Enhancement of the antibiotic activity mediated by the essential oil of Ocotea odorifera (VELL) ROWHER and safrole association.

In a recent study, our research group demonstrated that the essential oil of Ocotea odorifera (EOOO) and its major compound safrole potentiated the action fluoroquinolones, modulating bacterial resistance possibly due to direct inhibition of efflux pumps. Thus, in the present study, we investigated whether these treatments could enhance the activity of gentamicin and erythromycin against multidrug-resistant (MDR) bacteria. The EOOO was extracted by hydrodistillation, and the phytochemical analysis was performed by gas chromatography coupled to mass spectrometry (GC-MS). The antibiotic-enhancing effect of the EOOO and safrole against MDR strains of Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa was analyzed by the broth microdilution method. The chemical analysis confirmed the presence of safrole as a major component among the 16 compounds identified in the EOOO. Both the essential oil and the isolated compound showed clinically relevant antibacterial activities against S. aureus. Regarding the modulation of antibiotic resistance, the EOOO was found to enhance the activity of erythromycin against the strains of P. aeruginosa and S. aureus, as well as improving the action of gentamicin against S. aureus. On the other hand, safrole potentiated the activity of gentamicin against the S. aureus strain alone. It is concluded, therefore, that the EOOO and safrole can enhance the activity of macrolides and aminoglycosides, and as such are useful in the development of therapeutic tools to combat bacterial resistance against these classes of antibiotics.

Integralidade do cuidado de enfermagem do pré-natal ao puerpério / Completeness of nursing care from prenatal to puerperium

Objetivo: compreender a integralidade do cuidado de enfermagem do pré-natal ao puerpério. Método: pesquisa de campo, com abordagem qualitativa, realizada na unidade hospitalar, localizada na região metropolitana de Fortaleza/CE. A coleta de dados ocorreu no período de abril a maio de 2021, com a participação de 26 puérperas. Resultados: a mulher, no tocante à sua integralidade durante o ciclo do pré-natal ao puerpério, obteve um cuidado com o foco biológico, surgindo a família como um apoio para os aspectos emocionais. O enfermeiro é o profissional responsável pela criação da confiabilidade da gestante e família, durante o momento do pré-natal até o puerpério. Conclusão: a integralidade do cuidado desenvolvido pelo enfermeiro encontra desafios relacionados à necessidade de uma visão que contemple o processo saúde-doença que rodeia essa mulher.

Objective: To understand the comprehensiveness of nursing care from prenatal care to puerperium. Method: Field research, with a qualitative approach, carried out in a hospital located in the metropolitan region of Fortaleza/CE. Data collection took place from April to May 2021 with the participation of 26 postpartum women. Results: The woman, regarding her completeness during the cycle from prenatal to postpartum obtained a care with the biological focus, emerging the family as a support for the emotional aspects. The nurse is the professional responsible for creating the reliability of the pregnant woman and her family, from the prenatal period to postpartum. Conclusion: The integrality of care provided by nurses faces challenges related to the need for a vision that contemplates the health-disease process that surrounds this woman.