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1.

Mass Balance, Metabolic Pathways, Absolute Bioavailability, And Pharmacokinetics of Giredestrant In Healthy Subjects.

Kshirsagar, Smita; Chen, Ya-Chi; Yu, Jiajie; Gates, Mary R; Kawakatsu, Sonoko; Khojasteh, S Cyrus; Ma, Shuguang; Musib, Luna; Malhi, Vikram; Osaghae, Uyi; Wang, Jing; Cho, Sungjoon; Tang, Yang; Zhang, Donglu; Zhao, Weiping; De Bruyn, Tom.

Drug Metab Dispos; 2024 Jun 04.

Artículo en Inglés | MEDLINE | ID: mdl-38834357

2.

The oral selective estrogen receptor degrader GDC-0810 (ARN-810) in postmenopausal women with hormone receptor-positive HER2-negative (HR + /HER2 -) advanced/metastatic breast cancer.

Bardia, Aditya; Mayer, Ingrid; Winer, Eric; Linden, Hannah M; Ma, Cynthia X; Parker, Barbara A; Bellet, Meritxell; Arteaga, Carlos L; Cheeti, Sravanthi; Gates, Mary; Chang, Ching-Wei; Fredrickson, Jill; Spoerke, Jill M; Moore, Heather M; Giltnane, Jennifer; Friedman, Lori S; Chow Maneval, Edna; Chan, Iris; Jhaveri, Komal.

Breast Cancer Res Treat; 197(2): 319-331, 2023 Jan.

Artículo en Inglés | MEDLINE | ID: mdl-36401732

3.

Phase Ib study of the MEK inhibitor cobimetinib (GDC-0973) in combination with the PI3K inhibitor pictilisib (GDC-0941) in patients with advanced solid tumors.

Shapiro, Geoffrey I; LoRusso, Patricia; Kwak, Eunice; Pandya, Susan; Rudin, Charles M; Kurkjian, Carla; Cleary, James M; Pilat, Mary Jo; Jones, Suzanne; de Crespigny, Alex; Fredrickson, Jill; Musib, Luna; Yan, Yibing; Wongchenko, Matthew; Hsieh, Hsin-Ju; Gates, Mary R; Chan, Iris T; Bendell, Johanna.

Invest New Drugs; 38(2): 419-432, 2020 04.

Artículo en Inglés | MEDLINE | ID: mdl-31020608

4.

Correction to: Application of a Novel 'Make and Test in Parallel' Strategy to Investigate the Effect of Formulation on the Pharmacokinetics of GDC-0810 in Healthy Subjects.

Cheeti, Sravanthi; Hou, Hao Helen; Nelson, Eric; Walker, Helen; Chen, Buyun; Morley, Roland; Gates, Mary; Musib, Luna; Girish, Sandhya; Sahasranaman, Srikumar; Liu, Lichuan.

Pharm Res; 35(12): 244, 2018 10 26.

Artículo en Inglés | MEDLINE | ID: mdl-30367284

5.

Application of a Novel 'Make and Test in Parallel' Strategy to Investigate the Effect of Formulation on the Pharmacokinetics of GDC-0810 in Healthy Subjects.

Cheeti, Sravanthi; Hou, Hao Helen; Nelson, Eric; Walker, Helen; Chen, Buyun; Morley, Roland; Gates, Mary; Musib, Luna; Girish, Sandhya; Sahasranaman, Srikumar; Liu, Lichuan.

Pharm Res; 35(12): 233, 2018 Oct 15.

Artículo en Inglés | MEDLINE | ID: mdl-30324422

6.

Absorption, Metabolism, Excretion, and the Contribution of Intestinal Metabolism to the Oral Disposition of [14C]Cobimetinib, a MEK Inhibitor, in Humans.

Takahashi, Ryan H; Choo, Edna F; Ma, Shuguang; Wong, Susan; Halladay, Jason; Deng, Yuzhong; Rooney, Isabelle; Gates, Mary; Hop, Cornelis E C A; Khojasteh, S Cyrus; Dresser, Mark J; Musib, Luna.

Drug Metab Dispos; 44(1): 28-39, 2016 Jan.

Artículo en Inglés | MEDLINE | ID: mdl-26451002

7.

Phase Ia/b Study of Giredestrant ± Palbociclib and ± Luteinizing Hormone-Releasing Hormone Agonists in Estrogen Receptor-Positive, HER2-Negative, Locally Advanced/Metastatic Breast Cancer.

Jhaveri, Komal L; Bellet, Meritxell; Turner, Nicholas C; Loi, Sherene; Bardia, Aditya; Boni, Valentina; Sohn, Joohyuk; Neilan, Tomas G; Villanueva-Vázquez, Rafael; Kabos, Peter; García-Estévez, Laura; López-Miranda, Elena; Pérez-Fidalgo, J Alejandro; Pérez-García, Jose M; Yu, Jiajie; Fredrickson, Jill; Moore, Heather M; Chang, Ching-Wei; Bond, John W; Eng-Wong, Jennifer; Gates, Mary R; Lim, Elgene.

Clin Cancer Res; 30(4): 754-766, 2024 02 16.

Artículo en Inglés | MEDLINE | ID: mdl-37921755

8.

Optimizing Early-stage Clinical Pharmacology Evaluation to Accelerate Clinical Development of Giredestrant in Advanced Breast Cancer.

Malhi, Vikram; Agarwal, Priya; Gates, Mary R; Liu, Lichuan; Wang, Jianshuang; De Bruyn, Tom; Lam, Scott; Eng-Wong, Jennifer; Perez-Moreno, Pablo; Chen, Ya-Chi; Yu, Jiajie.

Cancer Res Commun; 3(12): 2551-2559, 2023 12 15.

Artículo en Inglés | MEDLINE | ID: mdl-38019116

9.

An Open-label Phase I Study of GDC-0927 in Postmenopausal Women with Locally Advanced or Metastatic Estrogen Receptor-Positive Breast Cancer.

Chandarlapaty, Sarat; Dickler, Maura N; Perez Fidalgo, Jose Alejandro; Villanueva-Vázquez, Rafael; Giltnane, Jennifer; Gates, Mary; Chang, Ching-Wei; Cheeti, Sravanthi; Fredrickson, Jill; Wang, Xiaojing; Collier, Ann; Moore, Heather M; Metcalfe, Ciara; Lauchle, Jennifer; Humke, Eric W; Bardia, Aditya.

Clin Cancer Res; 29(15): 2781-2790, 2023 08 01.

Artículo en Inglés | MEDLINE | ID: mdl-37261814

10.

Giredestrant reverses progesterone hypersensitivity driven by estrogen receptor mutations in breast cancer.

Liang, Jackson; Ingalla, Ellen Rei; Yao, Xiaosai; Wang, Bu-Er; Tai, Lisa; Giltnane, Jennifer; Liang, Yuxin; Daemen, Anneleen; Moore, Heather M; Aimi, Junko; Chang, Ching-Wei; Gates, Mary R; Eng-Wong, Jennifer; Tam, Lucinda; Bacarro, Natasha; Roose-Girma, Merone; Bellet, Meritxell; Hafner, Marc; Metcalfe, Ciara.

Sci Transl Med; 14(663): eabo5959, 2022 Sep 21.

Artículo en Inglés | MEDLINE | ID: mdl-36130016

11.

Effect of OATP1B1/1B3 Inhibitor GDC-0810 on the Pharmacokinetics of Pravastatin and Coproporphyrin I/III in Healthy Female Subjects.

Liu, Lichuan; Cheeti, Sravanthi; Yoshida, Kenta; Choo, Edna; Chen, Eugene; Chen, Buyun; Gates, Mary; Singel, Stina; Morley, Roland; Ware, Joseph; Sahasranaman, Srikumar.

J Clin Pharmacol; 58(11): 1427-1435, 2018 11.

Artículo en Inglés | MEDLINE | ID: mdl-29786857

12.

Role of endogenous Schwann cells in tissue repair after spinal cord injury.

Zhang, Shu-Xin; Huang, Fengfa; Gates, Mary; Holmberg, Eric G.

Neural Regen Res; 8(2): 177-85, 2013 Jan 15.

Artículo en Inglés | MEDLINE | ID: mdl-25206489

13.

Somatosensory evoked potentials can be recorded on the midline of the skull with subdermal electrodes in non-sedated rats elicited by magnetic stimulation of the tibial nerve.

Zhang, Shu-Xin; Huang, Fengfa; Gates, Mary; Holmberg, Eric G.

J Neurosci Methods; 208(2): 114-8, 2012 Jul 15.

Artículo en Inglés | MEDLINE | ID: mdl-22579876

14.

Tail nerve electrical stimulation combined with scar ablation and neural transplantation promotes locomotor recovery in rats with chronically contused spinal cord.

Zhang, Shu-xin; Huang, Fengfa; Gates, Mary; Holmberg, Eric G.

Brain Res; 1456: 22-35, 2012 May 25.

Artículo en Inglés | MEDLINE | ID: mdl-22516110

15.

Scar ablation combined with LP/OEC transplantation promotes anatomical recovery and P0-positive myelination in chronically contused spinal cord of rats.

Zhang, Shu-Xin; Huang, Fengfa; Gates, Mary; Holmberg, Eric G.

Brain Res; 1399: 1-14, 2011 Jul 05.

Artículo en Inglés | MEDLINE | ID: mdl-21621749

16.

Histological repair of damaged spinal cord tissue from chronic contusion injury of rat: a LM observation.

Zhang, Shu-xin; Huang, Fengfa; Gates, Mary; White, Jason; Holmberg, Eric G.

Histol Histopathol; 26(1): 45-58, 2011 01.

Artículo en Inglés | MEDLINE | ID: mdl-21117026

17.

Extensive scarring induced by chronic intrathecal tubing augmented cord tissue damage and worsened functional recovery after rat spinal cord injury.

Zhang, Shu-xin; Huang, Fengfa; Gates, Mary; White, Jason; Holmberg, Eric G.

J Neurosci Methods; 191(2): 201-7, 2010 Aug 30.

Artículo en Inglés | MEDLINE | ID: mdl-20600315

18.

Tail nerve electrical stimulation induces body weight-supported stepping in rats with spinal cord injury.

Zhang, Shu-Xin; Huang, Fengfa; Gates, Mary; White, Jason; Holmberg, Eric G.

J Neurosci Methods; 187(2): 183-9, 2010 Mar 30.

Artículo en Inglés | MEDLINE | ID: mdl-20079372

19.

Are you too sure of your stand on the right to die?

Gates, Mary S; Mayer, Gloria G.

RN; 41(12): 74-76+, 1978 Dec.

Artículo en Inglés | MEDLINE | ID: mdl-11643523

20.

Pharmacological characterization of the competitive GLUK5 receptor antagonist decahydroisoquinoline LY466195 in vitro and in vivo.

Weiss, Brianne; Alt, Andrew; Ogden, Ann Marie; Gates, Mary; Dieckman, Donna K; Clemens-Smith, Amy; Ho, Ken H; Jarvie, Keith; Rizkalla, Geihan; Wright, Rebecca A; Calligaro, David O; Schoepp, Darryle; Mattiuz, Edward L; Stratford, Robert E; Johnson, Bryan; Salhoff, Craig; Katofiasc, Mary; Phebus, Lee A; Schenck, Kathryn; Cohen, Marlene; Filla, Sandra A; Ornstein, Paul L; Johnson, Kirk W; Bleakman, David.

J Pharmacol Exp Ther; 318(2): 772-81, 2006 Aug.

Artículo en Inglés | MEDLINE | ID: mdl-16690725

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Mass Balance, Metabolic Pathways, Absolute Bioavailability, And Pharmacokinetics of Giredestrant In Healthy Subjects.

The oral selective estrogen receptor degrader GDC-0810 (ARN-810) in postmenopausal women with hormone receptor-positive HER2-negative (HR + /HER2 -) advanced/metastatic breast cancer.

Phase Ib study of the MEK inhibitor cobimetinib (GDC-0973) in combination with the PI3K inhibitor pictilisib (GDC-0941) in patients with advanced solid tumors.

Correction to: Application of a Novel 'Make and Test in Parallel' Strategy to Investigate the Effect of Formulation on the Pharmacokinetics of GDC-0810 in Healthy Subjects.

Application of a Novel 'Make and Test in Parallel' Strategy to Investigate the Effect of Formulation on the Pharmacokinetics of GDC-0810 in Healthy Subjects.

Absorption, Metabolism, Excretion, and the Contribution of Intestinal Metabolism to the Oral Disposition of [14C]Cobimetinib, a MEK Inhibitor, in Humans.

Phase Ia/b Study of Giredestrant ± Palbociclib and ± Luteinizing Hormone-Releasing Hormone Agonists in Estrogen Receptor-Positive, HER2-Negative, Locally Advanced/Metastatic Breast Cancer.

Optimizing Early-stage Clinical Pharmacology Evaluation to Accelerate Clinical Development of Giredestrant in Advanced Breast Cancer.

An Open-label Phase I Study of GDC-0927 in Postmenopausal Women with Locally Advanced or Metastatic Estrogen Receptor-Positive Breast Cancer.

Giredestrant reverses progesterone hypersensitivity driven by estrogen receptor mutations in breast cancer.

Effect of OATP1B1/1B3 Inhibitor GDC-0810 on the Pharmacokinetics of Pravastatin and Coproporphyrin I/III in Healthy Female Subjects.

Role of endogenous Schwann cells in tissue repair after spinal cord injury.

Somatosensory evoked potentials can be recorded on the midline of the skull with subdermal electrodes in non-sedated rats elicited by magnetic stimulation of the tibial nerve.

Tail nerve electrical stimulation combined with scar ablation and neural transplantation promotes locomotor recovery in rats with chronically contused spinal cord.

Scar ablation combined with LP/OEC transplantation promotes anatomical recovery and P0-positive myelination in chronically contused spinal cord of rats.

Histological repair of damaged spinal cord tissue from chronic contusion injury of rat: a LM observation.

Extensive scarring induced by chronic intrathecal tubing augmented cord tissue damage and worsened functional recovery after rat spinal cord injury.

Tail nerve electrical stimulation induces body weight-supported stepping in rats with spinal cord injury.

Are you too sure of your stand on the right to die?

Pharmacological characterization of the competitive GLUK5 receptor antagonist decahydroisoquinoline LY466195 in vitro and in vivo.