Long-term ayahuasca use is associated with preserved global cognitive function and improved memory: a cross-sectional study with ritual users.

Although several studies have been conducted to elucidate the relationship between psychedelic consumption and cognition, few have focused on understanding the long-term use influence of these substances on these variables, especially in ritualistic contexts.  To verify the influence of ritualistic ayahuasca consumption on the cognition of experienced ayahuasca religious users (> 20 years) and beginners (< 3 years), which participated in rituals of the Centro Luz Divina (CLD), a Santo Daime church in Brazil. Observational, descriptive, and cross-sectional study was carried out in which 48 people participated divided into three groups: (a) experienced ayahuasca users (n = 16), (b) beginner ayahuasca users (n = 16) and (c) control group (n = 16). All groups were matched by sex, age, and education and contained 8 women and 8 men. Cognition was assessed with the WASI (intelligence quotient), Digit Span (verbal working memory), Corsi Block-Tapping Task (visuospatial-related and working memory), Rey-Osterrieth Complex Figure test (visual perception, immediate memory), and Wisconsin Card Sorting and Five Digit Test (executive functions). Groups were homogenous in terms of sociodemographic characteristics, with participants presenting average intellectual performance. There was no evidence of cognitive decline amongst ayahuasca users. The experienced group showed higher scores compared to the less experienced group in the Digit Span and Corsi Block-Tapping tasks, which assess working verbal and visuospatial memories respectively. We confirmed the botanical identities of Psychotria viridis and Banisteriopsis caapi and the presence of the alkaloids both in the plants and in the brew. Short and long-term ayahuasca consumption does not seem to alter human cognition, while long-term use seems to be associated with improvements in aspects of working memory when compared with short-term use.

Decrease in tobacco use among Brazilian students: a possible consequence of the ban on cigarette advertising?

In 2000, cigarette advertising was banned from the Brazilian media [LEI N degrees 10.167, de 27 de dezembro de dezembro. (2000). http://www.planalto.gov.br/ccivil_03/Leis/L10167.htm]. Nevertheless, not enough surveys have been carried out to measure the impact of the prohibition. The objective of the present survey was to compare the use of tobacco by primary and secondary school students in 1997 and 2004, that is, before and after the ban on tobacco advertising in Brazil. Two surveys were conducted (in 1997 and 2004) using the same methodology, with a target population of primary (from the fifth grade on) and secondary public schools in ten different Brazilian capitals. The sampling was done by conglomerates, stratified, and obtained in two stages. In total, 15,501 students were surveyed in 1997, and 21,712 in 2004. The questionnaire was adapted from an instrument developed by WHO, anonymous, self-administered, and applied collectively in the classroom. In a comparison of the two surveys (1997 and 2004) tobacco lifetime use (used any psychotropic drug at least once in their life) decreased significantly in seven out of ten capitals surveyed. The 11-12 year old age group experienced the largest decrease in tobacco lifetime use. There was a decrease in lifetime use for males in nine capitals, and in eight capitals for females. A decrease was also observed in heavy tobacco use also in eight capitals. In conclusion there was a significant decrease in tobacco consumption among the surveyed students, suggesting that the decrease is related to changes in public policy in Brazil over the surveyed period.

When formulation procedures strongly matter: a case study of ayahuasca use in Centro Luz Divina, Piedade, São Paulo, Brazil

Objectives: The objectives of this study were (a) to describe the history of the formation of the Centro Luz Divina (CLD), Piedade, São Paulo, (b) to describe the plants and recipes involved in making ayahuasca, and (c) to provide information for future chemical and pharmacological studies of ayahuasca. Methods: During the 578 hours of fieldwork between 2017 and 2019, 10 interviewees were interviewed (two priests and eight CLD leaders). The methods and techniques from cultural anthropology were used to conduct a snowball sampling to select respondents and record data through unstructured interviews, participant observation and field diaries. Data on the history of the CLD's formation, plants and beverage recipes were recorded. The plants were dry collected and deposited at the UNIFESP Herbarium. Results: The history of the formation of the CLD, which was founded in 2002, was detailed. This center produces several recipes of the ayahuasca beverage during rituals named feitios in Portuguese by using the plants Psychotria viridis and Banisteriopsis caapi. The process of making two of these recipes was detailed in the present study, and they are the "First Degree beverage" and "Second Degree beverage", which vary in preparation time, concentration, diversity and amount of the plant used and may lead to different "potencies of the beverage", according to the interviewees' reports. From a pharmacological point of view, higher degree beverages are probably richer beverages from the chemical and pharmacological perspectives. Conclusion: Ayahuasca recipes produced at the CLD may have different "potencies". However, future chemical and pharmacological investigations should consider these and other types of ayahuasca found in other Daimist centers in their protocols since many studies suggest the use of the substances in this beverage for treating Parkinson's, anxiety, depression, and other ailments, as described in the scientific literature.

Comparison between two household surveys on psychotropic drug use in Brazil: 2001 and 2004.

CEBRID (Brazilian Center of Information on Psychotropic Drugs) conducted two household surveys on drug use in Brazil, the first in 2001 and the second in 2005, making it possible for researchers, for the first time ever, to have a timeline comparison using this type of methodology. The universe studied corresponded to the Brazilian population living in 107 Brazilian cities with more than 200.00 inhabitants. 8,589 people were interviewed in the first survey in 2001, and 7,939 people in the second. Data on prevalence of lifetime use for psychotropic drugs showed that there was a significant increase only in the number of people who had made lifetime use of psychotropic substances (including tobacco and alcohol). In 2001, 19.4% of the interviewees reported having used some type of drug, and the ranking of lifetime drug use in 2004 was 22.8%, a statistically significant increase. There was also a statistically significant increase in lifetime use of alcohol and tobacco in comparison between the two surveys.

Factors associated with heavy alcohol use among students in Brazilian capitals.

OBJECTIVE: To evaluate the association between heavy use of alcohol among students and family, personal and social factors. METHODS: Cross-sectional study including public school students aged ten to 18 from 27 Brazilian capital cities in 2004. Data was collected using an anonymous, self-report questionnaire that was adapted from a World Health Organization instrument. A representative sample comprising 48,155 students was stratified by census tracts and clusters (schools). The associations between heavy alcohol use and the factors studied were analyzed using logistic regression at a 5% significance level. RESULTS: Of all students, 4,286 (8.9%) reported heavy alcohol use in the month prior to the interview. The logistic regression analysis showed an association between fair or poor relationship with the father (OR = 1.46) and the mother (OR = 1.61) and heavy use of alcohol. Following a religion (OR = 0.83) was inversely associated with heavy alcohol consumption. Sports practice and mother perceived as a 'liberal' person had no significance in the model. However, a higher prevalence of heavy use of alcohol was seen among working students. CONCLUSIONS: Stronger family ties and religion may help preventing alcohol abuse among students.

Alcohol-related domestic violence: a household survey in Brazil.

OBJECTIVE: To describe situations of domestic violence committed by perpetrators under the influence of alcohol in the largest Brazilian cities. METHODS: A household survey was carried out in the 108 Brazilian cities with more than 200,000 inhabitants in 2005. A multistage probabilistic self-weighted sample stratified in terms of conglomerate units was performed in three selection stages: census tracts, households, and respondents (population between 12 and 65 years old). The instrument to collect the data was the Substance Abuse and Mental Health Services Administration, with questions on sociodemographics and psychotropic drug abuse.. RESULTS: The survey encompassed 7,939 households. In 33.5% of them there were reports of domestic violence, 17.1% out of which involving intoxicated perpetrators. The most frequently reported types of violence associated with the use of alcohol were: arguments among the people in the household (81,8%), loud arguments not aimed at a specific person (70.9%), threats of assault (39.5%), and breaking households objects (38.7%). The respondents also reported physical assault (27.8%), physical assault with weapon (5.5%), and sexual abuse (3.2%). More than half of perpetrators lived in the household and 88.8% were male. Most of the victims were female (63.9%); 33.9% were wives and 18.2% were children. In terms of recidivism, 14.1% of the cases lasted for a period between 1 and 5 years, and in 14.3% they lasted for over a decade. Most of the victims (86%) and perpetrators (77.9%) did not look for the help of either the health services or the police. CONCLUSIONS: In addition to the considerable number of Brazilian households with a history of violence involving intoxicated abusers, this kind of abuse has many specific characteristics. The low rate for the search for help at the health services/police stations point to the importance of actively identifying cases of domestic violence.

Comparison between two household surveys on psychotropic drug use in Brazil: 2001 and 2004 / O uso de drogas no Brasil: comparação de dois levantamentos domiciliares: 2001 e 2004

CEBRID (Brazilian Center of Information on Psychotropic Drugs) conducted two household surveys on drug use in Brazil, the first in 2001 and the second in 2005, making it possible for researchers, for the first time ever, to have a timeline comparison using this type of methodology. The universe studied corresponded to the Brazilian population living in 107 Brazilian cities with more than 200.00 inhabitants. 8,589 people were interviewed in the first survey in 2001, and 7,939 people in the second. Data on prevalence of lifetime use for psychotropic drugs showed that there was a significant increase only in the number of people who had made lifetime use of psychotropic substances (including tobacco and alcohol). In 2001, 19.4 percent of the interviewees reported having used some type of drug, and the ranking of lifetime drug use in 2004 was 22.8 percent, a statistically significant increase. There was also a statistically significant increase in lifetime use of alcohol and tobacco in comparison between the two surveys.

O CEBRID realizou duas pesquisas domiciliares sobre drogas no Brasil, uma em 2001 e uma em 2004, permitindo, pela primeira vez, uma comparação usando a mesma metodologia. O universo estudado correspondeu à população brasileira que vive nas 107 cidades brasileiras com mais de 200.00 habitantes. 8,589 pessoas foram entrevistadas na primeira pesquisa realizada em 2001 e 7,939 pessoas, na segunda. Os dados sobre a prevalência mostraram que houve um aumento significativo do uso na vida de drogas psicotrópicas (inclusive para o tabaco e o álcool). Em 2001, 19,4 por cento dos entrevistados relataram ter usado algum tipo de droga e, em 2004, foi 22,8 por cento de uso na vida de drogas, um aumento estatisticamente significativo. Verificou-se também um aumento estatisticamente significativo no uso na vida de álcool e tabaco na comparação entre os dois levantamentos.

Fatores associados ao uso pesado de álcool entre estudantes das capitais brasileiras / Factors associated with heavy alcohol use among students in Brazilian capitals

Objetivo: Analisar a associação entre o uso pesado de álcool entre estudantes e os fatores familiares, pessoais e sociais. Métodos: Estudo transversal realizado com estudantes de dez a 18 anos de escolas públicas de 27 capitais brasileiras, em 2004. Os dados foram coletados por meio de questionário anônimo, de autopreenchimento, adaptado de instrumento desenvolvido pela Organização Mundial da Saúde. A amostra representativa, composta por 48.155 estudantes, foi estratificada por setores censitários e por conglomerados (escolas). Associações entre o uso pesado de álcool e os fatores estudados foram analisadas por meio de regressão logística, considerando nível de significância de 5 por cento. Resultados: Do total de estudantes, 4.286 (8,9 por cento) fizeram uso pesado de álcool no mês anterior à entrevista. A análise por regressão logística mostrou associação entre relações ruins ou regulares com pai (OR=1,46) e mãe (OR=1,61) e uso pesado de álcool. Seguir uma religião (OR=0,83) mostrou-se inversamente associado a este tipo de consumo de álcool. A prática de esportes e o fato de a mãe se percebida como liberal não mostraram significância no modelo. Houve maior prevalência de uso pesado de álcool entre os estudantes que trabalhavam. Conclusões: Ligações familiares mais coesas e seguir uma religião podem prevenir o uso abusivo de álcool entre estudantes.

Padrões de violência domiciliar associada ao uso de álcool no Brasil / Alcohol-related domestic violence: a household survey in Brazil

OBJETIVO: Analisar as situações de violência domiciliar ocorridas com o agressor sob efeito do álcool. MÉTODOS: Foi realizado um levantamento domiciliar que incluiu as 108 cidades brasileiras com mais de 200 mil habitantes em 2005. A amostragem foi por conglomerados, estratificada, probabilística e autoponderada, obtida em três estágios de seleção: setores censitários, domicílios e respondentes (população entre 12-65 anos de idade). O instrumento utilizado para obtenção dos dados foi o Substance Abuse and Mental Health Services Administration, com perguntas sobre dados sociodemográficos e uso de drogas psicotrópicas. RESULTADOS: Foram pesquisados 7.939 domicílios. Em 33,5 por cento foi relatado histórico de violência domiciliar, sendo 17,1 por cento com agressores alcoolizados. Os tipos de violência em associação com uso de álcool mais freqüentes foram: discussões direcionadas a pessoas do domicílio (81,8 por cento), escândalos não direcionados a alguém específico (70,9 por cento), ameaça de agressão física (39,5 por cento) e de quebra de objetos (38,7 por cento), agressões físicas (27,8 por cento), com armas (5,5 por cento) e abuso sexual (3,2 por cento). Mais da metade dos agressores era morador do domicílio, 88,8 por cento deles do sexo masculino. A maioria das vítimas era do sexo feminino (63,9 por cento); 33,9 por cento eram esposas e 18,2 por cento filhos. Quanto às reincidências, 14,1 por cento dos casos perduraram por período entre um a cinco anos e em 14,3 por cento ultrapassaram uma década. A maior parte das vítimas (86 por cento) e dos agressores (77,9 por cento) não procurou por ajuda em serviço de saúde e/ou delegacia. CONCLUSÕES: Além da alta proporção de domicílios brasileiros com histórico de violência com agressores alcoolizados, as agressões apresentaram várias especificidades. A baixa procura por ajuda em serviços de saúde/segurança indica a importância da detecção ativa de casos de violência domiciliar.

OBJECTIVE: To describe situations of domestic violence committed by perpetrators under the influence of alcohol in the largest Brazilian cities. METHODS: A household survey was carried out in the 108 Brazilian cities with more than 200,000 inhabitants in 2005. A multistage probabilistic self-weighted sample stratified in terms of conglomerate units was performed in three selection stages: census tracts, households, and respondents (population between 12 and 65 years old). The instrument to collect the data was the Substance Abuse and Mental Health Services Administration, with questions on sociodemographics and psychotropic drug abuse.. RESULTS: The survey encompassed 7,939 households. In 33.5 percent of them there were reports of domestic violence, 17.1 percent out of which involving intoxicated perpetrators. The most frequently reported types of violence associated with the use of alcohol were: arguments among the people in the household (81,8 percent), loud arguments not aimed at a specific person (70.9 percent), threats of assault (39.5 percent), and breaking households objects (38.7 percent). The respondents also reported physical assault (27.8 percent), physical assault with weapon (5.5 percent), and sexual abuse (3.2 percent). More than half of perpetrators lived in the household and 88.8 percent were male. Most of the victims were female (63.9 percent); 33.9 percent were wives and 18.2 percent were children. In terms of recidivism, 14.1 percent of the cases lasted for a period between 1 and 5 years, and in 14.3 percent they lasted for over a decade. Most of the victims (86 percent) and perpetrators (77.9 percent) did not look for the help of either the health services or the police. CONCLUSIONS: In addition to the considerable number of Brazilian households with a history of violence involving intoxicated abusers, this kind of abuse has many specific characteristics. The low rate for the search for help at the health services/police ...