1.
Bioorg Med Chem Lett
; 21(1): 137-40, 2011 Jan 01.
Artículo
en Inglés
| MEDLINE
| ID: mdl-21129964
RESUMEN
High-throughput screening of 3.87 million compounds delivered a novel series of non-steroidal GR antagonists. Subsequent rounds of optimisation allowed progression from a non-selective ligand with a poor ADMET profile to an orally bioavailable, selective, stable, glucocorticoid receptor antagonist.