RESUMEN
To our knowledge, this is the first clinical report of a rofecoxib-associated upper gastrointestinal hemorrhage. We urge caution in prescribing rofecoxib to patients with risk factors for peptic ulcer disease and recommend limiting the dose to 25 mg per day for these patients.
Asunto(s)
Antiinflamatorios no Esteroideos/efectos adversos , Hemorragia Gastrointestinal/inducido químicamente , Lactonas/efectos adversos , Artritis Reumatoide/complicaciones , Artritis Reumatoide/tratamiento farmacológico , Enfermedad de Crohn/complicaciones , Humanos , Masculino , Persona de Mediana Edad , Úlcera Péptica/complicaciones , SulfonasRESUMEN
A case of a 16-year-old with herpes simplex virus type-1 infection with radicular arm pain is reported. The clinical implications of the case are discussed.
Asunto(s)
Herpes Simple/complicaciones , Radiculopatía/virología , Adolescente , Brazo , Vértebras Cervicales , Humanos , Masculino , Radiculopatía/diagnóstico , Radiculopatía/tratamiento farmacológicoRESUMEN
Effective management of chronic pain in older persons is attainable, although unnecessarily elusive. A host of factors can impede assessment and drug management, including impaired cognitive function, multiple potential causes of pain, pharmacokinetics and pharmacodynamics unique to the geriatric population, and clinician anxiety regarding analgesic addiction. In the geriatric population, some of the most prevalent chronic pain management cases involve osteoarthritis, low back pain, and neuropathy. Effective pain management is achieved with analgesics (acetaminophen and nonsteroidal anti-inflammatory drugs), opioids, non-opioid agents (e.g., tricyclic antidepressants, anticonvulsants) and invasive techniques (corticosteroid epidural injections/nerve blocks).