RESUMEN
PURPOSE: Neuroendocrine tumors (NETs) are, after lymphomas, the most frequent gastrointestinal tumors in children, mainly located in the appendix. Best management remains unclear, given the absence of pediatric guidelines. We present the first Spanish series of pediatric patients with NETs. PATIENTS AND METHODS: Retrospective study of all pediatric patients (<18 years) with NET treated in four oncology reference institutions in Spain between 1994 and 2015. RESULTS: Seventeen patients were included. All patients presented with acute abdomen. TNM stage was T1a (82%) and T1b (12%). Extension study was heterogenous, with only 4 patients undergoing an OctreoScan. Four patients met criteria for second surgery (affected surgical margins or mesoappendix invasion), but it was only performed in two. Despite the diverse management, none of the patients relapsed during follow-up. CONCLUSIONS: The disparity in diagnostic tests, second surgery criteria and follow-up shown in this study highlights the need for specific pediatric guidelines.
Asunto(s)
Neoplasias del Apéndice/diagnóstico , Neoplasias del Apéndice/patología , Tumores Neuroendocrinos/diagnóstico , Tumores Neuroendocrinos/patología , Adolescente , Neoplasias del Apéndice/cirugía , Niño , Femenino , Humanos , Masculino , Tumores Neuroendocrinos/cirugía , Estudios Retrospectivos , España , Resultado del TratamientoAsunto(s)
Balanitis/complicaciones , Pene/patología , Adulto , Balanitis/patología , Humanos , Masculino , Metaplasia/complicacionesRESUMEN
Purpose. Neuroendocrine tumors (NETs) are, after lymphomas, the most frequent gastrointestinal tumors in children, mainly located in the appendix. Best management remains unclear, given the absence of pediatric guidelines. We present the first Spanish series of pediatric patients with NETs. Patients and methods. Retrospective study of all pediatric patients (<18 years) with NET treated in four oncology reference institutions in Spain between 1994 and 2015. Results. Seventeen patients were included. All patients presented with acute abdomen. TNM stage was T1a (82%) and T1b (12%). Extension study was heterogenous, with only 4 patients undergoing an OctreoScan. Four patients met criteria for second surgery (affected surgical margins or mesoappendix invasion), but it was only performed in two. Despite the diverse management, none of the patients relapsed during follow-up. Conclusions. The disparity in diagnostic tests, second surgery criteria and follow-up shown in this study highlights the need for specific pediatric guidelines (AU)
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Asunto(s)
Humanos , Niño , Tumores Neuroendocrinos/cirugía , Neoplasias del Apéndice/complicaciones , Neoplasias del Apéndice/epidemiología , Tumor Carcinoide/complicaciones , Tumor Carcinoide/diagnóstico , Tumores Neuroendocrinos , Estudios Retrospectivos , Apéndice/patología , Pronóstico , Octreótido/administración & dosificación , Octreótido/análisis , Factores de RiesgoRESUMEN
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