Detalles de la búsqueda
1.
Pharmacological Characterization of the Imipridone Anticancer Drug ONC201 Reveals a Negative Allosteric Mechanism of Action at the D2 Dopamine Receptor.
Mol Pharmacol;
100(4): 372-387, 2021 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-34353882
2.
New roles for dopamine D2 and D3 receptors in pancreatic beta cell insulin secretion.
Mol Psychiatry;
25(9): 2070-2085, 2020 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-30626912
3.
The E2.65A mutation disrupts dynamic binding poses of SB269652 at the dopamine D2 and D3 receptors.
PLoS Comput Biol;
14(1): e1005948, 2018 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-29337986
4.
Identification of Positive Allosteric Modulators of the D1 Dopamine Receptor That Act at Diverse Binding Sites.
Mol Pharmacol;
94(4): 1197-1209, 2018 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-30068735
5.
Discovery and characterization of a G protein-biased agonist that inhibits ß-arrestin recruitment to the D2 dopamine receptor.
Mol Pharmacol;
86(1): 96-105, 2014 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-24755247
6.
D1-D2 dopamine receptor synergy promotes calcium signaling via multiple mechanisms.
Mol Pharmacol;
84(2): 190-200, 2013 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-23680635
7.
G Protein-Coupled Receptor Kinase 2 Selectively Enhances ß-Arrestin Recruitment to the D2 Dopamine Receptor through Mechanisms That Are Independent of Receptor Phosphorylation.
Biomolecules;
13(10)2023 10 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-37892234
8.
Identification and Characterization of ML321: A Novel and Highly Selective D2 Dopamine Receptor Antagonist with Efficacy in Animal Models That Predict Atypical Antipsychotic Activity.
ACS Pharmacol Transl Sci;
6(1): 151-170, 2023 Jan 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-36654757
9.
Pharmacology and Therapeutic Potential of Benzothiazole Analogues for Cocaine Use Disorder.
J Med Chem;
66(17): 12141-12162, 2023 09 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-37646374
10.
Dual pancreatic adrenergic and dopaminergic signaling as a therapeutic target of bromocriptine.
iScience;
25(8): 104771, 2022 Aug 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-35982797
11.
Evidence for a Stereoselective Mechanism for Bitopic Activity by Extended-Length Antagonists of the D3 Dopamine Receptor.
ACS Chem Neurosci;
11(20): 3309-3320, 2020 10 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-32969645
12.
Ligand with Two Modes of Interaction with the Dopamine D2 Receptor-An Induced-Fit Mechanism of Insurmountable Antagonism.
ACS Chem Neurosci;
11(19): 3130-3143, 2020 10 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-32865974
13.
A structural basis for how ligand binding site changes can allosterically regulate GPCR signaling and engender functional selectivity.
Sci Signal;
13(617)2020 02 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-32019899
14.
Discovery, Optimization, and Characterization of ML417: A Novel and Highly Selective D3 Dopamine Receptor Agonist.
J Med Chem;
63(10): 5526-5567, 2020 05 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-32342685
15.
Dopamine D4 Receptor-Selective Compounds Reveal Structure-Activity Relationships that Engender Agonist Efficacy.
J Med Chem;
62(7): 3722-3740, 2019 04 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-30883109
16.
Advances and challenges in the search for D2 and D3 dopamine receptor-selective compounds.
Cell Signal;
41: 75-81, 2018 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-28716664
17.
Structure-Activity Investigation of a G Protein-Biased Agonist Reveals Molecular Determinants for Biased Signaling of the D2 Dopamine Receptor.
Front Synaptic Neurosci;
10: 2, 2018.
Artículo
en Inglés
| MEDLINE | ID: mdl-29515433
18.
Synthesis and Pharmacological Characterization of Novel trans-Cyclopropylmethyl-Linked Bivalent Ligands That Exhibit Selectivity and Allosteric Pharmacology at the Dopamine D3 Receptor (D3R).
J Med Chem;
60(4): 1478-1494, 2017 02 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-28186762
19.
Receptor protection studies comparing recombinant and native nicotinic receptors: Evidence for a subpopulation of mecamylamine-sensitive native alpha3beta4* nicotinic receptors.
Neurosci Lett;
392(1-2): 135-9, 2006 Jan 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-16198480
20.
Novel Cryo-EM structures of the D1 dopamine receptor unlock its therapeutic potential.
Signal Transduct Target Ther;
6(1): 205, 2021 05 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-34023856