RESUMEN
Paranasal sinus development and pneumatisation variants are described, and rhinosinusitis and different patterns of inflammatory sinonasal diseases are reviewed. Other inflammatory sinonasal diseases, e.g., fungal sinusitis, mucocele, pyocele and sinonasal manifestations in systemic diseases, are briefly described. Computed tomography (CT) is the primary modality in diagnosing and mapping suspected inflammatory sinonasal disease. Magnetic resonance (MR) imaging is complementary to CT if fungal sinusitis, pyocele or malignancy are suspected.
Asunto(s)
Diagnóstico por Imagen , Cavidad Nasal/patología , Enfermedades de los Senos Paranasales/diagnóstico , Senos Paranasales/patología , Diagnóstico Diferencial , Humanos , Inflamación , Neoplasias de los Senos Paranasales/diagnóstico , Pólipos/diagnóstico , Sinusitis/diagnósticoRESUMEN
PURPOSE: To estimate the prevalence of adrenal expansive lesions in patients with bronchial carcinoma, and assess the relationships among adrenal masses, TNM classification, and histology of the bronchial carcinoma, and to reveal other signs of inoperability in these patients. MATERIAL AND METHODS: CT findings of the thorax and upper abdomen in 96 patients with bronchial carcinoma were reviewed. Brain- and upper abdominal metastases, together with TNM classification and histology of the bronchial carcinoma, was recorded. CT was performed with 10-mm slice thickness from the thorax aperture to the renal hilum under i.v. contrast medium injection. RESULTS: Eight adrenal expansive lesions (1.5-10 cm, mean 4.6 cm) were revealed in 6 of the 96 patients (6.3%). Two of these patients, classified as N0, had metastases in other organs; one had brain metastases and the other liver metastases. The bronchial carcinomas in the remaining 4 patients were classified as N3. Three of the patients had adenocarcinoma, one each of small-cell-, large-cell-, and unclassified bronchial carcinoma. Squamous cell carcinoma was most common in the total patient population, but no patient with adrenal masses showed this histologic type. CONCLUSION: The finding of adrenal expansive lesions in bronchial carcinoma has little clinical impact, because these patients usually show other signs of inoperability. Hence, the value of upper abdominal CT as a routine examination is questionable.
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Neoplasias de las Glándulas Suprarrenales/secundario , Carcinoma Broncogénico/secundario , Neoplasias Pulmonares/patología , Neoplasias de las Glándulas Suprarrenales/diagnóstico por imagen , Neoplasias de las Glándulas Suprarrenales/epidemiología , Neoplasias de las Glándulas Suprarrenales/patología , Anciano , Carcinoma Broncogénico/diagnóstico por imagen , Carcinoma Broncogénico/epidemiología , Carcinoma Broncogénico/patología , Femenino , Humanos , Masculino , Estadificación de Neoplasias , Prevalencia , Tomografía Computarizada por Rayos XRESUMEN
The incidence of bronchial carcinoma is increasing. The only curative treatment so far has been surgery. The correlation between preoperative CT thorax and peroperative/pathologic findings was evaluated in order to assess the value of preoperative CT thorax in patients with bronchial carcinoma. The thoracic CTs of 96 patients with bronchial carcinoma who were referred to our outpatient clinic from January 1992 to September 1994 were reviewed. Only 19 patients (20%) underwent surgery (seven pulmectomies, nine lobectomies, two wedge resections, one explorative thoracotomy). The remaining 77 patients received either irradiation, chemotherapy or other palliative treatment. The tumours were classified according to the TNM system (T = tumour, N = node, M = metastases) of UICC (Union Internationale Centre le Cancer). In 11 of the 19 patients who underwent surgery a correct TN classification was assessed at CT, while in four the T classification and in another four the N classification was changed after peroperative and pathologic assessment. CT showed a slight tendency to overestimate T classification. As for the N classification, overestimation and underestimation were equal. We conclude that CT thorax is valuable in the preoperative staging of bronchial carcinoma.
Asunto(s)
Carcinoma Broncogénico/diagnóstico por imagen , Neoplasias Pulmonares/diagnóstico por imagen , Cuidados Preoperatorios/métodos , Radiografía Torácica , Adulto , Anciano , Carcinoma Broncogénico/cirugía , Estudios de Evaluación como Asunto , Femenino , Humanos , Neoplasias Pulmonares/cirugía , Masculino , Persona de Mediana Edad , Neumonectomía/métodos , Tomografía Computarizada por Rayos XRESUMEN
PURPOSE: To measure and compare the size of the sphenoid sinuses in patients with cystic fibrosis (CF) to patients with inflammatory sinonasal disease, and to correlate the size with number of CF mutations in each patient. MATERIAL AND METHODS: Ninety-six CF patients aged 5-47 years (median 19 years) and 130 control patients aged 7-51 years (median 32 years) were examined using coronal CT of the paranasal sinuses. In each patient, the CT image with the largest coronal area of the sphenoid sinuses was scanned into a Macintosh computer with image processing and analysis software. Largest coronal area and largest circumference of the right and left sphenoid sinuses were automatically measured. Additionally, antero-posterior extension of the sphenoid sinuses was calculated from the lateral scanograms. CF patients were grouped according to number of confirmed mutations (CF-0, CF-1, or CF-2). RESULTS: CF patients generally had small sphenoid sinuses. The largest differences for all parameters were observed between the CF-2 and the control groups (p<0.0001). No CF-2 patient had pneumatization beyond the presphenoid. The CF-0 and CF-1 groups consisted of two populations, one overlapping the CF-2 group and another overlapping the control group. CONCLUSION: Hypoplasia of the sphenoid sinuses is a characteristic finding in CF patients. When pneumatization of the basisphenoid is present, the existing CF diagnosis should be questioned.
Asunto(s)
Fibrosis Quística/diagnóstico por imagen , Enfermedades de los Senos Paranasales/diagnóstico por imagen , Seno Esfenoidal/anomalías , Tomografía Computarizada por Rayos X , Adolescente , Adulto , Proteínas Sanguíneas/genética , Niño , Preescolar , Fibrosis Quística/complicaciones , Fibrosis Quística/genética , Regulador de Conductancia de Transmembrana de Fibrosis Quística , Diagnóstico Diferencial , Femenino , Humanos , Masculino , Persona de Mediana Edad , Mutación , Enfermedades de los Senos Paranasales/complicaciones , Enfermedades de los Senos Paranasales/genética , Seno Esfenoidal/diagnóstico por imagenRESUMEN
PURPOSE: To assess whether MR imaging can improve characterization of ethmomaxillary opacification diagnosed at CT in patients with cystic fibrosis (CF) in order to select patients that may benefit from functional endoscopic sinus surgery (FESS). MATERIAL AND METHODS: Sixty-two CF patients (26 females and 36 males) aged 4-50 years (median 20 years) with ethmomaxillary sinus disease at CT underwent MR examination of the paranasal sinuses (coronal T1 and STIR sequences). FESS had been performed in 28 of the patients prior to this study. MR signal intensities were interpreted as mucosal thickening or infectious material, according to a previous study. RESULTS: Three major maxillary sinus MR patterns could be distinguished: Air-filled, oval-shaped pus-filled, and streaky-shaped pus-filled sinus lumen. For air-filled maxillary sinuses with mucosal thickening, CT and MR imaging were diagnostically equivalent. Where CT showed homogeneous opacification of the maxillary sinuses, MR imaging differentiated between thickened mucosa and pus-filled areas. Patients who had undergone FESS most commonly had air-filled or streaky-shaped pus-filled maxillary sinus lumen. In non-operated patients oval-shaped pus-filled sinus lumen was most common and could occur without ethmoid disease. CONCLUSION: MR imaging of the paranasal sinuses can differentiate between infectious material and thickened mucosa and should be used to select CF patients with pus-filled areas that can be eradicated with FESS.
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Fibrosis Quística/complicaciones , Senos Etmoidales , Imagen por Resonancia Magnética , Seno Maxilar , Enfermedades de los Senos Paranasales/diagnóstico , Tomografía Computarizada por Rayos X , Adolescente , Adulto , Niño , Preescolar , Endoscopía , Femenino , Humanos , Masculino , Persona de Mediana Edad , Enfermedades de los Senos Paranasales/cirugía , Estudios ProspectivosRESUMEN
PURPOSE: To describe variations of paranasal sinus development in patients with cystic fibrosis (CF) and in non-CF patients examined for inflammatory sinonasal disease. We focused on anatomic variants that predispose to orbital and cerebral penetration during functional endoscopic sinus surgery (FESS), e.g. hypoplasia of the maxillary sinus and low ethmoid roof. MATERIAL AND METHODS: One hundred and sixteen CF patients (3-54 years, median 18) and 136 control patients (7-51 years, median 31) were examined with coronal CT of the paranasal sinuses. CF patients were grouped according to number of confirmed mutations: CF-2 (n=70), CF-1 (n=32), CF-0 (n=14). CT images were evaluated with respect to paranasal sinus development, pneumatization variants and bony variants. RESULTS: Frontal sinus aplasia and maxillary, ethmoid, and sphenoid sinus hypoplasia were markedly more frequent in CF-2 than in control patients. No CF-2 patient had pneumatization variants such as Haller cells or concha bullosa. Low ethmoid roof was seen in 30% of CF-2 children, but in no control children. CF-1 and CF-0 groups had prevalences of aplasia and hypoplasia intermediate to that of CF-2 and control patients. CONCLUSION: Genetically verified CF patients had less developed sinuses, lacked pneumatization variants, and more often had anatomic variants that predispose to complications during FESS. Normally developed sinuses and pneumatization variants in some genetically unverified CF patients (CF-1, CF-0) suggest that these patients may be erroneously diagnosed.
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Fibrosis Quística/diagnóstico por imagen , Senos Paranasales/diagnóstico por imagen , Tomografía Computarizada por Rayos X , Adulto , Niño , Fibrosis Quística/diagnóstico , Femenino , Seno Frontal/diagnóstico por imagen , Humanos , Masculino , Seno Maxilar/diagnóstico por imagen , Persona de Mediana Edad , Senos Paranasales/anomalías , Senos Paranasales/patología , Estudios Prospectivos , Seno Esfenoidal/diagnóstico por imagenRESUMEN
The purpose of this study was to develop a paranasal sinus CT scoring system that could be used as a diagnostic tool to discriminate cystic fibrosis (CF) patients from control patients examined for sinonasal disease. The model should include as few and easily applicable criteria as possible, supported by statistical analyses and clinical judgement. We used data from 116 CF and 136 control patients. The CF patients were grouped according to the number of confirmed CF mutations: genetically verified (CF-2), or based on sweat testing and clinical findings alone (CF-1, CF-0). Nine paranasal sinus CT criteria, including development, pneumatisation variants and inflammatory patterns, were evaluated. The final model included three criteria: (a) frontal and (b) sphenoid sinus development, and (c) absence of three pneumatisation variants. This model discriminated CF-2 from controls with overlap of summed scores in only 8 of 206 patients. When this model was applied in the CF-1 and CF-0 groups, two populations seemed to exist. A larger group with summed scores overlapping that of the CF-2 group and a smaller group with summed scores overlapping that of the control group. We conclude that this CT scoring system may support, as well as exclude, a CF diagnosis in cases of diagnostic uncertainty.
Asunto(s)
Fibrosis Quística/diagnóstico por imagen , Senos Paranasales/diagnóstico por imagen , Tomografía Computarizada por Rayos X , Adulto , Estudios de Casos y Controles , Fibrosis Quística/genética , Femenino , Seno Frontal/diagnóstico por imagen , Seno Frontal/crecimiento & desarrollo , Humanos , Modelos Logísticos , Masculino , Enfermedades de los Senos Paranasales/diagnóstico por imagen , Senos Paranasales/crecimiento & desarrollo , Estudios Prospectivos , Sinusitis/diagnóstico por imagen , Seno Esfenoidal/diagnóstico por imagen , Seno Esfenoidal/crecimiento & desarrolloRESUMEN
PURPOSE: To compare the findings at US, CT and contrast enema (CE) with the clinical, biochemical, and surgical findings in patients with suspected acute left-sided colonic diverticulitis (ALCD). MATERIAL AND METHODS: The study comprised 32 consecutive patients hospitalized with clinically diagnosed ALCD. During the first 3 days of hospitalization, they were examined by US and CT of the pelvis and abdomen, and CE. RESULTS: Of the 32 patients, 21 had ALCD according to the combined radiological, clinical, biochemical and surgical findings. Findings compatible with ALCD were verified by radiological examination alone in 12 patients (4 patients at US, 10 at CT, and 6 at CE). In 9 patients, only diverticula or tethering was found at either CE or CT, and the diagnoses were then supported by clinical and biochemical findings and clinical follow-up. The most common clinical symptoms and signs associated with ALCD were left lower quadrant pain, left-sided tenderness, and fever. Most patients showed elevations of the white blood-cell count, erythrocyte sedimentation rate, and C-reactive protein, but there was no statistical difference in the stages of severity of ALCD, or between ALCD and other abdominal disorders. CONCLUSION: Radiological examination is valuable in confirming the diagnosis of ALCD. CT was the radiological modality that best demonstrated ALCD and revealed complications (e.g. pericolic abscesses) during the course of the illness.
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Diverticulitis del Colon/diagnóstico , Enfermedad Aguda , Adulto , Anciano , Anciano de 80 o más Años , Sulfato de Bario , Diverticulitis del Colon/diagnóstico por imagen , Enema , Femenino , Humanos , Masculino , Persona de Mediana Edad , Sensibilidad y Especificidad , Tomografía Computarizada por Rayos X , UltrasonografíaRESUMEN
PURPOSE: To compare CT and MR findings of the paranasal sinuses in patients with cystic fibrosis (CF) with microbiology and histopathology. Further, to compare microbiology from the maxillary sinuses, nasopharynx and sputum. MATERIAL AND METHODS: CT and MR imaging of the paranasal sinuses were performed in 10 CF patients. Endoscopy and maxillary sinus aspirates were obtained (guided by the MR findings) and analyzed microbiologically and histologically. Samples from the nasopharynx and sputum were analyzed microbiologically. RESULTS: CT and MR were equal in displaying the extent of soft tissue masses, which at CT were homogeneous, while MR showed heterogeneous signals. MR images also demonstrated circumscribed areas with signal void at the STIR sequence with corresponding high to intermediate signal at the T1-weighted sequence. P. aeruginosa was frequently cultured from these areas which we named the "black hole sign". Maxillary sinus cultures revealed the same bacteria as nasopharynx and sputum cultures combined. CONCLUSION: MR images were superior to CT in differentiating soft tissue masses in the paranasal sinuses in CF patients. Bacteria with potential for specialized iron uptake mechanisms were present in areas with signal void at the STIR sequence. Our hypothesis is that the MR "black hole sign" can be explained by paramagnetic properties related to bacterial agents.