Monkeypox-Associated Central Nervous System Disease: A Case Series and Review.

OBJECTIVE: Monkeypox virus (MPXV) disease has been declared a public health emergency by the World Health Organization, creating an urgent need for neurologists to be able to recognize, diagnosis, and treat MPXV-associated neurologic disease. METHODS: Three cases of MPXV-associated central nervous system (CNS) disease occurring during the 2022 outbreak, and their associated imaging findings are presented, with 2 cases previously published in a limited capacity in a public health bulletin. RESULTS: Three previously healthy immunocompetent gay men in their 30s developed a febrile illness followed by progressive neurologic symptoms with presence of a vesiculopustular rash. MPXV nucleic acid was detected by polymerase chain reaction (PCR) from skin lesions of 2 patients, with the third patient having indeterminate testing but an epidemiologic link to a confirmed MPXV disease case. Cerebrospinal fluid demonstrated a lymphocytic pleocytosis, elevated protein, and negative MPXV-specific PCR. In 2 patients, magnetic resonance imaging of the brain and spine demonstrated partially enhancing, longitudinally extensive central spinal cord lesions with multifocal subcortical, basal ganglia, thalamic, cerebellar, and/or brainstem lesions. The third patient had thalamic and basal ganglia lesions. All patients received 14 days of tecovirimat, and 2 patients also received multiple forms of immunotherapy, including intravenous immunoglobulin, pulsed high-dose steroids, plasmapheresis, and/or rituximab. Good neurologic recovery was observed in all cases. INTERPRETATION: MPXV can be associated with CNS disease. It is unclear whether this is from a parainfectious immune-mediated injury or direct CNS viral invasion. ANN NEUROL 2023;93:893-905.

Internal pudendal artery embolization for management of a traumatic labial hematoma.

Non-obstetric perineal injuries often occur as a result of blunt trauma from sport or vehicular accidents. Due to the rich vascular supply of the vulva, this region is susceptible to hematoma formation. Traumatic arterial injury usually involves emergency embolization, typically utilizing coils or microspheres. This case describes an incidence of the utilization of gelfoam for temporary embolization to prevent vulvar and labial necrosis in a patient with an actively expanding hematoma.

Methicillin-Resistant Staphylococcus aureus (MRSA)-Positive Pericardial Abscess Presenting in a Hemodialysis Patient.

Purulent pericarditis is an uncommon infection of the pericardial space that can very rarely present as a pericardial abscess. Infection by hematogenous spread in dialysis patients is among the predisposing risk factors that can lead to purulent pericarditis. Herein, we present a pericardial abscess case due to methicillin-resistant Staphylococcus aureus (MRSA) infection in a male patient with end-stage renal disease (ESRD) on hemodialysis. The patient has a past surgical history of two prior pericardial effusions due to uremic pericarditis.