[Comparative study of the toxicity of cyanic derivatives and/or aromatic amides]. / Etude comparée de la toxicité de dérivés cyanés et/ou amides aromatiques.

The toxical potentiality of the cyanic radicle and the detoxicating characteristic of the amide group are studied following the evolution of the benzonitrile and benzamide toxicity when a cyanic or amide radicle is added to the original molecule. This comparative study shows that the presence of amide group has not always given a higher toxicity to the organic molecules that own it. It is the respective localization of the cyanic or amide radicles which appears to play the most important role.

[Pharmacologic effects of glycerolformal on the central nervous system]. / Effets pharmacologiques du glycérolformal sur le système nerveux central.

Glycerolformal is not devoid of action on mice psychomotor behaviour. Administered through the digestive tract with infralethal doses, it can exercice depressing effects on muscular strength and sensitivity to pain without affecting inquisitiveness. It opposes the stimulating effects specific to pentetrazol, amphetamine and apomorphine and is a protection against electric convulsions but tends to increase the toxicity of tryptamine.

[Research on the psychopharmacologic profile of new barbiturics]. / Recherche du profil psychopharmacologique de nouveaux barbituriques.

The detection of psychopharmacological properties of 8 synthetic substances derived from barbituric didn't allow to consider the existence of well characterised psychotropic properties, particularly hypnotical, but only antalgic and sedative effects (or stimulating activity very low). If the presence of a benzyl substituent can confer an affinity for the nervous central system superior to the one developed when an allyl rest is in the same position, the presence of an OH or OCH3 in other place inverse the sedative character in stimulant potentiality.

[Pharmalogic effects of benzonitrile on the central nervous system]. / Effets pharmacologiques du benzonitrile sur le système nerveux central.

The present experiments intended to explore the psychopharmacological properties of benzonitrile on mice. Benzonitrile decreased motility, muscular force and inquisitiveness. The hypnotic effects of chloral and pentobarbital were increased by benzonitrile. The drug antagonized reserpine-induced palpebral ptosis and apomorphine-induced stereotypy. That benzonitrile was more effective against convulsions induced by pentetrazol and electric shock than those induced by strychnine suggested a central site of action. Perhaps benzonitrile interfers with the release or the action of central amines.

[Benzonitrile and derivatives. Synthesis and pharmacological study of alkyl para-cyanophenoxy alkanoates on the central nervous system]. / Benzonitrile et dérivés. Synthèse et étude pharmacologique de para-cyanophénoxy-alcanoates d'alkyle sur le système nerveux central.

The results obtained by the pharmacological study of alkyl para-cyanophenoxy alkanoates seem to indicate that these derivatives present a sedative effect on the central nervous system. This activity increases with the number of methyl groups substituted, on ethyl para-cyanophenoxy acetate (except the motricity composent), most probably because of an increase in lipophily and therefore in the fixation on the central nervous system.