher, Daniel.

Nature; 559(7713): 285-289, 2018 07.

Artículo en Inglés | MEDLINE | ID: mdl-29973717

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