RESUMEN
The results of this open multicenter trial with 100 patients of both sexes show that a single 300-mg dose of rosoxacin (Win 35,213) was effective in achieving a 94% cure rate, both clinical and bacteriological, on the seventh day after treatment in patients with uncomplicated acute gonococcal infection. The cure rate in men was 94% (86/92) and in women 100% (8/8). All isolates of Neisseria gonorrhoeae were susceptible to rosoxacin, as determined by 5-micrograms sensitivity disks. Adverse effects were seen in 14 patients--13 men and one woman. Twelve patients reported dizziness, one drowsiness, and one visual changes. It is concluded that rosoxacin can be of great usefulness in the epidemiological control of acute gonococcal infection, because of the lack of in vitro resistance to it, its minimal adverse effects, the low dose requirements, and the effectiveness of a single dose. The drug does not appear to have any treponemicidal action.
Asunto(s)
4-Quinolonas , Antiinfecciosos/uso terapéutico , Gonorrea/tratamiento farmacológico , Quinolinas/uso terapéutico , Quinolonas , Adulto , Antiinfecciosos/efectos adversos , Femenino , Gonorrea/microbiología , Humanos , Masculino , Quinolinas/efectos adversos , Factores de TiempoRESUMEN
An 8-year-old boy with symptomatic late-onset congenital syphilis is reported. The child had been undertreated when he was 78 days of age, but his clinical and serologic follow-up did not occur until he was 3 years of age. At that time, he was asymptomatic, and cerebrospinal fluid disclosed not only hypercellularity but also a reactive Venereal Disease Research Laboratories test. Although he was then retreated at 4 years of age, he developed seizures. Cranial computed tomography and magnetic resonance imaging were normal, but two single photon emission computed tomography scans performed when he was 5 years of age and then 7 years of age demonstrated areas of hypoperfusion that closely agreed with the alterations on electroencephalograph. Brain single photon emission computed tomography was able to detect cerebral nervous system abnormalities in this young patient with neurosyphilis, whereas other image studies did not.
Asunto(s)
Neurosífilis/diagnóstico por imagen , Tomografía Computarizada de Emisión de Fotón Único , Edad de Inicio , Niño , Estudios de Seguimiento , Humanos , Masculino , Neurosífilis/congénitoAsunto(s)
Deficiencia de Magnesio/complicaciones , Tetania/etiología , Adolescente , Adulto , Anciano , Preescolar , Electrocardiografía , Electroencefalografía , Femenino , Humanos , Magnesio/sangre , Deficiencia de Magnesio/genética , Trastornos Mentales/genética , Persona de Mediana Edad , Trastornos Neuróticos/complicaciones , EspectrofotometríaRESUMEN
Para el diagnostico de infeccion genital por Chlamydia utilizamos la tecnica clasica de inmunofluorescencia indirecta con anticuerpos monoclonales y conjugado fluorescente. Las improntas fueron preparadas de muestras uretrales o cervicales directamente de los pacientes, contactos o controles postratamiento. Esta reaccion directa se basa en la deteccion de cuerpos elementales de clamidias intra y extracelulares. Se realizo la comparacion de la reaccion directa con sus respectivos cultivos coloreados con lugol en 60 muestras de pacientes, obteniendose una sensibidad del 85% y una especificidad del 79% para la tecnica monoclonal. El metodo directo es de gran importancia epidemiologica para el diagnostico de infeccion genital por Chlamydia y puede realizarse en laboratorios que no tienen posibilidades tecnologicas para cultivos celulares