RESUMEN
Cannabidiol (CBD) is a non-psychotomimetic constituent of the Cannabis plant, with potential therapeutic properties for many physical and neuropsychiatric conditions. Isolated CBD has been suggested to have favorable safety and tolerability. Although CBD-related rash is described, few case reports are well documented in the literature, and usually, CBD was used concomitantly with other medications. Thus, we report four women who presented a skin rash after ongoing CBD use. Other causes of these skin rashes were ruled out after conducting an extensive viral and serological detection panel, and three patients had their lesions biopsied. Two patients were re-exposed to the vehicle (MCT) without developing a new skin rash. Therefore, clinicians must be aware of this potential adverse effect of CBD use.
RESUMEN
Os autores estudaram a expressäo histológica das arteríolas do miocárdio, em casos de necrópsia, com o diagnóstico de diabetes mellitus, hipertensäo arterial sistêmica e lupus eritematoso sistêmico. Constararam incidência expressiva de lesöes arteriolares nas doenças estudadas. Guardando relaçäo com as arteríolas doentes, observaram áreas de fibrose substituindo o tecido miocárdico e, em um caso, necrose isquêmica focal. Consideram que, as lesöes das arteríolas intramiocárdicas possam ter importância no determinismo de isquemias regionais, com expressäo clínica de dor precordial e arritmias, representando eventual mecanismo fisiopatológico no contexto da cardiopatia isquêmica com artérias coronárias epicárdicas pérvias