Experimental Evaluation of the Properties of 3D Porous Bone Substitute Based on Calcium Phosphate on the Model of Monocortical Diaphysial Femur Defect in Rats.

A new alloplastic high-permeable material based on tricalcium phosphate with Kelvin architectonics created by stereolithographic 3D-printing was studied in vivo. A monocortical defect of the femur was modeled in rats and the material was implanted into the defect area. In 24 weeks, the animals were euthanized and histological examination of the defect area was performed. One femur fracture with fixator migration was recorded after implantation of the studied material and the reference chronOS synthetic material. The studied material demonstrated better osteoconductive properties then traditional osteoplastic material, which was seen from greater number of bone trabeculae and their area in the defect area.

[Morphological characteristics of stab and slush injuries to the skin inflicted by the ragged-spine knife].

The objective of the present study was to identify morphological features of stab and slush injuries to the skin inflicted with the ragged-spine knife. Visual and stereoscopic examination of experimental skin injuries to the biodummies revealed a number of peculiar characteristics of such wounds. Their severity is shown to depend on such factors as pressure on the spine or the blade.

[Knowledgebase as a tool for monitoring post-genomic medico-biological research].

On-going molecular biological researches are characterized by exponential increase in the amount of experimental data which dictates the necessity to develop relevant information technologies. The knowledge-based approach appears to be a most promising and flexible tool for analytical processing biomedical information that allows new relationships between study objects to be established. In this article we analyze the work of researchers based at the Institute of Biomedical Chemistry with the materials of the PubMed biomedical library. A list of publication IDs for a half-year period has been compiled to elucidate individual profiles of research activities. Statistical analysis of medical subject headings (MeSH) reveals typical profiles of research of interest for separate divisions of the Institute. The proposed approach may be recommended as a means for improving the efficiency and coordination of biomedical research.

Colloidal forming of macroporous calcium pyrophosphate bioceramics in 3D-printed molds.

A technique for colloidal forming of Ca2P2O7 macroporous bioceramics, based on low-pressure injection molding (LPIM) of a glycerol-water slip containing Ca2P2O7 and Ca(Н2PO4)2 into a plastic mold fabricated via FDM 3D-printing, was proposed. Chemical reaction between the solid phases of the water containing slip - Ca2P2O7 and Ca(Н2PO4)2, resulting in brushite (CaHPO4·2H2O) formation, led to consolidation of the casting and preserved its complex architecture in the course of mold burning-out. Macroporous ceramics of Kelvin structure (70% macropores with the sizes from 2 up to 4 mm), based on a pre-defined composition with 10 wt% Ca(PO3)2 and sintered in liquid-phase regime, demonstrated a compressive strength of 1.4 ± 0.1 MPa at a density of 22 ± 2%. In vitro tests on bioactivity in SBF solution, as well as on resorption of the ceramics in model solution of citric acid, were carried out.

[Knowledgebases in postgenomic molecular biology].

Knowledgebases can become an effective tool essentially raising quality of information retrieval in molecular biology, promoting the development of new methods of education and forecasting of the biomedical R&D. Knowledge-based technologies should induce "paradigm shift" in the life science due to integrative focusing of research groups towards the challenges of postgenomic era. This paper debates concept of the knowledgebase, which exploits web usage mining to personalize the access of molecular biologist to the Internet resources.