A survey on the use of gentamicin in infective endocarditis.

US and European guidelines recommend a daily divided gentamicin dose (3 mg/kg in two or three equally divided doses) for the treatment of infective endocarditis caused by staphylococci or enterococci, but once-daily dosing (3 mg/kg/day) is recommended for streptococcal endocarditis. However, studies have recommended the use of higher doses of gentamicin (4 or ≥5 mg/kg/day) administered once-daily. A survey was conducted in France by mailing a questionnaire to the 595 members of the French Infectious Disease Society regarding their gentamicin prescription patterns in infective endocarditis, focusing on the dosing regimen. The survey was answered by 137 physicians (23%). The proportions of physicians following guideline-based regimens were similar for each organism (30.9%, 38.8%, and 39.4% for staphylococci, enterococci, and streptococci, respectively [p=0.26]). In contrast, the proportions of physicians following literature-based regimens were significantly different for each organism (59.6%, 42.5%, and 27.7% for staphylococci, enterococci, and streptococci, respectively [p<0.001]). The number of years practicing and the type of practice (university vs. non-university hospital) did not influence the gentamicin dose or regimen. Although adherence to published guidelines for gentamicin administration in patients with infective endocarditis was poor, a large proportion of physicians who did not follow those guidelines used literature-based regimens.

[Disseminated arterial occlusions revealing bilateral venous thrombosis with paradoxical embolisms]. / Occlusions artérielles disséminées révélant une thrombose veineuse bilatérale avec embolies paradoxales.

Paradoxical embolism is a diagnosis of exclusion. Clinical triad associates deep venous thrombosis with or without pulmonary embolism, arterial embolism, and intracardiac communication with right-to-left shunt. The intracardiac communication is generally related to a patent foramen ovale (PFO). We report a 75-year-old patient, who presented with bilateral deep venous thrombosis of the legs, complicated by massive pulmonary embolism and paradoxical embolisms through a PFO. This resulted in cerebral, mesenteric, splenic and bilateral kidney infarctions. A promptly initiated anticoagulant treatment allowed a favourable outcome.

Benefit of CT scanning for assessing pulmonary disease in the immunodepressed patient.

INTRODUCTION: Management of pulmonary disease in immunodepressed patients requires a clear diagnostic and therapeutic strategy and multidisciplinary cooperation. DISCUSSION: The diagnostic approach should take into account the type of immunodepression, the clinical picture, the radiological signs and symptoms, and the microbiological, cytological and even histological examination of the pulmonary or extrapulmonary specimens. The high-resolution CT scan plays a central role and makes it possible to prioritize the diagnostic possibilities. CONCLUSION: The analysis of the literature shows three important points: the chest X-ray has low diagnostic value; the CT scan of the chest can reveal lesions that cannot be detected on a standard chest X-ray; the CT scan is helpful for early detection and monitoring of invasive pulmonary aspergillosis.

[An erysipelas revealing infection by Dermatobia hominis]. / Un érysipèle révélant une infection àDermatobia hominis.

Myiases are parasitic infections by larvae of flies. The development of intercontinental travels increases the incidence of tropical myiasis in travellers. We report the case of a patient, having recently stayed in Peru, presenting with an inflammatory plate of the right shoulder, covered with small papules with a hole inside. The initial aspect seemed like an erysipelas. Considering the resistance to the antibiotic treatment, the diagnosis of myiase was suspected. The local application of petroleum jelly allowed the exit of nine larvae of Dermatobia hominis and a fast good outcome. In human beings, the number of larvae usually infecting the same individual varies from one to four. This observation is original because of the number of implied larvae, which explains the intensity and the extent of the local inflammatory signs, which first looked like erysipelas. This diagnosis must be suspected in cases of erysipelas resistant to antibiotics in patients back from an endemic area.