Detalles de la búsqueda
1.
Unbound Brain-to-Plasma Partition Coefficient, Kp,uu,brain-a Game Changing Parameter for CNS Drug Discovery and Development.
Pharm Res;
39(7): 1321-1341, 2022 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-35411506
2.
Calculation of an Apical Efflux Ratio from P-Glycoprotein (P-gp) In Vitro Transport Experiments Shows an Improved Correlation with In Vivo Cerebrospinal Fluid Measurements in Rats: Impact on P-gp Screening and Compound Optimization.
J Pharmacol Exp Ther;
376(3): 322-329, 2021 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-33288523
3.
Modulation of Pharmacologically Relevant Properties of Piperidine Derivatives by Functional Groups in an Equatorial or Axial ß-Position to the Amino Group.
Chembiochem;
21(1-2): 212-234, 2020 01 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-31491045
4.
Benchmarking of a checklist for the identification of familial risk for breast and ovarian cancers in a prospective cohort.
Breast J;
25(3): 455-460, 2019 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-30953388
5.
31P and 1H NMR Studies of the Molecular Organization of Lipids in the Parallel Artificial Membrane Permeability Assay.
Mol Pharm;
14(1): 284-295, 2017 01 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-27977215
6.
Prospective cohort study using the breast cancer spheroid model as a predictor for response to neoadjuvant therapy--the SpheroNEO study.
BMC Cancer;
15: 519, 2015 Jul 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-26169261
7.
Estimation of Drug Binding to Brain Tissue: Methodology and in Vivo Application of a Distribution Assay in Brain Polar Lipids.
Mol Pharm;
12(12): 4529-41, 2015 Dec 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-26560069
8.
Lessons Learned From Clinical Studies in Centronuclear Myopathies: The Patient Perspective-A Qualitative Study.
Clin Ther;
2024 Apr 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-38670885
9.
The experience of clinical study and trial participation in rare diseases: A scoping review of centronuclear myopathy and other neuromuscular disorders.
Neuromuscul Disord;
38: 1-7, 2024 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-38290938
10.
Pharmacological Enhancement of Adult Hippocampal Neurogenesis Improves Behavioral Pattern Separation in Young and Aged Mice.
bioRxiv;
2024 Feb 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-38352378
11.
When the Going Gets Challenging-Motivational Theories as a Driver for Workplace Health Promotion, Employees Well-Being and Quality of Life.
Behav Sci (Basel);
13(11)2023 Oct 30.
Artículo
en Inglés
| MEDLINE | ID: mdl-37998645
12.
Leadership Theories and the Veterinary Health Care System.
Vet Sci;
9(10)2022 Sep 29.
Artículo
en Inglés
| MEDLINE | ID: mdl-36288151
13.
Multiorgan Crystal Deposition of an Amphoteric Drug in Rats Due to Lysosomal Accumulation and Conversion to a Poorly Soluble Hydrochloride Salt.
Toxicol Sci;
180(2): 383-394, 2021 04 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-33454789
14.
Discovery of carmegliptin: a potent and long-acting dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes.
Bioorg Med Chem Lett;
20(3): 1109-13, 2010 Feb 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-20031405
15.
Aryl- and heteroaryl-substituted aminobenzo[a]quinolizines as dipeptidyl peptidase IV inhibitors.
Bioorg Med Chem Lett;
20(3): 1106-8, 2010 Feb 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-20031408
16.
Discovery of benzoylisoindolines as a novel class of potent, selective and orally active GlyT1 inhibitors.
Bioorg Med Chem Lett;
20(23): 6960-5, 2010 Dec 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-20974532
17.
Entrectinib, a TRK/ROS1 inhibitor with anti-CNS tumor activity: differentiation from other inhibitors in its class due to weak interaction with P-glycoprotein.
Neuro Oncol;
22(6): 819-829, 2020 06 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-32383735
18.
The discovery and unique pharmacological profile of RO4938581 and RO4882224 as potent and selective GABAA alpha5 inverse agonists for the treatment of cognitive dysfunction.
Bioorg Med Chem Lett;
19(20): 5940-4, 2009 Oct 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-19762240
19.
Imidazo[1,5-a][1,2,4]-triazolo[1,5-d][1,4]benzodiazepines as potent and highly selective GABAA alpha5 inverse agonists with potential for the treatment of cognitive dysfunction.
Bioorg Med Chem Lett;
19(20): 5958-61, 2009 Oct 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-19740657
20.
Discovery of the imidazo[1,5-a][1,2,4]-triazolo[1,5-d][1,4]benzodiazepine scaffold as a novel, potent and selective GABA(A) alpha5 inverse agonist series.
Bioorg Med Chem Lett;
19(19): 5746-52, 2009 Oct 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-19726184