Detalles de la búsqueda
1.
Filling a nick in NIK: Extending the half-life of a NIK inhibitor through structure-based drug design.
Bioorg Med Chem Lett;
89: 129277, 2023 06 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-37105490
2.
Comparison of Tissue Abundance of Non-Cytochrome P450 Drug-Metabolizing Enzymes by Quantitative Proteomics between Humans and Laboratory Animal Species.
Drug Metab Dispos;
50(3): 197-203, 2022 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-34969659
3.
Regional Proteomic Quantification of Clinically Relevant Non-Cytochrome P450 Enzymes along the Human Small Intestine.
Drug Metab Dispos;
48(7): 528-536, 2020 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-32350063
4.
Characterization of Differential Tissue Abundance of Major Non-CYP Enzymes in Human.
Mol Pharm;
17(11): 4114-4124, 2020 11 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-32955894
5.
Immolation of p-Aminobenzyl Ether Linker and Payload Potency and Stability Determine the Cell-Killing Activity of Antibody-Drug Conjugates with Phenol-Containing Payloads.
Bioconjug Chem;
29(2): 267-274, 2018 02 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-29369629
6.
Strategy for CYP3A Induction Risk Assessment from Preclinical Signal to Human: a Case Example of a Late-Stage Discovery Compound.
Pharm Res;
34(11): 2403-2414, 2017 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-28815392
7.
Design, synthesis, and biological evaluation of pyrrolobenzodiazepine-containing hypoxia-activated prodrugs.
Bioorg Med Chem Lett;
27(23): 5300-5304, 2017 12 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-29079474
8.
Going Beyond Common Drug Metabolizing Enzymes: Case Studies of Biotransformation Involving Aldehyde Oxidase, γ-Glutamyl Transpeptidase, Cathepsin B, Flavin-Containing Monooxygenase, and ADP-Ribosyltransferase.
Drug Metab Dispos;
44(8): 1253-61, 2016 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-27117704
9.
4-Aminoindazolyl-dihydrofuro[3,4-d]pyrimidines as non-covalent inhibitors of mutant epidermal growth factor receptor tyrosine kinase.
Bioorg Med Chem Lett;
26(2): 534-539, 2016 Jan 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-26639762
10.
Solving time-dependent CYP3A4 inhibition for a series of indole-phenylacetic acid dual antagonists of the PGD(2) receptors CRTH2 and DP.
Bioorg Med Chem Lett;
24(13): 2877-80, 2014 Jul 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-24825301
11.
Elucidation of the mechanism of ribose conjugation in a pyrazole-containing compound in rodent liver.
Xenobiotica;
43(3): 236-45, 2013 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-22931212
12.
Phenylalanine derivatives as GPR142 agonists for the treatment of type II diabetes.
Bioorg Med Chem Lett;
22(19): 6218-23, 2012 Oct 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-22926069
13.
Ileocolonic-Targeted JAK Inhibitor: A Safer and More Effective Treatment for Inflammatory Bowel Disease.
Pharmaceutics;
14(11)2022 Nov 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-36365202
14.
Introduction and expression of PIK3CAE545K in a papillary thyroid cancer BRAFV600E cell line leads to a dedifferentiated aggressive phenotype.
J Otolaryngol Head Neck Surg;
51(1): 7, 2022 Feb 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-35193694
15.
Novel mechanism for dehalogenation and glutathione conjugation of dihalogenated anilines in human liver microsomes: evidence for ipso glutathione addition.
Chem Res Toxicol;
24(10): 1668-77, 2011 Oct 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-21905702
16.
Optimization of triazoles as novel and potent nonphlorizin SGLT2 inhibitors.
Bioorg Med Chem Lett;
21(12): 3774-9, 2011 Jun 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-21565497
17.
Structure-Based Discovery of Proline-Derived Arginase Inhibitors with Improved Oral Bioavailability for Immuno-Oncology.
ACS Med Chem Lett;
12(9): 1380-1388, 2021 Sep 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-34527178
18.
Bioactivation of a novel 2-methylindole-containing dual chemoattractant receptor-homologous molecule expressed on T-helper type-2 cells/D-prostanoid receptor antagonist leads to mechanism-based CYP3A inactivation: glutathione adduct characterization and prediction of in vivo drug-drug interaction.
Drug Metab Dispos;
38(5): 841-50, 2010 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-20100816
19.
Discovery and Optimization of Rationally Designed Bicyclic Inhibitors of Human Arginase to Enhance Cancer Immunotherapy.
ACS Med Chem Lett;
11(4): 582-588, 2020 Apr 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-32292567
20.
Investigation of Drug Delivery in Rats via Subcutaneous Injection: Case Study of Pharmacokinetic Modeling of Suspension Formulations.
J Pharm Sci;
108(1): 109-119, 2019 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-29909029