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1.

The next-generation Open Targets Platform: reimagined, redesigned, rebuilt.

Ochoa, David; Hercules, Andrew; Carmona, Miguel; Suveges, Daniel; Baker, Jarrod; Malangone, Cinzia; Lopez, Irene; Miranda, Alfredo; Cruz-Castillo, Carlos; Fumis, Luca; Bernal-Llinares, Manuel; Tsukanov, Kirill; Cornu, Helena; Tsirigos, Konstantinos; Razuvayevskaya, Olesya; Buniello, Annalisa; Schwartzentruber, Jeremy; Karim, Mohd; Ariano, Bruno; Martinez Osorio, Ricardo Esteban; Ferrer, Javier; Ge, Xiangyu; Machlitt-Northen, Sandra; Gonzalez-Uriarte, Asier; Saha, Shyamasree; Tirunagari, Santosh; Mehta, Chintan; Roldán-Romero, Juan María; Horswell, Stuart; Young, Sarah; Ghoussaini, Maya; Hulcoop, David G; Dunham, Ian; McDonagh, Ellen M.

Nucleic Acids Res; 51(D1): D1353-D1359, 2023 Jan 06.

Artículo en Inglés | MEDLINE | ID: mdl-36399499

2.

Association analysis identifies 65 new breast cancer risk loci.

Michailidou, Kyriaki; Lindström, Sara; Dennis, Joe; Beesley, Jonathan; Hui, Shirley; Kar, Siddhartha; Lemaçon, Audrey; Soucy, Penny; Glubb, Dylan; Rostamianfar, Asha; Bolla, Manjeet K; Wang, Qin; Tyrer, Jonathan; Dicks, Ed; Lee, Andrew; Wang, Zhaoming; Allen, Jamie; Keeman, Renske; Eilber, Ursula; French, Juliet D; Qing Chen, Xiao; Fachal, Laura; McCue, Karen; McCart Reed, Amy E; Ghoussaini, Maya; Carroll, Jason S; Jiang, Xia; Finucane, Hilary; Adams, Marcia; Adank, Muriel A; Ahsan, Habibul; Aittomäki, Kristiina; Anton-Culver, Hoda; Antonenkova, Natalia N; Arndt, Volker; Aronson, Kristan J; Arun, Banu; Auer, Paul L; Bacot, François; Barrdahl, Myrto; Baynes, Caroline; Beckmann, Matthias W; Behrens, Sabine; Benitez, Javier; Bermisheva, Marina; Bernstein, Leslie; Blomqvist, Carl; Bogdanova, Natalia V; Bojesen, Stig E; Bonanni, Bernardo.

Nature; 551(7678): 92-94, 2017 11 02.

Artículo en Inglés | MEDLINE | ID: mdl-29059683

3.

Open Targets Platform: supporting systematic drug-target identification and prioritisation.

Ochoa, David; Hercules, Andrew; Carmona, Miguel; Suveges, Daniel; Gonzalez-Uriarte, Asier; Malangone, Cinzia; Miranda, Alfredo; Fumis, Luca; Carvalho-Silva, Denise; Spitzer, Michaela; Baker, Jarrod; Ferrer, Javier; Raies, Arwa; Razuvayevskaya, Olesya; Faulconbridge, Adam; Petsalaki, Eirini; Mutowo, Prudence; Machlitt-Northen, Sandra; Peat, Gareth; McAuley, Elaine; Ong, Chuang Kee; Mountjoy, Edward; Ghoussaini, Maya; Pierleoni, Andrea; Papa, Eliseo; Pignatelli, Miguel; Koscielny, Gautier; Karim, Mohd; Schwartzentruber, Jeremy; Hulcoop, David G; Dunham, Ian; McDonagh, Ellen M.

Nucleic Acids Res; 49(D1): D1302-D1310, 2021 01 08.

Artículo en Inglés | MEDLINE | ID: mdl-33196847

4.

Open Targets Genetics: systematic identification of trait-associated genes using large-scale genetics and functional genomics.

Ghoussaini, Maya; Mountjoy, Edward; Carmona, Miguel; Peat, Gareth; Schmidt, Ellen M; Hercules, Andrew; Fumis, Luca; Miranda, Alfredo; Carvalho-Silva, Denise; Buniello, Annalisa; Burdett, Tony; Hayhurst, James; Baker, Jarrod; Ferrer, Javier; Gonzalez-Uriarte, Asier; Jupp, Simon; Karim, Mohd Anisul; Koscielny, Gautier; Machlitt-Northen, Sandra; Malangone, Cinzia; Pendlington, Zoe May; Roncaglia, Paola; Suveges, Daniel; Wright, Daniel; Vrousgou, Olga; Papa, Eliseo; Parkinson, Helen; MacArthur, Jacqueline A L; Todd, John A; Barrett, Jeffrey C; Schwartzentruber, Jeremy; Hulcoop, David G; Ochoa, David; McDonagh, Ellen M; Dunham, Ian.

Nucleic Acids Res; 49(D1): D1311-D1320, 2021 01 08.

Artículo en Inglés | MEDLINE | ID: mdl-33045747

5.

Evidence that the 5p12 Variant rs10941679 Confers Susceptibility to Estrogen-Receptor-Positive Breast Cancer through FGF10 and MRPS30 Regulation.

Ghoussaini, Maya; French, Juliet D; Michailidou, Kyriaki; Nord, Silje; Beesley, Jonathan; Canisus, Sander; Hillman, Kristine M; Kaufmann, Susanne; Sivakumaran, Haran; Moradi Marjaneh, Mahdi; Lee, Jason S; Dennis, Joe; Bolla, Manjeet K; Wang, Qin; Dicks, Ed; Milne, Roger L; Hopper, John L; Southey, Melissa C; Schmidt, Marjanka K; Broeks, Annegien; Muir, Kenneth; Lophatananon, Artitaya; Fasching, Peter A; Beckmann, Matthias W; Fletcher, Olivia; Johnson, Nichola; Sawyer, Elinor J; Tomlinson, Ian; Burwinkel, Barbara; Marme, Frederik; Guénel, Pascal; Truong, Thérèse; Bojesen, Stig E; Flyger, Henrik; Benitez, Javier; González-Neira, Anna; Alonso, M Rosario; Pita, Guillermo; Neuhausen, Susan L; Anton-Culver, Hoda; Brenner, Hermann; Arndt, Volker; Meindl, Alfons; Schmutzler, Rita K; Brauch, Hiltrud; Hamann, Ute; Tessier, Daniel C; Vincent, Daniel; Nevanlinna, Heli; Khan, Sofia.

Am J Hum Genet; 99(4): 903-911, 2016 Oct 06.

Artículo en Inglés | MEDLINE | ID: mdl-27640304

6.

Polymorphisms in a Putative Enhancer at the 10q21.2 Breast Cancer Risk Locus Regulate NRBF2 Expression.

Darabi, Hatef; McCue, Karen; Beesley, Jonathan; Michailidou, Kyriaki; Nord, Silje; Kar, Siddhartha; Humphreys, Keith; Thompson, Deborah; Ghoussaini, Maya; Bolla, Manjeet K; Dennis, Joe; Wang, Qin; Canisius, Sander; Scott, Christopher G; Apicella, Carmel; Hopper, John L; Southey, Melissa C; Stone, Jennifer; Broeks, Annegien; Schmidt, Marjanka K; Scott, Rodney J; Lophatananon, Artitaya; Muir, Kenneth; Beckmann, Matthias W; Ekici, Arif B; Fasching, Peter A; Heusinger, Katharina; Dos-Santos-Silva, Isabel; Peto, Julian; Tomlinson, Ian; Sawyer, Elinor J; Burwinkel, Barbara; Marme, Frederik; Guénel, Pascal; Truong, Thérèse; Bojesen, Stig E; Flyger, Henrik; Benitez, Javier; González-Neira, Anna; Anton-Culver, Hoda; Neuhausen, Susan L; Arndt, Volker; Brenner, Hermann; Engel, Christoph; Meindl, Alfons; Schmutzler, Rita K; Arnold, Norbert; Brauch, Hiltrud; Hamann, Ute; Chang-Claude, Jenny.

Am J Hum Genet; 97(1): 22-34, 2015 Jul 02.

Artículo en Inglés | MEDLINE | ID: mdl-26073781

7.

Mining a GWAS of Severe Covid-19.

Karim, Mohd; Dunham, Ian; Ghoussaini, Maya.

N Engl J Med; 383(26): 2588-2589, 2020 12 24.

Artículo en Inglés | MEDLINE | ID: mdl-33289971

8.

Fine-mapping identifies two additional breast cancer susceptibility loci at 9q31.2.

Orr, Nick; Dudbridge, Frank; Dryden, Nicola; Maguire, Sarah; Novo, Daniela; Perrakis, Eleni; Johnson, Nichola; Ghoussaini, Maya; Hopper, John L; Southey, Melissa C; Apicella, Carmel; Stone, Jennifer; Schmidt, Marjanka K; Broeks, Annegien; Van't Veer, Laura J; Hogervorst, Frans B; Fasching, Peter A; Haeberle, Lothar; Ekici, Arif B; Beckmann, Matthias W; Gibson, Lorna; Aitken, Zoe; Warren, Helen; Sawyer, Elinor; Tomlinson, Ian; Kerin, Michael J; Miller, Nicola; Burwinkel, Barbara; Marme, Frederik; Schneeweiss, Andreas; Sohn, Chistof; Guénel, Pascal; Truong, Thérèse; Cordina-Duverger, Emilie; Sanchez, Marie; Bojesen, Stig E; Nordestgaard, Børge G; Nielsen, Sune F; Flyger, Henrik; Benitez, Javier; Zamora, Maria Pilar; Arias Perez, Jose Ignacio; Menéndez, Primitiva; Anton-Culver, Hoda; Neuhausen, Susan L; Brenner, Hermann; Dieffenbach, Aida Karina; Arndt, Volker; Stegmaier, Christa; Hamann, Ute.

Hum Mol Genet; 24(10): 2966-84, 2015 May 15.

Artículo en Inglés | MEDLINE | ID: mdl-25652398

9.

Identification and characterization of novel associations in the CASP8/ALS2CR12 region on chromosome 2 with breast cancer risk.

Lin, Wei-Yu; Camp, Nicola J; Ghoussaini, Maya; Beesley, Jonathan; Michailidou, Kyriaki; Hopper, John L; Apicella, Carmel; Southey, Melissa C; Stone, Jennifer; Schmidt, Marjanka K; Broeks, Annegien; Van't Veer, Laura J; Th Rutgers, Emiel J; Muir, Kenneth; Lophatananon, Artitaya; Stewart-Brown, Sarah; Siriwanarangsan, Pornthep; Fasching, Peter A; Haeberle, Lothar; Ekici, Arif B; Beckmann, Matthias W; Peto, Julian; Dos-Santos-Silva, Isabel; Fletcher, Olivia; Johnson, Nichola; Bolla, Manjeet K; Wang, Qin; Dennis, Joe; Sawyer, Elinor J; Cheng, Timothy; Tomlinson, Ian; Kerin, Michael J; Miller, Nicola; Marmé, Frederik; Surowy, Harald M; Burwinkel, Barbara; Guénel, Pascal; Truong, Thérèse; Menegaux, Florence; Mulot, Claire; Bojesen, Stig E; Nordestgaard, Børge G; Nielsen, Sune F; Flyger, Henrik; Benitez, Javier; Zamora, M Pilar; Arias Perez, Jose Ignacio; Menéndez, Primitiva; González-Neira, Anna; Pita, Guillermo.

Hum Mol Genet; 24(1): 285-98, 2015 Jan 01.

Artículo en Inglés | MEDLINE | ID: mdl-25168388

10.

Identification of independent association signals and putative functional variants for breast cancer risk through fine-scale mapping of the 12p11 locus.

Zeng, Chenjie; Guo, Xingyi; Long, Jirong; Kuchenbaecker, Karoline B; Droit, Arnaud; Michailidou, Kyriaki; Ghoussaini, Maya; Kar, Siddhartha; Freeman, Adam; Hopper, John L; Milne, Roger L; Bolla, Manjeet K; Wang, Qin; Dennis, Joe; Agata, Simona; Ahmed, Shahana; Aittomäki, Kristiina; Andrulis, Irene L; Anton-Culver, Hoda; Antonenkova, Natalia N; Arason, Adalgeir; Arndt, Volker; Arun, Banu K; Arver, Brita; Bacot, Francois; Barrowdale, Daniel; Baynes, Caroline; Beeghly-Fadiel, Alicia; Benitez, Javier; Bermisheva, Marina; Blomqvist, Carl; Blot, William J; Bogdanova, Natalia V; Bojesen, Stig E; Bonanni, Bernardo; Borresen-Dale, Anne-Lise; Brand, Judith S; Brauch, Hiltrud; Brennan, Paul; Brenner, Hermann; Broeks, Annegien; Brüning, Thomas; Burwinkel, Barbara; Buys, Saundra S; Cai, Qiuyin; Caldes, Trinidad; Campbell, Ian; Carpenter, Jane; Chang-Claude, Jenny; Choi, Ji-Yeob.

Breast Cancer Res; 18(1): 64, 2016 06 21.

Artículo en Inglés | MEDLINE | ID: mdl-27459855

11.

Fine-scale mapping of 8q24 locus identifies multiple independent risk variants for breast cancer.

Shi, Jiajun; Zhang, Yanfeng; Zheng, Wei; Michailidou, Kyriaki; Ghoussaini, Maya; Bolla, Manjeet K; Wang, Qin; Dennis, Joe; Lush, Michael; Milne, Roger L; Shu, Xiao-Ou; Beesley, Jonathan; Kar, Siddhartha; Andrulis, Irene L; Anton-Culver, Hoda; Arndt, Volker; Beckmann, Matthias W; Zhao, Zhiguo; Guo, Xingyi; Benitez, Javier; Beeghly-Fadiel, Alicia; Blot, William; Bogdanova, Natalia V; Bojesen, Stig E; Brauch, Hiltrud; Brenner, Hermann; Brinton, Louise; Broeks, Annegien; Brüning, Thomas; Burwinkel, Barbara; Cai, Hui; Canisius, Sander; Chang-Claude, Jenny; Choi, Ji-Yeob; Couch, Fergus J; Cox, Angela; Cross, Simon S; Czene, Kamila; Darabi, Hatef; Devilee, Peter; Droit, Arnaud; Dork, Thilo; Fasching, Peter A; Fletcher, Olivia; Flyger, Henrik; Fostira, Florentia; Gaborieau, Valerie; García-Closas, Montserrat; Giles, Graham G; Guenel, Pascal.

Int J Cancer; 139(6): 1303-1317, 2016 Sep 15.

Artículo en Inglés | MEDLINE | ID: mdl-27087578

12.

Functional variants at the 11q13 risk locus for breast cancer regulate cyclin D1 expression through long-range enhancers.

French, Juliet D; Ghoussaini, Maya; Edwards, Stacey L; Meyer, Kerstin B; Michailidou, Kyriaki; Ahmed, Shahana; Khan, Sofia; Maranian, Mel J; O'Reilly, Martin; Hillman, Kristine M; Betts, Joshua A; Carroll, Thomas; Bailey, Peter J; Dicks, Ed; Beesley, Jonathan; Tyrer, Jonathan; Maia, Ana-Teresa; Beck, Andrew; Knoblauch, Nicholas W; Chen, Constance; Kraft, Peter; Barnes, Daniel; González-Neira, Anna; Alonso, M Rosario; Herrero, Daniel; Tessier, Daniel C; Vincent, Daniel; Bacot, Francois; Luccarini, Craig; Baynes, Caroline; Conroy, Don; Dennis, Joe; Bolla, Manjeet K; Wang, Qin; Hopper, John L; Southey, Melissa C; Schmidt, Marjanka K; Broeks, Annegien; Verhoef, Senno; Cornelissen, Sten; Muir, Kenneth; Lophatananon, Artitaya; Stewart-Brown, Sarah; Siriwanarangsan, Pornthep; Fasching, Peter A; Loehberg, Christian R; Ekici, Arif B; Beckmann, Matthias W; Peto, Julian; dos Santos Silva, Isabel.

Am J Hum Genet; 92(4): 489-503, 2013 Apr 04.

Artículo en Inglés | MEDLINE | ID: mdl-23540573

13.

Inherited genetic susceptibility to breast cancer: the beginning of the end or the end of the beginning?

Ghoussaini, Maya; Pharoah, Paul D P; Easton, Douglas F.

Am J Pathol; 183(4): 1038-1051, 2013 Oct.

Artículo en Inglés | MEDLINE | ID: mdl-23973388

14.

A functional variant at a prostate cancer predisposition locus at 8q24 is associated with PVT1 expression.

Meyer, Kerstin B; Maia, Ana-Teresa; O'Reilly, Martin; Ghoussaini, Maya; Prathalingam, Radhika; Porter-Gill, Patricia; Ambs, Stefan; Prokunina-Olsson, Ludmila; Carroll, Jason; Ponder, Bruce A J.

PLoS Genet; 7(7): e1002165, 2011 Jul.

Artículo en Inglés | MEDLINE | ID: mdl-21814516

15.

Variants of ENPP1 are associated with childhood and adult obesity and increase the risk of glucose intolerance and type 2 diabetes.

Meyre, David; Bouatia-Naji, Nabila; Tounian, Agnès; Samson, Chantal; Lecoeur, Cécile; Vatin, Vincent; Ghoussaini, Maya; Wachter, Christophe; Hercberg, Serge; Charpentier, Guillaume; Patsch, Wolfgang; Pattou, François; Charles, Marie-Aline; Tounian, Patrick; Clément, Karine; Jouret, Béatrice; Weill, Jacques; Maddux, Betty A; Goldfine, Ira D; Walley, Andrew; Boutin, Philippe; Dina, Christian; Froguel, Philippe.

Nat Genet; 37(8): 863-7, 2005 Aug.

Artículo en Inglés | MEDLINE | ID: mdl-16025115

16.

Future prospects for human genetics and genomics in drug discovery.

Ghoussaini, Maya; Nelson, Matthew R; Dunham, Ian.

Curr Opin Struct Biol; 80: 102568, 2023 06.

Artículo en Inglés | MEDLINE | ID: mdl-36963162

17.

Network expansion of genetic associations defines a pleiotropy map of human cell biology.

Barrio-Hernandez, Inigo; Schwartzentruber, Jeremy; Shrivastava, Anjali; Del-Toro, Noemi; Gonzalez, Asier; Zhang, Qian; Mountjoy, Edward; Suveges, Daniel; Ochoa, David; Ghoussaini, Maya; Bradley, Glyn; Hermjakob, Henning; Orchard, Sandra; Dunham, Ian; Anderson, Carl A; Porras, Pablo; Beltrao, Pedro.

Nat Genet; 55(3): 389-398, 2023 03.

Artículo en Inglés | MEDLINE | ID: mdl-36823319

18.

Mapping interindividual dynamics of innate immune response at single-cell resolution.

Kumasaka, Natsuhiko; Rostom, Raghd; Huang, Ni; Polanski, Krzysztof; Meyer, Kerstin B; Patel, Sharad; Boyd, Rachel; Gomez, Celine; Barnett, Sam N; Panousis, Nikolaos I; Schwartzentruber, Jeremy; Ghoussaini, Maya; Lyons, Paul A; Calero-Nieto, Fernando J; Göttgens, Berthold; Barnes, Josephine L; Worlock, Kaylee B; Yoshida, Masahiro; Nikolic, Marko Z; Stephenson, Emily; Reynolds, Gary; Haniffa, Muzlifah; Marioni, John C; Stegle, Oliver; Hagai, Tzachi; Teichmann, Sarah A.

Nat Genet; 55(6): 1066-1075, 2023 06.

Artículo en Inglés | MEDLINE | ID: mdl-37308670

19.

Multi-ancestry Mendelian randomization of omics traits revealing drug targets of COVID-19 severity.

Zheng, Jie; Zhang, Yuemiao; Zhao, Huiling; Liu, Yi; Baird, Denis; Karim, Mohd Anisul; Ghoussaini, Maya; Schwartzentruber, Jeremy; Dunham, Ian; Elsworth, Benjamin; Roberts, Katherine; Compton, Hannah; Miller-Molloy, Felix; Liu, Xingzi; Wang, Lin; Zhang, Hong; Smith, George Davey; Gaunt, Tom R.

EBioMedicine; 81: 104112, 2022 Jul.

Artículo en Inglés | MEDLINE | ID: mdl-35772218

20.

An open approach to systematically prioritize causal variants and genes at all published human GWAS trait-associated loci.

Mountjoy, Edward; Schmidt, Ellen M; Carmona, Miguel; Schwartzentruber, Jeremy; Peat, Gareth; Miranda, Alfredo; Fumis, Luca; Hayhurst, James; Buniello, Annalisa; Karim, Mohd Anisul; Wright, Daniel; Hercules, Andrew; Papa, Eliseo; Fauman, Eric B; Barrett, Jeffrey C; Todd, John A; Ochoa, David; Dunham, Ian; Ghoussaini, Maya.

Nat Genet; 53(11): 1527-1533, 2021 11.

Artículo en Inglés | MEDLINE | ID: mdl-34711957

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