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1.

Head-mounted central venous access during optical recordings and manipulations of neural activity in mice.

Liu, Christine; Freeman, Daniel J; Lammel, Stephan.

Nat Protoc; 19(3): 960-983, 2024 Mar.

Artículo en Inglés | MEDLINE | ID: mdl-38057625

2.

Wild-Type KRAS Is Required for Panitumumab Efficacy in Patients With Metastatic Colorectal Cancer.

Amado, Rafael G; Wolf, Michael; Peeters, Marc; Van Cutsem, Eric; Siena, Salvatore; Freeman, Daniel J; Juan, Todd; Sikorski, Robert; Suggs, Sid; Radinsky, Robert; Patterson, Scott D; Chang, David D.

J Clin Oncol; 41(18): 3278-3286, 2023 Jun 20.

Artículo en Inglés | MEDLINE | ID: mdl-37315390

3.

Tumor penetration and epidermal growth factor receptor saturation by panitumumab correlate with antitumor activity in a preclinical model of human cancer.

Freeman, Daniel J; McDorman, Kevin; Ogbagabriel, Selam; Kozlosky, Carl; Yang, Bing-Bing; Doshi, Sameer; Perez-Ruxio, Juan Jose; Fanslow, William; Starnes, Charlie; Radinsky, Robert.

Mol Cancer; 11: 47, 2012 Jul 25.

Artículo en Inglés | MEDLINE | ID: mdl-22830443

4.

Synthesis and structure-activity relationships of dual PI3K/mTOR inhibitors based on a 4-amino-6-methyl-1,3,5-triazine sulfonamide scaffold.

Wurz, Ryan P; Liu, Longbin; Yang, Kevin; Nishimura, Nobuko; Bo, Yunxin; Pettus, Liping H; Caenepeel, Sean; Freeman, Daniel J; McCarter, John D; Mullady, Erin L; Miguel, Tisha San; Wang, Ling; Zhang, Nancy; Andrews, Kristin L; Whittington, Douglas A; Jiang, Jian; Subramanian, Raju; Hughes, Paul E; Norman, Mark H.

Bioorg Med Chem Lett; 22(17): 5714-20, 2012 Sep 01.

Artículo en Inglés | MEDLINE | ID: mdl-22832322

5.

PTEN tumor suppressor regulates p53 protein levels and activity through phosphatase-dependent and -independent mechanisms.

Freeman, Daniel J; Li, Andrew G; Wei, Gang; Li, Heng-Hong; Kertesz, Nathalie; Lesche, Ralf; Whale, Andrew D; Martinez-Diaz, Hilda; Rozengurt, Nora; Cardiff, Robert D; Liu, Xuan; Wu, Hong.

Cancer Cell; 3(2): 117-30, 2003 Feb.

Artículo en Inglés | MEDLINE | ID: mdl-12620407

6.

Design and Efficacy of a Monovalent Bispecific PD-1/CTLA4 Antibody That Enhances CTLA4 Blockade on PD-1⁺ Activated T Cells.

Dovedi, Simon J; Elder, Matthew J; Yang, Chunning; Sitnikova, Suzanne I; Irving, Lorraine; Hansen, Anna; Hair, James; Jones, Des C; Hasani, Sumati; Wang, Bo; Im, Seock-Ah; Tran, Ben; Subramaniam, Deepa S; Gainer, Shelby D; Vashisht, Kapil; Lewis, Arthur; Jin, Xiaofang; Kentner, Stacy; Mulgrew, Kathy; Wang, Yaya; Overstreet, Michael G; Dodgson, James; Wu, Yanli; Palazon, Asis; Morrow, Michelle; Rainey, Godfrey J; Browne, Gareth J; Neal, Frances; Murray, Thomas V; Toloczko, Aleksandra D; Dall'Acqua, William; Achour, Ikbel; Freeman, Daniel J; Wilkinson, Robert W; Mazor, Yariv.

Cancer Discov; 11(5): 1100-1117, 2021 05.

Artículo en Inglés | MEDLINE | ID: mdl-33419761

7.

Azole-based inhibitors of AKT/PKB for the treatment of cancer.

Zeng, Qingping; Allen, John G; Bourbeau, Matthew P; Wang, Xianghong; Yao, Guomin; Tadesse, Seifu; Rider, James T; Yuan, Chester C; Hong, Fang-Tsao; Lee, Matthew R; Zhang, Shiwen; Lofgren, Julie A; Freeman, Daniel J; Yang, Suijin; Li, Chun; Tominey, Elizabeth; Huang, Xin; Hoffman, Douglas; Yamane, Harvey K; Fotsch, Christopher; Dominguez, Celia; Hungate, Randall; Zhang, Xiaoling.

Bioorg Med Chem Lett; 20(5): 1559-64, 2010 Mar 01.

Artículo en Inglés | MEDLINE | ID: mdl-20137943

8.

Optimizing oncolytic virotherapy in cancer treatment.

Harrington, Kevin; Freeman, Daniel J; Kelly, Beth; Harper, James; Soria, Jean-Charles.

Nat Rev Drug Discov; 18(9): 689-706, 2019 09.

Artículo en Inglés | MEDLINE | ID: mdl-31292532

9.

Augmentation of radiation response by panitumumab in models of upper aerodigestive tract cancer.

Kruser, Tim J; Armstrong, Eric A; Ghia, Amol J; Huang, Shyhmin; Wheeler, Deric L; Radinsky, Robert; Freeman, Daniel J; Harari, Paul M.

Int J Radiat Oncol Biol Phys; 72(2): 534-42, 2008 Oct 01.

Artículo en Inglés | MEDLINE | ID: mdl-18793955

10.

Association of K-ras mutational status and clinical outcomes in patients with metastatic colorectal cancer receiving panitumumab alone.

Freeman, Daniel J; Juan, Todd; Reiner, Maureen; Hecht, J Randolph; Meropol, Neal J; Berlin, Jordan; Mitchell, Edith; Sarosi, Ildiko; Radinsky, Robert; Amado, Rafael G.

Clin Colorectal Cancer; 7(3): 184-90, 2008 May.

Artículo en Inglés | MEDLINE | ID: mdl-18621636

11.

Clinical Translation and Validation of a Predictive Biomarker for Patritumab, an Anti-human Epidermal Growth Factor Receptor 3 (HER3) Monoclonal Antibody, in Patients With Advanced Non-small Cell Lung Cancer.

Mendell, Jeanne; Freeman, Daniel J; Feng, Wenqin; Hettmann, Thore; Schneider, Matthias; Blum, Sabine; Ruhe, Jens; Bange, Johannes; Nakamaru, Kenji; Chen, Shuquan; Tsuchihashi, Zenta; von Pawel, Joachim; Copigneaux, Catherine; Beckman, Robert A.

EBioMedicine; 2(3): 264-71, 2015 Mar.

Artículo en Inglés | MEDLINE | ID: mdl-26137564

12.

Gene expression profiles can predict panitumumab monotherapy responsiveness in human tumor xenograft models.

Boedigheimer, Michael J; Freeman, Daniel J; Kiaei, Panteha; Damore, Michael A; Radinsky, Robert.

Neoplasia; 15(2): 125-32, 2013 Feb.

Artículo en Inglés | MEDLINE | ID: mdl-23441127

13.

A phase 2 randomized trial of paclitaxel and carboplatin with or without panitumumab for first-line treatment of advanced non-small-cell lung cancer.

Crawford, Jeffrey; Swanson, Paul; Schwarzenberger, Paul; Sandler, Alan; Prager, Diane; Zhang, Kathy; Freeman, Daniel J; Johnson, Carol W; Krishnan, Kartik; Johnson, David.

J Thorac Oncol; 8(12): 1510-8, 2013 Dec.

Artículo en Inglés | MEDLINE | ID: mdl-24389433

14.

Structure-based design of a novel series of potent, selective inhibitors of the class I phosphatidylinositol 3-kinases.

Smith, Adrian L; D'Angelo, Noel D; Bo, Yunxin Y; Booker, Shon K; Cee, Victor J; Herberich, Brad; Hong, Fang-Tsao; Jackson, Claire L M; Lanman, Brian A; Liu, Longbin; Nishimura, Nobuko; Pettus, Liping H; Reed, Anthony B; Tadesse, Seifu; Tamayo, Nuria A; Wurz, Ryan P; Yang, Kevin; Andrews, Kristin L; Whittington, Douglas A; McCarter, John D; Miguel, Tisha San; Zalameda, Leeanne; Jiang, Jian; Subramanian, Raju; Mullady, Erin L; Caenepeel, Sean; Freeman, Daniel J; Wang, Ling; Zhang, Nancy; Wu, Tian; Hughes, Paul E; Norman, Mark H.

J Med Chem; 55(11): 5188-219, 2012 Jun 14.

Artículo en Inglés | MEDLINE | ID: mdl-22548365

15.

Selective class I phosphoinositide 3-kinase inhibitors: optimization of a series of pyridyltriazines leading to the identification of a clinical candidate, AMG 511.

Norman, Mark H; Andrews, Kristin L; Bo, Yunxin Y; Booker, Shon K; Caenepeel, Sean; Cee, Victor J; D'Angelo, Noel D; Freeman, Daniel J; Herberich, Bradley J; Hong, Fang-Tsao; Jackson, Claire L M; Jiang, Jian; Lanman, Brian A; Liu, Longbin; McCarter, John D; Mullady, Erin L; Nishimura, Nobuko; Pettus, Liping H; Reed, Anthony B; Miguel, Tisha San; Smith, Adrian L; Stec, Markian M; Tadesse, Seifu; Tasker, Andrew; Aidasani, Divesh; Zhu, Xiaochun; Subramanian, Raju; Tamayo, Nuria A; Wang, Ling; Whittington, Douglas A; Wu, Bin; Wu, Tian; Wurz, Ryan P; Yang, Kevin; Zalameda, Leeanne; Zhang, Nancy; Hughes, Paul E.

J Med Chem; 55(17): 7796-816, 2012 Sep 13.

Artículo en Inglés | MEDLINE | ID: mdl-22897589

16.

Structure-activity relationships of phosphoinositide 3-kinase (PI3K)/mammalian target of rapamycin (mTOR) dual inhibitors: investigations of various 6,5-heterocycles to improve metabolic stability.

Stec, Markian M; Andrews, Kristin L; Booker, Shon K; Caenepeel, Sean; Freeman, Daniel J; Jiang, Jian; Liao, Hongyu; McCarter, John; Mullady, Erin L; San Miguel, Tisha; Subramanian, Raju; Tamayo, Nuria; Wang, Ling; Yang, Kevin; Zalameda, Leeanne P; Zhang, Nancy; Hughes, Paul E; Norman, Mark H.

J Med Chem; 54(14): 5174-84, 2011 Jul 28.

Artículo en Inglés | MEDLINE | ID: mdl-21714526

17.

A comparability study of 5 commercial KRAS tests.

Oliner, Kelly; Juan, Todd; Suggs, Sid; Wolf, Michael; Sarosi, Ildiko; Freeman, Daniel J; Gyuris, Tibor; Baron, Will; Bakker, Andreas; Parker, Alex; Patterson, Scott D.

Diagn Pathol; 5: 23, 2010 Apr 16.

Artículo en Inglés | MEDLINE | ID: mdl-20398393

18.

Activity of panitumumab alone or with chemotherapy in non-small cell lung carcinoma cell lines expressing mutant epidermal growth factor receptor.

Freeman, Daniel J; Bush, Tammy; Ogbagabriel, Selam; Belmontes, Brian; Juan, Todd; Plewa, Cherylene; Van, Gwyneth; Johnson, Carol; Radinsky, Robert.

Mol Cancer Ther; 8(6): 1536-46, 2009 Jun.

Artículo en Inglés | MEDLINE | ID: mdl-19509246

19.

Wild-type KRAS is required for panitumumab efficacy in patients with metastatic colorectal cancer.

Amado, Rafael G; Wolf, Michael; Peeters, Marc; Van Cutsem, Eric; Siena, Salvatore; Freeman, Daniel J; Juan, Todd; Sikorski, Robert; Suggs, Sid; Radinsky, Robert; Patterson, Scott D; Chang, David D.

J Clin Oncol; 26(10): 1626-34, 2008 Apr 01.

Artículo en Inglés | MEDLINE | ID: mdl-18316791

20.

PTEN regulates Mdm2 expression through the P1 promoter.

Chang, Chun-Ju; Freeman, Daniel J; Wu, Hong.

J Biol Chem; 279(28): 29841-8, 2004 Jul 09.

Artículo en Inglés | MEDLINE | ID: mdl-15090541

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