Evaluation of the cytotoxic and immunomodulatory effects of sonodynamic therapy in human pancreatic cancer spheroids.

Sonodynamic therapy (SDT) exploits the energy generated by ultrasound (US) to activate sound-sensitive drugs (sonosensitizers), leading to the generation of reactive oxygen species (ROS) and cancer cell death. Two-dimensional (2D) and three-dimensional (3D) cultures of human pancreatic cancer BxPC-3 cells were chosen as the models with which to investigate the therapeutic effects of the US-activated sonosensitizer IR-780 as pancreatic cancer is still one of the most lethal types of cancer. The effects of SDT, including ROS production, cancer cell death and immunogenic cell death (ICD), were extensively investigated. When subjected to US, IR-780 triggered significant ROS production and caused cancer cell death after 24 h (p ≤ 0.01). Additionally, the activation of dendritic cells (DCs) led to an effective immune response against the cancer cells undergoing SDT-induced death. BxPC-3 spheroids were developed and studied extensively to validate the findings observed in 2D BxPC-3 cell cultures. An analysis of the pancreatic cancer spheroid section revealed significant SDT-induced cancer cell death after 48 h after the treatment (p ≤ 0.01), with this being accompanied by the presence of SDT-induced damage-associated molecular patterns (DAMPs), such as calreticulin (CRT) and high mobility group box 1 (HMGB1). In conclusion, the data obtained demonstrates the anticancer efficacy of SDT and its immunomodulatory potential via action as an ICD-inducer.

[Work and health of the Cordoba National University teachers: medicaments/legal drugs use and infantile-maternal plan]. / Trabajo y salud de las docentes de la Universidad Nacional de Córdoba: uso de medicamentos/sustancias lícitas y plan materno infantil.

This study aimed to investigate university teachers in reproductive age--life conditions, work and health process and medicaments use. Beside, aimed research the use, opinions and suggestions of Infantile-Maternal Plan of the University Social Assistance clients. In dialectic and historic materialism theory and method way, this is a social research developed by a strategic and correlative-descriptive fieldwork with 50 persons sample. The results showed degraded work and life conditions, affecting the teachers' health profile and medicaments use. The Infantile-Maternal Plan is good or very good and demands best information accord the teachers in high percent opinion.

Trabajo y salud de las docentes de la Universidad Nacional de Córdoba: uso de medicamentos/sustancias lícitas y plan materno infantil / Work and health of the Cordoba National University teachers: medicaments/legal drugs use and infantile-maternal plan

Este trabajo tuvo como objetivo investigar condiciones de existencia, proceso de trabajo y salud y consumo de medicamentos de docentes universitarias en edad reproductiva. Además, intentó conocer uso, opiniones y sugerencias de usuarias del Plan Materno Infantil de la Obra Social Universitaria. El estudio se encaminó desde la perspectiva teórico-metodológica del materialismo histórico y dialéctico, se delineó como investigación social desarrollada a través de un estudio de campo descriptivo-correlativo e estratégico en una muestra total de 50 personas. Los resultados indican presencia de condiciones de existencia y trabajo deterioradas, afectando el perfil de salud de las docentes y el consumo de medicamentos. Alto porcentaje de las entrevistadas consideró el Plan Materno Infantil muy bueno o bueno y enfatizó la necesidad de mejor información a cerca de ella

Programa de enseñanza de la prevencion y atencion de enfermeria en relacion al uso indebido de Drogas / Program of education of the prevention and attention of nursing in relation to the illegal drugs use

Presenta una sintesis historica de impacto del proyecto de enseñanza para la prevencion y atencion de enfermeria en relacion con el uso indebido de drogas. Se pretende demostrar las actividades educativas de grado y postgrado, de investigacion, y extension realizadas como asi tambien el impacto positivo y generador de nuevas estrategias para enfrentar la problematica de las adicciones que el proyecto logro en la comunidad en la que esta inmersa la escuela