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1.
5-Bromo-2-chloro-4-fluoro-3-iodopyridine as a Halogen-rich Intermediate for the Synthesis of Pentasubstituted Pyridines.
J Org Chem;
87(5): 2559-2568, 2022 03 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-35020387
2.
The discovery of BMS-737 as a potent, CYP17 lyase-selective inhibitor for the treatment of castration-resistant prostate cancer.
Bioorg Med Chem Lett;
75: 128951, 2022 11 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-36031020
3.
Potent Long-Acting Inhibitors Targeting the HIV-1 Capsid Based on a Versatile Quinazolin-4-one Scaffold.
J Med Chem;
66(3): 1941-1954, 2023 02 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-36719971
4.
Biochemical and transcriptional profiling to triage additional activities in a series of IGF-1R/IR inhibitors.
Bioorg Med Chem;
20(6): 1961-72, 2012 Mar 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-22137930
5.
Discovery and Preclinical Profiling of GSK3839919, a Potent HIV-1 Allosteric Integrase Inhibitor.
ACS Med Chem Lett;
13(6): 972-980, 2022 Jun 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-35707159
6.
Insulin-like growth factor-1 receptor (IGF-1R) kinase inhibitors: SAR of a series of 3-[6-(4-substituted-piperazin-1-yl)-4-methyl-1H-benzimidazol-2-yl]-1H-pyridine-2-one.
Bioorg Med Chem Lett;
20(10): 3182-5, 2010 May 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-20399649
7.
SAR of PXR transactivation in benzimidazole-based IGF-1R kinase inhibitors.
Bioorg Med Chem Lett;
20(5): 1744-8, 2010 Mar 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-20153189
8.
2-(1H-Imidazol-4-yl)ethanamine and 2-(1H-pyrazol-1-yl)ethanamine side chain variants of the IGF-1R inhibitor BMS-536924.
Bioorg Med Chem Lett;
18(5): 1702-7, 2008 Mar 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-18258427
9.
Balancing oral exposure with Cyp3A4 inhibition in benzimidazole-based IGF-IR inhibitors.
Bioorg Med Chem Lett;
18(14): 4075-80, 2008 Jul 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-18572407
10.
In vitro and in vivo antitumor effects of the dual insulin-like growth factor-I/insulin receptor inhibitor, BMS-554417.
Cancer Res;
66(1): 362-71, 2006 Jan 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-16397250
11.
Discovery of a fluoroindolo[2,3-a]carbazole clinical candidate with broad spectrum antitumor activity in preclinical tumor models superior to the marketed oncology drug, CPT-11.
J Med Chem;
48(7): 2258-61, 2005 Apr 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-15801816
12.
Discovery of a (1H-benzoimidazol-2-yl)-1H-pyridin-2-one (BMS-536924) inhibitor of insulin-like growth factor I receptor kinase with in vivo antitumor activity.
J Med Chem;
48(18): 5639-43, 2005 Sep 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-16134929
13.
Novel 3',6'-anhydro and N12,N13-bridged glycosylated fluoroindolo[2,3-a]carbazoles as topoisomerase I inhibitors. Fluorine as a leaving group from sp3 carbon.
Org Lett;
7(7): 1271-4, 2005 Mar 31.
Artículo
en Inglés
| MEDLINE | ID: mdl-15787484
14.
Design and synthesis of a fluoroindolocarbazole series as selective topoisomerase I active agents. Discovery of water-soluble 3,9-difluoro-12,13-dihydro-13-[6-amino-beta-D-glucopyranosyl]-5H,13H-benzo[b]- thienyl[2,3-a]pyrrolo[3,4-c]carbazole- 5,7(6H)-dione (BMS-251873) with curative antitumor activity against prostate carcinoma xenograft tumor model.
J Med Chem;
47(7): 1609-12, 2004 Mar 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-15027851
15.
Nucleophilic capture of the imino-quinone methide type intermediates generated from 2-aminothiazol-5-yl carbinols.
Org Lett;
11(22): 5154-7, 2009 Nov 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-19827772
16.
Discovery of a 2,4-disubstituted pyrrolo[1,2-f][1,2,4]triazine inhibitor (BMS-754807) of insulin-like growth factor receptor (IGF-1R) kinase in clinical development.
J Med Chem;
52(23): 7360-3, 2009 Dec 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-19778024
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