Detalles de la búsqueda
1.
The Current Status and Use of Microphysiological Systems by the Pharmaceutical Industry: The International Consortium for Innovation and Quality Microphysiological Systems Affiliate Survey and Commentary.
Drug Metab Dispos;
52(3): 198-209, 2024 Feb 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-38123948
2.
Liposome Click Membrane Permeability Assay for Identifying Permeable Peptides.
Pharm Res;
38(5): 843-850, 2021 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-33723794
3.
A Two-Tiered In Vitro Approach to De-Risk Drug Candidates for Potential Bile Salt Export Pump Inhibition Liabilities in Drug Discovery.
Drug Metab Dispos;
48(11): 1147-1160, 2020 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-32943412
4.
Is Overexpression of the Plasma Membrane Transporter (SLC29A4) a New Option to Stratify Patients with High-Risk Neuroblastoma for Treatment with 131I-mIBG?
J Pharmacol Exp Ther;
387(3): 236-238, 2023 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-37967896
5.
Transporter Expression in Noncancerous and Cancerous Liver Tissue from Donors with Hepatocellular Carcinoma and Chronic Hepatitis C Infection Quantified by LC-MS/MS Proteomics.
Drug Metab Dispos;
46(2): 189-196, 2018 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-29138286
6.
The Complexities of Interpreting Reversible Elevated Serum Creatinine Levels in Drug Development: Does a Correlation with Inhibition of Renal Transporters Exist?
Drug Metab Dispos;
44(9): 1498-509, 2016 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-26825641
7.
Transporter Expression in Liver Tissue from Subjects with Alcoholic or Hepatitis C Cirrhosis Quantified by Targeted Quantitative Proteomics.
Drug Metab Dispos;
44(11): 1752-1758, 2016 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-27543206
8.
Correction to: Liposome Click Membrane Permeability Assay for Identifying Permeable Peptides.
Pharm Res;
38(4): 735-736, 2021 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-33821425
9.
Interspecies variability in expression of hepatobiliary transporters across human, dog, monkey, and rat as determined by quantitative proteomics.
Drug Metab Dispos;
43(3): 367-74, 2015 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-25534768
10.
Quantitative transporter proteomics by liquid chromatography with tandem mass spectrometry: addressing methodologic issues of plasma membrane isolation and expression-activity relationship.
Drug Metab Dispos;
43(2): 284-8, 2015 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-25488931
11.
Establishment of a hepatocyte-kupffer cell coculture model for assessment of proinflammatory cytokine effects on metabolizing enzymes and drug transporters.
Drug Metab Dispos;
43(5): 774-85, 2015 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-25739975
12.
Evaluation of cynomolgus monkeys for the identification of endogenous biomarkers for hepatic transporter inhibition and as a translatable model to predict pharmacokinetic interactions with statins in humans.
Drug Metab Dispos;
43(6): 851-63, 2015 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-25813937
13.
Interindividual variability in hepatic organic anion-transporting polypeptides and P-glycoprotein (ABCB1) protein expression: quantification by liquid chromatography tandem mass spectroscopy and influence of genotype, age, and sex.
Drug Metab Dispos;
42(1): 78-88, 2014 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-24122874
14.
Evaluation of organic anion transporting polypeptide 1B1 and 1B3 humanized mice as a translational model to study the pharmacokinetics of statins.
Drug Metab Dispos;
42(8): 1301-13, 2014 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-24855184
15.
Pitavastatin is a more sensitive and selective organic anion-transporting polypeptide 1B clinical probe than rosuvastatin.
Br J Clin Pharmacol;
78(3): 587-98, 2014 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-24617605
16.
Toward improved predictions of pharmacokinetics of transported drugs in hepatic impairment: Insights from the extended clearance model.
CPT Pharmacometrics Syst Pharmacol;
13(1): 118-131, 2024 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-37833845
17.
Membrane transporters in drug development and as determinants of precision medicine.
Nat Rev Drug Discov;
23(4): 255-280, 2024 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-38267543
18.
Critical review of preclinical approaches to investigate cytochrome p450-mediated therapeutic protein drug-drug interactions and recommendations for best practices: a white paper.
Drug Metab Dispos;
41(9): 1598-609, 2013 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-23792813
19.
In vitro assessment of drug-drug interaction potential of boceprevir associated with drug metabolizing enzymes and transporters.
Drug Metab Dispos;
41(3): 668-81, 2013 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-23293300
20.
Predicting changes in the pharmacokinetics of CYP3A-metabolized drugs in hepatic impairment and insights into factors driving these changes.
CPT Pharmacometrics Syst Pharmacol;
12(2): 261-273, 2023 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-36540952