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Exp Clin Psychopharmacol ; 7(4): 427-43, 1999 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-10609977

RESUMEN

Changes in task-related mood and physiology associated with 31 days of smoking abstinence were assessed in smokers, 34 of whom were randomly assigned to a quit group and 22 to a continuing-to-smoke control group. A large financial incentive for smoking abstinence resulted in very low participant attrition. Individuals were tested during prequit baselines and at 3, 10, 17, and 31 days of abstinence. Abstinence was associated with decreases in heart rate and serum cortisol, a slowing of electroencephalogram (EEG) activity, and task-dependent and trait-depression-dependent hemispheric EEG asymmetries. Differences between the quit group and the smoking group showed no tendency to resolve across the 31 days of abstinence. Trait depression and neuroticism correlated with increases in left-relative-to-right frontal EEG slow-wave (low alpha) activity at both 3 and 31 days of abstinence. In contrast, prequit nicotine intake and Fagerström Tolerance scores correlated with alpha asymmetry and with greater EEG slowing only at Day 3. Thus, the effects of smoking abstinence appear to last for at least several months.


Asunto(s)
Afecto/fisiología , Trastorno Depresivo/psicología , Electroencefalografía/efectos de los fármacos , Nicotina/farmacología , Agonistas Nicotínicos/farmacología , Cese del Hábito de Fumar/psicología , Trastornos Relacionados con Sustancias/psicología , Adulto , Afecto/efectos de los fármacos , Ritmo alfa/efectos de los fármacos , Cafeína/farmacología , Estimulantes del Sistema Nervioso Central/farmacología , Cotinina/farmacología , Frecuencia Cardíaca/efectos de los fármacos , Humanos , Hidrocortisona/sangre , Masculino , Encuestas y Cuestionarios , Ritmo Teta/efectos de los fármacos
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