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1.

AutoPH4: An Automated Method for Generating Pharmacophore Models from Protein Binding Pockets.

Jiang, Siduo; Feher, Miklos; Williams, Chris; Cole, Brian; Shaw, David E.

J Chem Inf Model; 60(9): 4326-4338, 2020 09 28.

Artículo en Inglés | MEDLINE | ID: mdl-32639159

2.

Discovery of 4-(4-aminopyrazolo[1,5-a][1,3,5]triazin-8-yl)benzamides as novel, highly potent and selective, orally bioavailable inhibitors of Tyrosine Threonine Kinase, TTK.

Laufer, Radoslaw; Li, Sze-Wan; Liu, Yong; Ng, Grace; Lang, Yunhui; Feher, Miklos; Brokx, Richard; Beletskaya, Irina; Hodgson, Richard; Mao, Guodong; Plotnikova, Olga; Awrey, Donald E; Mason, Jacqueline M; Wei, Xin; Lin, Dan Chi-Chia; Che, Yi; Kiarash, Reza; Madeira, Brian; Fletcher, Graham C; Mak, Tak W; Bray, Mark R; Pauls, Henry W.

Bioorg Med Chem Lett; 26(15): 3562-6, 2016 08 01.

Artículo en Inglés | MEDLINE | ID: mdl-27335255

3.

Design and optimization of (3-aryl-1H-indazol-6-yl)spiro[cyclopropane-1,3'-indolin]-2'-ones as potent PLK4 inhibitors with oral antitumor efficacy.

Li, Sze-Wan; Liu, Yong; Sampson, Peter B; Patel, Narendra Kumar; Forrest, Bryan T; Edwards, Louise; Laufer, Radoslaw; Feher, Miklos; Ban, Fuqiang; Awrey, Donald E; Hodgson, Richard; Beletskaya, Irina; Mao, Guodong; Mason, Jacqueline M; Wei, Xin; Luo, Xunyi; Kiarash, Reza; Green, Erin; Mak, Tak W; Pan, Guohua; Pauls, Henry W.

Bioorg Med Chem Lett; 26(19): 4625-4630, 2016 10 01.

Artículo en Inglés | MEDLINE | ID: mdl-27592744

4.

[Operation - rehabilitation - employment]. / Mutét - rehabilitáció - munkavállalás.

Mészáros, Gabriella; Fehér, Miklós; Borbély, Csaba.

Ideggyogy Sz; 69(9-10): 349-354, 2016 Sep 30.

Artículo en Húngaro | MEDLINE | ID: mdl-29638101

5.

Discovery of inhibitors of the mitotic kinase TTK based on N-(3-(3-sulfamoylphenyl)-1H-indazol-5-yl)-acetamides and carboxamides.

Laufer, Radoslaw; Ng, Grace; Liu, Yong; Patel, Narendra Kumar B; Edwards, Louise G; Lang, Yunhui; Li, Sze-Wan; Feher, Miklos; Awrey, Don E; Leung, Genie; Beletskaya, Irina; Plotnikova, Olga; Mason, Jacqueline M; Hodgson, Richard; Wei, Xin; Mao, Guodong; Luo, Xunyi; Huang, Ping; Green, Erin; Kiarash, Reza; Lin, Dan Chi-Chia; Harris-Brandts, Marees; Ban, Fuqiang; Nadeem, Vincent; Mak, Tak W; Pan, Guohua J; Qiu, Wei; Chirgadze, Nickolay Y; Pauls, Henry W.

Bioorg Med Chem; 22(17): 4968-97, 2014 Sep 01.

Artículo en Inglés | MEDLINE | ID: mdl-25043312

6.

Numerical errors in minimization based binding energy calculations.

Feher, Miklos; Williams, Christopher I.

J Chem Inf Model; 52(12): 3200-12, 2012 Dec 21.

Artículo en Inglés | MEDLINE | ID: mdl-23146112

7.

Numerical errors and chaotic behavior in docking simulations.

Feher, Miklos; Williams, Christopher I.

J Chem Inf Model; 52(3): 724-38, 2012 Mar 26.

Artículo en Inglés | MEDLINE | ID: mdl-22379951

8.

Automated generation of turn mimetics: proof of concept study for the MC4 receptor.

Baber, J Christian; Lowe, Richard; Saunders, John; Feher, Miklos.

Bioorg Med Chem; 20(11): 3565-74, 2012 Jun 01.

Artículo en Inglés | MEDLINE | ID: mdl-22551631

9.

Structural chemistry of the histone methyltransferases cofactor binding site.

Campagna-Slater, Valérie; Mok, Man Wai; Nguyen, Kong T; Feher, Miklos; Najmanovich, Rafael; Schapira, Matthieu.

J Chem Inf Model; 51(3): 612-23, 2011 Mar 28.

Artículo en Inglés | MEDLINE | ID: mdl-21366357

10.

Reducing docking score variations arising from input differences.

Feher, Miklos; Williams, Christopher I.

J Chem Inf Model; 50(9): 1549-60, 2010 Sep 27.

Artículo en Inglés | MEDLINE | ID: mdl-20698562

11.

Fragment Hits: What do They Look Like and How do They Bind?

Giordanetto, Fabrizio; Jin, Chentian; Willmore, Lindsay; Feher, Miklos; Shaw, David E.

J Med Chem; 62(7): 3381-3394, 2019 04 11.

Artículo en Inglés | MEDLINE | ID: mdl-30875465

12.

The use of ligand-based de novo design for scaffold hopping and sidechain optimization: two case studies.

Feher, Miklos; Gao, Yinghong; Baber, J Christian; Shirley, William A; Saunders, John.

Bioorg Med Chem; 16(1): 422-7, 2008 Jan 01.

Artículo en Inglés | MEDLINE | ID: mdl-17920281

13.

[Treatment of spastic upper limb with botulinum toxin]. / A felso végtagi spasticitas kezelése botulinustoxinnal.

Dénes, Zoltán; Fehér, Miklós; Várkonyi, Andrea.

Ideggyogy Sz; 60(5-6): 245-50, 2007 May 30.

Artículo en Húngaro | MEDLINE | ID: mdl-17578272

14.

Consensus scoring for protein-ligand interactions.

Feher, Miklos.

Drug Discov Today; 11(9-10): 421-8, 2006 May.

Artículo en Inglés | MEDLINE | ID: mdl-16635804

15.

Discovery of Pyrazolo[1,5-a]pyrimidine TTK Inhibitors: CFI-402257 is a Potent, Selective, Bioavailable Anticancer Agent.

Liu, Yong; Laufer, Radoslaw; Patel, Narendra Kumar; Ng, Grace; Sampson, Peter B; Li, Sze-Wan; Lang, Yunhui; Feher, Miklos; Brokx, Richard; Beletskaya, Irina; Hodgson, Richard; Plotnikova, Olga; Awrey, Donald E; Qiu, Wei; Chirgadze, Nickolay Y; Mason, Jacqueline M; Wei, Xin; Lin, Dan Chi-Chia; Che, Yi; Kiarash, Reza; Fletcher, Graham C; Mak, Tak W; Bray, Mark R; Pauls, Henry W.

ACS Med Chem Lett; 7(7): 671-5, 2016 Jul 14.

Artículo en Inglés | MEDLINE | ID: mdl-27437075

16.

Administration of estramustine in response to changes in the prostate-specific antigen and Karnofsky index in the treatment of prostate cancer.

Pintér, Olivér; Molnár, Joseph; Tóth, Csaba; Szabó, Zoltán; Lipták, Joseph; Fél, Pál; Papp, György; Hollman, Endre; Hazay, Lajos; Streit, Béla; Kisbenedek, László; Fehér, Miklós; Kocsis, István; Pajor, László.

In Vivo; 19(4): 787-92, 2005.

Artículo en Inglés | MEDLINE | ID: mdl-15999550

17.

[The place of estramustine in the treatment of prostate cancer]. / Az estramustin helye a prostatarák kezelésében.

Pintér, Olivér; Tóth, Csaba; Szabó, Zoltán; Lipták, József; Fél, Pál; Papp, György; Holman, Endre; Hazay, Lajos; Streit, Béla; Kisbenedek, László; Fehér, Miklós; Kocsis, István.

Orv Hetil; 146(12): 553-7, 2005 Mar 20.

Artículo en Húngaro | MEDLINE | ID: mdl-15853064

18.

The discovery of Polo-like kinase 4 inhibitors: design and optimization of spiro[cyclopropane-1,3'[3H]indol]-2'(1'H).ones as orally bioavailable antitumor agents.

Sampson, Peter B; Liu, Yong; Patel, Narendra Kumar; Feher, Miklos; Forrest, Bryan; Li, Sze-Wan; Edwards, Louise; Laufer, Radoslaw; Lang, Yunhui; Ban, Fuqiang; Awrey, Donald E; Mao, Guodong; Plotnikova, Olga; Leung, Genie; Hodgson, Richard; Mason, Jacqueline M; Wei, Xin; Kiarash, Reza; Green, Erin; Qiu, Wei; Chirgadze, Nickolay Y; Mak, Tak W; Pan, Guohua; Pauls, Henry W.

J Med Chem; 58(1): 130-46, 2015 Jan 08.

Artículo en Inglés | MEDLINE | ID: mdl-24867403

19.

The discovery of Polo-like kinase 4 inhibitors: identification of (1R,2S).2-(3-((E).4-(((cis).2,6-dimethylmorpholino)methyl)styryl). 1H.indazol-6-yl)-5'-methoxyspiro[cyclopropane-1,3'-indolin]-2'-one (CFI-400945) as a potent, orally active antitumor agent.

Sampson, Peter B; Liu, Yong; Forrest, Bryan; Cumming, Graham; Li, Sze-Wan; Patel, Narendra Kumar; Edwards, Louise; Laufer, Radoslaw; Feher, Miklos; Ban, Fuqiang; Awrey, Donald E; Mao, Guodong; Plotnikova, Olga; Hodgson, Richard; Beletskaya, Irina; Mason, Jacqueline M; Luo, Xunyi; Nadeem, Vincent; Wei, Xin; Kiarash, Reza; Madeira, Brian; Huang, Ping; Mak, Tak W; Pan, Guohua; Pauls, Henry W.

J Med Chem; 58(1): 147-69, 2015 Jan 08.

Artículo en Inglés | MEDLINE | ID: mdl-25723005

20.

The Discovery of Orally Bioavailable Tyrosine Threonine Kinase (TTK) Inhibitors: 3-(4-(heterocyclyl)phenyl)-1H-indazole-5-carboxamides as Anticancer Agents.

Liu, Yong; Lang, Yunhui; Patel, Narendra Kumar; Ng, Grace; Laufer, Radoslaw; Li, Sze-Wan; Edwards, Louise; Forrest, Bryan; Sampson, Peter B; Feher, Miklos; Ban, Fuqiang; Awrey, Donald E; Beletskaya, Irina; Mao, Guodong; Hodgson, Richard; Plotnikova, Olga; Qiu, Wei; Chirgadze, Nickolay Y; Mason, Jacqueline M; Wei, Xin; Lin, Dan Chi-Chia; Che, Yi; Kiarash, Reza; Madeira, Brian; Fletcher, Graham C; Mak, Tak W; Bray, Mark R; Pauls, Henry W.

J Med Chem; 58(8): 3366-92, 2015 Apr 23.

Artículo en Inglés | MEDLINE | ID: mdl-25763473

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AutoPH4: An Automated Method for Generating Pharmacophore Models from Protein Binding Pockets.

Discovery of 4-(4-aminopyrazolo[1,5-a][1,3,5]triazin-8-yl)benzamides as novel, highly potent and selective, orally bioavailable inhibitors of Tyrosine Threonine Kinase, TTK.

Design and optimization of (3-aryl-1H-indazol-6-yl)spiro[cyclopropane-1,3'-indolin]-2'-ones as potent PLK4 inhibitors with oral antitumor efficacy.

[Operation - rehabilitation - employment]. / Mutét - rehabilitáció - munkavállalás.

Discovery of inhibitors of the mitotic kinase TTK based on N-(3-(3-sulfamoylphenyl)-1H-indazol-5-yl)-acetamides and carboxamides.

Numerical errors in minimization based binding energy calculations.

Numerical errors and chaotic behavior in docking simulations.

Automated generation of turn mimetics: proof of concept study for the MC4 receptor.

Structural chemistry of the histone methyltransferases cofactor binding site.

Reducing docking score variations arising from input differences.

Fragment Hits: What do They Look Like and How do They Bind?

The use of ligand-based de novo design for scaffold hopping and sidechain optimization: two case studies.

[Treatment of spastic upper limb with botulinum toxin]. / A felso végtagi spasticitas kezelése botulinustoxinnal.

Consensus scoring for protein-ligand interactions.

Discovery of Pyrazolo[1,5-a]pyrimidine TTK Inhibitors: CFI-402257 is a Potent, Selective, Bioavailable Anticancer Agent.

Administration of estramustine in response to changes in the prostate-specific antigen and Karnofsky index in the treatment of prostate cancer.

[The place of estramustine in the treatment of prostate cancer]. / Az estramustin helye a prostatarák kezelésében.

The discovery of Polo-like kinase 4 inhibitors: design and optimization of spiro[cyclopropane-1,3'[3H]indol]-2'(1'H).ones as orally bioavailable antitumor agents.

The discovery of Polo-like kinase 4 inhibitors: identification of (1R,2S).2-(3-((E).4-(((cis).2,6-dimethylmorpholino)methyl)styryl). 1H.indazol-6-yl)-5'-methoxyspiro[cyclopropane-1,3'-indolin]-2'-one (CFI-400945) as a potent, orally active antitumor agent.

The Discovery of Orally Bioavailable Tyrosine Threonine Kinase (TTK) Inhibitors: 3-(4-(heterocyclyl)phenyl)-1H-indazole-5-carboxamides as Anticancer Agents.