Detalles de la búsqueda
1.
Discovery of novel pyrazole based Urea/Thiourea derivatives as multiple targeting VEGFR-2, EGFRWT, EGFRT790M tyrosine kinases and COX-2 Inhibitors, with anti-cancer and anti-inflammatory activities.
Bioorg Chem;
147: 107403, 2024 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-38691909
2.
Vicinal diaryl pyrazole with tetrazole/urea scaffolds as selective angiotensin converting enzyme-1/cyclooxygenase-2 inhibitors: Design, synthesis, anti-hypertensive, anti-fibrotic, and anti-inflammatory.
Drug Dev Res;
85(4): e22217, 2024 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-38845214
3.
New pyrazolyl-thiazolidinone/thiazole derivatives as celecoxib/dasatinib analogues with selective COX-2, HER-2 and EGFR inhibitory effects: design, synthesis, anti-inflammatory/anti-proliferative activities, apoptosis, molecular modelling and ADME studies.
J Enzyme Inhib Med Chem;
38(1): 2281262, 2023 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-38010912
4.
New 1,2,3-triazole/1,2,4-triazole hybrids linked to oxime moiety as nitric oxide donor selective COX-2, aromatase, B-RAFV600E and EGFR inhibitors celecoxib analogs: design, synthesis, anti-inflammatory/anti-proliferative activities, apoptosis and molecular modeling study.
J Enzyme Inhib Med Chem;
38(1): 2290461, 2023 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-38061801
5.
Synthesis of novel halogenated triarylpyrazoles as selective COX-2 inhibitors: Anti-inflammatory activity, histopatholgical profile and in-silico studies.
Bioorg Chem;
105: 104418, 2020 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-33166844
6.
New 1,2,4-triazole/pyrazole hybrids linked to oxime moiety as nitric oxide donor celecoxib analogs: Synthesis, cyclooxygenase inhibition anti-inflammatory, ulcerogenicity, anti-proliferative activities, apoptosis, molecular modeling and nitric oxide release studies.
Bioorg Chem;
98: 103752, 2020 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-32197148
7.
Thiohydantoin derivatives incorporating a pyrazole core: Design, synthesis and biological evaluation as dual inhibitors of topoisomerase-I and cycloxygenase-2 with anti-cancer and anti-inflammatory activities.
Bioorg Chem;
91: 103132, 2019 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-31374529
8.
Design, synthesis, modeling studies and biological evaluation of thiazolidine derivatives containing pyrazole core as potential anti-diabetic PPAR-γ agonists and anti-inflammatory COX-2 selective inhibitors.
Bioorg Chem;
82: 86-99, 2019 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-30278282
9.
Design, synthesis of celecoxib-tolmetin drug hybrids as selective and potent COX-2 inhibitors.
Bioorg Chem;
90: 103029, 2019 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-31212177
10.
Non-acidic 1,3,4-trisubstituted-pyrazole derivatives as lonazolac analogs with promising COX-2 selectivity, anti-inflammatory activity and gastric safety profile.
Bioorg Chem;
77: 568-578, 2018 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-29475165
11.
New 1,2-diaryl-4-substituted-benzylidene-5-4H-imidazolone derivatives: Design, synthesis and biological evaluation as potential anti-inflammatory and analgesic agents.
Bioorg Chem;
72: 123-129, 2017 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-28411407
12.
Design, synthesis, cyclooxygenase inhibition and biological evaluation of new 1,3,5-triaryl-4,5-dihydro-1H-pyrazole derivatives possessing amino/methanesulfonyl pharmacophore.
Bioorg Chem;
70: 57-66, 2017 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-27894776
13.
Synthesis, cyclooxygenase inhibition, anti-inflammatory evaluation and ulcerogenic liability of new 1,3,5-triarylpyrazoline and 1,5-diarylpyrazole derivatives as selective COX-2 inhibitors.
Bioorg Med Chem Lett;
26(2): 406-412, 2016 Jan 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-26691756
14.
Synthesis, cyclooxygenase inhibition, anti-inflammatory evaluation and ulcerogenic liability of new 1,5-diarylpyrazole derivatives.
J Enzyme Inhib Med Chem;
31(sup3): 54-60, 2016.
Artículo
en Inglés
| MEDLINE | ID: mdl-27541738
15.
Synthesis, Cyclooxygenase Inhibition, Anti-Inflammatory Evaluation, and Ulcerogenic Liability of New 1,3,5-Triarylpyrazoline Derivatives Possessing a Methanesulfonyl Pharmacophore.
Arch Pharm (Weinheim);
349(10): 801-807, 2016 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-27601359
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