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1.
A microfluidic system that replicates pharmacokinetic (PK) profiles in vitro improves prediction of in vivo efficacy in preclinical models.
PLoS Biol;
20(5): e3001624, 2022 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-35617197
2.
Challenges and Opportunities in Cancer Drug Resistance.
Chem Rev;
121(6): 3297-3351, 2021 03 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-32692162
3.
Identification and optimization of a novel series of selective PIP5K inhibitors.
Bioorg Med Chem;
54: 116557, 2022 01 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-34922306
4.
Development of isotope-enriched phosphatidylinositol-4- and 5-phosphate cellular mass spectrometry probes.
Chem Sci;
12(7): 2549-2557, 2021 Feb 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-34820112
5.
AZD0364 Is a Potent and Selective ERK1/2 Inhibitor That Enhances Antitumor Activity in KRAS-Mutant Tumor Models when Combined with the MEK Inhibitor, Selumetinib.
Mol Cancer Ther;
20(2): 238-249, 2021 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-33273059
6.
Targeting melanoma's MCL1 bias unleashes the apoptotic potential of BRAF and ERK1/2 pathway inhibitors.
Nat Commun;
10(1): 5167, 2019 11 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-31727888
7.
Discovery of a Potent and Selective Oral Inhibitor of ERK1/2 (AZD0364) That Is Efficacious in Both Monotherapy and Combination Therapy in Models of Nonsmall Cell Lung Cancer (NSCLC).
J Med Chem;
62(24): 11004-11018, 2019 12 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-31710489
8.
Structure-Guided Discovery of Potent and Selective Inhibitors of ERK1/2 from a Modestly Active and Promiscuous Chemical Start Point.
J Med Chem;
60(8): 3438-3450, 2017 04 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-28376306
9.
Structure-Guided Design of Highly Selective and Potent Covalent Inhibitors of ERK1/2.
J Med Chem;
58(11): 4790-801, 2015 Jun 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-25977981
10.
Potent, selective small molecule inhibitors of type III phosphatidylinositol-4-kinase α- but not ß-inhibit the phosphatidylinositol signaling cascade and cancer cell proliferation.
Chem Commun (Camb);
50(40): 5388-90, 2014 May 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-24366037
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