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1.

FXR Regulates Intestinal Cancer Stem Cell Proliferation.

Fu, Ting; Coulter, Sally; Yoshihara, Eiji; Oh, Tae Gyu; Fang, Sungsoon; Cayabyab, Fritz; Zhu, Qiyun; Zhang, Tong; Leblanc, Mathias; Liu, Sihao; He, Mingxiao; Waizenegger, Wanda; Gasser, Emanuel; Schnabl, Bernd; Atkins, Annette R; Yu, Ruth T; Knight, Rob; Liddle, Christopher; Downes, Michael; Evans, Ronald M.

Cell; 176(5): 1098-1112.e18, 2019 02 21.

Artículo en Inglés | MEDLINE | ID: mdl-30794774

2.

Vitamin D Switches BAF Complexes to Protect ß Cells.

Wei, Zong; Yoshihara, Eiji; He, Nanhai; Hah, Nasun; Fan, Weiwei; Pinto, Antonio F M; Huddy, Timothy; Wang, Yuhao; Ross, Brittany; Estepa, Gabriela; Dai, Yang; Ding, Ning; Sherman, Mara H; Fang, Sungsoon; Zhao, Xuan; Liddle, Christopher; Atkins, Annette R; Yu, Ruth T; Downes, Michael; Evans, Ronald M.

Cell; 173(5): 1135-1149.e15, 2018 05 17.

Artículo en Inglés | MEDLINE | ID: mdl-29754817

3.

Circadian Amplitude Regulation via FBXW7-Targeted REV-ERBα Degradation.

Zhao, Xuan; Hirota, Tsuyoshi; Han, Xuemei; Cho, Han; Chong, Ling-Wa; Lamia, Katja; Liu, Sihao; Atkins, Annette R; Banayo, Ester; Liddle, Christopher; Yu, Ruth T; Yates, John R; Kay, Steve A; Downes, Michael; Evans, Ronald M.

Cell; 165(7): 1644-1657, 2016 Jun 16.

Artículo en Inglés | MEDLINE | ID: mdl-27238018

4.

RANK ligand converts the NCoR/HDAC3 co-repressor to a PGC1ß- and RNA-dependent co-activator of osteoclast gene expression.

Abe, Yohei; Kofman, Eric R; Almeida, Maria; Ouyang, Zhengyu; Ponte, Filipa; Mueller, Jasmine R; Cruz-Becerra, Grisel; Sakai, Mashito; Prohaska, Thomas A; Spann, Nathanael J; Resende-Coelho, Ana; Seidman, Jason S; Stender, Joshua D; Taylor, Havilah; Fan, Weiwei; Link, Verena M; Cobo, Isidoro; Schlachetzki, Johannes C M; Hamakubo, Takao; Jepsen, Kristen; Sakai, Juro; Downes, Michael; Evans, Ronald M; Yeo, Gene W; Kadonaga, James T; Manolagas, Stavros C; Rosenfeld, Michael G; Glass, Christopher K.

Mol Cell; 83(19): 3421-3437.e11, 2023 10 05.

Artículo en Inglés | MEDLINE | ID: mdl-37751740

5.

Uptake of oxidized lipids by the scavenger receptor CD36 promotes lipid peroxidation and dysfunction in CD8⁺ T cells in tumors.

Xu, Shihao; Chaudhary, Omkar; Rodríguez-Morales, Patricia; Sun, Xiaoli; Chen, Dan; Zappasodi, Roberta; Xu, Ziyan; Pinto, Antonio F M; Williams, April; Schulze, Isabell; Farsakoglu, Yagmur; Varanasi, Siva Karthik; Low, Jun Siong; Tang, Wenxi; Wang, Haiping; McDonald, Bryan; Tripple, Victoria; Downes, Michael; Evans, Ronald M; Abumrad, Nada A; Merghoub, Taha; Wolchok, Jedd D; Shokhirev, Maxim N; Ho, Ping-Chih; Witztum, Joseph L; Emu, Brinda; Cui, Guoliang; Kaech, Susan M.

Immunity; 54(7): 1561-1577.e7, 2021 07 13.

Artículo en Inglés | MEDLINE | ID: mdl-34102100

6.

Turning up the heat on membrane fluidity.

Fan, Weiwei; Evans, Ronald M.

Cell; 161(5): 962-963, 2015 May 21.

Artículo en Inglés | MEDLINE | ID: mdl-26000475

7.

Niche-Specific Reprogramming of Epigenetic Landscapes Drives Myeloid Cell Diversity in Nonalcoholic Steatohepatitis.

Seidman, Jason S; Troutman, Ty D; Sakai, Mashito; Gola, Anita; Spann, Nathanael J; Bennett, Hunter; Bruni, Cassi M; Ouyang, Zhengyu; Li, Rick Z; Sun, Xiaoli; Vu, BaoChau T; Pasillas, Martina P; Ego, Kaori M; Gosselin, David; Link, Verena M; Chong, Ling-Wa; Evans, Ronald M; Thompson, Bonne M; McDonald, Jeffrey G; Hosseini, Mojgan; Witztum, Joseph L; Germain, Ronald N; Glass, Christopher K.

Immunity; 52(6): 1057-1074.e7, 2020 06 16.

Artículo en Inglés | MEDLINE | ID: mdl-32362324

8.

Nuclear Receptors, RXR, and the Big Bang.

Evans, Ronald M; Mangelsdorf, David J.

Cell; 157(1): 255-66, 2014 Mar 27.

Artículo en Inglés | MEDLINE | ID: mdl-24679540

9.

Vitamin D receptor-mediated stromal reprogramming suppresses pancreatitis and enhances pancreatic cancer therapy.

Sherman, Mara H; Yu, Ruth T; Engle, Dannielle D; Ding, Ning; Atkins, Annette R; Tiriac, Herve; Collisson, Eric A; Connor, Frances; Van Dyke, Terry; Kozlov, Serguei; Martin, Philip; Tseng, Tiffany W; Dawson, David W; Donahue, Timothy R; Masamune, Atsushi; Shimosegawa, Tooru; Apte, Minoti V; Wilson, Jeremy S; Ng, Beverly; Lau, Sue Lynn; Gunton, Jenny E; Wahl, Geoffrey M; Hunter, Tony; Drebin, Jeffrey A; O'Dwyer, Peter J; Liddle, Christopher; Tuveson, David A; Downes, Michael; Evans, Ronald M.

Cell; 159(1): 80-93, 2014 Sep 25.

Artículo en Inglés | MEDLINE | ID: mdl-25259922

10.

SRF'ing around the clock.

Zhao, Xuan; Cho, Han; Evans, Ronald M.

Cell; 152(3): 381-2, 2013 Jan 31.

Artículo en Inglés | MEDLINE | ID: mdl-23374332

11.

A vitamin D receptor/SMAD genomic circuit gates hepatic fibrotic response.

Ding, Ning; Yu, Ruth T; Subramaniam, Nanthakumar; Sherman, Mara H; Wilson, Caroline; Rao, Renuka; Leblanc, Mathias; Coulter, Sally; He, Mingxiao; Scott, Christopher; Lau, Sue L; Atkins, Annette R; Barish, Grant D; Gunton, Jenny E; Liddle, Christopher; Downes, Michael; Evans, Ronald M.

Cell; 153(3): 601-13, 2013 Apr 25.

Artículo en Inglés | MEDLINE | ID: mdl-23622244

12.

Obesity alters pathology and treatment response in inflammatory disease.

Bapat, Sagar P; Whitty, Caroline; Mowery, Cody T; Liang, Yuqiong; Yoo, Arum; Jiang, Zewen; Peters, Michael C; Zhang, Ling-Juan; Vogel, Ian; Zhou, Carmen; Nguyen, Vinh Q; Li, Zhongmei; Chang, Christina; Zhu, Wandi S; Hastie, Annette T; He, Helen; Ren, Xin; Qiu, Wenli; Gayer, Sarah G; Liu, Chang; Choi, Eun Jung; Fassett, Marlys; Cohen, Jarish N; Sturgill, Jamie L; Crotty Alexander, Laura E; Suh, Jae Myoung; Liddle, Christopher; Atkins, Annette R; Yu, Ruth T; Downes, Michael; Liu, Sihao; Nikolajczyk, Barbara S; Lee, In-Kyu; Guttman-Yassky, Emma; Ansel, K Mark; Woodruff, Prescott G; Fahy, John V; Sheppard, Dean; Gallo, Richard L; Ye, Chun Jimmie; Evans, Ronald M; Zheng, Ye; Marson, Alexander.

Nature; 604(7905): 337-342, 2022 04.

Artículo en Inglés | MEDLINE | ID: mdl-35355021

13.

Glycogen metabolism links glucose homeostasis to thermogenesis in adipocytes.

Keinan, Omer; Valentine, Joseph M; Xiao, Haopeng; Mahata, Sushil K; Reilly, Shannon M; Abu-Odeh, Mohammad; Deluca, Julia H; Dadpey, Benyamin; Cho, Leslie; Pan, Austin; Yu, Ruth T; Dai, Yang; Liddle, Christopher; Downes, Michael; Evans, Ronald M; Lusis, Aldons J; Laakso, Markku; Chouchani, Edward T; Rydén, Mikael; Saltiel, Alan R.

Nature; 599(7884): 296-301, 2021 11.

Artículo en Inglés | MEDLINE | ID: mdl-34707293

14.

Targeting nuclear receptor corepressors for reversible male contraception.

Hong, Suk-Hyun; Castro, Glenda; Wang, Dan; Nofsinger, Russell; Kane, Maureen; Folias, Alexandra; Atkins, Annette R; Yu, Ruth T; Napoli, Joseph L; Sassone-Corsi, Paolo; de Rooij, Dirk G; Liddle, Christopher; Downes, Michael; Evans, Ronald M.

Proc Natl Acad Sci U S A; 121(9): e2320129121, 2024 Feb 27.

Artículo en Inglés | MEDLINE | ID: mdl-38377195

15.

A TLR4/TRAF6-dependent signaling pathway mediates NCoR coactivator complex formation for inflammatory gene activation.

Abe, Yohei; Kofman, Eric R; Ouyang, Zhengyu; Cruz-Becerra, Grisel; Spann, Nathanael J; Seidman, Jason S; Troutman, Ty D; Stender, Joshua D; Taylor, Havilah; Fan, Weiwei; Link, Verena M; Shen, Zeyang; Sakai, Juro; Downes, Michael; Evans, Ronald M; Kadonaga, James T; Rosenfeld, Michael G; Glass, Christopher K.

Proc Natl Acad Sci U S A; 121(2): e2316104121, 2024 Jan 09.

Artículo en Inglés | MEDLINE | ID: mdl-38165941

16.

Class IIa histone deacetylases are hormone-activated regulators of FOXO and mammalian glucose homeostasis.

Mihaylova, Maria M; Vasquez, Debbie S; Ravnskjaer, Kim; Denechaud, Pierre-Damien; Yu, Ruth T; Alvarez, Jacqueline G; Downes, Michael; Evans, Ronald M; Montminy, Marc; Shaw, Reuben J.

Cell; 145(4): 607-21, 2011 May 13.

Artículo en Inglés | MEDLINE | ID: mdl-21565617

17.

NCoR1 is a conserved physiological modulator of muscle mass and oxidative function.

Yamamoto, Hiroyasu; Williams, Evan G; Mouchiroud, Laurent; Cantó, Carles; Fan, Weiwei; Downes, Michael; Héligon, Christophe; Barish, Grant D; Desvergne, Béatrice; Evans, Ronald M; Schoonjans, Kristina; Auwerx, Johan.

Cell; 147(4): 827-39, 2011 Nov 11.

Artículo en Inglés | MEDLINE | ID: mdl-22078881

18.

Immune-evasive human islet-like organoids ameliorate diabetes.

Yoshihara, Eiji; O'Connor, Carolyn; Gasser, Emanuel; Wei, Zong; Oh, Tae Gyu; Tseng, Tiffany W; Wang, Dan; Cayabyab, Fritz; Dai, Yang; Yu, Ruth T; Liddle, Christopher; Atkins, Annette R; Downes, Michael; Evans, Ronald M.

Nature; 586(7830): 606-611, 2020 10.

Artículo en Inglés | MEDLINE | ID: mdl-32814902

19.

Silver electroceutical technology to treat sarcopenia.

Kim, Min Young; Shin, Hyun Young; Cho, Sung Chun; Yang, Sohae; Intisar, Aseer; Woo, Hyeong Jung; Choi, Youn-Suk; You, Chang-Lim; Kang, Jong-Sun; Lee, Yun-Il; Park, Sang Chul; Yea, Kyungmoo; Oh, Tae Gyu; Downes, Michael; Evans, Ronald M; Kim, Minseok S.

Proc Natl Acad Sci U S A; 120(33): e2300036120, 2023 08 15.

Artículo en Inglés | MEDLINE | ID: mdl-37549292

20.

PHGDH preserves one-carbon cycle to confer metabolic plasticity in chemoresistant gastric cancer during nutrient stress.

Yoon, Bo Kyung; Kim, Hyeonhui; Oh, Tae Gyu; Oh, Se Kyu; Jo, Sugyeong; Kim, Minki; Chun, Kyu-Hye; Hwang, Nahee; Lee, Suji; Jin, Suyon; Atkins, Annette R; Yu, Ruth T; Downes, Michael; Kim, Jae-Woo; Kim, Hyunkyung; Evans, Ronald M; Cheong, Jae-Ho; Fang, Sungsoon.

Proc Natl Acad Sci U S A; 120(21): e2217826120, 2023 05 23.

Artículo en Inglés | MEDLINE | ID: mdl-37192160

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