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1.
Phys Rev Lett ; 128(11): 112503, 2022 Mar 18.
Artículo en Inglés | MEDLINE | ID: mdl-35363014

RESUMEN

We have measured the 3d→2p transition x rays of kaonic ^{3}He and ^{4}He atoms using superconducting transition-edge-sensor microcalorimeters with an energy resolution better than 6 eV (FWHM). We determined the energies to be 6224.5±0.4(stat)±0.2(syst) eV and 6463.7±0.3(stat)±0.1(syst) eV, and widths to be 2.5±1.0(stat)±0.4(syst) eV and 1.0±0.6(stat)±0.3(stat) eV, for kaonic ^{3}He and ^{4}He, respectively. These values are nearly 10 times more precise than in previous measurements. Our results exclude the large strong-interaction shifts and widths that are suggested by a coupled-channel approach and agree with calculations based on optical-potential models.

2.
Phys Rev Lett ; 121(24): 242501, 2018 Dec 14.
Artículo en Inglés | MEDLINE | ID: mdl-30608744

RESUMEN

The isospin character of p-n pairs at large relative momentum has been observed for the first time in the ^{16}O ground state. A strong population of the J,T=1,0 state and a very weak population of the J,T=0,1 state were observed in the neutron pickup domain of ^{16}O(p,pd) at 392 MeV. This strong isospin dependence at large momentum transfer is not reproduced by the distorted-wave impulse approximation calculations with known spectroscopic amplitudes. The results indicate the presence of high-momentum protons and neutrons induced by the tensor interactions in the ground state of ^{16}O.

3.
Phys Rev Lett ; 120(15): 152505, 2018 Apr 13.
Artículo en Inglés | MEDLINE | ID: mdl-29756883

RESUMEN

We observed the atomic 1s and 2p states of π^{-} bound to ^{121}Sn nuclei as distinct peak structures in the missing mass spectra of the ^{122}Sn(d,^{3}He) nuclear reaction. A very intense deuteron beam and a spectrometer with a large angular acceptance let us achieve a potential of discovery, which includes the capability of determining the angle-dependent cross sections with high statistics. The 2p state in a Sn nucleus was observed for the first time. The binding energies and widths of the pionic states are determined and found to be consistent with previous experimental results of other Sn isotopes. The spectrum is measured at finite reaction angles for the first time. The formation cross sections at the reaction angles between 0° and 2° are determined. The observed reaction-angle dependence of each state is reproduced by theoretical calculations. However, the quantitative comparison with our high-precision data reveals a significant discrepancy between the measured and calculated formation cross sections of the pionic 1s state.

4.
Phys Rev Lett ; 126(1): 019201, 2021 01 08.
Artículo en Inglés | MEDLINE | ID: mdl-33480758
5.
Phys Rev Lett ; 117(20): 202501, 2016 Nov 11.
Artículo en Inglés | MEDLINE | ID: mdl-27886506

RESUMEN

Excitation spectra of ^{11}C are measured in the ^{12}C(p,d) reaction near the η^{'} emission threshold. A proton beam extracted from the synchrotron SIS-18 at GSI with an incident energy of 2.5 GeV impinges on a carbon target. The momenta of deuterons emitted at 0° are precisely measured with the fragment separator (FRS) operated as a spectrometer. In contrast to theoretical predictions on the possible existence of deeply bound η^{'}-mesic states in carbon nuclei, no distinct structures are observed associated with the formation of bound states. The spectra are analyzed to set stringent constraints on the formation cross section and on the hitherto barely known η^{'}-nucleus interaction.

6.
J Fish Dis ; 38(6): 507-14, 2015 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-24820532

RESUMEN

A new cell line named CCF-K104 predominantly consisting of fibroblastic cells showed optimal growth at temperatures from 25 °C to 30 °C. Serial morphological changes in the cells induced by Cyprinid herpesvirus 3 (CyHV-3) included cytoplasmic vacuolar formation, cell rounding and detachment. Mature virions were purified from CyHV-3-infected CCF-K104 cells by sucrose gradient ultracentrifugation and had a typical herpesvirus structure on electron microscopy. Infectious CyHV-3 was produced stably in CCF-K104 cells over 30 viral passages. Our findings showed that CCF-K104 is a useful cell line for isolation and productive replication of CyHV-3. A temperature shift from 25 °C to 15 °C or 35 °C did not allow serial morphological changes as observed at 25 °C for 14 days. Under the same conditions, real-time PCR showed that CyHV-3 was present with low viral DNA loads, suggesting that CyHV-3 may establish latent infection in CCF-K104 cells. Amplification of the left and right terminal repeat sequences of the CyHV-3 genome arranged in a head-to-tail manner was detected by nested PCR following an upshift in temperature from 25 °C to 35 °C. The PCR results suggested that the circular genome may represent a latent form of CyHV-3.


Asunto(s)
Línea Celular , Enfermedades de los Peces/virología , Infecciones por Herpesviridae/veterinaria , Herpesviridae/fisiología , Temperatura , Latencia del Virus/fisiología , Animales , Carpas , Genoma Viral/genética , Herpesviridae/genética , Herpesviridae/crecimiento & desarrollo , Herpesviridae/aislamiento & purificación , Herpesviridae/ultraestructura , Infecciones por Herpesviridae/virología , Datos de Secuencia Molecular , Latencia del Virus/genética , Replicación Viral/fisiología
7.
Ultrastruct Pathol ; 38(3): 204-10, 2014 May.
Artículo en Inglés | MEDLINE | ID: mdl-24579828

RESUMEN

Mitochondrial alterations are the most common feature of human myopathies. A biopsy of quadriceps muscle from a 50-year-old woman exhibiting myopathic symptoms was examined by transmission electron microscopy. Biopsied fibers from quadriceps muscle displayed numerous subsarcolemmal mitochondria that contained crystalloids. Numbering 1-6 per organelle, these consisted of rows of punctuate densities measuring ∼0.34 nm; the parallel rows of these dots had a periodicity of ∼0.8 nm. The crystalloids were ensconced within cristae or in the outer compartment. Some mitochondria without crystalloids had circumferential cristae, leaving a membrane-free center that was filled with a farinaceous material. Other scattered fibrocyte defects included disruption of the contractile apparatus or its sporadic replacement by a finely punctuate material in some myofibers. Intramitochondrial crystalloids, although morphologically striking, do not impair organelle physiology to a significant degree, so the muscle weakness of the patient must originate elsewhere.


Asunto(s)
Mitocondrias Musculares/ultraestructura , Fibras Musculares Esqueléticas/ultraestructura , Enfermedades Musculares/patología , Músculo Cuádriceps/ultraestructura , Biopsia , Femenino , Humanos , Microscopía Electrónica de Transmisión , Persona de Mediana Edad , Mitocondrias Musculares/química , Fibras Musculares Esqueléticas/química , Enfermedades Musculares/metabolismo , Músculo Cuádriceps/química
8.
Phys Rev Lett ; 108(4): 042501, 2012 Jan 27.
Artículo en Inglés | MEDLINE | ID: mdl-22400828

RESUMEN

Evidence for the neutron-rich hypernucleus (Λ)(6)H is presented from the FINUDA experiment at DAΦNE, Frascati, studying (π+,π-) pairs in coincidence from the K(stop)(-) + (6)Li →(Λ)(6)H + π+ production reaction followed by (Λ)(6)H → (6)He + π- weak decay. The production rate of (Λ)(6) undergoing this two-body π- decay is determined to be (2.9 ± 2.0) × 10(-6)/K(stop)(-). Its binding energy, evaluated jointly from production and decay, is BΛ((Λ)(6)H) = (4.0 ± 1.1) MeV with respect to (5)H+Λ. A systematic difference of (0.98 ± 0.74) MeV between BΛ values derived separately from decay and from production is tentatively assigned to the (Λ)(6)H 0(g.s.)(+) → 1+ excitation.

9.
Phys Rev Lett ; 109(13): 132002, 2012 Sep 28.
Artículo en Inglés | MEDLINE | ID: mdl-23030084

RESUMEN

The Θ(+) pentaquark baryon was searched for via the π(-)p→K(-)X reaction with a missing mass resolution of 1.4 MeV/c(2) (FWHM) at the Japan Proton Accelerator Research Complex (J-PARC). π(-) meson beams were incident on the liquid hydrogen target with a beam momentum of 1.92 GeV/c. No peak structure corresponding to the Θ(+) mass was observed. The upper limit of the production cross section averaged over the scattering angle of 2° to 15° in the laboratory frame is obtained to be 0.26 µb/sr in the mass region of 1.51-1.55 GeV/c(2). The upper limit of the Θ(+) decay width is obtained to be 0.72 and 3.1 MeV for J(Θ)(P)=1/2(+) and J(Θ)(P)=1/2(-), respectively, using the effective Lagrangian approach.

10.
J Fluid Mech ; 9132021 Apr 25.
Artículo en Inglés | MEDLINE | ID: mdl-33776140

RESUMEN

The closure of a human lung airway is modeled as a pipe coated internally with a liquid that takes into account the viscoelastic properties of mucus. For a thick enough coating, the Plateau-Rayleigh instability blocks the airway by the creation of a liquid plug, and the pre-closure phase is dominated by the Newtonian behavior of the liquid. Our previous study with a Newtonian-liquid model demonstrated that the bifrontal plug growth consequent to airway closure induces a high level of stress and stress gradients on the airway wall, which is large enough to damage the epithelial cells, causing sub-lethal or lethal responses. In this study, we explore the effect of the viscoelastic properties of mucus by means of the Oldroyd-B and FENE-CR model. Viscoelasticity is shown to be very relevant in the post-coalescence process, introducing a second peak of the wall shear stresses. This second peak is related to an elastic instability due to the presence of the polymeric extra stresses. For high-enough Weissenberg and Laplace numbers, this second shear stress peak is as severe as the first one. Consequently, a second lethal or sub-lethal response of the epithelial cells is induced.

11.
J Exp Med ; 188(7): 1223-9, 1998 Oct 05.
Artículo en Inglés | MEDLINE | ID: mdl-9763601

RESUMEN

Immunoglobulin (Ig)A provides the initial immune barrier to viruses at mucosal surfaces. Specific IgA interrupts viral replication in polarized epithelium during receptor-mediated transport, probably by binding to newly synthesized viral proteins. Here, we demonstrate by immunoelectron microscopy that specific IgA monoclonal antibodies (mAbs) accumulate within Sendai virus-infected polarized cell monolayers and colocalize with the hemagglutinin- neuraminidase (HN) viral protein in a novel intracellular structure. Neither IgG specific for HN nor irrelevant IgA mAbs colocalize with viral protein. Treatment of cultures with viral-specific IgA but not with viral-specific IgG or irrelevant IgA decreases viral titers. These observations provide definitive ultrastructural evidence of a subcellular compartment in which specific IgA and viral envelope proteins interact, further strengthening our hypothesis of intracellular neutralization of virus by specific IgA antibodies. Our results have important implications for intracellular protein trafficking, viral replication, and viral vaccine development.


Asunto(s)
Proteína HN/análisis , Inmunoglobulina A/análisis , Respirovirus/enzimología , Animales , Línea Celular , Polaridad Celular , Perros , Epitelio/metabolismo , Epitelio/virología , Ratones , Ratones Endogámicos BALB C , Respirovirus/fisiología
12.
J Exp Med ; 177(2): 273-81, 1993 Feb 01.
Artículo en Inglés | MEDLINE | ID: mdl-8426106

RESUMEN

Monoclonal antibodies (mAb) have been raised against Plasmodium falciparum gametocyte stage protein extracts, in an effort to identify novel parasite antigens that might mediate malaria transmission-blocking immunity. mAb 1A1 identified Pfs2400, a sexual stage-specific antigen of greater than 2 megadaltons, that is associated with the outer leaflet of the parasitophorous vacuole membrane in mature circulating gametocyte-infected red blood cells. Upon induction of gametogenesis, Pfs2400 partitions between the gamete plasmalemma and the degenerating erythrocyte membrane. The antigen is no longer detectable in the fully emerged gamete. mAb 1A1 dramatically reduces the number of oocysts formed in P. falciparum gametocyte-fed mosquitoes. The cognate antigen is probably the product of the Pf11.1 gene (Scherf et al. 1988. EMBO [Eur. Mol. Biol. Organ.]J. 7:1129) on the basis that a peptide composed of two copies of the degenerate nine amino acid repeat sequence in the Pf11.1 protein, can inhibit binding of mAb1A1 to the native antigen. The mechanism of transmission inhibition mediated by the Pfs2400 is discussed.


Asunto(s)
Anticuerpos Monoclonales/inmunología , Anticuerpos Antiprotozoarios/inmunología , Antígenos de Protozoos/inmunología , Plasmodium falciparum/inmunología , Secuencia de Aminoácidos , Animales , Antígenos de Protozoos/genética , Eritrocitos/parasitología , Genes Protozoarios , Humanos , Inmunohistoquímica , Técnicas In Vitro , Malaria Falciparum/transmisión , Datos de Secuencia Molecular , Plasmodium falciparum/genética , Plasmodium falciparum/crecimiento & desarrollo
13.
J Cell Biol ; 147(5): 937-44, 1999 Nov 29.
Artículo en Inglés | MEDLINE | ID: mdl-10579715

RESUMEN

Most Apicomplexan parasites, including the human pathogens Plasmodium, Toxoplasma, and Cryptosporidium, actively invade host cells and display gliding motility, both actions powered by parasite microfilaments. In Plasmodium sporozoites, thrombospondin-related anonymous protein (TRAP), a member of a group of Apicomplexan transmembrane proteins that have common adhesion domains, is necessary for gliding motility and infection of the vertebrate host. Here, we provide genetic evidence that TRAP is directly involved in a capping process that drives both sporozoite gliding and cell invasion. We also demonstrate that TRAP-related proteins in other Apicomplexa fulfill the same function and that their cytoplasmic tails interact with homologous partners in the respective parasite. Therefore, a mechanism of surface redistribution of TRAP-related proteins driving gliding locomotion and cell invasion is conserved among Apicomplexan parasites.


Asunto(s)
Apicomplexa/fisiología , Apicomplexa/patogenicidad , Infecciones por Protozoos/parasitología , Antígeno 12E7 , Secuencia de Aminoácidos , Sustitución de Aminoácidos/genética , Animales , Antígenos CD/química , Antígenos CD/fisiología , Moléculas de Adhesión Celular/química , Moléculas de Adhesión Celular/genética , Moléculas de Adhesión Celular/fisiología , Citoplasma/genética , Citoplasma/fisiología , Humanos , Datos de Secuencia Molecular , Movimiento , Péptidos/metabolismo , Plasmodium berghei/patogenicidad , Plasmodium berghei/fisiología , Infecciones por Protozoos/metabolismo , Proteínas Protozoarias/química , Proteínas Protozoarias/genética , Proteínas Recombinantes/metabolismo , Alineación de Secuencia , Eliminación de Secuencia , Homología de Secuencia de Aminoácido , Toxoplasma/patogenicidad , Toxoplasma/fisiología
14.
J Cell Biol ; 135(1): 269-78, 1996 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-8858179

RESUMEN

Asexually replicating populations of Plasmodium parasites, including those from cloned lines, generate both male and female gametes to complete the malaria life cycle through the mosquito. The generation of these sexual forms begins with the induction of gametocytes from haploid asexual stage parasites in the blood of the vertebrate host. The molecular processes that govern the differentiation and development of the sexual forms are largely unknown. Here we describe a defect that affects the development of competent male gametocytes from a mutant clone of P. falciparum (Dd2). Comparison of the Dd2 clone to the predecessor clone from which it was derived (W2'82) shows that the defect is a mutation that arose during the long-term cultivation of asexual stages in vitro. Light and electron microscopic images, and indirect immunofluorescence assays with male-specific anti-alpha-tubulin II antibodies, indicate a global disruption of male development at the gametocyte level with at least a 70-90% reduction in the proportion of mature male gametocytes by the Dd2 clone relative to W2'82. A high prevalence of abnormal gametocyte forms, frequently containing multiple and unusually large vacuoles, is associated with the defect. The reduced production of mature male gametocytes may reflect a problem in processes that commit a gametocyte to male development or a progressive attrition of viable male gametocytes during maturation. The defect is genetically linked to an almost complete absence of male gamete production and of infectivity to mosquitoes. This is the first sex-specific developmental mutation identified and characterized in Plasmodium.


Asunto(s)
Plasmodium falciparum/crecimiento & desarrollo , Animales , Anopheles/parasitología , Antimaláricos/farmacología , Dermatoglifia del ADN , Femenino , Gametogénesis , Masculino , Mefloquina/farmacología , Mutación , Plasmodium falciparum/citología , Plasmodium falciparum/genética , Polimorfismo de Longitud del Fragmento de Restricción , Tubulina (Proteína)/análisis , Vacuolas
15.
J Fluid Mech ; 872: 407-437, 2019 Aug 10.
Artículo en Inglés | MEDLINE | ID: mdl-31844335

RESUMEN

Surfactant-laden liquid plug propagation and rupture occurring in lower lung airways are studied computationally using a front-tracking method. The plug is driven by an applied constant pressure in a rigid axisymmetric tube whose inner surface is coated by a thin liquid film. The evolution equations of the interfacial and bulk surfactant concentrations coupled with the incompressible Navier-Stokes equations are solved in the front-tracking framework. The numerical method is first validated for a surfactant-free case and the results are found to be in good agreement with the earlier simulations of Fujioka et al. (2008) and Hassan et al. (2011). Then extensive simulations are performed to investigate the effects of surfactant on the mechanical stresses that could be injurious to epithelial cells such as pressure and shear stress. It is found that the liquid plug ruptures violently to induce large pressure and shear stress on airway walls and even a tiny amount of surfactant significantly reduces the pressure and shear stress and thus improves cell survivability. However, addition of surfactant also delays the plug rupture and thus airway reopening.

16.
Phys Rev Fluids ; 4(9)2019 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-33907725

RESUMEN

The closure of a human lung airway is modeled as an instability of a two-phase flow in a pipe coated internally with a Newtonian liquid. For a thick enough coating, the Plateau-Rayleigh instability creates a liquid plug which blocks the airway, halting distal gas exchange. Owing to a bi-frontal plug growth, this airway closure flow induces high stress levels on the wall, which is the location of airway epithelial cells. A parametric numerical study is carried out simulating relevant conditions for human lungs, either in ordinary or pathological situations. Our simulations can represent the physical process from pre- to post-coalescence phases. Previous studies have been limited to pre-coalescence only. The topological change during coalescence induces a high level of stress and stress gradients on the epithelial cells, which are large enough to damage them, causing sub-lethal or lethal responses. We find that post-coalescence wall stresses can be in the range of 300% to 600% greater than pre-coalescence values, so introduce a new important source of mechanical perturbation to the cells.

17.
Mol Cell Biol ; 11(5): 2873-80, 1991 May.
Artículo en Inglés | MEDLINE | ID: mdl-1901951

RESUMEN

We have recently purified to near homogeneity the stimulatory GDP/GTP exchange protein for smg p21s (ras p21-like GTP-binding proteins) from bovine brain cytosol. This regulatory protein, named GDP dissociation stimulator (GDS), stimulates the GDP/GTP exchange reaction of smg p21s by stimulating the dissociation of GDP from and the subsequent binding of GTP to them. In this study, we have isolated and sequenced the cDNA of smg p21 GDS from a bovine brain cDNA library by using an oligonucleotide probe designed from the partial amino acid sequence of the purified smg p21 GDS. The cDNA has an open reading frame encoding a protein of 558 amino acids with a calculated Mr value of 61,066, similar to the Mr of 53,000 estimated for the purified smg p21 GDS by sodium dodecyl sulfate-polyacrylamide gel electrophoresis and sucrose density gradient ultracentrifugation. The isolated cDNA is expressed in Escherichia coli, and the encoded protein exhibits smg p21 GDS activity. smg p21 GDS is overall hydrophilic, but there are several short hydrophobic regions. The smg p21 GDS mRNA is present in bovine brain and various rat tissues. smg p21 GDS has low amino acid sequence homology with the yeast CDC25 and SCD25 proteins, which may regulate the GDP/GTP exchange reaction of the yeast RAS2 protein, but not with ras p21 GTPase-activating protein, the inhibitory GDP/GTP exchange proteins (GDP dissociation inhibitor) for smg p25A and rho p21s, and the beta gamma subunits of heterotrimeric GTP-binding proteins such as Gs and Gi.


Asunto(s)
Proteínas de Unión al GTP/genética , Proteínas Proto-Oncogénicas/genética , Secuencia de Aminoácidos , Animales , Secuencia de Bases , Encéfalo/metabolismo , Bovinos , Clonación Molecular , Citosol/metabolismo , Escherichia coli/genética , Proteínas de Unión al GTP/aislamiento & purificación , Proteínas de Unión al GTP/metabolismo , Guanosina Difosfato/metabolismo , Cinética , Datos de Secuencia Molecular , Peso Molecular , Mapeo Peptídico , Proteínas Recombinantes/aislamiento & purificación , Proteínas Recombinantes/metabolismo , Mapeo Restrictivo , Homología de Secuencia de Ácido Nucleico , Proteínas de Unión al GTP rap
18.
Mol Cell Biol ; 18(4): 2118-29, 1998 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-9528784

RESUMEN

The mei4+ gene of the fission yeast Schizosaccharomyces pombe was cloned by functional complementation. The mei4 disruptant failed to complete meiosis-I but could proliferate normally. mei4+ was transcribed only in meiosis-proficient diploid cells after premeiotic DNA replication. The mei4+ open reading frame encodes a 57-kDa serine-rich protein comprised of 517 amino acids with a forkhead/HNF3 DNA-binding domain in the amino-terminal region. Transcription of spo6+, a gene required for sporulation, was dependent on the mei4+ function. Two copies of the GTAAAYA consensus sequence, proposed as the binding site for human forkhead proteins, were found in the promoter region of spo6+. A gel mobility shift assay demonstrated the sequence-dependent binding of the GST-Mei4 forkhead domain fusion protein to DNA fragments with one of the consensus elements. Deletion of this consensus element from the spo6 promoter abolished the transcription of spo6+ and resulted in a sporulation deficiency. One-hybrid assay of Mei4 which was fused to the Gal4 DNA-binding domain localized the transcriptional activation domain in the C-terminal 140 amino acids of Mei4. These results indicate that Mei4 functions as a meiosis-specific transcription factor of S. pombe.


Asunto(s)
ADN de Hongos/química , Proteínas de Unión al ADN/genética , Proteínas Fúngicas/genética , Meiosis , Proteínas de Schizosaccharomyces pombe , Schizosaccharomyces/genética , Factores de Transcripción/genética , Secuencia de Aminoácidos , Sitios de Unión , Clonación Molecular , Replicación del ADN , ADN de Hongos/metabolismo , Proteínas de Unión al ADN/metabolismo , Proteínas Fúngicas/metabolismo , Humanos , Datos de Secuencia Molecular , Proteínas Recombinantes de Fusión/metabolismo , Mapeo Restrictivo , Factores de Transcripción/metabolismo
19.
J Bone Joint Surg Br ; 89(2): 258-64, 2007 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-17322449

RESUMEN

We developed a new porous scaffold made from a synthetic polymer, poly(DL-lactide-co-glycolide) (PLG), and evaluated its use in the repair of cartilage. Osteochondral defects made on the femoral trochlear of rabbits were treated by transplantation of the PLG scaffold, examined histologically and compared with an untreated control group. Fibrous tissue was initially organised in an arcade array with poor cellularity at the articular surface of the scaffold. The tissue regenerated to cartilage at the articular surface. In the subchondral area, new bone formed and the scaffold was absorbed. The histological scores were significantly higher in the defects treated by the scaffold than in the control group (p<0.05). Our findings suggest that in an animal model the new porous PLG scaffold is effective for repairing full-thickness osteochondral defects without cultured cells and growth factors.


Asunto(s)
Implantes Absorbibles , Cartílago Articular/lesiones , Cartílago Articular/patología , Ácido Láctico/uso terapéutico , Ácido Poliglicólico/uso terapéutico , Polímeros/uso terapéutico , Animales , Cartílago Articular/cirugía , Condrocitos/patología , Modelos Animales de Enfermedad , Microscopía Electrónica de Rastreo , Oseointegración , Copolímero de Ácido Poliláctico-Ácido Poliglicólico , Periodo Posoperatorio , Conejos
20.
J Orthop Surg (Hong Kong) ; 15(2): 251-4, 2007 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-17709874

RESUMEN

Osteopetrosis is a rare disease characterised by generalised sclerosis of the bone. Surgical treatment for fractures in osteopetrotic bones is difficult due to their hardness. We report successful surgical treatment of humeral and clavicular fractures in a 30-year-old osteopetrotic patient with severe multiple trauma. Two years after surgery, the patient had a full range of movement at the shoulder and elbow, with good bone union and alignment.


Asunto(s)
Clavícula/lesiones , Fijación Interna de Fracturas/métodos , Fracturas del Húmero/cirugía , Osteoporosis/complicaciones , Adulto , Tornillos Óseos , Estudios de Seguimiento , Fracturas Espontáneas , Humanos , Fracturas del Húmero/diagnóstico por imagen , Masculino , Osteoporosis/diagnóstico por imagen , Radiografía
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