Detalles de la búsqueda
1.
The ß-Blocker Carvedilol and Related Aryloxypropanolamines Promote ERK1/2 Phosphorylation in HEK293 Cells with K A Values Distinct From Their Equilibrium Dissociation Constants as ß 2-Adrenoceptor Antagonists: Evidence for Functional Affinity.
J Pharmacol Exp Ther;
388(2): 688-700, 2024 01 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-38129128
2.
ß 2-Adrenoceptor Agonists Promote Extracellular Signal-Regulated Kinase 1/2 Dephosphorylation in Human Airway Epithelial Cells by Canonical, cAMP-Driven Signaling Independently of ß-Arrestin 2.
Mol Pharmacol;
100(4): 388-405, 2021 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-34341099
3.
Transcriptome-Level Interactions between Budesonide and Formoterol Provide Insight into the Mechanism of Action of Inhaled Corticosteroid/Long-Acting ß 2-Adrenoceptor Agonist Combination Therapy in Asthma.
Mol Pharmacol;
99(3): 197-216, 2021 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-33376135
4.
Prostanoid Receptors of the EP4-Subtype Mediate Gene Expression Changes in Human Airway Epithelial Cells with Potential Anti-Inflammatory Activity.
J Pharmacol Exp Ther;
376(2): 161-180, 2021 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-33158942
5.
Impact of Phosphodiesterase 4 Inhibition on the Operational Efficacy, Response Maxima, and Kinetics of Indacaterol-Induced Gene Expression Changes in BEAS-2B Airway Epithelial Cells: A Global Transcriptomic Analysis.
Mol Pharmacol;
96(1): 56-72, 2019 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-31036559
6.
Long-Acting ß2-Adrenoceptor Agonists Enhance Glucocorticoid Receptor (GR)-Mediated Transcription by Gene-Specific Mechanisms Rather Than Generic Effects via GR.
Mol Pharmacol;
94(3): 1031-1046, 2018 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-29959223
7.
Analysis of the Indacaterol-Regulated Transcriptome in Human Airway Epithelial Cells Implicates Gene Expression Changes in the Adverse and Therapeutic Effects of ß2-Adrenoceptor Agonists.
J Pharmacol Exp Ther;
366(1): 220-236, 2018 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-29653961
8.
GS-5759, a Bifunctional ß2-Adrenoceptor Agonist and Phosphodiesterase 4 Inhibitor for Chronic Obstructive Pulmonary Disease with a Unique Mode of Action: Effects on Gene Expression in Human Airway Epithelial Cells.
J Pharmacol Exp Ther;
360(2): 324-340, 2017 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-27927912
9.
Superiority of combined phosphodiesterase PDE3/PDE4 inhibition over PDE4 inhibition alone on glucocorticoid- and long-acting ß2-adrenoceptor agonist-induced gene expression in human airway epithelial cells.
Mol Pharmacol;
87(1): 64-76, 2015 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-25324049
10.
Induction of regulator of G-protein signaling 2 expression by long-acting ß2-adrenoceptor agonists and glucocorticoids in human airway epithelial cells.
J Pharmacol Exp Ther;
348(1): 12-24, 2014 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-24163441
11.
ß2-Adrenoceptor agonist-induced RGS2 expression is a genomic mechanism of bronchoprotection that is enhanced by glucocorticoids.
Proc Natl Acad Sci U S A;
108(49): 19713-8, 2011 Dec 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-22080612
12.
Inhibition of ABCC4 potentiates combination beta agonist and glucocorticoid responses in human airway epithelial cells.
J Allergy Clin Immunol;
141(3): 1127-1130.e5, 2018 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-29103996
13.
Phosphodiesterase 4 inhibitors augment the ability of formoterol to enhance glucocorticoid-dependent gene transcription in human airway epithelial cells: a novel mechanism for the clinical efficacy of roflumilast in severe chronic obstructive pulmonary disease.
Mol Pharmacol;
83(4): 894-906, 2013 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-23389862
14.
Concurrent agonism of adenosine A2B and glucocorticoid receptors in human airway epithelial cells cooperatively induces genes with anti-inflammatory potential: a novel approach to treat chronic obstructive pulmonary disease.
J Pharmacol Exp Ther;
346(3): 473-85, 2013 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-23820127
15.
Prostaglandin E2 represses interleukin 1 beta-induced inflammatory mediator output from pregnant human myometrial cells through the EP2 and EP4 receptors.
Biol Reprod;
87(1): 7, 1-10, 2012 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-22517618
16.
α and ß catalytic subunits of cAMP-dependent protein kinase regulate formoterol-induced inflammatory gene expression changes in human bronchial epithelial cells.
Br J Pharmacol;
179(18): 4593-4614, 2022 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-35735057
17.
Evidence for a second receptor for prostacyclin on human airway epithelial cells that mediates inhibition of CXCL9 and CXCL10 release.
Mol Pharmacol;
79(3): 586-95, 2011 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-21173040
18.
Inflammatory stimuli inhibit glucocorticoid-dependent transactivation in human pulmonary epithelial cells: rescue by long-acting beta2-adrenoceptor agonists.
J Pharmacol Exp Ther;
338(3): 860-9, 2011 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-21622733
19.
Salbutamol delays human eosinophil apoptosis via a cAMP-dependent mechanism.
Pulm Pharmacol Ther;
24(4): 394-400, 2011 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-21396479
20.
Selective prostacyclin receptor agonism augments glucocorticoid-induced gene expression in human bronchial epithelial cells.
J Immunol;
183(10): 6788-99, 2009 Nov 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-19880449