RESUMEN
BACKGROUND: Postoperative mortality associated with pancreaticoduodenectomy (PD) in high-volume hospitals is below 5%, yet morbidity rates range between 45% and 60%. Recent studies show a lower incidence of complications and postoperative pancreatic fistula (POPF) in pancreaticogastrostomy (PG). The primary objective was to assess the incidence and predictive factors for complications: POPF, post-pancreatectomy hemorrhage (PPH) and delayed gastric emptying (DGE) following the criteria of the ISGPS and Clavien-Dindo classifications. METHODS: A prospective observational study that included all patients who underwent PD between 2008 and 2016. PG was the surgical procedure of choice for PD reconstruction. RESULTS: Two hundred forty-nine patients underwent surgery with intention of performing a PD. The feasibility of PG was 90.5%. One hundred and six (53%) patients had complications, 36 (18%) were severe (Clavien-Dindo grade ≥III). Death within 90 postoperative days was 4%. DGE was the most frequent complication (22.5%), followed by PPH (21%). The clinical POPF rate was 15% (6% Clavien-Dindo grade ≥III). The primary risk factors associated with complications were age >70 years (1.9 [1-3.55]), being male (1.89 [1; 3.6]) and soft pancreatic texture (3.38 [1.5; 7.37]). CONCLUSIONS: In this paper, we report a feasibility study for PG (90.5%). The primary risk factors associated with complications were age >70 years, being male and soft pancreatic texture. Soft pancreatic texture is also associated with the development and severity of POPF.
Asunto(s)
Gastrostomía/mortalidad , Páncreas/cirugía , Fístula Pancreática/etiología , Pancreaticoduodenectomía/efectos adversos , Complicaciones Posoperatorias/epidemiología , Factores de Edad , Anciano , Estudios de Factibilidad , Femenino , Humanos , Incidencia , Masculino , Persona de Mediana Edad , Morbilidad , Páncreas/patología , Complicaciones Posoperatorias/mortalidad , Hemorragia Posoperatoria/epidemiología , Valor Predictivo de las Pruebas , Estudios Prospectivos , Factores de Riesgo , Factores SexualesRESUMEN
Introducción: La mortalidad postoperatoria asociada a la duodenopancreatectomía (DP) en centros de alto volumen es inferior al 5%, sin embargo, las tasas de morbilidad oscilan entre el 45% y el 60%. Estudios recientes muestran una menor incidencia de complicaciones y fístula pancreática postoperatoria (POPF) con el uso de la pancreaticogastrostomía (PG). El objetivo de nuestro estudio es evaluar la incidencia y los factores predictivos de las complicaciones: POPF, hemorragia pospancreatectomía y retraso del vaciamiento gástrico según los criterios de las clasificaciones ISGPS y Clavien-Dindo. Material y métodos: Estudio prospectivo observacional en el que se incluyeron todos los pacientes sometidos a DP entre 2008 y 2016. La PG fue la técnica de elección en la reconstrucción de la DP. Resultados. Doscientos cuarenta y nueve pacientes se sometieron a cirugía con la intención de realizar una DP. La viabilidad de PG fue del 90,5%. Ciento seis (53%) pacientes tuvieron complicaciones, 36 (18%) fueron graves (grado Clavien-Dindo ≥ III). La mortalidad a 90 días fue del 4%. El retraso del vaciamiento gástrico fue la complicación más frecuente (22,5%), seguida de la hemorragia pospancreatectomía (21%). La tasa clínica de POPF fue del 15% (6% grado Clavien-Dindo ≥ III). Los principales factores de riesgo asociados a las complicaciones fueron la edad > 70 años (1,9 [1-3,55]), el sexo masculino (1,89 [1; 3,6]) y la textura blanda del páncreas (3,38 [1,5; 7,37]). Conclusiones: En nuestra experiencia la factibilidad de la PG fue del 90,5%. Los principales factores de riesgo asociados a las complicaciones fueron la edad > 70 años, el sexo masculino y la textura blanda del páncreas. La textura blanda del páncreas también está asociada al desarrollo y la gravedad de la POPF
Background: Postoperative mortality associated with pancreaticoduodenectomy (PD) in high-volume hospitals is below 5%, yet morbidity rates range between 45% and 60%. Recent studies show a lower incidence of complications and postoperative pancreatic fistula (POPF) in pancreaticogastrostomy (PG). The primary objective was to assess the incidence and predictive factors for complications: POPF, post-pancreatectomy hemorrhage (PPH) and delayed gastric emptying (DGE) following the criteria of the ISGPS and Clavien-Dindo classifications. Methods: A prospective observational study that included all patients who underwent PD between 2008 and 2016. PG was the surgical procedure of choice for PD reconstruction. Results: Two hundred forty-nine patients underwent surgery with intention of performing a PD. The feasibility of PG was 90.5%. One hundred and six (53%) patients had complications, 36 (18%) were severe (Clavien-Dindo grade ≥ III). Death within 90 postoperative days was 4%. DGE was the most frequent complication (22.5%), followed by PPH (21%). The clinical POPF rate was 15% (6% Clavien-Dindo grade ≥ III). The primary risk factors associated with complications were age > 70 years (1.9 [1-3.55]), being male (1.89 [1; 3.6]) and soft pancreatic texture (3.38 [1.5; 7.37]). Conclusions: In this paper, we report a feasibility study for PG (90.5%). The primary risk factors associated with complications were age > 70 years, being male and soft pancreatic texture. Soft pancreatic texture is also associated with the development and severity of POPF