[Primary cutaneous diffuse large B-cell lymphoma of the leg according to the new WHO-EORTC classification. Two cases]. / Linfoma primario cutáneo B de célula grande difuso tipo piernas según la nueva clasificación de la OMS-EORTC. Dos casos.

Primary cutaneous lymphomas are a heterogeneous group of lymphoproliferative disorders characterized by skin involvement with no evidence of systemic disease at the time of diagnosis. Their clinical behavior is generally indolent, and only occasionally is the development of extracutaneous disease observed. Since the 1980s, primary cutaneous B-cell lymphomas have been considered a specific group of lymphomas, differentiated from both T-cell lymphomas and from secondary cutaneous B-cell lymphomas. Both the EORTC and the WHO have proposed alternative classifications for these entities, with significant discrepancies that were finally resolved through the development of a new classification (WHO-EORTC classification for cutaneous lymphomas), which standardizes criteria that had previously been different. We present two new cases of primary cutaneous diffuse large B-cell lymphoma of the leg according to the new classification.

Linfoma primario cutáneo B de célula grande difuso tipo piernas según la nueva clasificación de la OMS-EORTC. Dos casos / Primary cutaneous diffuse large B-cell lymphoma of the leg according to the new WHO-EORTC classification. Two cases

Los linfomas primarios cutáneos son un grupo heterogéneo de procesos linfoproliferativos que se caracterizan por afectación cutánea sin evidencia de enfermedad sistémica en el momento del diagnóstico. Por lo general tienen un comportamiento clínico indolente, y sólo ocasionalmente suele observarse el desarrollo de enfermedad extracutánea. A partir de la década de 1980, se han considerado los linfomas primarios cutáneos de células B como un grupo específico de linfomas, diferenciándose tanto de los linfomas de células T como de los linfomas cutáneos secundarios de células B. Tanto la EORTC como la OMS han propuesto clasificaciones alternativas para estas entidades con discrepancias importantes que últimamente se han aclarado elaborando una nueva clasificación (clasificación de la OMS-EORTC de los linfomas cutáneos) que unifica criterios hasta ahora dispares. Se presentan dos nuevos casos de linfoma primario cutáneo B de célula grande difuso tipo piernas según esta nueva clasificación

Primary cutaneous lymphomas are a heterogeneous group of lymphoproliferative disorders characterized by skin involvement with no evidence of systemic disease at the time of diagnosis. Their clinical behavior is generally indolent, and only occasionally is the development of extracutaneous disease observed. Since the 1980s, primary cutaneous B-cell lymphomas have been considered a specific group of lymphomas, differentiated from both T-cell lymphomas and from secondary cutaneous B-cell lymphomas. Both the EORTC and the WHO have proposed alternative classifications for these entities, with significant discrepancies that were finally resolved through the development of a new classification (WHO-EORTC classification for cutaneous lymphomas), which standardizes criteria that had previously been different. We present two new cases of primary cutaneous diffuse large B-cell lymphoma of the leg according to the new classification