RESUMEN
A 75-year-old woman was diagnosed of MCD plasma cell (PC) variant with B symptoms. Diffuse lymph-node enlargement, splenomegaly and pancytopenia were detected. Induction with Rituximab was made because pancytopenia was present. Actually patient is free of disease. This is the first complete response of MCD published, VIH negative, induced with anti CD20.
Asunto(s)
Anticuerpos Monoclonales/uso terapéutico , Enfermedad de Castleman/tratamiento farmacológico , Anciano , Anticuerpos Monoclonales de Origen Murino , Antígenos CD20 , Protocolos de Quimioterapia Combinada Antineoplásica/uso terapéutico , Enfermedad de Castleman/complicaciones , Enfermedad de Castleman/inmunología , Femenino , Seronegatividad para VIH , Infecciones por Herpesviridae/complicaciones , Herpesvirus Humano 8 , Humanos , Pancitopenia/complicaciones , Inducción de Remisión , RituximabRESUMEN
A patient with advanced multiple myeloma (MM) and renal failure presented a severe chronic anemia requiring frequent blood transfusions. Treatment with recombinant human erythropoietin (rHuEPO) led to a rapid improvement of anemia, and further blood transfusions were not required. Pathophysiological studies about the erythropoiesis in patients with MM and trials with rHuEPO in myeloma-associated anemia are commented.