RESUMEN
OBJECTIVE: Indication-specific optimum field-of-views (FOVs) have been assessed for CBCT scans of impacted maxillary canines and mandibular third molars, as 40∅ × 35 mm and 35∅ × 35 mm, respectively. The objective was to investigate possible changes in absorbed organs and effective doses, for these two imaging indications, performing CBCT examinations with optimum FOV sizes instead of commonly used FOVs. Additionally, radiation exposure-induced cancer risk was calculated for both imaging indications with optimum FOVs. METHODS: An adult female head phantom (ATOM 702-D, CIRS, Norfolk, VA, USA) was scanned using Planmeca Viso G7 CBCT-device (Planmeca, Helsinki, Finland). Scanning factors, different FOV sizes, dose-area product (DAP) values and anatomical FOV locations were used for Monte Carlo PCXMC-simulation and ImpactMC software. In the PCXMC- simulation, 10-year-old child and 30-year-old adult phantoms were used to estimating effective and absorbed organ doses. RESULTS: The effective dose varied from 58 µSv to 284 µSv for impacted maxillary canines, and from 38 µSv to 122 µSv for mandibular third molars, the lowest dose value for each corresponding to optimum FOV. Effective dose reduction between the optimum FOV and the smallest common FOV of 50∅ × 50 mm, maintaining other scanning factors constant, was 33% for impacted maxillary canines, and 45% for mandibular third molars. At all examinations, the highest absorbed organ doses were in salivary glands or in oral mucosa. CONCLUSIONS: Optimum FOVs, 40∅ × 35 mm for impacted maxillary canine and 35∅ × 35 mm for mandibular third molar, could decrease effective doses received by young patients, and improve radiation safety in these common CBCT imaging procedures.
Asunto(s)
Exposición a la Radiación , Tomografía Computarizada de Haz Cónico Espiral , Diente Impactado , Niño , Adulto , Humanos , Femenino , Dosis de Radiación , Tercer Molar/diagnóstico por imagen , Tomografía Computarizada de Haz Cónico/métodos , Fantasmas de Imagen , Diente Impactado/diagnóstico por imagenRESUMEN
OBJECTIVE: We examined whether dental panoramic radiography (PAN) can be used to identify the clinical stage of eruption of mandibular third molars at the time of radiological examination. MATERIALS AND METHODS: Cross-sectional data included records from clinical oral examination and PANs of university students. In the retrospective analysis of 345 mandibular third molars in 189 participants (20% men, 80% women; mean age 20.7 years; standard deviation [SD] ± 0.6), clinical stages of eruption were compared with their radiographic depth in bone, inclination, and root development. Statistics included χ2, Mann-Whitney U tests, and logistic regression. RESULTS: Significant (p < 0.001) predictor variables for assessing the clinical stage of eruption were radiographic depth in bone and inclination. All teeth radiologically at a depth of the cementoenamel (CE) junction of the neighbouring second molar or deeper were clinically unerupted. Above the CE junction, 80% of vertical and 97% of distoangular teeth were connected to the oral cavity, and 82% of mesioangular and 69% of horizontal teeth were clinically unerupted. CONCLUSION: All teeth below or at the CE junction are clinically unerupted. Above the CE junction, stage of eruption should be assessed together with the inclination, but horizontally inclined teeth are recommended to be verified clinically.
Asunto(s)
Mandíbula , Tercer Molar , Radiografía Panorámica , Erupción Dental , Humanos , Tercer Molar/diagnóstico por imagen , Erupción Dental/fisiología , Masculino , Femenino , Estudios Transversales , Mandíbula/diagnóstico por imagen , Adulto Joven , Estudios Retrospectivos , AdultoRESUMEN
OBJECTIVES: The aim of this study was to update the much-cited knowledge, published over half a century ago, of the age of eruption of the third molar in the Finnish population. METHODS: The study followed a retrospective and cross-sectional protocol and included 710 digital panoramic radiographs of patients (49.3% men, 50.7% women) aged 15-23 years visiting the public oral health care services of the City of Helsinki in 2015. Age and sex of the subjects were recorded. The radiographs were examined for inclination of the third molars in both jaws and vertically located teeth were further classified into four stages of eruption: (A) in bone, (B) alveolar emergence, (C) gingival emergence, and (D) complete emergence. Statistics included chi-squared, Mann-Whitney U, and median tests. RESULTS: Of altogether 2502 third molars, 53.0% (n = 1325) were in vertical position. The median age of gingival emergence (stage C) of the third molar varied between 19.8 and 20.8 years, and the median age of reaching the occlusal level (stage D) between 20.8 and 21.8 years depending on sex and the jaw. CONCLUSION: The median ages for the third molar to pierce the gum were lower than reported over half a century ago.
Asunto(s)
Tercer Molar , Erupción Dental , Adulto , Estudios Transversales , Femenino , Humanos , Masculino , Mandíbula , Tercer Molar/diagnóstico por imagen , Radiografía Panorámica , Estudios Retrospectivos , Adulto JovenRESUMEN
OBJECTIVE: The purpose of this study was to determine, if a dental panoramic tomograph (DPT) is appropriate for every young adult due to third molars. MATERIALS AND METHODS: The study sample consisted of 217 university students (20% men and 80% women; mean age 20.7 years; SD ± 0.6 years) and included a questionnaire about symptoms caused by third molars, clinical oral examination of third molars, and a DPT. Subjects were divided into the following groups: subjects with a clinical indication for a DPT and subjects without such indication. The DPTs were then examined for findings regarding third molars. RESULTS: Clinical indication for a DPT was observed in 64% of the subjects. Radiography revealed an additional 1.4% of the subjects with ≥1 radiographic signs of disease in relation to their third molars. Also, an additional 27% of the subjects had ≥1 other radiographic findings in relation to third molars that may have affected the clinical decision making. CONCLUSIONS: In our study population, clinically undetectable pathology cannot be considered as an indication for a DPT. However, if prevailing clinical practice supports preventive removals and detecting or monitoring of unerupted third molars, a referral to DPT can be considered as good clinical practice.
Asunto(s)
Tercer Molar , Diente Impactado , Adulto , Diagnóstico Bucal , Femenino , Humanos , Masculino , Mandíbula , Tercer Molar/diagnóstico por imagen , Radiografía Panorámica , Encuestas y Cuestionarios , Tomografía Computarizada por Rayos X , Diente Impactado/diagnóstico por imagen , Adulto JovenRESUMEN
BACKGROUND: Cone-beam Computed Tomography (CBCT) is widely used for preoperative 3D imaging of lower third molars. Hence, for this imaging indication, the present study aimed to define the minimum field-of-view (FOV) size and its optimum placement, to decrease radiation exposure, and highlight the need of computer-assisted FOV centering technique for dental CBCT devices. To facilitate proper placement of image field, lower second molar was chosen as reference. METHODS: The retrospective study included 50 CBCT-scans of 46 patients with mean age of 34 years. Based on the lower second molar, a three-dimensional coordinate was formed and the location of mandibular canal (MC) and the dimensions and locations of the lower third molars, and possible associated pathological findings were assessed. Accordingly, the FOV size and position for third-molar imaging were optimized, while ensuring encompassment of all relevant structures. RESULTS: The minimum cylindrical volume, covering lower third molars and MC, was 32.1 (diameter) × 31.6 (height) mm, placed in relation to the second molar crown, top 2.2 mm above cusp tips, anterior edge 6.7 mm in the front of the most distal point of the crown, and lingual edge 7.9 mm on the medial side of the lingual wall. CONCLUSIONS: The optimized FOV for lower third molars was smaller than common standard small FOVs. We recommend using FOV volume 3.5∅ × 3.5 cm for third molars without associated pathology. Accurate FOV protocols are essential for development of new CBCT-devices with computer-assisted and indication-specific FOV placement.
Asunto(s)
Tomografía Computarizada de Haz Cónico Espiral , Diente Impactado , Adulto , Tomografía Computarizada de Haz Cónico , Humanos , Mandíbula/diagnóstico por imagen , Canal Mandibular , Tercer Molar/diagnóstico por imagen , Estudios Retrospectivos , Diente Impactado/diagnóstico por imagenRESUMEN
OBJECTIVES: In children and adolescents, cone-beam computed tomography (CBCT) is frequently used for localization of unerupted or impacted teeth in the anterior maxilla. CBCT causes a higher radiation dose than conventional intraoral and panoramic imaging. The objective was to analyze the location of impacted canines in a three-dimensional coordinate and thereby optimize the CBCT field-of-view (FOV), for radiation dose reduction. MATERIALS AND METHODS: Location of 50 impacted maxillary canines of children under 17 years was retrospectively evaluated from CBCT scans. The minimum and maximum distances of any part of the right- and left-side canines to three anatomic reference planes were measured to assess the adequate size and position of a cylindrical image volume. RESULTS: A cylinder sized 39.0 (diameter)×33.2 (height) mm, with its top situated 13.8 mm above the hard palate, its medial edge 8.4 mm across the midline, and anterior edge 2.5 mm in front of the labial surface of maxillary central incisors fitted all the analyzed canines. CONCLUSIONS: In this sample, the FOV required for imaging maxillary impacted canines was smaller than the smallest FOV offered by common CBCT devices. We encourage development of indication-specific CBCT imaging programs and aids to facilitate optimum patient positioning. CLINICAL RELEVANCE: An impacted maxillary canine is a common dental problem and a frequent indication for 3D imaging particularly in growing individuals. This article focuses on the optimization of CBCT of impacted canines. Our recommendation of a reduced FOV promotes radiation safety.
Asunto(s)
Resorción Radicular , Diente Impactado , Adolescente , Niño , Tomografía Computarizada de Haz Cónico , Diente Canino , Humanos , Imagenología Tridimensional , Maxilar , Estudios RetrospectivosRESUMEN
OBJECTIVE: The Radiation and Nuclear Safety Authority in Finland has paid attention to the large numbers of dental panoramic tomographs (DPTs), particularly in 7-12-year-old children. The majority of these radiographs are taken for orthodontic reasons. Because of the high radiosensitivity of children, the size of the irradiated field should be carefully chosen to yield the necessary diagnostic information at the lowest possible dose. The purpose of the present study was, therefore, to assess the outcome of DPTs within this age group in terms of type and location of pathological findings. It was also hypothesized that DPTs of orthodontic patients rarely display unrestored caries. MATERIALS AND METHODS: Four hundred and forty-one DPTs, taken of 7-12-year-old children in 2010-2014, were randomly sampled. The 413 of them (94%) that had been taken for orthodontic reasons were analysed. RESULTS: All pathologic findings were restricted to the tooth-bearing area and there was no pathology in the bone structure or any incidental findings in the region of temporomandibular joint. Unlike hypothesized, 27% of the orthodontic DPTs showed caries in deciduous teeth and 16% in permanent teeth. A sub-sample of 229 DPTs, analysed for developmental dental and occlusal problems, most commonly displayed crowding (50%), positional anomalies and local problems with tooth eruption (32%), as well as hyperodontia (15%). CONCLUSION: Inclusion of only the actual area of interest in the image field should be considered case-specifically as a means to reduce the radiation dose.
Asunto(s)
Maloclusión/diagnóstico por imagen , Radiografía Panorámica/estadística & datos numéricos , Enfermedades Dentales/diagnóstico por imagen , Anodoncia/diagnóstico por imagen , Niño , Caries Dental/diagnóstico por imagen , Femenino , Finlandia , Humanos , Masculino , Cóndilo Mandibular/diagnóstico por imagen , Enfermedades Periapicales/diagnóstico por imagen , Dosis de Radiación , Radiografía Dental Digital/estadística & datos numéricos , Anomalías Dentarias/diagnóstico por imagen , Erupción Dental , Erupción Ectópica de Dientes/diagnóstico por imagen , Diente Primario/diagnóstico por imagen , Diente Supernumerario/diagnóstico por imagenRESUMEN
OBJECTIVES: Numbers of dental panoramic tomographs (DPTs) and lateral cephalometric radiographs (LCRs) outweigh other radiographic examinations in 7- to 12-year-old Finns. Orthodontists and general practitioners (GPs) involved in orthodontics hold therefore the highest responsibility of the exposure of children to ionising radiation with its risks. Against this background, lack of reports on the quality of orthodontic radiography is surprising. The purpose of our study was to shed some light and draw the awareness of the orthodontic community on the subject by analyzing the quality of orthodontic radiography in Oral Healthcare Department of City of Helsinki, in the capital of Finland. MATERIALS AND METHODS: We analyzed randomly selected 241 patient files with DPTs and 118 patient files with LCRs of 7- to 12-year-olds for the indications of radiography, quality of referrals, status of interpretation, and number of failed radiographs. RESULTS: The majority of DPTs (95%) and all LCRs had been ordered for orthodontic reasons. Of the DPTs, 60% were ordered by GPs, and of the LCRs, 64% by orthodontists. The referrals were adequate for most DPTs (78%) and LCRs (73%), orthodontists being responsible for the majority of inadequate referrals. Of the DPTs, 80% had been interpreted. Of the LCRs, 65% lacked interpretation, but 67% had been analysed cephalometrically. Failed radiographs, leading to repeated exposure, were found in 2-3%. CONCLUSION: The quality assessment revealed that orthodontic radiography may not completely fulfill the criteria of good practice. Our results stress further need of continuing education in radiation protection among both orthodontists and GPs involved in orthodontics.
Asunto(s)
Ortodoncia/normas , Garantía de la Calidad de Atención de Salud , Radiografía Panorámica/normas , Tomografía Computarizada por Rayos X/normas , Distribución por Edad , Cefalometría/métodos , Cefalometría/normas , Niño , Escolaridad , Femenino , Finlandia , Humanos , Interpretación de Imagen Asistida por Computador/métodos , Masculino , Ortodoncia/educación , Protección Radiológica , Radiografía Panorámica/métodos , Distribución Aleatoria , Derivación y Consulta/normas , Tomografía Computarizada por Rayos X/métodosRESUMEN
OBJECTIVES: Children are especially vulnerable to harmful effects of ionizing radiation. Cutting down the dimensions of the X-ray beam is the most effective way to reduce the patient dose. We evaluated the appropriateness of field-size in the most frequent radiographs, dental panoramic tomographs (DPTs) and lateral cephalometric radiographs (LCRs) among 7- to 12-year-olds. MATERIALS AND METHODS: The image field-size of 241 DPTs and 118 LCRs was analysed. The image field was considered appropriate when it did not include anatomic structures beyond the area of clinical interest. The image field was compared with factors such as the age of the patient, the radiographic equipment used and the programme selected. Moreover, we assessed the use of thyroid shield in LCR. RESULTS: The field-size was too large in 70% of the DPTs horizontally and in 96% vertically. None of the DPTs were segmented. Every LCR showed appropriate limitation anteriorly, but the image field was too large in 54% posteriorly, in 86% superiorly, and in 76% inferiorly. A thyroid shield had been used in only 71% of cases. CONCLUSION: Most DPTs and LCRs had been performed sub-optimally. An abundancy of DPTs had been taken using an adult programme, and the field-size had not been sufficiently adjusted in LCRs, possibly for technical reasons. To facilitate adherence to radiological best practice the equipment used for DPTs and LCRs should facilitate the adjustment of field-size in both the vertical and horizontal planes. In addition, those involved in taking radiographs should maintain their skills through regular update courses.
Asunto(s)
Radiografía Dental Digital/normas , Radiografía Panorámica/normas , Adulto , Factores de Edad , Cefalometría/métodos , Cefalometría/normas , Niño , Humanos , Tratamientos Conservadores del Órgano/instrumentación , Tratamientos Conservadores del Órgano/métodos , Tratamientos Conservadores del Órgano/normas , Dosis de Radiación , Protección Radiológica/normas , Radiografía Dental Digital/instrumentación , Radiografía Dental Digital/métodos , Radiografía Panorámica/instrumentación , Radiografía Panorámica/métodos , Glándula Tiroides/efectos de la radiación , Tomografía Computarizada por Rayos X/instrumentación , Tomografía Computarizada por Rayos X/métodos , Tomografía Computarizada por Rayos X/normasRESUMEN
OBJECTIVES: Doses induced by individual dental examinations are low. However, dental radiography accounts for nearly one third of the total number of radiological examinations in the European Union. Therefore, special attention is needed with regard to radiation protection. In order to lower patient doses, the staff performing dental examinations must have competence in imaging as well as in radiation protection issues. This paper presents a systematic review about the core competencies needed by the healthcare staff in performing digital dental radiological imaging quality assurance. MATERIALS AND METHODS: The following databases were searched: Pubmed, Cinahl, Pro Quest and IEEXplore digital library. Also volumes of some dental imaging journals and doctoral theses of the Finnish universities educating dentists were searched. The search was performed using both MeSH terms and keywords using the option 'search all text'. The original keywords were: dental imaging, digital, x-ray, panoramic, quality, assurance, competence, competency, skills, knowledge, radiographer, radiologist technician, dentist, oral hygienist, radiation protection and their Finnish synonyms. RESULTS: Core competencies needed by the healthcare staff performing digital dental radiological imaging quality assurance described in the selected studies were: management of dental imaging equipment, competence in image quality and factors associated with it, dose optimization and quality assurance. CONCLUSIONS: In the future there will be higher doses in dental imaging due to increasing use of CBCT and digital imaging. The staff performing dental imaging must have competence in dental imaging quality assurance issues found in this review. They also have to practice ethical radiation safety culture in clinical practice.
Asunto(s)
Garantía de la Calidad de Atención de Salud , Intensificación de Imagen Radiográfica , Radiografía Dental , Finlandia , HumanosRESUMEN
Cone beam computed tomography (CBCT) is a diverse 3D x-ray imaging technique that has gained significant popularity in dental radiology in the last two decades. CBCT overcomes the limitations of traditional two-dimensional dental imaging and enables accurate depiction of multiplanar details of maxillofacial bony structures and surrounding soft tissues. In this review article, we provide an updated status on dental CBCT imaging and summarise the technical features of currently used CBCT scanner models, extending to recent developments in scanner technology, clinical aspects, and regulatory perspectives on dose optimisation, dosimetry, and diagnostic reference levels. We also consider the outlook of potential techniques along with issues that should be resolved in providing clinically more effective CBCT examinations that are optimised for the benefit of the patient.
Asunto(s)
Tomografía Computarizada de Haz Cónico , Radiometría , Humanos , Imagenología Tridimensional , Dosis de Radiación , Rayos XRESUMEN
Bisphosphonates have established their role as medical therapy for pediatric osteogenesis imperfecta (OI) patients. Since bisphosphonates have also been shown to delay tooth development in animal models, we aimed to assess whether the medication has a similar effect on children with OI. In this cross-sectional study, bisphosphonate-treated OI patients of whom dental panoramic tomograph was taken between 3 and 16years of age formed the study group. The patients, 22 in total, had been treated with pamidronate, zoledronic acid or risedronate for at least one year before the radiography. Developmental stage of the permanent teeth, resorption of the deciduous teeth, and number of the erupted permanent teeth were radiographically assessed in the left mandibular quadrant. Dental panoramic tomographs of 50 OI patients, naïve to bisphosphonates, and of 50 healthy individuals of the same age were used as controls. The dental development was statistically significantly accelerated in the OI group naïve to bisphosphonates showing median advancement of dental age by 0.63years from chronological age and median increase in the number of erupted teeth by 0.31 as compared to Finnish norms. Bisphosphonate-treated OI patients displayed, however, age-appropriate dental development. The OI patients not treated with bisphosphonates also showed statistically significantly faster resorption of the deciduous teeth than the treated ones, and displayed an altered interrelationship between the resorption stage of an individual primary tooth and the developmental stage of the succedaneous permanent tooth, unlike the OI patients treated with bisphosphonate. No correlation between either cumulative bisphosphonate dose or between treatment length and any measured component of the dental development was found. To conclude, OI itself was found to lead to advanced dental development. Bisphosphonate treatment had a delaying effect in all the three aspects studied, resulting in a rate of dental development indistinguishable from normal.
Asunto(s)
Difosfonatos/uso terapéutico , Odontogénesis , Osteogénesis Imperfecta/tratamiento farmacológico , Adolescente , Resorción Ósea/complicaciones , Resorción Ósea/diagnóstico por imagen , Resorción Ósea/tratamiento farmacológico , Niño , Preescolar , Difosfonatos/farmacología , Femenino , Humanos , Masculino , Odontogénesis/efectos de los fármacos , Osteogénesis Imperfecta/diagnóstico por imagen , Osteogénesis Imperfecta/patología , Factores de Tiempo , Diente Primario/diagnóstico por imagen , Diente Primario/efectos de los fármacos , Diente Primario/patologíaRESUMEN
OBJECTIVES: Dental radiography may involve situations where the patient is known to be pregnant or the pregnancy is noticed after the X-ray procedure. In such cases, the radiation dose to the foetus, though low, needs to be estimated. Uniform and widely used guidance on dental X-ray procedures during pregnancy are presently lacking, the usefulness of lead shields is unclear and practices vary. METHODS: Upper estimates of radiation doses to the foetus and breasts of the pregnant patient were estimated with an anthropomorphic female phantom in intraoral, panoramic, cephalometric and CBCT dental modalities with and without lead shields. RESULTS: The upper estimates of foetal doses varied from 0.009 to 6.9 µGy, and doses at the breast level varied from 0.602 to 75.4 µGy. With lead shields, the foetal doses varied from 0.005 to 2.1 µGy, and breast doses varied from 0.002 to 10.4 µGy. CONCLUSIONS: The foetal dose levels without lead shielding were <1% of the annual dose limit of 1 mSv for a member of the public. Albeit the relative shielding effect, the exposure-induced increase in the risk of breast cancer death for the pregnant patient (based on the breast dose only) and the exposure-induced increase in the risk of childhood cancer death for the unborn child are minimal, and therefore, need for foetal and breast lead shielding was considered irrelevant. Most important is that pregnancy is never a reason to avoid or to postpone a clinically justified dental radiographic examination.
Asunto(s)
Mama/efectos de la radiación , Feto/efectos de la radiación , Dosis de Radiación , Protección Radiológica/instrumentación , Radiografía Dental/métodos , Cefalometría/métodos , Tomografía Computarizada de Haz Cónico/métodos , Femenino , Humanos , Concentración Máxima Admisible , Fantasmas de Imagen , Embarazo/efectos de la radiación , Radiografía de Mordida Lateral/métodos , Radiografía Panorámica/métodosRESUMEN
OBJECTIVES:: Dental panoramic tomography is the most frequent examination among 7-12-year olds, according to the Radiation Safety and Nuclear Authority of Finland. At those ages, dental panoramic tomographs (DPTs) are mostly obtained for orthodontic reasons. Children's dose reduction by trimming the field size to the area of interest is important because of their high radiosensitivity. Yet, the majority of DPTs in this age group are still taken by using an adult programme and never by using a segmented programme. The purpose of the present study was to raise the awareness of dental staff with respect to children's radiation safety, to increase the application of segmented and child DPT programmes by further educating the whole dental team and to evaluate the outcome of the educational intervention. METHODS:: A five-step intervention programme, focusing on DPT field limitation possibilities, was carried out in community-based dental care as a part of mandatory continuing education in radiation protection. Application of segmented and child DPT programmes was thereafter prospectively followed up during a 1-year period and compared with our similar data from 2010 using a logistic regression analysis. RESULTS:: Application of the child programme increased by 9% and the segmented programme by 2%, reaching statistical significance (odds ratios 1.68; 95% confidence interval 1.23-2.30; p-value < 0.001). The number of repeated exposures remained at an acceptable level. The segmented DPTs were most frequently taken from the maxillary lateral incisor-canine area. CONCLUSIONS:: The educational intervention resulted in improvement of radiological practice in respect to radiation safety of children during dental panoramic tomography. Segmented and child DPT programmes can be applied successfully in dental practice for children.
RESUMEN
Pathology in the craniocervical junction is a serious complication of osteogenesis imperfecta (OI). Our aim was to analyze the prevalence and natural course of craniocervical junction anomalies in patients with OI during growth. In a one-center retrospective study, we analyzed lateral skull radiographs and midsagittal magnetic resonance images of 76 patients with either type I, III, or IV OI. The material included longitudinal series of 31 patients. In total, 150 patient images taken at ages 0 to 39 years were analyzed and compared with age-matched control data. Craniocervical anomalies were observed in 37% of patients and in all OI types studied. Of the three types of anomalies, basilar invagination was seen in 13%, basilar impression in 15%, and platybasia in 29% of the patients. From those with an abnormal finding, 44% displayed more than one type of anomaly. At a group level, we found no evidence of progression of craniocervical junction pathology with age. We provide longitudinal and cross-sectional data on craniocervical junction dimensions in growing patients with OI and, based on those, suggest a radiological management strategy for diagnosis of cranial base pathology. A higher risk of having any of the pathological conditions was associated with a lower height Z-score. Careful follow-up of cranial base anomalies particularly in subjects with OI and severe growth failure is warranted.
Asunto(s)
Osteogénesis Imperfecta/patología , Base del Cráneo/patología , Adolescente , Adulto , Estudios de Casos y Controles , Niño , Preescolar , Femenino , Humanos , Lactante , Recién Nacido , Estudios Longitudinales , Masculino , Osteogénesis Imperfecta/fisiopatología , Estudios RetrospectivosRESUMEN
Biodegradable polymers, mainly derivates of alpha-hydroxy acids, are widely used today in oral- and maxillofacial surgery, orthopedics, and other fields of surgery. These biomaterials are well tolerated by living tissue and fracture fixation devices made of polylactic or polyglycolic acid are clinically widely used today. Still, there are some problems in application of biodegradable polymers. Abacterial inflammatory reactions have been noticed after the clinical introduction of these devices. Both swelling and pain at the site of implantation have also been reported. The etiology of this inflammatory reaction is still unknown, despite the numerous studies. Therefore, the aim of the present study was to further characterize this inflammatory reaction in detail, by electronmicroscopy. We prepared a mixture of epsilon-caprolactone-lactide copolymer and tricalcium phosphate and placed it in the dermis in 12 sheep. Follow-up times were 9, 14, 24, and 52 weeks. We found that the mixture caused a mild inflammatory reaction. There were no signs of cell damage. Fibroblasts, macrophages, and eosinophils were found adjacent to the copolymer. The mixture is easy to handle and can be moulded into different shapes in room temperature. The results encourage us to continue our studies to develop a filling material for bone defects.