Detalles de la búsqueda
1.
The PDE4 inhibitor tanimilast shows distinct immunomodulatory properties associated with a type 2 endotype and CD141 upregulation.
J Transl Med;
20(1): 203, 2022 05 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-35538539
2.
The PDE4 Inhibitor Tanimilast Restrains the Tissue-Damaging Properties of Human Neutrophils.
Int J Mol Sci;
23(9)2022 Apr 29.
Artículo
en Inglés
| MEDLINE | ID: mdl-35563373
3.
The PDE4 inhibitor CHF6001 affects keratinocyte proliferation via cellular redox pathways.
Arch Biochem Biophys;
685: 108355, 2020 05 30.
Artículo
en Inglés
| MEDLINE | ID: mdl-32268137
4.
Melatonin as an adjunct to therapeutic hypothermia in a piglet model of neonatal encephalopathy: A translational study.
Neurobiol Dis;
121: 240-251, 2019 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-30300675
5.
Potential biomarkers for neuroinflammation and neurodegeneration at short and long term after neonatal hypoxic-ischemic insult in rat.
J Neuroinflammation;
16(1): 194, 2019 Oct 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-31660990
6.
Anti-inflammatory effects of the phosphodiesterase type 4 inhibitor CHF6001 on bronchoalveolar lavage lymphocytes from asthma patients.
Cytokine;
113: 68-73, 2019 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-29934047
7.
The modulatory effects of the PDE4 inhibitors CHF6001 and roflumilast in alveolar macrophages and lung tissue from COPD patients.
Cytokine;
123: 154739, 2019 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-31319374
8.
The PDE4 inhibitor CHF-6001 and LAMAs inhibit bronchoconstriction-induced remodeling in lung slices.
Am J Physiol Lung Cell Mol Physiol;
313(3): L507-L515, 2017 Sep 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-28596292
9.
CHF6001 II: a novel phosphodiesterase 4 inhibitor, suitable for topical pulmonary administration--in vivo preclinical pharmacology profile defines a potent anti-inflammatory compound with a wide therapeutic window.
J Pharmacol Exp Ther;
352(3): 568-78, 2015 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-25576073
10.
CHF6001 I: a novel highly potent and selective phosphodiesterase 4 inhibitor with robust anti-inflammatory activity and suitable for topical pulmonary administration.
J Pharmacol Exp Ther;
352(3): 559-67, 2015 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-25576075
11.
CHF6297: a novel potent and selective p38 MAPK inhibitor with robust anti-inflammatory activity and suitable for inhaled pulmonary administration as dry powder.
Front Pharmacol;
15: 1343941, 2024.
Artículo
en Inglés
| MEDLINE | ID: mdl-38549671
12.
Receptor for advanced glycation end products contributes to postnatal pulmonary development and adult lung maintenance program in mice.
Am J Respir Cell Mol Biol;
48(2): 164-71, 2013 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-23144333
13.
Modulation of Human Dendritic Cell Functions by Phosphodiesterase-4 Inhibitors: Potential Relevance for the Treatment of Respiratory Diseases.
Pharmaceutics;
15(9)2023 Aug 31.
Artículo
en Inglés
| MEDLINE | ID: mdl-37765223
14.
Cigarette smoke and its component acrolein augment IL-8/CXCL8 mRNA stability via p38 MAPK/MK2 signaling in human pulmonary cells.
Am J Physiol Lung Cell Mol Physiol;
303(10): L929-38, 2012 Nov 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-22983351
15.
Experimental Models for Testing the Efficacy of Pharmacological Treatments for Neonatal Hypoxic-Ischemic Encephalopathy.
Biomedicines;
10(5)2022 Apr 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-35625674
16.
The benefits, limitations and opportunities of preclinical models for neonatal drug development.
Dis Model Mech;
15(4)2022 04 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-35466995
17.
Design, Synthesis, and Biological Characterization of Inhaled p38α/ß MAPK Inhibitors for the Treatment of Lung Inflammatory Diseases.
J Med Chem;
65(10): 7170-7192, 2022 05 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-35546685
18.
A PI3Kγ mimetic peptide triggers CFTR gating, bronchodilation, and reduced inflammation in obstructive airway diseases.
Sci Transl Med;
14(638): eabl6328, 2022 03 30.
Artículo
en Inglés
| MEDLINE | ID: mdl-35353541
19.
Tanimilast, A Novel Inhaled Pde4 Inhibitor for the Treatment of Asthma and Chronic Obstructive Pulmonary Disease.
Front Pharmacol;
12: 740803, 2021.
Artículo
en Inglés
| MEDLINE | ID: mdl-34887752
20.
The PDE4 Inhibitor Tanimilast Blunts Proinflammatory Dendritic Cell Activation by SARS-CoV-2 ssRNAs.
Front Immunol;
12: 797390, 2021.
Artículo
en Inglés
| MEDLINE | ID: mdl-35140709