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1.

Statistics of the distribution of the abundance of molecules with various drug loads in maytansinoid antibody-drug conjugates.

Goldmacher, Victor S; Amphlett, Godfrey; Wang, Lintao; Lazar, Alexandru C.

Mol Pharm; 12(6): 1738-44, 2015 Jun 01.

Artículo en Inglés | MEDLINE | ID: mdl-25635630

2.

Cytopathic effects of the cytomegalovirus-encoded apoptosis inhibitory protein vMIA.

Poncet, Delphine; Pauleau, Anne-Laure; Szabadkai, Gyorgy; Vozza, Angelo; Scholz, Sebastian R; Le Bras, Morgane; Brière, Jean-Jacques; Jalil, Abdelali; Le Moigne, Ronan; Brenner, Catherine; Hahn, Gabriele; Wittig, Ilka; Schägger, Hermann; Lemaire, Christophe; Bianchi, Katiuscia; Souquère, Sylvie; Pierron, Gerard; Rustin, Pierre; Goldmacher, Victor S; Rizzuto, Rosario; Palmieri, Ferdinando; Kroemer, Guido.

J Cell Biol; 174(7): 985-96, 2006 Sep 25.

Artículo en Inglés | MEDLINE | ID: mdl-16982800

3.

The effect of the cell death suppressor vMIA on the production of a recombinant protein in the adenovirus-293 expression system.

Vieira, Helena L A; Cunha, Liliana; Goldmacher, Victor S; Alves, Paula M.

Protein Expr Purif; 64(2): 179-84, 2009 Apr.

Artículo en Inglés | MEDLINE | ID: mdl-19041945

4.

Folate receptor-specific antitumor activity of EC131, a folate-maytansinoid conjugate.

Reddy, Joseph A; Westrick, Elaine; Santhapuram, Hari K R; Howard, Stephen J; Miller, Michael L; Vetzel, Marilynn; Vlahov, Iontcho; Chari, Ravi V J; Goldmacher, Victor S; Leamon, Christopher P.

Cancer Res; 67(13): 6376-82, 2007 Jul 01.

Artículo en Inglés | MEDLINE | ID: mdl-17616697

5.

The murine cytomegalovirus cell death suppressor m38.5 binds Bax and blocks Bax-mediated mitochondrial outer membrane permeabilization.

Arnoult, Damien; Skaletskaya, Anna; Estaquier, Jérôme; Dufour, Cecilie; Goldmacher, Victor S.

Apoptosis; 13(9): 1100-10, 2008 Sep.

Artículo en Inglés | MEDLINE | ID: mdl-18670882

6.

Antibody-maytansinoid conjugates are activated in targeted cancer cells by lysosomal degradation and linker-dependent intracellular processing.

Erickson, Hans K; Park, Peter U; Widdison, Wayne C; Kovtun, Yelena V; Garrett, Lisa M; Hoffman, Karen; Lutz, Robert J; Goldmacher, Victor S; Blättler, Walter A.

Cancer Res; 66(8): 4426-33, 2006 Apr 15.

Artículo en Inglés | MEDLINE | ID: mdl-16618769

7.

Antibody-drug conjugates designed to eradicate tumors with homogeneous and heterogeneous expression of the target antigen.

Kovtun, Yelena V; Audette, Charlene A; Ye, Yumei; Xie, Hongsheng; Ruberti, Mary F; Phinney, Sara J; Leece, Barbara A; Chittenden, Thomas; Blättler, Walter A; Goldmacher, Victor S.

Cancer Res; 66(6): 3214-21, 2006 Mar 15.

Artículo en Inglés | MEDLINE | ID: mdl-16540673

8.

A CD123-targeting antibody-drug conjugate, IMGN632, designed to eradicate AML while sparing normal bone marrow cells.

Kovtun, Yelena; Jones, Gregory E; Adams, Sharlene; Harvey, Lauren; Audette, Charlene A; Wilhelm, Alan; Bai, Chen; Rui, Lingyun; Laleau, Rassol; Liu, Fenghua; Ab, Olga; Setiady, Yulius; Yoder, Nicholas C; Goldmacher, Victor S; Chari, Ravi V J; Pinkas, Jan; Chittenden, Thomas.

Blood Adv; 2(8): 848-858, 2018 04 24.

Artículo en Inglés | MEDLINE | ID: mdl-29661755

9.

Cell killing by antibody-drug conjugates.

Kovtun, Yelena V; Goldmacher, Victor S.

Cancer Lett; 255(2): 232-40, 2007 Oct 08.

Artículo en Inglés | MEDLINE | ID: mdl-17553616

10.

Semisynthetic maytansine analogues for the targeted treatment of cancer.

Widdison, Wayne C; Wilhelm, Sharon D; Cavanagh, Emily E; Whiteman, Kathleen R; Leece, Barbara A; Kovtun, Yelena; Goldmacher, Victor S; Xie, Hongsheng; Steeves, Rita M; Lutz, Robert J; Zhao, Robert; Wang, Lintao; Blättler, Walter A; Chari, Ravi V J.

J Med Chem; 49(14): 4392-408, 2006 Jul 13.

Artículo en Inglés | MEDLINE | ID: mdl-16821799

11.

High-affinity accumulation of a maytansinoid in cells via weak tubulin interaction.

Goldmacher, Victor S; Audette, Charlene A; Guan, Yinghua; Sidhom, Eriene-Heidi; Shah, Jagesh V; Whiteman, Kathleen R; Kovtun, Yelena V.

PLoS One; 10(2): e0117523, 2015.

Artículo en Inglés | MEDLINE | ID: mdl-25671541

12.

IMGN853, a Folate Receptor-α (FRα)-Targeting Antibody-Drug Conjugate, Exhibits Potent Targeted Antitumor Activity against FRα-Expressing Tumors.

Ab, Olga; Whiteman, Kathleen R; Bartle, Laura M; Sun, Xiuxia; Singh, Rajeeva; Tavares, Daniel; LaBelle, Alyssa; Payne, Gillian; Lutz, Robert J; Pinkas, Jan; Goldmacher, Victor S; Chittenden, Thomas; Lambert, John M.

Mol Cancer Ther; 14(7): 1605-13, 2015 Jul.

Artículo en Inglés | MEDLINE | ID: mdl-25904506

13.

vMIA, a viral inhibitor of apoptosis targeting mitochondria.

Goldmacher, Victor S.

Biochimie; 84(2-3): 177-85, 2002.

Artículo en Inglés | MEDLINE | ID: mdl-12022948

14.

Synthesis of taxoids with improved cytotoxicity and solubility for use in tumor-specific delivery.

Miller, Michael L; Roller, Elizabeth E; Zhao, Robert Y; Leece, Barbara A; Ab, Olga; Baloglu, Erkan; Goldmacher, Victor S; Chari, Ravi V J.

J Med Chem; 47(20): 4802-5, 2004 Sep 23.

Artículo en Inglés | MEDLINE | ID: mdl-15369381

15.

Tumor-specific novel taxoid-monoclonal antibody conjugates.

Ojima, Iwao; Geng, Xudong; Wu, Xinyuan; Qu, Chuanxing; Borella, Christopher P; Xie, Hongsheng; Wilhelm, Sharon D; Leece, Barbara A; Bartle, Laura M; Goldmacher, Victor S; Chari, Ravi V J.

J Med Chem; 45(26): 5620-3, 2002 Dec 19.

Artículo en Inglés | MEDLINE | ID: mdl-12477344

16.

SAR650984, a novel humanized CD38-targeting antibody, demonstrates potent antitumor activity in models of multiple myeloma and other CD38+ hematologic malignancies.

Deckert, Jutta; Wetzel, Marie-Cécile; Bartle, Laura M; Skaletskaya, Anna; Goldmacher, Victor S; Vallée, François; Zhou-Liu, Qing; Ferrari, Paul; Pouzieux, Stéphanie; Lahoute, Charlotte; Dumontet, Charles; Plesa, Adriana; Chiron, Marielle; Lejeune, Pascale; Chittenden, Thomas; Park, Peter U; Blanc, Véronique.

Clin Cancer Res; 20(17): 4574-83, 2014 Sep 01.

Artículo en Inglés | MEDLINE | ID: mdl-24987056

17.

Targeting CD56 by the maytansinoid immunoconjugate IMGN901 (huN901-DM1): a potential therapeutic modality implication against natural killer/T cell malignancy.

Ishitsuka, Kenji; Jimi, Shiro; Goldmacher, Victor S; Ab, Olga; Tamura, Kazuo.

Br J Haematol; 141(1): 129-31, 2008 Apr.

Artículo en Inglés | MEDLINE | ID: mdl-18279455

18.

The isolation and characterization of renal cancer initiating cells from human Wilms' tumour xenografts unveils new therapeutic targets.

Pode-Shakked, Naomi; Shukrun, Rachel; Mark-Danieli, Michal; Tsvetkov, Peter; Bahar, Sarit; Pri-Chen, Sara; Goldstein, Ronald S; Rom-Gross, Eithan; Mor, Yoram; Fridman, Edward; Meir, Karen; Simon, Amos; Magister, Marcus; Kaminski, Naftali; Goldmacher, Victor S; Harari-Steinberg, Orit; Dekel, Benjamin.

EMBO Mol Med; 5(1): 18-37, 2013 01.

Artículo en Inglés | MEDLINE | ID: mdl-23239665

19.

Synthesis and biological evaluation of antibody conjugates of phosphate prodrugs of cytotoxic DNA alkylators for the targeted treatment of cancer.

Zhao, Robert Yongxin; Erickson, Hans K; Leece, Barbara A; Reid, Emily E; Goldmacher, Victor S; Lambert, John M; Chari, Ravi V J.

J Med Chem; 55(2): 766-82, 2012 Jan 26.

Artículo en Inglés | MEDLINE | ID: mdl-22148292

20.

Antibody-drug conjugates: using monoclonal antibodies for delivery of cytotoxic payloads to cancer cells.

Goldmacher, Victor S; Kovtun, Yelena V.

Ther Deliv; 2(3): 397-416, 2011 Mar.

Artículo en Inglés | MEDLINE | ID: mdl-22834009

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