RESUMEN
The effect of short and long-term therapy with aspirin (50 mg/day) on platelet alpha granule secretion was studied in 11 healthy controls and 57 patients suffering from transient cerebral ischemic attacks (TIA) with and without accompanying diabetes and hypertension. Plasma levels of beta-thromboglobulin (beta-TG) and platelet factor 4 (PF 4) were measured as indicators of platelet alpha granule secretion. beta-TG and PF 4 levels were increased following cerebral ischemia. Aspirin treatment failed to suppress plasma levels of both proteins when measured a month and then a year after initiation of treatment. Therefore, these proteins may be poor indicators of platelet inhibition by aspirin.
Asunto(s)
Aspirina/uso terapéutico , Plaquetas/metabolismo , Ataque Isquémico Transitorio/tratamiento farmacológico , Glicoproteínas de Membrana Plaquetaria/sangre , Adulto , Anciano , Plaquetas/efectos de los fármacos , Femenino , Humanos , Ataque Isquémico Transitorio/sangre , Masculino , Persona de Mediana Edad , Selectina-P , Factor Plaquetario 4/sangre , beta-Tromboglobulina/sangreRESUMEN
In order to evaluate the role of the sympathetic autonomic nervous system (SANS) in common migraine we measured platelet catecholamine levels in a group of patients and in control subjects after 1 and 30 min of supine rest. Common migraine patients showed, at 1 min of supine rest, higher platelet norepinephrine (NE) content in comparison with the controls. This result may reflect a decreased release of platelet dense bodies in migraineurs. The same patients showed after 30' of supine rest a hardly significant increase of platelet NE levels in contrast to the clearly significant increase found in controls. These findings support the hypothesis of sympathetic hypofunction in migraine.