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1.
Biol Pharm Bull ; 45(6): 709-719, 2022.
Artículo en Inglés | MEDLINE | ID: mdl-35650099

RESUMEN

In many epidemiological studies, the dust extinction coefficient measured by light detection and ranging (LIDAR) is used as an indicator of exposure to Asian dust. However, few reports on the relationship between the distribution of total suspended particles (TSPs) near the ground surface and the dust extinction coefficient exist. In this study, we examined the relationship between the concentrations of TSPs near the ground surface, substances indicative of mineral content, and air pollutants that may be transported with Asian dust and dust extinction coefficients in two regions: Imizu and Yurihama-Matsue, from March to May in 2011 and 2013. In both years, large dust extinction coefficients were observed in Imizu and Matsue on days when the concentrations of TSPs and mineral content indicators were high near the ground surface in Imizu and Yurihama, and Asian dust was expected to be highly suspended. In both regions, the concentrations of TSPs and mineral content indicators were significantly positively correlated with the dust extinction coefficient. The concentrations of all air pollutants analyzed were significantly positively correlated with the dust extinction coefficient in each region in 2013, but not in 2011. These results suggest that the dust extinction coefficient is a useful indicator of Asian dust near the ground surface; however, as harmful air pollutants occasionally move with Asian dust, it is necessary to monitor these pollutants near the ground surface when conducting an epidemiological study on the health effect of airborne particles.


Asunto(s)
Contaminantes Atmosféricos , Polvo , Contaminantes Atmosféricos/análisis , Polvo/análisis , Minerales
2.
Biol Pharm Bull ; 39(3): 415-22, 2016.
Artículo en Inglés | MEDLINE | ID: mdl-26934931

RESUMEN

Public concern regarding the transport of air pollutants from mainland East Asia to the leeward area by the prevailing westerlies in spring and winter monsoon has been growing in recent years. We collected total suspended particle (TSP) in Beijing, a metropolis of China located windward of Japan, in spring (late February 2011-May 2011) and in winter (November 2012-early February 2013), then analyzed metals, ions, and organic compounds and mutagenicity, and compared the pollution levels with samples collected at two Japanese metropolises (Osaka and Nagoya) during the same periods. The medians of concentration of TSP and other factors in Beijing were much larger than those in the Japanese metropolises. Especially, the concentrations of polycyclic aromatic hydrocarbons (PAHs) were remarkably high in Beijing in winter, and the median of total PAHs concentration in Beijing was 62-63 times larger than that in the Japanese sites. The mutagenicity of TSP from Beijing toward Salmonella typhimurium YG1024, with and without a mammalian metabolic system (S9 mix), was 13-25 times higher than that from the Japanese sites in winter. These results suggest that air pollution levels in Beijing are very high compared with those at the two Japanese metropolises we evaluated. The diagnostic ratios of PAHs and nitrated polycyclic aromatic hydrocarbons (NPAHs) suggest that the major sources of PAHs and NPAHs in Beijing are different from those at the two Japanese sites in winter, and that the major source in Beijing is coal/biomass combustion.


Asunto(s)
Contaminantes Atmosféricos/análisis , Contaminación del Aire/análisis , Mutágenos/análisis , China , Ciudades , Monitoreo del Ambiente , Hierro/análisis , Japón , Plomo/análisis , Hidrocarburos Policíclicos Aromáticos/análisis , Estaciones del Año
3.
Environ Monit Assess ; 188(2): 85, 2016 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-26753629

RESUMEN

The simultaneous sampling of total suspended particles was performed at 14 sites in Japan during July 2008-June 2009. The spatial correlativity of each particulate composition toward Osaka was obtained for nine selected sites to overview the chemical composition and geographical distribution of particulate components across a wide range of areas nationwide. The spatial correlatives of atmospheric particulate components were extended to an even wider range of areas up to 950 km distance (meso-alpha scale region, >200 km) for a far-reaching distance analysis unique in the literature. Overall, the spatial correlations of ionic species and both organic and elemental carbons were significant, suggesting their shared advections, including their long-range transport from East Asia. Although sulfate ions are widely dispersed across Japan, such is not necessarily correlated with organic and elemental carbon, possibly indicating that the sulfate emission source, including long-range transport, differs from that of carbonaceous particulates. By contrast, the characteristics of spatial correlatives of metallic constituents vary; for example, particulate Pb and Cd show a significantly wide range of spatial correlatives to Osaka, while Mn-though limited to cities neighboring Osaka-shows significant spatial correlations. Other metallic constituents showed no significant spatial correlatives, indicating the effects of local pollutants. Moreover, the extent of the spatial dispersion of the particulate components and the relationships among chemical components were analyzed via factor analysis to highlight the effects of long-range inflow and local original emissions. In this treatment, 13 particulate components among the 19 measured were implicated in long-range transport.


Asunto(s)
Contaminantes Atmosféricos/análisis , Monitoreo del Ambiente , Material Particulado/análisis , Atmósfera/química , Carbono/análisis , Ciudades , Sustancias Peligrosas/análisis , Japón
4.
Biol Pharm Bull ; 38(9): 1395-403, 2015.
Artículo en Inglés | MEDLINE | ID: mdl-26328496

RESUMEN

To clarify the seasonal fluctuations in air pollution and the effect of long-range transport, we collected airborne particles (n=118) at Dazaifu in Fukuoka, Japan, from June 2012 to May 2013 and measured Pb and SO4(2-), which are indicators of the long-range transport of anthropogenic air pollutants, as well as their mutagenicity, and other factors. The levels of airborne particles, Pb, and SO4(2-) were very high on March 4, 8, 9, and 19, and May 13, 21, and 22, 2013. The backward trajectories indicated that air masses had arrived from the Gobi Desert and northern China on those days. The mutagenicity of airborne particles was examined using the Ames test on Salmonella typhimurium YG1024. Highly mutagenic airborne particles were mostly collected in winter, and most of them showed high activity both with and without S9 mix. High levels of polycyclic aromatic hydrocarbons (PAHs) were found in many samples that showed high mutagenicity. For the samples collected on January 30, February 21, and March 4, the levels of Pb, SO4(2-), PAHs, and mutagenicity were high, and the backward trajectories indicated that air masses present on those days had passed through northern or central China. The Japan Meteorological Agency registered Asian dust events at Fukuoka on March 8, 9, and 19, 2013. The results of the present study suggest that high levels of anthropogenic air pollutants were transported with Asian dust. Similarly, long-range transport of air pollutants including mutagens occurred on days when Asian dust events were not registered.


Asunto(s)
Contaminantes Atmosféricos/análisis , Contaminación del Aire/análisis , Polvo/análisis , Movimientos del Aire , Contaminantes Atmosféricos/toxicidad , Contaminación del Aire/efectos adversos , Monitoreo del Ambiente , Asia Oriental , Hierro/análisis , Hierro/toxicidad , Plomo/análisis , Plomo/toxicidad , Pruebas de Mutagenicidad , Nitratos/análisis , Nitratos/toxicidad , Hidrocarburos Policíclicos Aromáticos/análisis , Hidrocarburos Policíclicos Aromáticos/toxicidad , Salmonella typhimurium/efectos de los fármacos , Salmonella typhimurium/genética , Estaciones del Año , Sulfatos/análisis , Sulfatos/toxicidad
5.
Analyst ; 138(18): 5437-43, 2013 Sep 21.
Artículo en Inglés | MEDLINE | ID: mdl-23885351

RESUMEN

The aim of this study was to develop a novel evaluation method for air particles using surface plasmon resonance spectroscopy (SPR) analysis. An L1 sensor chip modified with immobilized liposome was used as a model of the membrane of epithelial cells in organs of respiration. A test suspension of dispersed air particles was flowed onto the sensor chip. The interaction between the surface of the sensor chip and particulates in the sample solution was detected by SPR. It is deduced that the SPR measurement provides information about the adsorption/desorption behavior of the particles on the membrane. Environmentally certified reference materials, diesel particulate matter, vehicle exhaust particulates, urban particulate matter, coal fly ash, and rocks, were used as air particulate samples. Filtrates of suspensions of these samples were analyzed by SPR. Each sample revealed characteristic SPR sensor-gram patterns. For example, diesel particulate matter strongly interacted with the lipid bilayer, and was hardly dissociated. On the other hand, coal fly ash and rock particles interacted poorly with the membrane. The presented method could be used to evaluate or characterize air particles.


Asunto(s)
Material Particulado/análisis , Análisis Espectral , Resonancia por Plasmón de Superficie/métodos , Liposomas/química , Material Particulado/química
6.
Environ Sci Pollut Res Int ; 27(28): 35782-35791, 2020 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-32601871

RESUMEN

In this study, hexabromocyclododecane (HBCD) in riverine and estuarine sediments was investigated in Osaka, Japan. The mean total HBCD concentration detected in sediments ranged from < 0.50 to 130 ng g-1 dry weight. This exceeded the ubiquitous HBCD contamination level found globally but was lower than that in areas affected by point sources, such as textile industries and expanded polystyrene plants. Sewage effluent was one of the suspected point sources of HBCD in the study area. The HBCD concentrations in sediments were highly dependent on certain factors, such as the location of the sampling site (proximity to possible emission sources), sediment properties (silt or sand), and organic substance content. The range of the diastereomer composition of α- and γ-HBCD was wider than that in other studies. Repeatability tests (n = 3) were conducted for all samples to assess the variability in the HBCD concentrations within identical sediment samples. Some variations were observed in the HBCD concentrations and diastereomer compositions within the repeatability test results at some sampling sites; nevertheless, the same samples were extracted and analyzed in triplicate. The bromine contents of the extracts of these samples were analyzed by X-ray fluorescence, and the results agreed well with those estimated from the LC-MS/MS results. From these results, it was confirmed that several sediment samples contained heterogeneously distributed HBCD. The risk characterization ratios (predicted environmental concentration/predicted no-effect concentration) of sites with high HBCD concentrations ranged from 0.1 to 1; thus, further information is required, and the sediment HBCD levels in this region should be continuously studied.


Asunto(s)
Retardadores de Llama/análisis , Hidrocarburos Bromados/análisis , Contaminantes Químicos del Agua/análisis , Cromatografía Liquida , Monitoreo del Ambiente , Sedimentos Geológicos , Japón , Ríos , Espectrometría de Masas en Tándem
7.
Mutat Res ; 572(1-2): 98-112, 2005 May 02.
Artículo en Inglés | MEDLINE | ID: mdl-15790493

RESUMEN

1,1-Dichloropropene (1,1-DCPe) is a contaminant of some source waters used to make drinking water. Because of this and the fact that no toxicological data were available for this compound, which is structurally similar to the rodent carcinogen 1,3-dichloropropene (1,3-DCPe), 1,1-DCPe was placed on the Contaminant Candidate List of the US Environmental Protection Agency. Consequently, we have performed a hazard characterization of 1,1-DCPe by evaluating its mutagenicity in the Salmonella assay and its DNA damaging (comet assay) and apoptotic (caspase assay) activities in human lymphoblastoid cells. In Salmonella, 1,1-DCPe was not mutagenic in strains TA98, TA100, TA1535, or TA104 +/-S9 mix. However, it was clearly mutagenic in strain RSJ100, which expresses the rat GSTT1-1 gene. 1,1-DCPe did not induce DNA damage in GSTT1-1-deficient human lymphoblastoid cells, and it induced apoptosis in these cells only at 5 mM. Consistent with its mutagenesis in RSJ100, 1,1-DCPe reacted with glutathione (GSH) in vitro, suggesting an addition-elimination mechanism to account for the detected GSH conjugate. 1,1-DCPe was approximately 5000 times more mutagenic than its ethene congener 1,1-dichloroethylene (1,1-DCE or vinylidene chloride). Neither 1,1-DCE nor 1,3-DCPe showed enhanced mutagenicity in strain RSJ100, indicating a lack of activation of these congeners by GSTT1-1. Thus, 1,1-DCPe is a base-substitution mutagen requiring activation by GSTT1-1, possibly involving the production of a reactive episulfonium ion. This bioactivation mechanism of 1,1-DCPe is different from that of its congeners 1,1-DCE and 1,3-DCPe. The presence of 1,1-DCPe in source waters could pose an ecological or human health risk. Occurrence data for 1,1-DCPe in finished drinking water are needed to estimate human exposure to, and possible health risks from, this mutagenic compound.


Asunto(s)
Compuestos Alílicos/toxicidad , Glutatión Transferasa/metabolismo , Mutágenos/toxicidad , Contaminantes Químicos del Agua/toxicidad , Compuestos Alílicos/metabolismo , Animales , Apoptosis , Biotransformación , Línea Celular , Ensayo Cometa , Humanos , Hidrocarburos Clorados , Microsomas Hepáticos/metabolismo , Mutágenos/metabolismo , Ratas , Salmonella typhimurium/genética , Relación Estructura-Actividad , Contaminantes Químicos del Agua/metabolismo
8.
Genes Environ ; 37: 25, 2015.
Artículo en Inglés | MEDLINE | ID: mdl-27350820

RESUMEN

INTRODUCTION: Asian dust events, transport of dust particles from arid and semi-arid areas in China and Mongolia to the east by prevailing westerlies, are often observed in Japan in spring. In recent decades, consumption of fossil fuels has markedly increased in mainland East Asia with rapid economic growth, and severe air pollution has occurred. A part of air pollutants including mutagens, such as polycyclic aromatic hydrocarbons (PAHs), generated in mainland East Asia are thought to be transported to Japan by the prevailing westerlies, like Asian dust, and winter monsoon. The objective of this study was to clarify the long-range transport of mutagens and other air pollutants in East Asia. Thus, we collected total suspended particles (TSP) at a rural town in western Japan, namely, Yurihama in Tottori Prefecture, for 1 year (June 2012-May 2013), and investigated their chemical constituents and mutagenicity. RESULTS: Many TSP collected from January to March showed high mutagenicity toward Salmonella typhimurium YG1024 with and without S9 mix, and high levels of lead (Pb) and sulfate ions (SO4 (2-)), which are indicators of transboundary air pollutions from mainland East Asia, were detected in those TSP. A large amount of iron, which is an indicator of sand, was found in highly mutagenic TSP collected in March, but not in TSP collected in January and February. High levels of PAHs were detected in highly mutagenic TSP collected from January to March. The ratios of the concentration of fluoranthene to those of fluoranthene and pyrene suggested that the main source of PAHs in TSP collected in winter and spring was coal and biomass combustion. Backward trajectories of air masses on days when high levels of mutagenicity were found indicated that these air masses had traveled from eastern or northern China to Yurihama. CONCLUSIONS: These results suggest that high levels of mutagens were transported from mainland East Asia to western Japan, and this transportation accompanied Asian dust in March, but not in January and February.

9.
Environ Mol Mutagen ; 43(1): 10-9, 2004.
Artículo en Inglés | MEDLINE | ID: mdl-14743341

RESUMEN

In the present study, we developed a rapid umu-microplate test system that uses the nitroreductase- and O-acetyltransferase-overproducing Salmonella typhimurium strain NM3009 and the O-acetyltransferase-overproducing S. typhimurium strain NM2009 to detect genotoxic activity in small volume samples. The assay was used to test the genotoxicity of several standard mutagens and environmental samples. Exponentially growing cultures of NM3009, NM2009, and the parental strain TA1535/pSK1002 were incubated in 96-well microplates with test chemicals both in the presence and in the absence of rat liver S9. The relative beta-galactosidase activities were then determined colorimetrically using either chlorophenol red-beta-D-galactopyranoside (CPRG) or O-nitrophenyl-beta-D-galactopyranoside (ONPG) as a measure of umuC gene induction activity. The sensitivities of NM3009 without S9 mix and NM2009 with S9 mix to nitroarenes and aromatic amines were up to 24- to 75-fold higher than those of the parent strain. Induction of umuC gene expression was detected more readily with CPRG than ONPG. The umu-microplate assay also detected genotoxicity in organic extracts of particulate matter from air samples collected in Osaka City, Japan. The pattern of the responses suggested that the genotoxic activity of the particulate extract was due primarily to nitrated polycyclic aromatic hydrocarbons. Our results indicate that the umu-microplate assay may be a useful way of carrying out rapid screens for genotoxicity in small-volume environmental samples.


Asunto(s)
Contaminantes Atmosféricos/toxicidad , Carcinógenos Ambientales/toxicidad , Regulación Bacteriana de la Expresión Génica/efectos de los fármacos , Genes Bacterianos/efectos de los fármacos , Pruebas de Mutagenicidad/métodos , Salmonella typhimurium/efectos de los fármacos , Biotransformación , Relación Dosis-Respuesta a Droga , Mutágenos/toxicidad , Salmonella typhimurium/enzimología , Salmonella typhimurium/genética , Sensibilidad y Especificidad , Activación Transcripcional , beta-Galactosidasa/genética , beta-Galactosidasa/metabolismo
10.
Environ Mol Mutagen ; 42(3): 192-205, 2003.
Artículo en Inglés | MEDLINE | ID: mdl-14556226

RESUMEN

Arsenic is a prevalent human carcinogen whose mutagenicity has not been characterized fully. Exposure to either form of inorganic arsenic, As(III) or As(V), can result in the formation of at least four organic metabolites: monomethylarsonic acid, monomethylarsonous acid (MMA(III)), dimethylarsinic acid, and dimethylarsinous acid (DMA(III)). The methylated trivalent species, as well as some of the other species, have not been evaluated previously for the induction of chromosome aberrations, sister chromatid exchanges (SCE), or toxicity in cultured human peripheral blood lymphocytes; for mutagenicity in L5178Y/Tk(+/-) mouse lymphoma cells or in the Salmonella reversion assay; or for prophage-induction in Escherichia coli. Here we evaluated the arsenicals in these assays and found that MMA(III) and DMA(III) were the most potent clastogens of the six arsenicals in human lymphocytes and the most potent mutagens of the six arsenicals at the Tk(+/-) locus in mouse lymphoma cells. The dimethylated arsenicals were also spindle poisons, suggesting that they may be ultimate forms of arsenic that induce aneuploidy. Although the arsenicals were potent clastogens, none were potent SCE inducers, similar to clastogens that act via reactive oxygen species. None of the six arsenicals were gene mutagens in Salmonella TA98, TA100, or TA104; and neither MMA(III) nor DMA(III) induced prophage. Our results show that both methylated As(V) compounds were less cytotoxic and genotoxic than As(V), whereas both methylated As(III) compounds were more cytotoxic and genotoxic than As(III). Our data support the view that MMA(III) and DMA(III) are candidate ultimate genotoxic forms of arsenic and that they are clastogens and not gene mutagens. We suggest that the clastogenicity of the other arsenicals is due to their metabolism by cells to MMA(III) or DMA(III).


Asunto(s)
Arsenicales/farmacología , Mutágenos/toxicidad , Mutación , Aberraciones Cromosómicas , Daño del ADN , Humanos , Linfocitos/efectos de los fármacos , Linfocitos/ultraestructura , Metilación , Salmonella/genética
11.
Acta Biochim Pol ; 50(1): 291-6, 2003.
Artículo en Inglés | MEDLINE | ID: mdl-12673371

RESUMEN

A previously developed and highly sensitive umu-microplate test system based on the nitroreductase- and O-acetyltransferase-overproducing strain Salmonella typhimurium NM3009 and the O-acetyltransferase-overproducing strain S. typhimurium NM2009 was applied to the detection of genotoxic activity in atmospheric particles in urban areas using a relatively small sample load. The results showed that the test system was able to detect slight increases in induced genotoxicity in atmospheric particles and that genotoxicity was detected mainly in the fine fraction but also partially in the coarse fraction. The present sensitive microplate test system has potential for application to the screening of various other environmental samples.


Asunto(s)
Microbiología del Aire , Contaminantes Atmosféricos/análisis , Salmonella typhimurium/aislamiento & purificación , Acetiltransferasas/metabolismo , Pruebas de Mutagenicidad , Nitrorreductasas/metabolismo , Salmonella typhimurium/clasificación , Salmonella typhimurium/enzimología , Sensibilidad y Especificidad
12.
Chemosphere ; 52(5): 909-15, 2003 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-12757792

RESUMEN

Natural organic polyelectrolytes (humic and fulvic acids) and their metal complexes were removed by adsorption onto xonotlite. The removal percentages of humic and fulvic acids by xonotlite were approximately 80% and 30%, respectively. Humic acid removal from solution by adsorption onto xonotlite took place more readily than fulvic acid removal. The molecular weight distributions of the humic substances remaining in solution after adsorption with the xonotlite were measured with size exclusion chromatography. A comparison of molecular weight distributions demonstrated conclusively that large molecular weight components were adsorbed preferentially, indicating that adsorption efficiency depends on the number of functional groups of humic substances. Furthermore, the surface topography of the adsorbent was observed before and after adsorption by scanning electron microscopy. The calculated heat of adsorption was of 330 kJ mol(-1) which was evaluated from the Clapeyron-Clausius equation. Therefore, the adsorption type can be considered chemical. Since xonotlite can be easily synthesized and obtained at low cost, the adsorption method of humic and fulvic acids is superior to their precipitation.


Asunto(s)
Aluminio/química , Benzopiranos/química , Compuestos de Calcio/química , Cobre/química , Sustancias Húmicas/química , Silicatos/química , Adsorción , Cromatografía en Gel , Concentración de Iones de Hidrógeno , Microscopía Electrónica de Rastreo , Peso Molecular , Contaminantes del Suelo/análisis , Propiedades de Superficie , Termodinámica
13.
J Environ Manage ; 69(2): 187-91, 2003 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-14550661

RESUMEN

The removal of heavy metals from plating factory wastewater with economical materials was investigated by the column method. Montmorillonite, kaolin, tobermorite, magnetite, silica gel and alumina were used as the economical adsorbents to wastewater containing Cd(II), Cr(VI), Cu(II) and Pb(II). This removal method of heavy metals proved highly effective as removal efficiency tended to increase with increasing pH and decrease with increasing metal concentration. The removal percentages by adsorption onto montmorillonite, tobermorite, magnetite, and silica gel showed high values for all metals. From the results for the heat of adsorption, the adsorption process in the present study might be chemisorption. The proposed method was successfully applied to the removal of Cd(II), Cr(VI) and Cu(II) in rinsing wastewater from plating factory in Nagoya City, Aichi Prefecture, Japan. Since the economical adsorbents used can be obtained commercially because they are easily synthesized, the wastewater treatment system developed is rapid, simple and cheap for the removal of heavy metals.


Asunto(s)
Galvanoplastia , Metales Pesados/aislamiento & purificación , Contaminantes del Agua/aislamiento & purificación , Purificación del Agua/métodos , Adsorción , Control de Costos , Metales Pesados/química , Eliminación de Residuos
14.
Environ Sci Technol ; 38(15): 4140-8, 2004 Aug 01.
Artículo en Inglés | MEDLINE | ID: mdl-15352453

RESUMEN

Seafood frequently contains high concentrations of arsenic (approximately 10-100 mg/kg dry weight). In marine algae (seaweed), this arsenic occurs predominantly as ribose derivatives known collectively as arsenosugars. Although it is clear that arsenosugars are not acutely toxic, there is a possibility of arsenosugars having slight chronic toxicity. In general, trivalent arsenicals are more toxic than their pentavalent counterparts, so in this work we examine the hypothesis that trivalent arsenosugars might be significantly more toxic than pentavalent arsenosugars in vitro. We compared the in vitro toxicity of (R)-2,3-dihydroxypropyl-5-deoxy-5-dimethylarsinoyl-beta-D-riboside, a pentavalent arsenosugar, to that of its trivalent counterpart, (R)-2,3-dihydroxypropyl-5-deoxy-5-dimethylarsino-beta-D-riboside. The trivalent arsenosugar nicked plasmid DNA, whereas the pentavalent arsenosugar did not. The trivalent arsenosugar was more cytotoxic (IC50 = 200 microM, 48 h exposure) than its pentavalent counterpart (IC50 > 6000 microM, 48 h exposure) in normal human epidermal keratinocytes in vitro as determined via the neutral red uptake assay. However, both the trivalent and the pentavalent arsenosugars were significantly less toxic than MMA(III), DMA(III), and arsenate. Neither the pentavalent arsenosugar nor the trivalent arsenosugar were mutagenic in Salmonella TA104. The trivalent arsenosugar was readily formed by reaction of the pentavalent arsenosugar with thiol compounds, including, cysteine, glutathione, and dithioerythritol. This work suggests that the reduction of pentavalent arsenosugars to trivalent arsenosugars in biology might have environmental consequences, especially because seaweed consumption is a significant environmental source for human exposure to arsenicals.


Asunto(s)
Arseniatos/toxicidad , Arsenitos/toxicidad , Contaminación de Alimentos , Monosacáridos/toxicidad , Arseniatos/síntesis química , Arsénico/análisis , Arsenitos/síntesis química , Supervivencia Celular , Células Cultivadas , Cromatografía Líquida de Alta Presión , Contaminación de Alimentos/análisis , Humanos , Queratinocitos/efectos de los fármacos , Monosacáridos/síntesis química , Pruebas de Mutagenicidad , Salud Pública , Ribosa/análogos & derivados , Ribosa/síntesis química , Medición de Riesgo , Algas Marinas/química , Contaminantes Químicos del Agua/análisis
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