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1.

The PI3K Pathway in Human Disease.

Fruman, David A; Chiu, Honyin; Hopkins, Benjamin D; Bagrodia, Shubha; Cantley, Lewis C; Abraham, Robert T.

Cell; 170(4): 605-635, 2017 Aug 10.

Artículo en Inglés | MEDLINE | ID: mdl-28802037

2.

Simultaneous inhibition of endocytic recycling and lysosomal fusion sensitizes cells and tissues to oligonucleotide therapeutics.

Finicle, Brendan T; Eckenstein, Kazumi H; Revenko, Alexey S; Anderson, Brooke A; Wan, W Brad; McCracken, Alison N; Gil, Daniel; Fruman, David A; Hanessian, Stephen; Seth, Punit P; Edinger, Aimee L.

Nucleic Acids Res; 51(4): 1583-1599, 2023 02 28.

Artículo en Inglés | MEDLINE | ID: mdl-36727438

3.

A cross-institutional analysis of the effects of broadening trainee professional development on research productivity.

Brandt, Patrick D; Sturzenegger Varvayanis, Susi; Baas, Tracey; Bolgioni, Amanda F; Alder, Janet; Petrie, Kimberly A; Dominguez, Isabel; Brown, Abigail M; Stayart, C Abigail; Singh, Harinder; Van Wart, Audra; Chow, Christine S; Mathur, Ambika; Schreiber, Barbara M; Fruman, David A; Bowden, Brent; Wiesen, Christopher A; Golightly, Yvonne M; Holmquist, Chris E; Arneman, Daniel; Hall, Joshua D; Hyman, Linda E; Gould, Kathleen L; Chalkley, Roger; Brennwald, Patrick J; Layton, Rebekah L.

PLoS Biol; 19(7): e3000956, 2021 07.

Artículo en Inglés | MEDLINE | ID: mdl-34264929

4.

PI3K/AKT/mTOR signaling transduction pathway and targeted therapies in cancer.

Glaviano, Antonino; Foo, Aaron S C; Lam, Hiu Y; Yap, Kenneth C H; Jacot, William; Jones, Robert H; Eng, Huiyan; Nair, Madhumathy G; Makvandi, Pooyan; Geoerger, Birgit; Kulke, Matthew H; Baird, Richard D; Prabhu, Jyothi S; Carbone, Daniela; Pecoraro, Camilla; Teh, Daniel B L; Sethi, Gautam; Cavalieri, Vincenzo; Lin, Kevin H; Javidi-Sharifi, Nathalie R; Toska, Eneda; Davids, Matthew S; Brown, Jennifer R; Diana, Patrizia; Stebbing, Justin; Fruman, David A; Kumar, Alan P.

Mol Cancer; 22(1): 138, 2023 08 18.

Artículo en Inglés | MEDLINE | ID: mdl-37596643

5.

An integrative model of pathway convergence in genetically heterogeneous blast crisis chronic myeloid leukemia.

Ko, Tun Kiat; Javed, Asif; Lee, Kian Leong; Pathiraja, Thushangi N; Liu, Xingliang; Malik, Simeen; Soh, Sheila Xinxuan; Heng, Xiu Ting; Takahashi, Naoto; Tan, Joanna H J; Bhatia, Ravi; Khng, Alexis J; Chng, Wee-Joo; Sia, Yee Yen; Fruman, David A; Ng, King Pan; Chan, Zhu En; Xie, Kim Jiajing; Hoi, Qiangze; Chan, Cheryl Xueli; Teo, Audrey S M; Velazquez Camacho, Oscar; Meah, Wee Yang; Khor, Chiea Chuen; Ong, Chin Thing J; Soon, Wei Jia W; Tan, Patrick; Ng, Pauline C; Chuah, Charles; Hillmer, Axel M; Ong, S Tiong.

Blood; 135(26): 2337-2353, 2020 06 25.

Artículo en Inglés | MEDLINE | ID: mdl-32157296

6.

A Case for Phosphoinositide 3-Kinase-Targeted Therapy for Infectious Disease.

Adefemi, Folayemi; Fruman, David A; Marshall, Aaron J.

J Immunol; 205(12): 3237-3245, 2020 12 15.

Artículo en Inglés | MEDLINE | ID: mdl-33288538

7.

Targeting eIF4F translation initiation complex with SBI-756 sensitises B lymphoma cells to venetoclax.

Herzog, Lee-Or; Walters, Beth; Buono, Roberta; Lee, J Scott; Mallya, Sharmila; Fung, Amos; Chiu, Honyin; Nguyen, Nancy; Li, Boyang; Pinkerton, Anthony B; Jackson, Michael R; Schneider, Robert J; Ronai, Ze'ev A; Fruman, David A.

Br J Cancer; 124(6): 1098-1109, 2021 03.

Artículo en Inglés | MEDLINE | ID: mdl-33318657

8.

The mTORC1/4E-BP/eIF4E Axis Promotes Antibody Class Switching in B Lymphocytes.

Chiu, Honyin; Jackson, Leandra V; Oh, Kwon Ik; Mai, Annie; Ronai, Ze'ev A; Ruggero, Davide; Fruman, David A.

J Immunol; 202(2): 579-590, 2019 01 15.

Artículo en Inglés | MEDLINE | ID: mdl-30530594

9.

Silencing c-Myc translation as a therapeutic strategy through targeting PI3KÎ´ and CK1Îµ in hematological malignancies.

Deng, Changchun; Lipstein, Mark R; Scotto, Luigi; Jirau Serrano, Xavier O; Mangone, Michael A; Li, Shirong; Vendome, Jeremie; Hao, Yun; Xu, Xiaoming; Deng, Shi-Xian; Realubit, Ronald B; Tatonetti, Nicholas P; Karan, Charles; Lentzsch, Suzanne; Fruman, David A; Honig, Barry; Landry, Donald W; O'Connor, Owen A.

Blood; 129(1): 88-99, 2017 01 05.

Artículo en Inglés | MEDLINE | ID: mdl-27784673

10.

Context-Specific Function of S6K2 in Th Cell Differentiation.

Pai, Christine; Walsh, Craig M; Fruman, David A.

J Immunol; 197(8): 3049-3058, 2016 10 15.

Artículo en Inglés | MEDLINE | ID: mdl-27613697

11.

Cancer: A targeted treatment with off-target risks.

Fruman, David A; O'Brien, Susan.

Nature; 542(7642): 424-425, 2017 02 23.

Artículo en Inglés | MEDLINE | ID: mdl-28199308

12.

mTOR kinase inhibitors promote antibody class switching via mTORC2 inhibition.

Limon, Jose J; So, Lomon; Jellbauer, Stefan; Chiu, Honyin; Corado, Juana; Sykes, Stephen M; Raffatellu, Manuela; Fruman, David A.

Proc Natl Acad Sci U S A; 111(47): E5076-85, 2014 Nov 25.

Artículo en Inglés | MEDLINE | ID: mdl-25385646

13.

Targeting mTOR for the treatment of B cell malignancies.

Lee, Jong-Hoon Scott; Vo, Thanh-Trang; Fruman, David A.

Br J Clin Pharmacol; 82(5): 1213-1228, 2016 11.

Artículo en Inglés | MEDLINE | ID: mdl-26805380

14.

Targeting of the MNK-eIF4E axis in blast crisis chronic myeloid leukemia inhibits leukemia stem cell function.

Lim, Sharon; Saw, Tzuen Yih; Zhang, Min; Janes, Matthew R; Nacro, Kassoum; Hill, Jeffrey; Lim, An Qi; Chang, Chia-Tien; Fruman, David A; Rizzieri, David A; Tan, Soo Yong; Fan, Hung; Chuah, Charles T H; Ong, S Tiong.

Proc Natl Acad Sci U S A; 110(25): E2298-307, 2013 Jun 18.

Artículo en Inglés | MEDLINE | ID: mdl-23737503

15.

Selective inhibition of phosphoinositide 3-kinase p110α preserves lymphocyte function.

So, Lomon; Yea, Sung Su; Oak, Jean S; Lu, Mengrou; Manmadhan, Arun; Ke, Qiao Han; Janes, Matthew R; Kessler, Linda V; Kucharski, Jeff M; Li, Lian-Sheng; Martin, Michael B; Ren, Pingda; Jessen, Katti A; Liu, Yi; Rommel, Christian; Fruman, David A.

J Biol Chem; 288(8): 5718-31, 2013 Feb 22.

Artículo en Inglés | MEDLINE | ID: mdl-23275335

16.

DNA-scaffolded multivalent ligands to modulate cell function.

Zhang, Zhiqing; Eckert, Mark A; Ali, M Monsur; Liu, Linan; Kang, Dong-Ku; Chang, Elizabeth; Pone, Egest J; Sender, Leonard S; Fruman, David A; Zhao, Weian.

Chembiochem; 15(9): 1268-73, 2014 Jun 16.

Artículo en Inglés | MEDLINE | ID: mdl-24803415

17.

Targeting of mTORC1/2 by the mTOR kinase inhibitor PP242 induces apoptosis in AML cells under conditions mimicking the bone marrow microenvironment.

Zeng, Zhihong; Shi, Yue Xi; Tsao, Twee; Qiu, YiHua; Kornblau, Steven M; Baggerly, Keith A; Liu, Wenbin; Jessen, Katti; Liu, Yi; Kantarjian, Hagop; Rommel, Christian; Fruman, David A; Andreeff, Michael; Konopleva, Marina.

Blood; 120(13): 2679-89, 2012 Sep 27.

Artículo en Inglés | MEDLINE | ID: mdl-22826565

18.

Positive and negative roles of p85α and p85ß regulatory subunits of phosphoinositide 3-kinase in insulin signaling.

Ueki, Kohjiro; Fruman, David A; Yballe, Claudine M; Fasshauer, Mathias; Klein, Johannes; Asano, Tomoichiro; Cantley, Lewis C; Kahn, C Ronald.

J Biol Chem; 292(13): 5608, 2017 03 31.

Artículo en Inglés | MEDLINE | ID: mdl-28363934

19.

mTOR signaling: new networks for ALL.

Fruman, David A.

Blood; 127(22): 2658-9, 2016 06 02.

Artículo en Inglés | MEDLINE | ID: mdl-27257176

20.

PI3K signalling in B- and T-lymphocytes: new developments and therapeutic advances.

So, Lomon; Fruman, David A.

Biochem J; 442(3): 465-81, 2012 Mar 15.

Artículo en Inglés | MEDLINE | ID: mdl-22364281

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