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Background and Objectives: Non-alcoholic fatty liver disease (NAFLD) is highly prevalent worldwide. It progresses from simple steatosis to non-alcoholic steatohepatitis (NASH). Fibrosis is often present during NAFLD progression; however, factors determining which subjects develop NASH or fibrosis are unclear. Insulin-like growth factor binding proteins (IGFBPs) are a family of secreted proteins involved in senescence and scarring, mainly synthetized in the liver. Here, we aimed to study the association of IGFBPs and their induced senescence with the progression of NAFLD and liver fibrosis. Materials and Methods: A total of 16-week-old male C57BL/6 mice weighing 23 ± 3 g were fed either methionine/choline-deficient (MCD) or control diet for 2, 8, or 12 weeks. Blood and liver samples were collected, and a histological assessment of NAFLD and fibrosis was performed. Fat contents were measured. Cellular senescence was evaluated in the liver. IGFBP levels were assessed in the liver and serum. Data were expressed as mean ± SD and analyzed by a one-way ANOVA followed by Tukey's test. Lineal regression models were applied for NAFLD and fibrosis progression. p < 0.05 was considered significant. Results: IGFBP-1 and -2 were increased in serum during NAFLD. IGFBP-7 was significantly increased in the serum in NASH compared with the controls. Senescence increased in NAFLD. Serum and liver IGFBP-7 as well as SA-ß-gal activity increased as fibrosis progressed. Both IGFBP-7 and cellular senescence were significantly higher during NAFLD and fibrosis in MCD-fed mice. Conclusions: IGFBP-1, -2, and -7, through their consequent senescence, have a role in the progression of NAFLD and its associated fibrosis, being a plausible determinant in the progression from steatosis to NASH.
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Enfermedad del Hígado Graso no Alcohólico , Masculino , Humanos , Ratones , Animales , Enfermedad del Hígado Graso no Alcohólico/complicaciones , Proteína 1 de Unión a Factor de Crecimiento Similar a la Insulina , Péptidos Similares a la Insulina , Ratones Endogámicos C57BL , Hígado , Cirrosis Hepática/complicaciones , Colina/metabolismo , Colina/farmacología , Senescencia Celular , Modelos Animales de EnfermedadRESUMEN
The success of service members' transition from military to civilian life is an ongoing concern for their personal well-being, for their families, and for our communities. There is a need for interventions to promote improved social integration. This one-arm feasibility study examined the ease of use, satisfaction, and desire for social interaction in response to the Warrior Spirit/Mission Homefront (WS/MH) self-guided dialogue program, which facilitates conversations among small groups of fellow service members through gamified activities (N = 299 service members). Through the use of a specially designed card deck and game, service members answer questions written to elicit responses about themselves and their military service. WS/MH dialogs and discussions model how persons can speak about deployment and military service with others. These discussions facilitate the articulation of experiences across a range of difficulties - according to persons' own comfort threshold - in order to cultivate language that can translate to conversations with which to reconnect with family and community. The activity demonstrated high satisfaction, and yielded the anticipated increases in positive emotion (p = .013) and desire for social interaction (p = .001) in pre-post comparisons. Satisfaction was associated with change in positive emotions and change in willingness to talk with others. This provides initial evidence of good feasibility and satisfaction with WS/MH, as a promising and readily scalable tool in the ongoing efforts to improve service members' and Veterans' social interactions, belongingness and emotional well-being as they come home.
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OBJECTIVES: While financial deprivation, social isolation, and low emotional intelligence (EI) have been separately identified as important predictors of mental illness, no research has assessed the contribution of these factors together in understanding early markers of severe psychological distress. This information can have key implications for the development of comprehensive interventions and psychological treatment programmes. This study investigated the shared and unique contribution of financial well-being, social support, and trait EI on different types of psychological distress. DESIGN: A total of 309 patients seeking psychological treatment at an outpatient mental health clinic in the United States provided consent to participate in this study. Patients responded to online questionnaires corresponding to symptomatology, demographic characteristics, and psychometric assessments. METHODS: Hierarchical linear regressions identified the common and unique role of each set of variables in predicting nine different symptom clusters of psychological distress. RESULTS: Financial well-being, social support, and trait EI were negatively related to the majority of symptom clusters, together explaining between 20% and 53% of the variance. Whereas financial well-being and social support uniquely captured a significant amount of the variance in all outcomes, trait EI, most notably the well-being and self-control dimensions, captured the most. CONCLUSIONS: The results highlight the importance of all factors in understanding variations in mental health among help-seeking urban individuals. Furthermore, the results identify well-being and self-control as emotional facets to consider in therapeutic programmes in as much as to mitigate the risk of severe psychological distress within this population. PRACTITIONER POINTS: Together, financial well-being, social support, and trait emotional intelligence (EI) can help prevent psychological distress in help-seeking urban individuals. Perceived social support and social contact differentially contributed to improved symptoms of psychological distress. Studies should examine the impact of targeting well-being and self-control in psychological treatment. The correlational nature of this study highlights the need to replicate findings via experimental or longitudinal designs.
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Inteligencia Emocional/fisiología , Salud Mental/economía , Salud Mental/normas , Distrés Psicológico , Apoyo Social , Adulto , Anciano , Femenino , Humanos , Masculino , Persona de Mediana Edad , Factores de Riesgo , Adulto JovenRESUMEN
Background: Cannabis and tobacco use are significant public health concerns among young adults, with concurrent (in the same time period) and simultaneous (at the same time so the effects overlap) use of both substances on the rise. Few studies have examined these behaviors among college students. Objective: We examined the prevalence of concurrent and simultaneous cannabis and cigarette (combustible or electronic) use among a sample of college students and characterized the psychosocial predictors of concurrent and simultaneous use compared to using cannabis alone. Methods: Data on past-3 months cannabis and cigarette use were collected on 1352 college students who were past-year cannabis and alcohol users yielding four groups: cannabis-only users (n = 686), concurrent cannabis and cigarette users (CCAC; n = 235), simultaneous cannabis and cigarette users (SCAC; n = 293), and non-recent users of either substance (n = 138). Multinomial logistic regression analyses were utilized to predict group membership. Results: Relative to the cannabis-only group, White, compared to Non-White students, males, compared to females, frequent, compared to infrequent, alcohol users, including those who used alcohol simultaneously with cigarettes, and illicit drug users were more likely to belong to the CCAC or SCAC group. Conclusions: Findings suggest the need for unique intervention efforts to prevent onset or reduce co-use among male and White students as well as illicit drug users and frequent alcohol users.
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Consumo de Bebidas Alcohólicas/epidemiología , Fumar Cigarrillos/epidemiología , Fumar Marihuana/epidemiología , Estudiantes/estadística & datos numéricos , Trastornos Relacionados con Sustancias/epidemiología , Universidades/estadística & datos numéricos , Adolescente , Comorbilidad , Etnicidad/estadística & datos numéricos , Femenino , Humanos , Masculino , Prevalencia , Estudios Prospectivos , Factores Sexuales , Estados Unidos/epidemiología , Adulto JovenRESUMEN
Objective: The high prevalence of alcohol/substance use among individuals with psychiatric disorders elucidates the import of investigations into associations between types and severity of psychiatric symptoms and alcohol/substance use. This study examined the likelihood of alcohol use disorder and substance use among individuals with varying depression and anxiety symptoms and severity thereof. Differences across sex were also examined.Methods: Using data from the National Epidemiological Survey on Alcohol and Related Conditions, a nationally representative sample from the United States (N = 43,093), separate logistic regressions estimated the odds of lifetime alcohol use disorder, depressant, stimulant, hallucinogen, and comorbid substance use across psychiatric symptom clusters controlling for age, sex, and ethnicity.Results: Symptom severity was a more important correlate of alcohol use disorder and substance use than symptom type. In particular, the odds ratio of lifetime use of depressants, stimulants, hallucinogens, or any combination of these types of substances were higher for individuals with either severe depression or severe depression and anxiety relative to a healthy control. Moreover, the odds of having a diagnosis of lifetime alcohol use disorder were higher for individuals with severe symptoms of depression, anxiety, and both depression and anxiety, relative to healthy individuals. Those with mild depression were more likely to engage in substance use than individuals with anxiety alone. Patterns of association among males and females were highly consistent.Conclusions: The findings highlight an enhanced risk of alcohol and substance use among individuals with severe depression and/or anxiety symptoms above what is seen among individuals with less severe symptomatology. In addition, this study shows a unique risk posed by the presence of depression on substance use. This study offers a framework for future studies to examine the causal mechanisms explaining the connection between psychiatric symptoms and alcohol/substance use.
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Alcoholismo/epidemiología , Trastornos de Ansiedad/epidemiología , Trastorno Depresivo/epidemiología , Trastornos Relacionados con Sustancias/epidemiología , Adulto , Comorbilidad , Femenino , Humanos , Masculino , Persona de Mediana Edad , Riesgo , Índice de Severidad de la Enfermedad , Estados Unidos/epidemiologíaRESUMEN
OBJECTIVES: In this study, we examined the association of ethnic and American identity with depression and anxiety and whether this relation is mediated by Bicultural Identity Integration. METHOD: We recruited racial and ethnic minority immigrant college students (N = 766, Mage = 19.89, 60.4% women, 19.8% Black, 34.2% Hispanic, 36.6% Asian, and 9.4% other) who completed a series of self-report questionnaires. Participants answered questions relating to their ethnic and American identities, the degree to which these identities are compatible (i.e., Bicultural Identity Integration; BII), and presence of depression and anxiety symptoms. We conducted hierarchical linear regressions to test the direct relations between ethnic and American identity, BII, and depression and anxiety symptoms. We used bootstrapping to test the mediating role of BII. RESULTS: Our analyses showed significant negative associations between American identity and BII cultural harmony with depression symptoms. BII cultural harmony was also negatively associated with anxiety symptoms. BII cultural harmony mediated the relations between American identity and both depression and anxiety symptoms. CONCLUSIONS: Perceived compatibility between ethnic and American identities is seemingly important for understanding the relation between national identity and mental health among racial and ethnic minority immigrants. However, longitudinal research designs would help assess causality in the relations found herein. (PsycINFO Database Record (c) 2019 APA, all rights reserved).
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Emigrantes e Inmigrantes/psicología , Etnicidad/psicología , Salud Mental , Grupos Minoritarios/psicología , Adolescente , Adulto , Negro o Afroamericano/psicología , Depresión/psicología , Femenino , Hispánicos o Latinos/psicología , Humanos , Masculino , Estudiantes/psicología , Encuestas y Cuestionarios , Estados Unidos , Adulto JovenRESUMEN
Non-alcoholic fatty liver disease is a highly prevalent condition worldwide that increases the risk to develop liver fibrosis, cirrhosis, and hepatocellular carcinoma. Thus, it is imperative to develop novel diagnostic tools that together with liver biopsy help to differentiate mild and advanced degrees of steatosis. Ex-vivo liver samples were collected from mice fed a methionine-choline deficient diet for two or eight weeks, and from a control group. The degree of hepatic steatosis was histologically evaluated, and fat content was assessed by Oil-Red O staining. On the other hand, fluorescence spectroscopy was used for the assessment of the steatosis progression. Fluorescence spectra were recorded at excitation wavelengths of 330, 365, 385, 405, and 415 nm by establishing surface contact of the fiber optic probe with the liver specimens. A multi-variate statistical approach based on principal component analysis followed by quadratic discriminant analysis was applied to spectral data to obtain classifiers able to distinguish mild and moderate stages of steatosis at the different excitation wavelengths. Receiver Operating Characteristic (ROC) curves were computed to compare classifier's performances for each one of the five excitation wavelengths and steatosis stages. Optimal sensitivity and specificity were calculated from the corresponding ROC curves using the Youden index. Intensity in the endogenous fluorescence spectra at the given wavelengths progressively increased according to the time of exposure to diet. The area under the curve of the spectra was able to discriminate control liver samples from those with steatosis and differentiate among the time of exposure to the diet for most of the used excitation wavelengths. High specificities and sensitivities were obtained for every case; however, fluorescence spectra obtained by exciting with 405 nm yielded the best results distinguishing between the mentioned classes with a total classification error of 1.5% and optimal sensitivities and specificities better than 98.6% and 99.3%, respectively.
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Tejido Adiposo/diagnóstico por imagen , Deficiencia de Colina/diagnóstico por imagen , Hígado/diagnóstico por imagen , Metionina/deficiencia , Enfermedad del Hígado Graso no Alcohólico/diagnóstico por imagen , Espectrometría de Fluorescencia/métodos , Tejido Adiposo/química , Tejido Adiposo/patología , Animales , Área Bajo la Curva , Deficiencia de Colina/metabolismo , Deficiencia de Colina/patología , Análisis Discriminante , Modelos Animales de Enfermedad , Progresión de la Enfermedad , Humanos , Hígado/química , Hígado/patología , Masculino , Ratones , Ratones Endogámicos C57BL , Enfermedad del Hígado Graso no Alcohólico/metabolismo , Enfermedad del Hígado Graso no Alcohólico/patología , Análisis de Componente Principal , Curva ROC , Sensibilidad y Especificidad , Índice de Severidad de la Enfermedad , Espectrometría de Fluorescencia/normasRESUMEN
To promote a better understanding of the impact of refugee resettlement work on refugee resettlement workers, this study examined the prevalence rates of deleterious mental health and occupational outcomes, such as secondary traumatic stress and burnout, among a sample of 210 refugee resettlement workers at six refugee resettlement agencies in the United States. The study also explored coping mechanisms used by service providers to manage work-related stress and the influence of such strategies and emotional intelligence on secondary traumatic stress and burnout. Our findings show that certain coping strategies, including self-distraction, humor, venting, substance use, behavioral disengagement, and self-blame, were strongly related to deleterious outcomes, ßs = .18 to .38, ps = .023 to < .001. Emotional intelligence was a negative correlate for all outcomes, ßs = -.25 to -.30, ps < .001, above and beyond the effects of trauma, coping styles, job, and demographic characteristics. These findings have potential implications for clinical training and organizational policy regarding refugee mental health.
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Adaptación Psicológica , Agotamiento Profesional/epidemiología , Desgaste por Empatía/epidemiología , Inteligencia Emocional , Adulto , Agotamiento Profesional/psicología , Desgaste por Empatía/psicología , Emigración e Inmigración , Femenino , Humanos , Masculino , Prevalencia , Factores de Riesgo , Encuestas y Cuestionarios , Estados Unidos/epidemiología , Adulto JovenRESUMEN
OBJECTIVE: Black individuals are disproportionately affected by tobacco-related illnesses. Although tobacco use is often initiated in adolescence and risk factors thereof originate from multiple domains of influence, investigations of tobacco use among Black adolescents seldom consider these multiple domains simultaneously. These examinations are needed to identify the influence of co-occurring risk factors on tobacco use and inform comprehensive tobacco prevention and treatment programs. Our study sought to identify the combined influence of factors across multiple domains on tobacco use among Black adolescents. METHOD: Participants were Non-Hispanic Black (N = 1,801) adolescent (age 12-17 years) respondents from Wave 1 of the Population Assessment of Tobacco and Health study. Latent class analysis identified unique response patterns to items assessing risk of tobacco use across sociocultural, environmental, psychological, and behavioral (e.g., alcohol use) domains. Subsequent logistic regressions compared the odds of ever and current tobacco use between the classes. RESULTS: Four latent classes were identified. According to item response probabilities they were named: Low Risk (LR: 36.5%), Low Psychological (LP: 19.0 %), High Psychological (HP: 30.4%) and High Social, Psychological, and Behavioral (HSPB: 14.1%) risk. The odds of ever and current tobacco use were highest among adolescents in the HSPB latent class compared to the other latent classes (odds ratio: 6.5 to 42.1). CONCLUSIONS: Adolescents with the highest odds of tobacco use endorse multiple risks including feeling distress, perceiving tobacco as beneficial for handling stress, and using substances, and may prioritize the management of negative emotions over perceived health consequences from tobacco use. Multi-level interventions that incorporate the development of coping strategies for effectively handling negative affect may prove highly effective in preventing tobacco use among Black adolescents.
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Different cellular mechanisms influence steatotic liver disease (SLD) progression. The influence of different levels of steatogenic inputs has not been studied in hepatocytes and hepatic stellate cells (HSCs). METHODS: HepG2 hepatocytes and LX-2 HSCs were cultured in mild (MS) and severe (SS) steatogenic conditions. TGF-ß stimulation was also tested for HSCs in control (T) and steatogenic conditions (MS-T and SS-T). Steatosis was stained with Oil Red, and the proliferation was assayed via WST-8 reduction, apoptosis via flow cytometry, and senescence via SA-ß-galactosidase activity. RESULTS: Regarding hepatocytes, steatosis progressively increased; proliferation was lower in MS and SS; and the viability of both conditions significantly decreased at 72 h. Apoptosis increased in MS at 72 h, while it decreased in SS. Senescence increased in MS and diminished in SS. Regarding HSCs, the SS and SS-T groups showed no proliferation, and the viability was reduced in MS at 72 h and in SS and SS-T. The LX-2 cells showed increased apoptosis in SS and SS-T at 24 h, and in MS and MS-T at 72 h. Senescence decreased in MS, SS, and SS-T. CONCLUSIONS: Lipid overload induces differential effects depending on the cell type, the steatogenic input level, and the exposure time. Hepatocytes are resilient to mild steatosis but susceptible to high lipotoxicity. HSCs are sensitive to lipid overload, undergoing apoptosis and lowering senescence and proliferation. Collectively, these data may help explain the development of steatosis and fibrosis in SLD.
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Hígado Graso , Células Estrelladas Hepáticas , Humanos , Células Estrelladas Hepáticas/metabolismo , Hepatocitos/metabolismo , Hígado Graso/metabolismo , Proliferación Celular , Hiperplasia/metabolismo , Apoptosis , LípidosRESUMEN
Given the COVID-19 pandemic's disproportionate impact on Hispanic individuals in the United States, research examining modifiable psychosocial correlates of COVID-19 preventive behaviors in this population is warranted. Prior research highlights health literacy and health consciousness as integral for the establishment of health-promoting behaviors. Notwithstanding, very little research has validated theory-based measures for health literacy and health consciousness and no research has investigated their relative importance in explaining behaviors that prevent COVID-19 illness among Hispanic individuals. This information is necessary for informing behavioral interventions seeking to promote the well-being of Hispanic people during the current pandemic and in future ones. This study provides a psychometric evaluation of the General Health Literacy Scale (GHLS) and the Health Consciousness Scale (HCS) and further examines their association with conventional COVID-19 preventive behaviors. Confirmatory factor analyses evaluated the psychometric properties of GHLS and HCS. Four separate hierarchical linear regressions, followed by dominance analyses, estimated the relative importance of health literacy and health consciousness on COVID-19 preventive behaviors, adjusting for sociodemographic characteristics. Both GHLS and HCS achieved adequate psychometric criteria, and holding constant sociodemographic characteristics, positively related to COVID-19 preventive behaviors. Although both health literacy and health consciousness were more important than sociodemographic characteristics in explaining COVID-19 preventive behaviors, health consciousness was most important, exceeding the explanatory power of health literacy in all regressions. COVID-19 public health campaigns that seek to raise health awareness among Hispanic people might prove more effective than campaigns that only seek to improve their health literacy.
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COVID-19 , Alfabetización en Salud , Humanos , Adulto , Estados Unidos , COVID-19/prevención & control , Pandemias/prevención & control , Estado de Conciencia , Psicometría , Hispánicos o Latinos , Encuestas y CuestionariosRESUMEN
Few studies have focused on the impact of body image disturbance on mental health among African immigrant women, particularly as it pertains to female genital mutilation/cutting (FGM/C). This study surveyed 231 West African immigrant women in New York city with and without FGM/C experience and investigated each group's level of body image disturbance and its relation to mental health (i.e., well-being, psychological distress, and PTSD). Body image concerns of FGM/C-experienced women were centered on genital disturbance, whereas the concerns of non-FGM/C women were mostly weight-related. Regression analysis revealed that greater genital image disturbance in FGM/C-experienced group and body image disturbance in non-FGM/C group significantly related to lower well-being and higher psychological distress and PTSD, with stronger relationships appearing in FGM/C-experienced group. This study brings to the fore West African immigrant women's body-related concerns and its potential impact to mental health in the context of acculturation, and suggests the importance of culturally informed interventions for African immigrant women who face body image concerns.
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Circuncisión Femenina , Emigrantes e Inmigrantes , Femenino , Humanos , Imagen Corporal , Circuncisión Femenina/psicología , Salud Mental , Encuestas y CuestionariosRESUMEN
INTRODUCTION: Racial/ethnic discrimination and ethnic identity, the affiliation and connection to one's ethnic group, are important for understanding alcohol, tobacco, and drug use disorders (AUD, TUD, DUD, respectively) among Hispanic/Latin American individuals. Although discrimination is a well-recognized risk factor, the role of ethnic identity is less understood. Moreover, no study has examined which of these factors is more important for informing AUD, TUD, and DUD. This information is necessary for creating effective prevention and treatment programs tailored for Hispanic/Latin American people. Herein we examined the role and relative importance of racial/ethnic discrimination and Hispanic ethnic identity on past year AUD, TUD, and DUD. METHODS: Hispanic/Latin American participants of the National Epidemiologic Survey on Alcohol and Related Conditions-III constituted the sample for this cross-sectional secondary data analysis. Participants (N = 7037) were 39.93 years old on average (SD = 15.32). More than half were female (56.1 %) and had family incomes below the median household income in the United States (58.7 %). Most had national origins in North America (79.3 %), including US dependent territories and Mexico. Confirmatory factor analysis (CFA) verified the psychometric properties of the discrimination and Hispanic ethnic identity measures. Logistic regressions, supplemented with dominance analysis, estimated the role and relative contribution of discrimination and Hispanic ethnic identity on the probability of past year AUD, TUD, and DUD. RESULTS: The CFAs yielded adequate convergent validity and reliability for each construct. More racial/ethnic discrimination and a higher Hispanic ethnic identity related to a higher and lower probability of AUD, TUD, and DUD, respectively. The magnitude of the association between Hispanic ethnic identity and the probability of TUD exceeded that of racial/ethnic discrimination, but the converse was the case for AUD and DUD. CONCLUSIONS: Prevention and treatment programs for TUD that highlight the value of having a strong sense of self as a member of a Hispanic ethnic group, and that encourage the individual to explore their Hispanic ancestry may prove effective among Hispanic/Latin American individuals, particularly those who have experienced racial/ethnic discrimination. Programs for AUD and DUD tailored for Hispanic Latin/American adults should also incorporate coping strategies to address experiences with racial/ethnic discrimination.
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Alcoholismo , Trastornos Relacionados con Sustancias , Tabaquismo , Adulto , Femenino , Humanos , Masculino , Estudios Transversales , Hispánicos o Latinos , Reproducibilidad de los Resultados , Trastornos Relacionados con Sustancias/etnología , Tabaquismo/etnología , Alcoholismo/etnología , Estados UnidosRESUMEN
INTRODUCTION: Tobacco use remains a primary cause of health disparities between Black and White Americans. Current approaches have not improved tobacco-related racial health disparities. This study aimed to identify differences in factors associated with tobacco product use among Black and White adolescents. METHODS: This cross-sectional design used data from Wave One (2013-2014) of the Population Assessment of Tobacco and Health Study. Adolescents aged 12-17 years who identified as non-Hispanic Black or African American (n=1800) or non-Hispanic White (n=6495) were included. Primary outcomes were the ever use and current use of any tobacco products. Sociocultural, household environment, psychological, and behavioral factors were included. Logistic regressions, stratified by race, were used to determine significance. Dominance analysis was used to rank significant factors by their level of importance. RESULTS: Although there were many Black-White commonalities, there were also important differences. Black adolescents in the Northeast were more likely to have ever used tobacco compared to those in the South (OR=0.6; 95% CI: 0.6-0.7, p<0.001) and Midwest (OR=0.6; 95% CI: 0.5-0.7, p<0.001). White adolescents in the Northeast were less likely to use tobacco products than in other regions. Peer influences (OR=1.9; 95% CI: 1.1-3.2, p<0.05) were uniquely associated with ever use among Black adolescents. Access to tobacco in the home (OR=2.0; 95% CI: 1.4-3.0, p<0.001) and thinking that tobacco use would help reduce stress (OR=1.3; 95% CI: 1.1-1.6, p<0.01) were uniquely associated with current use among Black adolescents. CONCLUSIONS: There are significant Black-White differences in the factors associated with tobacco use. Factors uniquely associated with Black adolescent tobacco use should be considered in developing strategies to prevent adolescent tobacco use in Black communities.
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Drawing from the rejection-identification and rejection-disidentification models (RIM/RDIM), we proposed a model of the association between racial/ethnic discrimination and symptoms of depression and anxiety among racially/ethnically minoritized immigrant individuals. We hypothesized that this relation would be sequentially mediated by discordance in ethnic and national cultural identities and bicultural identity conflict. First- and second-generation racially/ethnically minoritized immigrant college students in the United States (N = 877) completed a battery of self-report measures. We tested two models, one each for depression and anxiety symptoms. Racial/ethnic discrimination was positively associated with discordance in ethnic and national identity, which was positively associated with bicultural identity conflict. These were in turn, positively related to depression and anxiety symptoms. Immigrant individuals who experience racial/ethnic discrimination may perceive higher conflict between their ethnic and national identities. This conflict can in turn be associated with poor mental health. Clinicians should address cultural identity processes when working with racial/ethnic minoritized immigrant clients.
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Salud Mental , Racismo , Humanos , Estados Unidos/epidemiología , Etnicidad/psicología , Racismo/psicología , Autoinforme , Estudiantes/psicología , Identificación SocialRESUMEN
BACKGROUND: Cocaine overdose death rates among Black people are higher than that of any other racial/ethnic group, attributable to synthetic opioids in the cocaine supply. Understanding the most effective psychostimulant use treatment interventions for Black people is a high priority. While some interventions have proven effective for the general population, their comparative effectiveness among Black people remains unknown. To address this gap, our NIDA-funded Clinical Trials Network (CTN) study (0125), will use Integrative Data Analysis (IDA) to examine treatment effectiveness across 9 CTN studies. This manuscript describes the study protocol for CTN-0125. METHODS: Of the 59 completed randomized clinical trials in the CTN with available datasets, nine met our inclusion criteria: 1) behavioral intervention, 2) targeted cocaine use or use disorder, 3) included sub-samples of participants who self-identified as Black and 4) included outcome measures of cocaine and psychostimulant use and consequences. We aim to 1) estimate scale scores of cocaine use severity while considering study-level measurement non-invariance, 2) compare the effectiveness of psychosocial treatments for psychostimulant use, and 3) explore individual (e.g., concomitant opioid use, age, sex, employment, pre-treatment psychiatric status) and study-level moderators (e.g., attendance/retention) to evaluate subgroup differences in treatment effectiveness. CONCLUSION: The NIDA CTN provides a unique collection of studies that can offer insight into what interventions are most efficacious for Black people. Findings from our CTN-0125 study have the potential to substantially inform treatment approaches specifically designed for Black people who use psychostimulants.
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Trastornos Relacionados con Cocaína , Cocaína , Intervención Psicosocial , Humanos , Población Negra , Trastornos Relacionados con Cocaína/terapia , Resultado del Tratamiento , Ensayos Clínicos Controlados Aleatorios como AsuntoRESUMEN
Importance: The protective ethnic density effect hypothesis, which suggests that minoritized individuals who grow up in neighborhoods with a high proportion of ethnoracial minoritized groups are protected from the effects of perceived discrimination, has not been examined among individuals at clinical high risk of psychosis (CHR-P). This level of examination may help identify intervention targets for preventing psychosis among high-risk individuals. Objective: To examine the association between area-level ethnic density during childhood, perceived discrimination, and psychosis risk outcomes among ethnoracial minoritized individuals with CHR-P. Design, Setting, and Participants: Data were collected as part of the North American Prodrome Longitudinal Study-2 (NAPLS 2) between November 2008 and March 2013. Participants included ethnoracial minoritized youth with CHR-P. Area-level ethnoracial minoritized density pertained to the percent of ethnoracial minoritized individuals within the participant's county during childhood. Generalized mixed-effects models with random intercepts for participants, NAPLS 2 site, and county estimated the associations between area-level ethnic density and the risk of psychosis risk outcomes. Self-reported experience of discrimination was assessed. Mediation analyses computed the indirect association of perceived discrimination in the prospective correlation between ethnic density and psychosis risk outcomes. Analyses took place between December 2021 and June 2023. Main Outcomes and Measures: Psychosis risk outcomes included remission, symptomatic, progression, and conversion to psychosis and were assessed throughout 24-month follow-up. Results: Of 193 individuals, the mean (SD) age was 17.5 (3.4) years and 113 males (58.5%) were included. Participants self-identified as Asian (29 [15.0%]), Black (57 [29.0%]), Hispanic (any race; 87 [45.0%]), or other (First Nations, Middle Eastern, and interracial individuals; 20 [10.4%]). Greater area-level minoritized density was associated with a lower likelihood of remaining symptomatic (relative risk [RR], 0.54 [95% CI, 0.33-0.89]) and having progressively worsening symptoms (RR, 0.52 [95% CI, 0.32-0.86]) compared with being in remission. More perceived discrimination was associated with a higher risk of staying symptomatic (RR, 1.43 [95% CI, 1.09-1.88]) and progressively worsening (RR, 1.34 [95% CI, 1.02-1.78]) compared with being in remission. Perceived discrimination significantly mediated 21.7% (95% CI, 4.1%-67.0%; P = .02) of the association between area-level minoritized density and the likelihood of being in remission. Conclusions and Relevance: This study found that among ethnoracial minority youth with CHR-P, growing up in communities with a greater proportion of ethnically minoritized individuals was associated with remission of psychosis risk symptoms partly through lower levels of perceived discrimination. Understanding how the social environment impacts early psychosis risk may help develop effective interventions to prevent psychosis, especially for vulnerable minoritized youth.
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Trastornos Psicóticos , Masculino , Adolescente , Humanos , Estudios Longitudinales , Estudios Prospectivos , Trastornos Psicóticos/diagnóstico , Riesgo , Probabilidad , Síntomas ProdrómicosRESUMEN
Research has demonstrated that ethnoracially minoritized college students face negative mental health outcomes associated with racism. However, little is known about the intersections between microaggressions and institution-specific racial discrimination, their relationship with psychological distress, and the role of coping in this relationship. An ethnoracially diverse sample of 915 young adults attending an urban minority-serving institution (MSI) completed self-report measures on sociodemographics, microaggressions and institution-specific racial discrimination, coping, anxiety and depression, and perceived stress. Latent class analysis (LCA) determined the number and nature of classes for both forms of racism. Hierarchical linear regressions assessed the association between the LCA classes and anxiety/depression and examined the moderating role of coping in said association. The LCA revealed two classes: "exoticization and environmental microaggressions" (EM), whose members reported experiencing these two types of microaggressions, and "institution-specific racial discrimination and microaggressions" (IRM), whose members reported both institution-specific racial discrimination and microaggressions in multiple domains. Belonging to the IRM group was associated with depression but not anxiety after adjusting for perceived stress. Black students and those reporting lower family income were more likely to belong to the IRM group. Coping moderated the relation between IRM group membership and depression, which was weaker for those who reported active coping in response to racism. College students from MSIs who experience both institution-specific racial discrimination and microaggressions may be at greater risk for depression than those who experience exoticization and environmental microaggressions alone. Active coping may ameliorate depression risk. (PsycInfo Database Record (c) 2022 APA, all rights reserved).
Asunto(s)
Racismo , Adulto Joven , Humanos , Racismo/psicología , Salud Mental , Universidades , Análisis de Clases Latentes , Microagresión , Adaptación PsicológicaRESUMEN
Race-based discrimination has been identified as a risk factor for psychotic-like experiences (PLE) among immigrant populations of color. Although ethnic identity is theorized to protect against the negative mental health impact of discrimination, empirical confirmation remains mixed. We posit mixed results are in part due to the omission of individual differences in trait emotional self-efficacy, which includes self-perceptions about emotional capabilities necessary to navigate in a multicultural world. Accordingly, this study assessed the interrelation between trait emotional self-efficacy, formally recognized as trait emotional intelligence or trait EI, ethnic identity, and racial discrimination in predicting PLE using a sample of racial and ethnic minority immigrant emerging adults (N = 456; Mage = 19.97). Hierarchical linear regressions indicated that discrimination and trait EI were associated with higher and lower PLE respectively, regardless of ethnic identity. Additionally, the association between ethnic identity and PLE, in the presence of discrimination, was negative and significant only among individuals with low trait EI as indicated by slope difference tests and the Johnson-Neyman method. We discuss the practical and theoretical implications of our findings. (PsycInfo Database Record (c) 2022 APA, all rights reserved).
Asunto(s)
Trastornos Mentales , Racismo , Adulto , Etnicidad , Humanos , Grupos Minoritarios , Racismo/psicología , Autoeficacia , Adulto JovenRESUMEN
Three models of recalled childhood gender nonconformity (GNC) and maltreatment are proposed to explain disparities in current psychological distress and lifetime suicidality among sexual minority individuals, using a United States probability sample of cisgender lesbian/gay (n = 701), bisexual (n = 606), and other (e.g., queer, n = 182) adults. Indirect effects indicated that lesbian/gay individuals were more likely than bisexual individuals to experience maltreatment and suicidal ideation as childhood GNC increased. Other indirect effects found that bisexual individuals reported more psychological distress and greater likelihood of lifetime suicidal ideation and attempts than lesbian/gay individuals as maltreatment increased. The direct effects of sexual orientation were stronger than the indirect effects via maltreatment or GNC, with bisexual individuals reporting more maltreatment, distress, and suicidality than lesbian/gay individuals. Significant findings for individuals with other identities were similar to those of bisexual individuals. Adjusted findings were comparable for women and men. The findings indicated that sexual minority individuals reported experiences consistent with sexual minority stress during early developmental periods, before being aware of their sexual orientation. It is necessary to understand the early lived experiences of sexual minority individuals, differences between lesbian/gay and bisexual individuals in those experiences, and their implications for adaptation.