Detalles de la búsqueda
1.
Active-Site Tryptophan, the Target of Antineoplastic C-Terminal Binding Protein Inhibitors, Mediates Inhibitor Disruption of CtBP Oligomerization and Transcription Coregulatory Activities.
Mol Pharmacol;
96(1): 99-108, 2019 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-31036695
2.
A Combined Offline and Online Algorithm for Real-Time and Long-Term Classification of Sheep Behaviour: Novel Approach for Precision Livestock Farming.
Sensors (Basel);
19(14)2019 Jul 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-31330790
3.
Feature Selection and Comparison of Machine Learning Algorithms in Classification of Grazing and Rumination Behaviour in Sheep.
Sensors (Basel);
18(10)2018 Oct 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-30347653
4.
Characterization of PKACα enzyme kinetics and inhibition in an HPLC assay with a chromophoric substrate.
Anal Biochem;
532: 45-52, 2017 09 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-28595966
5.
Design, synthesis, and in vitro evaluation of a fluorescently labeled irreversible inhibitor of the catalytic subunit of cAMP-dependent protein kinase (PKACα).
Org Biomol Chem;
14(20): 4576-81, 2016 May 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-27126273
6.
Design, synthesis, and biological evaluation of substrate-competitive inhibitors of C-terminal Binding Protein (CtBP).
Bioorg Med Chem;
24(12): 2707-15, 2016 06 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-27156192
7.
Preparation and evaluation of deconstruction analogues of 7-deoxykalafungin as AKT kinase inhibitors.
Bioorg Med Chem Lett;
24(1): 271-4, 2014 Jan 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-24321345
8.
Flavone-based analogues inspired by the natural product simocyclinone D8 as DNA gyrase inhibitors.
Bioorg Med Chem Lett;
23(21): 5874-7, 2013 Nov 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-24060488
9.
Combined Targeting of NAD Biosynthesis and the NAD-dependent Transcription Factor C-terminal Binding Protein as a Promising Novel Therapy for Pancreatic Cancer.
Cancer Res Commun;
3(10): 2003-2013, 2023 10 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-37707363
10.
Merging cultures and disciplines to create a drug discovery ecosystem at Virginia commonwealth university: Medicinal chemistry, structural biology, molecular and behavioral pharmacology and computational chemistry.
SLAS Discov;
28(6): 255-269, 2023 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-36863508
11.
Inhibition of human topoisomerases I and II by simocyclinone D8.
J Nat Prod;
75(8): 1485-9, 2012 Aug 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-22867097
12.
Anti-proliferative effects of simocyclinone D8 (SD8), a novel catalytic inhibitor of topoisomerase II.
Invest New Drugs;
28(1): 20-5, 2010 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-19132295
13.
Automated detection of lameness in sheep using machine learning approaches: novel insights into behavioural differences among lame and non-lame sheep.
R Soc Open Sci;
7(1): 190824, 2020 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-32218931
14.
In vivo and in vitro patterns of the activity of simocyclinone D8, an angucyclinone antibiotic from Streptomyces antibioticus.
Antimicrob Agents Chemother;
53(5): 2110-9, 2009 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-19273673
15.
CtBP-a targetable dependency for tumor-initiating cell activity and metastasis in pancreatic adenocarcinoma.
Oncogenesis;
8(10): 55, 2019 Oct 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-31586042
16.
Enantiospecific synthesis and cytotoxicity of 7-(4-methoxyphenyl)-6-phenyl-2,3,8,8a-tetrahydroindolizin-5(1H)-one enantiomers.
Bioorg Med Chem;
16(8): 4367-77, 2008 Apr 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-18343127
17.
Kinetics and inhibition studies of the L205R mutant of cAMP-dependent protein kinase involved in Cushing's syndrome.
FEBS Open Bio;
8(4): 606-613, 2018 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-29632813
18.
An intestinal stem cell niche in Apc mutated neoplasia targetable by CtBP inhibition.
Oncotarget;
9(65): 32408-32418, 2018 Aug 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-30197752
19.
Evaluation of sampling frequency, window size and sensor position for classification of sheep behaviour.
R Soc Open Sci;
5(2): 171442, 2018 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-29515862
20.
Incidence of atrial fibrillation post-cavotricuspid isthmus ablation in patients with typical atrial flutter: left-atrial size as an independent predictor of atrial fibrillation recurrence.
J Cardiovasc Electrophysiol;
18(8): 799-802, 2007 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-17593230