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1.

Dominant-activating germline mutations in the gene encoding the PI(3)K catalytic subunit p110Î´ result in T cell senescence and human immunodeficiency.

Lucas, Carrie L; Kuehn, Hye Sun; Zhao, Fang; Niemela, Julie E; Deenick, Elissa K; Palendira, Umaimainthan; Avery, Danielle T; Moens, Leen; Cannons, Jennifer L; Biancalana, Matthew; Stoddard, Jennifer; Ouyang, Weiming; Frucht, David M; Rao, V Koneti; Atkinson, T Prescott; Agharahimi, Anahita; Hussey, Ashleigh A; Folio, Les R; Olivier, Kenneth N; Fleisher, Thomas A; Pittaluga, Stefania; Holland, Steven M; Cohen, Jeffrey I; Oliveira, Joao B; Tangye, Stuart G; Schwartzberg, Pamela L; Lenardo, Michael J; Uzel, Gulbu.

Nat Immunol; 15(1): 88-97, 2014 Jan.

Artículo en Inglés | MEDLINE | ID: mdl-24165795

2.

Erk1/2 inactivation promotes a rapid redistribution of COP1 and degradation of COP1 substrates.

Ouyang, Weiming; Guo, Pengfei; Takeda, Kazuyo; Fu, Qiong; Fang, Hui; Frucht, David M.

Proc Natl Acad Sci U S A; 117(8): 4078-4087, 2020 02 25.

Artículo en Inglés | MEDLINE | ID: mdl-32041890

3.

Erk1/2 Inactivation-Induced c-Jun Degradation Is Regulated by Protein Phosphatases, UBE2d3, and the C-Terminus of c-Jun.

Ouyang, Weiming; Frucht, David M.

Int J Mol Sci; 22(8)2021 Apr 09.

Artículo en Inglés | MEDLINE | ID: mdl-33918729

4.

Variable Induction of Pro-Inflammatory Cytokines by Commercial SARS CoV-2 Spike Protein Reagents: Potential Impacts of LPS on In Vitro Modeling and Pathogenic Mechanisms In Vivo.

Ouyang, Weiming; Xie, Tao; Fang, Hui; Gao, Chunling; Stantchev, Tzanko; Clouse, Kathleen A; Yuan, Kun; Ju, Tongzhong; Frucht, David M.

Int J Mol Sci; 22(14)2021 Jul 14.

Artículo en Inglés | MEDLINE | ID: mdl-34299155

5.

Anthrax lethal toxin rapidly reduces c-Jun levels by inhibiting c-Jun gene transcription and promoting c-Jun protein degradation.

Ouyang, Weiming; Guo, Pengfei; Fang, Hui; Frucht, David M.

J Biol Chem; 292(43): 17919-17927, 2017 10 27.

Artículo en Inglés | MEDLINE | ID: mdl-28893904

6.

Gastric pH and Toxin Factors Modulate Infectivity and Disease Progression After Gastrointestinal Exposure to Bacillus anthracis.

Xie, Tao; Rotstein, David; Sun, Chen; Fang, Hui; Frucht, David M.

J Infect Dis; 216(11): 1471-1475, 2017 12 12.

Artículo en Inglés | MEDLINE | ID: mdl-28968672

7.

Anthrax lethal toxin inhibits translation of hypoxia-inducible factor 1α and causes decreased tolerance to hypoxic stress.

Ouyang, Weiming; Torigoe, Chikako; Fang, Hui; Xie, Tao; Frucht, David M.

J Biol Chem; 289(7): 4180-90, 2014 Feb 14.

Artículo en Inglés | MEDLINE | ID: mdl-24366872

8.

Correlating interleukin-12 stimulated interferon-Î³ production and the absence of ectodermal dysplasia and anhidrosis (EDA) in patients with mutations in NF-κB essential modulator (NEMO).

Haverkamp, Margje H; Marciano, Beatriz E; Frucht, David M; Jain, Ashish; van de Vosse, Esther; Holland, Steven M.

J Clin Immunol; 34(4): 436-43, 2014 May.

Artículo en Inglés | MEDLINE | ID: mdl-24682681

9.

Mutations in GATA2 are associated with the autosomal dominant and sporadic monocytopenia and mycobacterial infection (MonoMAC) syndrome.

Hsu, Amy P; Sampaio, Elizabeth P; Khan, Javed; Calvo, Katherine R; Lemieux, Jacob E; Patel, Smita Y; Frucht, David M; Vinh, Donald C; Auth, Roger D; Freeman, Alexandra F; Olivier, Kenneth N; Uzel, Gulbu; Zerbe, Christa S; Spalding, Christine; Pittaluga, Stefania; Raffeld, Mark; Kuhns, Douglas B; Ding, Li; Paulson, Michelle L; Marciano, Beatriz E; Gea-Banacloche, Juan C; Orange, Jordan S; Cuellar-Rodriguez, Jennifer; Hickstein, Dennis D; Holland, Steven M.

Blood; 118(10): 2653-5, 2011 Sep 08.

Artículo en Inglés | MEDLINE | ID: mdl-21670465

10.

Development of a New Cell-Based AP-1 Gene Reporter Potency Assay for Anti-Anthrax Toxin Therapeutics.

Ouyang, Weiming; Xie, Tao; Fang, Hui; Frucht, David M.

Toxins (Basel); 15(9)2023 08 28.

Artículo en Inglés | MEDLINE | ID: mdl-37755954

11.

Interchangeability of the Assays Used to Assess the Activity of Anti-SARS-CoV-2 Monoclonal Antibodies.

Hickerson, Brady T; Khalenkov, Alexey M; Xie, Tao; Frucht, David M; Scott, Dorothy E; Ilyushina, Natalia A.

Viruses; 15(8)2023 08 05.

Artículo en Inglés | MEDLINE | ID: mdl-37632039

12.

X-linked susceptibility to mycobacteria is caused by mutations in NEMO impairing CD40-dependent IL-12 production.

Filipe-Santos, Orchidée; Bustamante, Jacinta; Haverkamp, Margje H; Vinolo, Emilie; Ku, Cheng-Lung; Puel, Anne; Frucht, David M; Christel, Karin; von Bernuth, Horst; Jouanguy, Emmanuelle; Feinberg, Jacqueline; Durandy, Anne; Senechal, Brigitte; Chapgier, Ariane; Vogt, Guillaume; de Beaucoudrey, Ludovic; Fieschi, Claire; Picard, Capucine; Garfa, Meriem; Chemli, Jalel; Bejaoui, Mohamed; Tsolia, Maria N; Kutukculer, Necil; Plebani, Alessandro; Notarangelo, Luigi; Bodemer, Christine; Geissmann, Frédéric; Israël, Alain; Véron, Michel; Knackstedt, Maike; Barbouche, Ridha; Abel, Laurent; Magdorf, Klaus; Gendrel, Dominique; Agou, Fabrice; Holland, Steven M; Casanova, Jean-Laurent.

J Exp Med; 203(7): 1745-59, 2006 Jul 10.

Artículo en Inglés | MEDLINE | ID: mdl-16818673

13.

Autosomal dominant and sporadic monocytopenia with susceptibility to mycobacteria, fungi, papillomaviruses, and myelodysplasia.

Vinh, Donald C; Patel, Smita Y; Uzel, Gulbu; Anderson, Victoria L; Freeman, Alexandra F; Olivier, Kenneth N; Spalding, Christine; Hughes, Stephen; Pittaluga, Stefania; Raffeld, Mark; Sorbara, Lynn R; Elloumi, Houda Z; Kuhns, Douglas B; Turner, Maria L; Cowen, Edward W; Fink, Danielle; Long-Priel, Debra; Hsu, Amy P; Ding, Li; Paulson, Michelle L; Whitney, Adeline R; Sampaio, Elizabeth P; Frucht, David M; DeLeo, Frank R; Holland, Steven M.

Blood; 115(8): 1519-29, 2010 Feb 25.

Artículo en Inglés | MEDLINE | ID: mdl-20040766

14.

Neutrophil elastase mediates pathogenic effects of anthrax lethal toxin in the murine intestinal tract.

Fang, Hui; Sun, Chen; Xu, Lixin; Owen, Robert J; Auth, Roger D; Snoy, Philip J; Frucht, David M.

J Immunol; 185(9): 5463-7, 2010 Nov 01.

Artículo en Inglés | MEDLINE | ID: mdl-20921524

15.

STAT3 mutations in the hyper-IgE syndrome.

Holland, Steven M; DeLeo, Frank R; Elloumi, Houda Z; Hsu, Amy P; Uzel, Gulbu; Brodsky, Nina; Freeman, Alexandra F; Demidowich, Andrew; Davis, Joie; Turner, Maria L; Anderson, Victoria L; Darnell, Dirk N; Welch, Pamela A; Kuhns, Douglas B; Frucht, David M; Malech, Harry L; Gallin, John I; Kobayashi, Scott D; Whitney, Adeline R; Voyich, Jovanka M; Musser, James M; Woellner, Cristina; Schäffer, Alejandro A; Puck, Jennifer M; Grimbacher, Bodo.

N Engl J Med; 357(16): 1608-19, 2007 Oct 18.

Artículo en Inglés | MEDLINE | ID: mdl-17881745

16.

The ELISA Detectability and Potency of Pegfilgrastim Decrease in Physiological Conditions: Key Roles for Aggregation and Individual Variability.

Xie, Tao; Fang, Hui; Ouyang, Weiming; Angart, Phillip; Chiang, Meng-Jung; Bhirde, Ashwinkumar A; Sheikh, Faruk; Lynch, Patrick; Shah, Ankit B; Patil, Sharadrao M; Chen, Kang; Shen, Meiyu; Agarabi, Cyrus; Donnelly, Raymond P; Brorson, Kurt; Schrieber, Sarah J; Howard, Kristina E; Rogstad, Sarah M; Frucht, David M.

Sci Rep; 10(1): 2476, 2020 02 12.

Artículo en Inglés | MEDLINE | ID: mdl-32051479

17.

Bacillus anthracis: a multi-faceted role for anthrax lethal toxin in thwarting host immune defenses.

Xu, Lixin; Frucht, David M.

Int J Biochem Cell Biol; 39(1): 20-4, 2007.

Artículo en Inglés | MEDLINE | ID: mdl-17008119

18.

HIV regulation of the IL-7R: a viral mechanism for enhancing HIV-1 replication in human macrophages in vitro.

Zhang, Mingjie; Drenkow, Jorg; Lankford, Carla S R; Frucht, David M; Rabin, Ronald L; Gingeras, Thomas R; Venkateshan, Chettemegre; Schwartzkopff, Franziska; Clouse, Kathleen A; Dayton, Andrew I.

J Leukoc Biol; 79(6): 1328-38, 2006 Jun.

Artículo en Inglés | MEDLINE | ID: mdl-16614257

19.

IL-23: a cytokine that acts on memory T cells.

Frucht, David M.

Sci STKE; 2002(114): pe1, 2002 Jan 08.

Artículo en Inglés | MEDLINE | ID: mdl-11784889

20.

A unique role for IL-23 in promoting cellular immunity.

Lankford, Carla S R; Frucht, David M.

J Leukoc Biol; 73(1): 49-56, 2003 Jan.

Artículo en Inglés | MEDLINE | ID: mdl-12525561

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