Socioeconomic and environmental factors associated with waterpipe tobacco smoking among Iranian adults: a PERSIAN cohort-based cross-sectional study.

BACKGROUND: Waterpipe tobacco smoking (WTS) is associated with several deleterious health outcomes. We sought to estimate the prevalence of WTS and explore socioeconomic inequalities associated with this culturally-rooted tobacco smoking practice among Iranian adults. METHODS: A cross-sectional analysis was conducted among 20,460 adults (ages 18 and older) enrolled in the PERSIAN cohort study during 2020. Data were collected on socioeconomic status (SES), lifestyle, alcohol consumption, cigarette smoking, and several risk factors related to non-communicable diseases. The concentration curve and relative concentration index (RCI) were administered to assess and quantify the SES-based inequality in WTS. RESULTS: Overall age-adjusted prevalence of past-month WTS was 5.1% (95%CI:4.6-5.8), with about 1% for women and 10.6 for men. Age-adjusted prevalence of WTS was higher among younger adults, men, cigarette smokers, obese adults, and those with higher SES. The RCI estimation showed that WTS is more popular among adults with high income and education. WTS was higher among younger adults, cigarette smokers, obese adults, and those with higher SES. CONCLUSION: There is a clear socioeconomic inequality in WTS, with a higher prevalence among adults with higher income and education. The findings suggest the need for targeted interventions to address this inequality and reduce the prevalence of WTS among high-income communities.

Urinary concentrations of BTEX in waterpipe smokers and nonsmokers: Investigating the influence of conventional activities and multiple factors.

The aim of this study was to compare the concentrations of the benzene, toluene, ethylbenzene, and xylene (BTEX) compounds in the urine of smokers and the control group considering the role of age, weight, job, history of waterpipe and cigarette smoking, and driving time. The chemicals in the urine of 99 smokers and 31 nonsmokers were extracted by liquid-liquid extraction method and their concentrations were measured by liquid injection GC/MS. The mean concentration of benzene, toluene, ethylbenzene, m-xylene, o-xylene, p-xylene, and total BTEX in waterpipe smokers were found to be 471.40, 670.90, 127.91, 167.64, 90.62, 46.04, and 1574.50 ng/g. creatinine, respectively. For the waterpipe&cigarette smokers, the concentration of the compounds were 708.00, 959.00, 146.40, 192.50, 93.30, 53.07, and 2152.00 ng/g.creatinine, respectively. For nonsmokers the concentrations of these compounds were 88.12, 140.40, 36.68, 57.29, 31.53, 26.21, and 380.30 ng/g.creatinine, respectively. Driving time, waterpipe smoking and cigarette smoking were positively associated with BTEX concentration (p < 0.05). Fruity tobacco showed higher concentrations of BTEX compared to the regular tobacco, and athlete persons had les urinary BTEX than the non-athletes. There was not significant correlation between the BTEX and age, height, weight, and BMI. High concentrations of BTEX compounds in the urine of waterpipe and cigarette smokers compared to nonsmokers indicate that waterpipe and cigarette can be an important source of exposure to these compounds and the known adverse effects of these compounds, especially carcinogenicity, threaten the health of smokers.

Effect of portable air purifier on indoor air quality: reduced exposure to particulate matter and health risk assessment.

We sought to investigate the impact of air purifiers in the removal of particular matter (PM)10, PM2.5, PM1, and particle number concentration (PNC) in the indoor air of dormitories located at Iran's largest medical university, Tehran University of Medical Sciences. Twelve rooms were selected and randomly assigned to two rooms: sham air purifier system deployed room (SR) and true air purifier system deployed room (TR). All study samples were drawn simultaneously from assigned rooms using portable GRIMM dust monitors for 24 h. The PM monitors of air were positioned in the middle of each room next to the air purifier at the height of the breathing zone (1.5 m in height). The mean PM10, PM2.5, PM1, and PNC removal efficiency in rooms with and without a smoker were measured to be 40.7 vs 83.8%, 31.2 vs 78.4%, 29.9 vs 72.3%, and 44.3 vs 75.6%, respectively. The results showed that smoking is an important influencing factor on the indoor air quality; smoking lowered the removal efficiency of PM10, PM2.5, PM1, and PNC by 43%, 47%, 43%, and 31%, respectively. An air purifier could decline the PM10 and PM2.5 even lower than the WHO 24-h guideline level in non-smoker rooms. This study revealed that using household air purifiers in rooms with smokers and non-smokers significantly reduces the non-carcinogenic risks of exposure to PM10 and PM2.5.

Level of air BTEX in urban, rural and industrial regions of Bandar Abbas, Iran; indoor-outdoor relationships and probabilistic health risk assessment.

This study focused on the measurement of BTEX (benzene, toluene, ethylbenzene and xylene) concentrations in the air of various regions and indoor-outdoor environments in Bandar Abbas, Iran. Air samples were taken actively and analyzed by gas chromatography-mass spectrometry (GC-MS) during two one-month periods i.e., Feb 2020 (period I) and Sep/Oct 2020 (period II). The mean air temperature and the levels of all BTEX compounds were higher in period II. The highest total BTEX (t-BTEX) levels (median [min-max]) were found in the urban region (18.00 [5.21-67.24] µg m-3), followed by industrial region (7.00 [2.05-14.76] µg m-3) and rural region (2.81 [ND-7.38] µg m-3). The significant positive correlations between all BTEX compounds and T/B ratio >1 indicated the vehicular traffic as the main source of emission. At 95th percentile probability, the non-cancer risk of t-BTEX in urban region was only less than one order of magnitude below the threshold level of unity (1.91E-01) and the cancer risk of benzene exceeded the recommended level of 1.0E-06 by U.S. EPA in urban (7.69E-06) and industrial (2.97E-06) regions. It was found that the indoor/outdoor ratio of BTEX concentration in beauty salon and hospital was greater than 1. Overall, the current levels of BTEX in the ambient air of study area, especially near urban roadside and in some indoor environments, should not be overlooked and appropriate mitigation actions should be undertaken.

The effect of price on cigarette consumption, distribution, and sale in Tehran: a qualitative study.

BACKGROUND: Appropriate increases in tobacco taxes and prices are an essential component of comprehensive tobacco control strategies. This study investigates factors related to the use, sale, and distribution of cigarettes in Iran, focusing on the relationship between cigarette price and its consumption. METHODS: This interview-based qualitative study was conducted among 20 participants, including cigarette smokers, retail shop owners, large-scale distributors, and an expert in tobacco control research. RESULTS: Seven themes were extracted from participant interviews, including the type and price of cigarette, the best time to sell cigarettes, profits from the sale of cigarette, affordability, rise in cigarette price and smokers' reaction to it, lobbying and black-market sales of cigarettes, and the sale and distribution of cigarettes across the country. Although the price of cigarettes in Iran has shown some increases in the past decade, the timing of these increases are not predictable and the limited amount of these increases has not reduced the use of cigarettes. Following a price increase, consumers are more likely to switch from buying packets to single cigarettes, or buy a less expensive brand, then to quit. Moreover, increases in prices may encourage smokers and sellers to buy a large number of cigarettes and store them for a rainy day. Another adverse effect may be increased smuggling of illicit cigarettes to balance the pressure caused by rising prices. CONCLUSIONS: Our findings highlight two important aspects concerning cigarette pricing in Iran. First is the change in the type of purchase from the whole box of cigarettes to the single stick cigarette or swapping to less expensive cigarettes. Second, increase in cigarette price (either through taxing or regular increases) could be offset by flooding smuggled cigarettes into the market. Therefore, in addition to raising cigarette prices, reducing cigarette consumption rates in Iran requires the development and effective implementation of regulatory policies to control cigarette smuggling, reduce purchasing, and subsequently curb the use of this leading cause of premature morbidity and mortality.

Process modeling, characterization, optimization, and mechanisms of fluoride adsorption using magnetic agro-based adsorbent.

In this study, fluoride removal from polluted potable water using magnetic carbon-based adsorbents derived from agricultural biomass was thoroughly investigated. An experimental matrix is designed considering the interactive effects of independent process variables (pH, adsorbent dose, contact time, and initial fluoride concentration) on the removal efficiency. Isotherms and kinetics studies, as well as anions interactions, were also investigated to understand the adsorption mechanisms further. The model parameters of isotherms and kinetics are estimated using nonlinear differential evolution optimization (DEO). Approaches like adaptive neuro-fuzzy inference system (ANFIS) and response surface methodology (RSM) are implemented to predict the fluoride removal and identify the optimal process values. The optimum removal efficiency of GAC-Fe3O4 (89.34%) was found to be higher than that of PAC-Fe3O4 (85.14%). Kinetics experiments indicated that they follow the intraparticle diffusion model, and adsorption isotherms indicated that they follow Langmuir and Freundlich models. Both PAC-Fe3O4 and GAC-Fe3O4 adsorbents have shown an adsorption capacity of 1.20 and 2.74 mg/g, respectively. The model predictions from ANFIS have a strong correlation with experimental results and superior to RSM predictions. The shape of the contours depicts the nonlinearity of the interactive effects and the mechanisms in the adsorption process.

Assessment of types of bacterial bio-aerosols and concentrations in the indoor air of gyms.

The presence of airborne microorganisms in indoor air (home and work) is a serious public health concern. Bio-aerosols have a significant role in indoor air pollution as they can be pathogenic or cause an allergic reaction following inhalation, ingestion or skin absorption. This study aimed to assess bacterial bio-aerosols in the indoor air concentration of gyms, and its relationship with gym area per person, temperature, and relative humidity. Sampling was performed by the National Institute for Occupational Safety and Health (NIOSH) method 0800-0999 and using an Anderson single-step sampler. Fifty-five gyms were selected with simple random sampling method and 165 samples collected for evaluation of bacterial bio-aerosols. The concentrations of airborne bacteria were measured as colony-forming units per cubic meter of air (CFU/m3) collected by impaction on to tryptic soy agar plates. The maximum and minimum densities of bacteria in the air of gyms were 877 and 117 CFU/m3, respectively. Pseudomonas, Staphylococcus and Escherichia Coli had an order of the highest to lowest frequency among the microorganisms, respectively. Generally, with increasing temperature and humidity, the density of bacteria was increased. The higher amount of the microorganisms was observed in the air of gyms in the lower available area per person. Athletes are at risk of high exposure to the bacterial bio-aerosol that can affect their health.

Occurrence, potential sources, in vitro bioaccessibility and health risk assessment of heavy metal in indoor dust from different microenvironment of Bushehr, Iran.

Indoor dust samples were collected from 42 microenvironments of residential buildings (RB, 15 samples), official buildings (OB, 10 samples), laboratory rooms (LR, 7 samples), and school classroom (SCR, 10 samples) in Bushehr, whereby the concentration of zinc, copper, lead, cadmium, nickel, and chromium was studied. The results of this study indicated that the mean concentrations of Zn, Cu, Pb, Cd, Cr, and Ni in the indoor dust samples were 567.18, 186.09, 209.01, 5.31, 143.20, and 57.09 mg/kg in RB, 1077.34, 539.67, 274.89, 8.12, 155.30, and 92.55 mg/kg in OB, 246.40, 149.56, 127.2, 1.96, 43.45, and 91.09 mg/kg in LR and 271.43, 189.84, 164.44, 3.06, 124.20, and 70.09 mg/kg in SCR. The results of principal cluster analysis showed that the heavy metals in indoor environments were mostly originated from smoking tobacco and cigarette, traffic sources, old building materials, and building paint colors. The results of this study also revealed that the concentration of heavy metals in indoor dust had a negative and significant relationship (P value < 0.05 in most cases) with rate of ventilation, and a positive and significant relationship with smoking inside buildings (P value < 0.05 in most cases). The bioaccessibility for zinc, copper, lead, cadmium, nickel, and chromium was 69.12, 40.08, 43.33, 79.81, 31.10, and 6.31%, respectively, in indoor dust. Further, risk assessment showed that the risk values of carcinogenicity and non-carcinogenicity resulting from heavy metals inside the studied microenvironments had exceeded the recommended safe limit by EPA. In terms of potential ecological risks, it was found that heavy metals in these microenvironments have exceeded the hazardous ecological levels presented by different indices and can have considerable negative ecological effects. Thus, it is essential that further and better studies and monitoring be performed on these environments, and suitable control recommendations and solutions should be regulated for this public health threat.

Gamma radiation in the mineral hot springs of Ardabil, Iran: Assessment of Environmental Dose Rate and health risk for swimmers.

The main aim of this study was to evaluate gamma radiation level in the mineral hot springs of Ardabil province in Iran. In addition, the cancer risk of gamma radiation was assessed for swimmers. Natural gamma radiation was measured using Ion Chamber Survey Meter 451B in 22 springs throughout the province. Gamma was measured at 20 cm and 100 cm above the ground level in 15 locations of each spring. Excess lifetime cancer risk was calculated to investigate the risk of exposure to gamma radiation. The highest and lowest annual absorbed dose rate of gamma were found to be 1.17(10-3) and 1.99(10-3) Sv/y at the height of 20 cm above the ground level and 5.26(10-4) and 1.52(10-3) Sv/y at the height of 100 cm above the ground level, respectively. Excess lifetime cancer risk ranged from 4.57(10-4) to 7.76(10-4) at the height of 20 cm and from 2.06(10-4) to 5.94(10-4) at the height of 100 cm which are lower than global average of 1.45(10-3) declared by the United Nations. Although the risk level in this study is lower than the global average, protective and preventive measures should be considered by individuals and authorities in these areas to reduce the effects of gamma radiation on the health of the swimmers.

Phthalate acid esters (PAEs) accumulation in coastal sediments from regions with different land use configuration along the Persian Gulf.

Phthalate acid esters (PAEs) are widely used as plasticizers in various plastic products and have aroused considerable concern over their ubiquitous presence and potentially hazardous effects on the environment. This research provides the first data on PAEs distribution in the sediments of northern part of the Persian Gulf. To determine the concentration of 16 PAEs, 26 samples of sediments were collected from industrial stations (IS), urban stations (US), agricultural stations (AGS), and natural field stations (NS) from Asalouyeh Harbor coasts from Nov 2016 to Jan 2017. The mean values of Æ©16PAEs in the samples taken from IS, AGS, US, and NS were 78.08, 11.69, 46.56, and 5.180 µg/g, respectively. The results indicated that the mean concentrations of Æ©16PAEs in the samples taken from IS and AGS areas were significantly higher (p < 0.05) than the ones taken from US and NS areas. The order of PAEs concentrations in sediment samples were as di(2-ethylhexyl) phthalate (DEHP), di-n-butyl phthalate (DnBP), butylbenzyl phthalate (BBP), and di-n-octyl phthalate (DnOP), respectively. DEHP was detected in all collected samples and the mean ±â€¯SD of its concentration in the IS, US, AGS, and NS regions were as 28.15 ±â€¯4.9, 4.040 ±â€¯0.53, 11.58 ±â€¯1.2, and 1.780 ±â€¯0.78 µg/g, respectively. The major sources of PAEs in the sediments collected from the study region were associated with the industrial and agricultural activities. The findings of this study indicated that the sediments of the Asalouyeh coasts are heavily contaminated with PAEs. They have shown potential ecotoxicological effects on the aquatic organisms and benthic. Therefore, more attention should be paid to prediction of the marine ecosystem in this region by the authorities.

BTEX in indoor air of beauty salons: Risk assessment, levels and factors influencing their concentrations.

Concentrations of benzene, toluene, ethylbenzene, and xylene (BTEX) were investigated in indoor air quality of 50 beauty salons in Ardabil, Iran (2017). Ten liters of air samples were collected from each salons regarding the recommended method and analyzed by GC-FID for BTEX concentration. Also, structural and operational conditions of the salons were studied with a self-designed questioner. The results of this study show that the mean concentration of benzene (32.40 ±â€¯26.38) higher than the recommended levels by Health Canada, ANSES and HKSAR. Among the BTEX, ethylbenzene (62.38 ±â€¯32.37) has the most concentrations in the salons. Subsequently, the cancer risk values in different age groups of birth to <6, 6 to <21, and 21 to <81 for benzene (1.83 × 10-3, 2.76 × 10-4 and 1.50 × 10-4, respectively) and ethylbenzene (4.9 × 10-4, 7.30 × 10-5 and 3.52 × 10-5, respectively) for long time exposure were drastically higher than the recommended levels. The results showed that the benzene concentration is significantly influenced by the structural and operational conditions of type of ventilation system, area of the salons, the number of people in the salon, number of services in the salons, and while doing of bridal makeup.

Characteristics and health effects of BTEX in a hot spot for urban pollution.

This study reports a spatiotemporal characterization of toluene, benzene, ethylbenzene, and xylenes concentrations (BTEX) in an urban hot spot in Iran, specifically at an bus terminal region in Shiraz. Sampling was carried out according to NIOSH Compendium Method 1501. The inverse distance weighting (IDW) method was applied for spatial mapping. The Monte Carlo simulation technique was applied to evaluate carcinogenic and non-carcinogenic risk owing to BTEX exposure. The highest average BTEX concentrations were observed for benzene in the morning (at 7:00-9:00 A.M. local time) (26.15 ±â€¯17.65 µg/m3) and evening (at 6:00-8:00 P.M. local time) (34.44 ±â€¯15.63 µg/m3). The benzene to toluene ratios in the morning and evening were 2.02 and 3.07, respectively. The main sources of BTEX were gas stations and a municipal solid waste transfer station. The inhalation lifetime cancer risk (LTCR) for benzene in the morning and evening were 1.96 × 10-4 and 2.49 × 10-4, respectively, which exceeds the recommended value by US EPA and WHO. The hazard quotient (HQ) of all these pollutants was less than 1. The results of this work have implications for public health near 'hot spots' such as IKBT where large populations are exposed to carcinogenic emissions.

Microbial quality and physical-chemical characteristics of thermal springs.

Microbial quality and physical-chemical properties of recreational spas were surveyed to investigate the health aspect of the spas' water. A total of 195 samples were collected from pools and springs of the spas in five sites from Ardebil Province of Iran. The effects of an independent factor defined as 'condition' and its component sub-factors (i.e., sampling point, location, and sampling date) on microbial quality and physical-chemical properties of the spas were studied by applying path analysis. The influence of physical-chemical properties on microbial quality was also considered. The percentage of samples exceeding the ISIRI (Swimming pool water microbiological specifications (vol 9412), Institute of Standards and Industrial Research of Iran, Tehran, 2007) limits for Staphylococcus (spp.) was up to 55.8 in the springs and 87.8 in the pools, 58.1 and 99.2 for HPC, 90.7 and 97.8 for total coliform and fecal coliform, and 9.3 and 34.4 for Pseudomonas aeruginosa, respectively. There were significant differences between the pools and springs for both physical-chemical properties and microbial quality. From the path analysis, sampling point was the most effective sub-factor of 'condition' on both the physical-chemical properties and microbial quality. Among the physical-chemical properties, water color had the most enhancing or additive influence on microbial pollution, while EC indicated a reducing or subtractive effect.

Assessing exposure to secondhand smoke among Iranian patients with cardiac diseases; a cross-sectional study.

Introduction: Studies have linked secondhand smoke (SHS) exposure to adverse health effects. The high prevalence of heart disease necessitates the need for studies in this field. Therefore, the aim of the present study was to assess the exposure to SHS in cardiac patients. Method: This study is a cross-sectional descriptive study. A total of 430 patients who were referred to Imam Ali Hospital in Kermanshah, Iran, in 2020 were included in the study based on predetermined inclusion and exclusion criteria. The researchers collected and recorded demographic information, disease history, and exposure to secondhand smoke (SHS) through a digital questionnaire. Bivariate analysis was conducted using a chi-square test and an independent T-test, depending on the variable scale. Results: The results of the study showed that 237 patients were male (55.12 %) and 193 were female (44.8 %). The prevalence of exposure to secondhand smoke was 72.09 %. Notably, the highest rate of exposure to secondhand smoke was associated with 'exposure to tobacco smoke in public places' with a rate of 69.30 %. Additionally, it was observed that approximately 39.07 % of patients reported exposure to secondhand smoke in public places at least once a week. Conclusion: The present study has found that cardiac patients frequently experience secondhand smoking exposure, with public settings being the primary location of exposure. Implementing intervention strategies and enacting laws that prohibit smoking can effectively mitigate the negative impact of SHS exposure.

Para-occupational exposure to chemical substances: a systematic review.

Today, many health problems related to work have overshadowed workers and their families. In the meantime, chemicals are among the risk factors that have created many problems due to para-occupational exposure. In para-occupational exposures, family members are exposed to work pollutants transferred to the home environment. This study was conducted to investigate para-occupational exposure to chemicals. To conduct this systematic review, databases such as "Web of Science", "Google Scholar", "Scopus", and "SID" were used. Relevant articles in these databases were extracted by searching keywords such as "take-home exposure", "para-occupational exposure", and "chemicals" from 2000 to 2022. To extract the required data, all parts of the articles were reviewed following the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA 2020). Among the 44 identified articles, 23 were selected as final articles, of which 10 were related to agriculture workers and their families, and 13 were related to other occupations. These studies mainly investigated para-occupational exposure to pesticides (14 studies) and metals (four studies). Also, contaminated work clothes, the washing place of contaminated clothes, and storage of working clothes, equipment, and chemicals were proposed as the main routes of contamination transmission. As a result of these para-occupational exposures, problems like neuro-behavioral disorders in children, end-stage renal disease, black gingival borders, and autism spectrum disorder were created or aggravated. Limiting the transmission routes and taking measures such as training and providing facilities like devoting places for washing and storing clothes in the workplaces can decrease this type of exposure.

BTEX in indoor air of barbershops and beauty salons: Characterization, source apportionment and health risk assessment.

BACKGROUND: Volatile organic compounds, mainly BTEX, are among the pollutants of concern in beauty salons and barbershops that threaten both staff personnel and clients' health. This study aimed to determine the concentration of BTEX in barbershops and beauty salons and assess the carcinogenic and non-carcinogenic risks based on the actual risk coefficients. Also, possible sources of BTEX were determined. METHOD: Samples were collected by passive sampling. Quantitative and qualitative measurements of BTEX compounds were performed using gas chromatography-mass spectrometry (GC-MASS). Subsequently, the health risks were assessed according to the US Environmental Protection Agency. SPSS24 software and positive matrix factorization (PMF) analysis were used for statistical analysis and source apportionment respectively. RESULTS: Toluene is the most abundant compound in beauty salons, with a maximum concentration of 219.4 (µg/m3) in beauty salons. Results indicated that the mean ELCR value estimated for benzene regarding female staff exposure (1.04 × 10-5) was higher than that for men (4.05 × 10-6). Also, ELCR values of ethylbenzene for staff exposure were 2.08 × 10-6 and 3.8 × 10-6 for men and women, respectively, and possess possible carcinogenesis risks. CONCLUSION: Use of solvents and cosmetic products, improper heating systems, and type of service are the sources that probably contribute to BTEX emissions in beauty salons. It is necessary to follow health guidelines and conduct continuous monitoring for their implementation, in addition to setting a mandated occupational regulation framework or air quality requirements, to improve the health conditions in beauty salons.

Effect of saffron supplementation on oxidative stress markers (MDA, TAC, TOS, GPx, SOD, and pro-oxidant/antioxidant balance): An updated systematic review and meta-analysis of randomized placebo-controlled trials.

Introduction: This study aimed to perform an updated systematic review and meta-analysis to evaluate the effectiveness of saffron supplementation on oxidative stress markers [malondialdehyde (MDA), total antioxidant capacity (TAC), total oxidant status (TOS), glutathione peroxidase (GPx), superoxide dismutase (SOD), and prooxidant/antioxidant balance (PAB)] in randomized controlled trials (RCTs). Methods: We searched PubMed/Medline, Web of Science, Scopus, Cochrane CENTRAL, and Google Scholar until December 2022. Trial studies investigating the effects of oral saffron supplements on MDA, TAC, TOS, GPx, SOD, and PAB concentrations were included in the study. To analyze the results, mean differences (SMD) and 95% confidence intervals (CI) were pooled using a random effects model. Heterogeneity was assessed using the Cochrane Q and I 2 values. Sixteen cases were included in the meta-analysis (468 and 466 subjects in the saffron and control groups, respectively). Results: It was found that saffron consumption caused a significant decrease in MDA (SMD: -0.322; 95% CI: -0.53, -0.16; I 2 = 32.58%) and TOS (SMD: -0.654; 95% CI: -1.08, -0.23; I 2 = 68%) levels as well as a significant increase in TAC (SMD: 0.302; 95% CI: 0.13, 0.47; I 2 = 10.12%) and GPx (SMD: 0.447; 95% CI: 0.10, 0.80; I 2 = 35%). Subgroup analysis demonstrated a significant reduction in MDA levels in studies with a saffron dosage of >30 mg/day, age of <50 years, and study duration of <12 weeks. Among the limitations of the study, we can point out that the studies were from Iran, the different nature of the diseases included, and were not considered of some potential confounders such as smoking, physical activity, and diet in the studies. Discussion: In summary, the results showed that saffron has beneficial effects on oxidative stress markers.

Urinary levels of potentially toxic elements (PTEs) in female beauticians and their association with urinary biomarkers of oxidative stress/inflammation and kidney injury.

The present research was aimed to assess the urinary levels of potentially toxic elements (PTEs) in female beauticians and its correlation with oxidative stress/inflammation and kidney injury. To this end, the urine samples were collected from 50 female beauticians from beauty salons (exposed group) and 35 housewives (control group), and then, the level of PTEs was determined. The mean levels of the sum of urinary PTEs (∑PTEs) biomarkers in before and after exposure and control group were 83.55, 114.27 and 13.61 µg/L, respectively. Results also showed that the urinary level of PTEs biomarkers is significantly higher in women occupationally exposed to cosmetics compared to control group. The urinary levels of arsenic (As), cadmium (Cd), lead (Pb), and chromium (Cr) biomarkers have high correlation coefficients with early oxidative stress effects such as 8-Hydroxyguanosine (8-OHdG), 8-isoprostane and Malondialdehyde (MDA). Moreover, As and Cd biomarker levels were positively and significantly associated with kidney damages such as urinary kidney injury molecule-1 (uKIM-1) and tissue inhibitor matrix metalloproteinase 1 (uTIMP-1) (P < 0.01). Therefore, women who working in beauty salons can probably be categorized as high - exposure and high-risk workers in terms of DNA oxidative and kidney damages.