Detalles de la búsqueda
1.
Heterobicyclic inhibitors of transforming growth factor beta receptor I (TGFßRI).
Bioorg Med Chem;
26(5): 1026-1034, 2018 03 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-29422332
2.
Pharmacology of smac mimetics; chemotype differentiation based on physical association with caspase regulators and cellular transport.
Exp Cell Res;
338(2): 251-60, 2015 Nov 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-26302264
3.
Discovery and Preclinical Evaluation of BMS-986242, a Potent, Selective Inhibitor of Indoleamine-2,3-dioxygenase 1.
ACS Med Chem Lett;
12(2): 288-294, 2021 Feb 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-33603977
4.
Design, synthesis and structure-activity relationships of novel biarylamine-based Met kinase inhibitors.
Bioorg Med Chem Lett;
20(9): 2998-3002, 2010 May 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-20382527
5.
Discovery of BMS-986260, a Potent, Selective, and Orally Bioavailable TGFßR1 Inhibitor as an Immuno-oncology Agent.
ACS Med Chem Lett;
11(2): 172-178, 2020 Feb 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-32071685
6.
Synergistic antitumor activity of ixabepilone (BMS-247550) plus bevacizumab in multiple in vivo tumor models.
Clin Cancer Res;
14(24): 8123-31, 2008 Dec 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-19088027
7.
Brivanib alaninate, a dual inhibitor of vascular endothelial growth factor receptor and fibroblast growth factor receptor tyrosine kinases, induces growth inhibition in mouse models of human hepatocellular carcinoma.
Clin Cancer Res;
14(19): 6146-53, 2008 Oct 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-18829493
8.
Discovery and validation of biomarkers that respond to treatment with brivanib alaninate, a small-molecule VEGFR-2/FGFR-1 antagonist.
Cancer Res;
67(14): 6899-906, 2007 Jul 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-17638901
9.
Discovery of brivanib alaninate ((S)-((R)-1-(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yloxy)propan-2-yl)2-aminopropanoate), a novel prodrug of dual vascular endothelial growth factor receptor-2 and fibroblast growth factor receptor-1 kinase inhibitor (BMS-540215).
J Med Chem;
51(6): 1976-80, 2008 Mar 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-18288793
10.
Synthesis, SAR, and Evaluation of 4-[2,4-Difluoro-5-(cyclopropylcarbamoyl)phenylamino]pyrrolo[2,1-f][1,2,4]triazine-based VEGFR-2 kinase inhibitors.
Bioorg Med Chem Lett;
18(4): 1354-8, 2008 Feb 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-18221875
11.
Discovery of orally active pyrrolopyridine- and aminopyridine-based Met kinase inhibitors.
Bioorg Med Chem Lett;
18(11): 3224-9, 2008 Jun 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-18479916
12.
Identification of pyrrolo[2,1-f][1,2,4]triazine-based inhibitors of Met kinase.
Bioorg Med Chem Lett;
18(6): 1945-51, 2008 Mar 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-18289854
13.
Discovery and preclinical studies of 5-isopropyl-6-(5-methyl-1,3,4-oxadiazol-2-yl)-N-(2-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)pyrrolo[2,1-f][1,2,4]triazin-4-amine (BMS-645737), an in vivo active potent VEGFR-2 inhibitor.
Bioorg Med Chem Lett;
18(9): 2985-9, 2008 May 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-18395443
14.
Discovery of 4-Azaindole Inhibitors of TGFßRI as Immuno-oncology Agents.
ACS Med Chem Lett;
9(11): 1117-1122, 2018 Nov 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-30429955
15.
Discovery and evaluation of N-cyclopropyl- 2,4-difluoro-5-((2-(pyridin-2-ylamino)thiazol-5- ylmethyl)amino)benzamide (BMS-605541), a selective and orally efficacious inhibitor of vascular endothelial growth factor receptor-2.
J Med Chem;
49(13): 3766-9, 2006 Jun 29.
Artículo
en Inglés
| MEDLINE | ID: mdl-16789733
16.
Discovery and preclinical studies of (R)-1-(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5- methylpyrrolo[2,1-f][1,2,4]triazin-6-yloxy)propan- 2-ol (BMS-540215), an in vivo active potent VEGFR-2 inhibitor.
J Med Chem;
49(7): 2143-6, 2006 Apr 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-16570908
17.
Antroquinonol A: Scalable Synthesis and Preclinical Biology of a Phase 2 Drug Candidate.
ACS Cent Sci;
2(1): 27-31, 2016 Jan 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-27163023
18.
Design, synthesis, and evaluation of orally active 4-(2,4-difluoro-5-(methoxycarbamoyl)phenylamino)pyrrolo[2,1-f][1,2,4]triazines as dual vascular endothelial growth factor receptor-2 and fibroblast growth factor receptor-1 inhibitors.
J Med Chem;
48(12): 3991-4008, 2005 Jun 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-15943473
19.
The discovery of macrocyclic XIAP antagonists from a DNA-programmed chemistry library, and their optimization to give lead compounds with in vivo antitumor activity.
J Med Chem;
58(6): 2855-61, 2015 Mar 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-25695766
20.
Discovery of potent heterodimeric antagonists of inhibitor of apoptosis proteins (IAPs) with sustained antitumor activity.
J Med Chem;
58(3): 1556-62, 2015 Feb 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-25584393