Potentially toxic elements in groundwater of the upper Brahmaputra floodplains of Assam, India: water quality and health risk.

This paper presents the groundwater quality assessment of the upper Brahmaputra floodplains of Assam on a seasonal basis. A total of 88 samples were analyzed for the presence of potentially toxic elements in two seasons. In addition, an attempt is made to identify any possible associated health risks to the residents via the drinking water pathway. The study reveals the presence of various potentially toxic elements, in particular, manganese, iron, nickel, and fluoride concentration exceeding the drinking water specifications set by BIS and WHO drinking water standards. The degree of groundwater contamination was assessed using the Water Quality Index, Heavy metal Pollution Index, Heavy metal Evaluation Index, and Degree of Contamination. The spatial distribution maps of groundwater quality were prepared using geographical information system. The non-carcinogenic health risk was evaluated using hazard quotients and hazard index as per the United States Environmental Protection Agency methodology. The hazard quotient of fluoride and manganese have values > 1, which exceeds USEPA recommended benchmark. The health risk assessment identified that the risk was highest during the pre-monsoon season, and the child population is more vulnerable to non-carcinogenic risk than the adults. Findings of cancer risk identified that pre-monsoon groundwater samples from the Golaghat District pose the highest health risks in the upper Brahmaputra floodplains. The risk is highest in the southwest of the study area, followed by the south and then by the north.

Asenapine versus placebo for schizophrenia.

BACKGROUND: Schizophrenia is a highly prevalent and chronic disorder that comprises a wide range of symptomatology. Asenapine is a recently developed atypical antipsychotic that is approved by the US Food and Drug Administration (FDA) for the treatment of schizophrenia. OBJECTIVES: To determine the clinical effects of asenapine for adults with schizophrenia or other schizophrenia-like disorders by comparing it with placebo. SEARCH METHODS: We searched the Cochrane Schizophrenia Group's Trials Register (July 04, 2014) which is based on regular searches of MEDLINE, EMBASE, CINAHL, BIOSIS, AMED, PubMed, PsycINFO, and registries of clinical trials. There are no language, date, document type, or publication status limitation for inclusion of records into the register. We inspected references of all included studies for further relevant studies. SELECTION CRITERIA: Our review includes randomised controlled trials (RCTs) comparing asenapine with placebo in adults (however defined) with schizophrenia or related disorders, including schizophreniform disorder, schizoaffective disorder and delusional disorder, again, by any means of diagnosis. DATA COLLECTION AND ANALYSIS: We inspected citations from the searches and identified relevant abstracts, and extracted data from all included studies. For binary data we calculated risk ratio (RR) with 95% confidence intervals (CI), and for continuous data we calculated mean differences (MD). We used the GRADE approach to produce a 'Summary of findings' table which included our outcomes of interest, where possible. We used a fixed-effect model for our analyses. MAIN RESULTS: We obtained and scrutinised 41 potentially relevant records, and from these we could include only six trials (n = 1835). Five of the six trials had high risk of attrition bias and all trials were sponsored by pharmaceutical companies. Results showed a clinically important change in global state (1 RCT, n = 336, RR 0.81, 95% CI 0.68 to 0.97, low-quality evidence) and mental state (1 RCT, n = 336, RR 0.72, 95% CI 0.59 to 0.86, very low-quality evidence) at short-term amongst people receiving asenapine. People receiving asenapine demonstrated significant reductions in negative symptoms (1 RCT, n = 336, MD -1.10, 95% CI -2.29 to 0.09, very low-quality evidence) at short-term. Individuals receiving asenapine demonstrated significantly fewer incidents of serious adverse effects (1 RCT, n = 386, RR 0.29, 95% CI 0.14 to 0.63, very low-quality evidence) at medium-term. There was no clear difference in people discontinuing the study for any reason between asenapine and placebo at short-term (5 RCTs, n = 1046, RR 0.91, 95% CI 0.80 to 1.04, very low-quality evidence). No trial reported data for extrapyramidal symptoms or costs. AUTHORS' CONCLUSIONS: There is some, albeit preliminary, evidence that asenapine provides an improvement in positive, negative, and depressive symptoms, whilst minimising the risk of adverse effects. However due to the low-quality and limited quantity of evidence, it remains difficult to recommend the use of asenapine for people with schizophrenia. We identify a need for large-scale, longer-term, better-designed and conducted randomised controlled trials investigating the clinical effects and safety of asenapine.

Investigating the role of corrole as an excitation energy relay in light-induced processes in closely connected N,N'-bis(biphenyl-4-yl)aniline functionalized corrole donor-acceptor dyad.

A photosynthetic antenna-reaction center model, BBA-PFCor comprised of N,N'-bis(biphenyl-4-yl)aniline (BBA) covalently functionalized to bis(pentafluoro)corrole moiety has been prepared and the contribution of the BBA as the photoinduced energy transfer antenna was investigated. UV-visible studies have shown that integrating the electron-rich BBA chromophore into the corrole core has broadened the soret band of the corrole moiety with the absorption spanning from 300 to 700 nm. Electrochemical studies, in corroboration with the computational calculations, revealed that, BBA moiety can act as an electron reservoir and, in the excited state, it would transfer the excited energy to the corrole moiety in the dyad. Steady-state fluorescence studies have demonstrated that, upon photoexcitation of the BBA moiety of BBA-PFCor at 310 nm in solvents of varied polarity, the BBA emission centered at 400 nm was observed to be quenched, with the concomitant appearance of the corrole emission from 500 to 700 nm, indicating the happening of photoinduced energy transfer (PEnT) from 1BBA* to corrole moiety. Parallel control experiments involving the excitation of the corrole moiety at 410 nm did not result in the diminishing of the corrole emission, suggesting that the quenching of the BBA emission in BBA-PFCor is majorly due to intramolecular PEnT from 1BBA* to corrole moiety leading to the formation of singlet excited corrole, that is, 1BBA*-PFCor ➔ BBA-1PFCor*. The free energy changes of PEnT, ΔGEnT, were found to be thermodynamically feasible in all the solvents used for the study. Parallel time-resolved fluorescence studies were congruent with the steady-state fluorescence results and provided further evidence for the occurrence of ultrafast PEnT from 1BBA*➔corrole in the dyad with the rates of energy transfer (kEnT) of ~108 s-1.

Effectiveness of Digital Interventions for Deficit-Oriented and Asset-Oriented Psychological Outcomes in the Workplace: A Systematic Review and Narrative Synthesis.

BACKGROUND: Digital psychological interventions can target deficit-oriented and asset-oriented psychological outcomes in the workplace. This review examined: (a) the effectiveness of digital interventions for psychological well-being at work, (b) associations with workplace outcomes, and (c) associations between interventions' effectiveness and their theory-base. METHODS: six electronic databases were searched for randomised controlled trials (RCT) and quasi-experimental studies. The methodological quality of studies that used randomisation was conducted with the "Cochrane Collaboration's Risk of Bias" tool, while the "JBI Critical Appraisal Checklist" was used for non-randomised studies. Studies' theory-base was evaluated using an adaptation of the "theory coding scheme" (TSC). Due to heterogeneity, narrative synthesis was performed. RESULTS: 51 studies were included in a synthesis describing four clusters of digital interventions: (a) cognitive behavioural therapy, (b) stress-management interventions and workplace well-being promotion, (c) meditation training and mindfulness-based interventions, and (d) self-help interventions. Studies demonstrated a high risk of contamination effects and high attrition bias. Theory-informed interventions demonstrated greater effectiveness. Cognitive behavioural therapy demonstrated the most robust evidence for reducing depression symptoms among healthy employees. With the exception of the Headspace application, there was weak evidence for meditation training apps, while relaxation training was a key component of effective stress-management interventions.

Unveiling the Role of Hydrogen Bonding and g-Tensor in the Interaction of Ru-Bis-DMSO with Amino Acid Residue and Human Serum Albumin.

Density functional theory calculations have been carried out to observe the role of hydrogen bonding in hydrolysis and the coordination mechanism of three amino acid residues (histidine, cysteine, and alanine) with Ru-bis-DMSO complex via which the complex tends to interact with the HSA protein receptor. The interaction mechanism shows that ruthenium complexes prefer to bind protein receptor through cysteine and histidine residues rather than through alanine, which has been confirmed by DFT evaluated H-bonding and g-tensor analysis. The number of H-bonds plays a major role in stabilizing the intermediates and transition states involved in the Ru-bis-DMSO and amino acid residue interactions. Our theoretical g-tensor values are in good agreement with the available experimental results. Further QM/MM calculation on the Ru-bis-DMSO-HSA adducts reveals that the adduct is more stable when Ru gets coordinated with histidine imidazole rather than cysteine. These investigations helped us in understanding the type of amino acid residue responsible for binding the metal complex Ru-bis-DMSO with the carrier protein HSA.

Experiences and Perceptions of Nursing Staff Working With Long-Stay Patients in a High Secure Psychiatric Hospital Setting.

BACKGROUND AND OBJECTIVE: Forensic psychiatric nursing is a demanding nursing specialty that deals with a highly complex group of patients who are detained in restrictive environments, often for lengthy periods. There is little information about the daily experiences of these nurses. This study sought to explore the roles and relationships of forensic psychiatric nurses with long-stay patients in a high secure hospital in England. METHOD AND ANALYSIS: The study obtained data via three focus groups, and thematic analysis was carried out using NVIVO 10 software. RESULTS: Five prominent themes emerged: First, nurses elaborated on their roles with patients and the kinds of interactions they had with them. The next two themes explored the reasons why some patients are long-stay patients and the challenges nurses face while working with this group. The fourth theme was the impact of external support, such as the patient's families, on length of stay. The final theme covered the changes that the nurses observed in these patients and in themselves over time. CONCLUSION: It was noticeable that those interviewed were committed professionals, eager to provide an optimistic and hopeful environment for the patients to help them progress through "the system". The study presents a number of pertinent issues regarding long-stay patients that provide a basis for further research and to inform policy, educational reforms, and clinical practice.

Modulation of the coordination environment: a convenient approach to tailor magnetic anisotropy in seven coordinate Co(II) complexes.

The possibility of controlling magnetic anisotropy by tuning contribution of second order perturbation to spin-orbit coupling through modulation of the coordination environment is investigated. Subtle variation of the coordination environment triggers a remarkable deviation in the axial zero field splitting parameter of seven coordinate Co(II) complexes.