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1.
Safety, tolerability, and antiviral effect of RG-101 in patients with chronic hepatitis C: a phase 1B, double-blind, randomised controlled trial.
Lancet;
389(10070): 709-717, 2017 02 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-28087069
2.
Imidazo[1,5-a]pyrazines: orally efficacious inhibitors of mTORC1 and mTORC2.
Bioorg Med Chem Lett;
21(7): 2092-7, 2011 Apr 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-21353551
3.
Bypassing cellular EGF receptor dependence through epithelial-to-mesenchymal-like transitions.
Clin Exp Metastasis;
25(6): 685-93, 2008.
Artículo
en Inglés
| MEDLINE | ID: mdl-18236164
4.
Novel 2-phenylquinolin-7-yl-derived imidazo[1,5-a]pyrazines as potent insulin-like growth factor-I receptor (IGF-IR) inhibitors.
Bioorg Med Chem;
16(3): 1359-75, 2008 Feb 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-17983756
5.
OSI-930: a novel selective inhibitor of Kit and kinase insert domain receptor tyrosine kinases with antitumor activity in mouse xenograft models.
Cancer Res;
66(2): 1015-24, 2006 Jan 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-16424037
6.
Colon carcinoma cells harboring PIK3CA mutations display resistance to growth factor deprivation induced apoptosis.
Mol Cancer Ther;
6(3): 1143-50, 2007 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-17363507
7.
Loss of homotypic cell adhesion by epithelial-mesenchymal transition or mutation limits sensitivity to epidermal growth factor receptor inhibition.
Mol Cancer Ther;
6(2): 532-41, 2007 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-17308052
8.
A novel, potent, and selective insulin-like growth factor-I receptor kinase inhibitor blocks insulin-like growth factor-I receptor signaling in vitro and inhibits insulin-like growth factor-I receptor dependent tumor growth in vivo.
Mol Cancer Ther;
6(8): 2158-67, 2007 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-17671083
9.
Inactivation of Akt by the epidermal growth factor receptor inhibitor erlotinib is mediated by HER-3 in pancreatic and colorectal tumor cell lines and contributes to erlotinib sensitivity.
Mol Cancer Ther;
5(8): 2051-9, 2006 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-16928826
10.
Rapamycin synergizes with the epidermal growth factor receptor inhibitor erlotinib in non-small-cell lung, pancreatic, colon, and breast tumors.
Mol Cancer Ther;
5(11): 2676-84, 2006 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-17121914
11.
NOTCH1 signaling promotes human T-cell acute lymphoblastic leukemia initiating cell regeneration in supportive niches.
PLoS One;
7(6): e39725, 2012.
Artículo
en Inglés
| MEDLINE | ID: mdl-22768113
12.
Preclinical characterization of OSI-027, a potent and selective inhibitor of mTORC1 and mTORC2: distinct from rapamycin.
Mol Cancer Ther;
10(8): 1394-406, 2011 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-21673091
13.
Exome sequencing identifies frequent mutation of ARID1A in molecular subtypes of gastric cancer.
Nat Genet;
43(12): 1219-23, 2011 Oct 30.
Artículo
en Inglés
| MEDLINE | ID: mdl-22037554
14.
Complexity in common diseases: big biology for all.
Sci Transl Med;
2(25): 25cm11, 2010 Mar 31.
Artículo
en Inglés
| MEDLINE | ID: mdl-20424010
15.
Discovery of OSI-906: a selective and orally efficacious dual inhibitor of the IGF-1 receptor and insulin receptor.
Future Med Chem;
1(6): 1153-71, 2009 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-21425998
16.
Knockdown of Ron kinase inhibits mutant phosphatidylinositol 3-kinase and reduces metastasis in human colon carcinoma.
J Biol Chem;
284(16): 10912-22, 2009 Apr 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-19224914
17.
Feedback mechanisms promote cooperativity for small molecule inhibitors of epidermal and insulin-like growth factor receptors.
Cancer Res;
68(20): 8322-32, 2008 Oct 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-18922904
18.
3-[6-(2-Dimethylamino-1-imidazol-1-yl-butyl)-naphthalen-2-yloxy]-2,2-dimethyl-propionic acid as a highly potent and selective retinoic acid metabolic blocking agent.
Bioorg Med Chem Lett;
16(10): 2729-33, 2006 May 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-16504501
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