Polydopamine-Based Material and Their Potential in Head and Neck Cancer Therapy-Current State of Knowledge.

Head and neck cancers (HNC) are among the most common cancers in the world. In terms of frequency of occurrence in the world, HNC ranks sixth. However, the problem of modern oncology is the low specificity of the therapies used, which is why most of the currently used chemotherapeutic agents have a systemic effect. The use of nanomaterials could overcome the limitations of traditional therapies. Researchers are increasingly using polydopamine (PDA) in nanotherapeutic systems for HNC due to its unique properties. PDA has found applications in chemotherapy, photothermal therapy, targeted therapy, and combination therapies that facilitate better carrier control for the effective reduction of cancer cells than individual therapies. The purpose of this review was to present the current knowledge on the potential use of polydopamine in head and neck cancer research.

[Dental examination integral part of preventive testing head and neck cancers].

In recent years, in Poland and in Europe, we have seen a steady increase in the incidence of malignant tumors of the head and neck. On the basis of national cancer registries, the increase in new cases in the last ten years is over 15% and that worries epidemiologists and the medical community. Taken in Europe prevention programs aimed at reducing new cases. In Grater Poland from 2012 has initiated an innovative program for Early Detection of Cancer, Department of Head and Neck Surgery Medical University in Poznan and the Department of Health Marshal's Office in Poznan. The aim of the study was to evaluate dental and oral hygiene habits analysis of patients reporting to the Programme for Early Detection of Head and Neck Cancer. The study conducted involved 678 patients reporting to the Department of Head and Neck Surgery in Grater Poland Cancer Center under the prevention of cancers of the head and neck. All patients underwent ENT assessment and standard dental examination assessing condition of teeth and oral mucosa. All patients were asked to fill out prepared questionnaire, which included questions concerning socio-economic conditions of the patient, hygiene habits and risk factors for oral cancer. Most of the patients participating in the study, 441 people (65.9%) smoke or smoked cigarettes. Smoking habit among female dominated. Within smokers responders declared, at the same time,consumption of alcohol at least three times a week; 192 people (81.1%). Almost half (49.8%) of all respondents reported consuming alcohol occasionally. Regular practice of oral sex with frequent change of partner, belonging to the high risk of head and neck cancer, were found in 21.9% of patients. During the assessment of oral hygiene was observed 155 patients (23.4%) correctly cleansing the teeth and oral cavity, while more than half (62.4%) did not abide rules of daily oral hygiene. The use of additional tools to correct hygienization (dental floss, interdental brushes, rinses the mouth) was recorded in 51.7% of patients. As a result, 85% of the patients of the head and neck cancer prevention program was found bad condition of the oral cavity, and dental procedures in 30% of patients were applied. Patients diagnosed with invasive cancer was in 19 cases. Results of this study indicate that, the dentist should be an integral part of interdisciplinary team treating patients with head and neck cancer, and regular dental care plays a key role in the early diagnosis of patients with head and neck cancer.

[Periodonta disease in smokers, and the parameters of oxidative stress]. / Choroby przyzebia u palaczy tytoniu a parametry stresu oksydacyjnego.

Periodontal disease, periodontitis, and caries disease, are the two most common disease occurring in the mouth. They affect a large proportion of the world's population. The causes of periodontitis are varied, but the largest group are those caused by infections. The characteristic long asymptomatic period of development of periodontitis, make that patients are not aware of their condition. In-addition, it was observed that tobacco abuse affects the growth of disease and advancing disease state for periodontal diseases. Free radicals and other reactive particles are capable of destroying many cellular structures. They are produced mostly during the breathing process and the immune response or come from the environment. The evolution of living organisms ensure the proper tools to fight against reactive oxygen species after enzymatic and non-enzymatic by antioxidants. Sometimes this protection is not sufficient and the balance between antioxidants and oxidants is compromised. This condition is called oxidative stress. A number of studies looking for a link between oxidative stress, and diseases affecting human and determined that it is an important risk factor in many diseases. Evaluating the parameters of oxidative stress in the saliva allows for effective monitoring of disease progression, evaluation of the therapy and taking preventive measures in a timely manner.

Current Role of Surgery in the Management of Oropharyngeal Cancer.

In the last few decades, the surgical treatment of oropharyngeal squamous cell carcinoma (OPSCC) has undergone enormous changes. Until the 1990s, open surgery was the primary treatment for OPSCC. However, due to the potentially severe functional morbidity of this approach, open surgery was largely displaced by concurrent chemoradiotherapy (CRT) in the 1990s. At the same time, new, less-invasive surgical approaches such as transoral surgery with monopolar cautery began to emerge, with the potential to reduce functional morbidity and avoid the late-onset toxicity of CRT. More recently, the growing incidence of HPV-positive disease has altered the patient profile of OPSCC, as these patients tend to be younger and have a better long-term prognosis. Consequently, this has further bolstered interest in minimally-invasive techniques to de-intensify treatment to reduce long-term toxicity and treatment-related morbidity. In this context, there has been a renewed interest in the primary surgery, which allows for accurate pathologic staging and thus-potentially-de-intensification of postoperative CRT. The continuous advances in minimally-invasive surgical approaches, including transoral laser microsurgery (TLM) and transoral robotic surgery (TORS), have also altered the surgical landscape. These minimally-invasive approaches offer excellent functional outcomes, without the severe toxicity associated with intensive CRT, thus substantially reducing treatment-related morbidity. In short, given the increasing prevalence of HPV-positive OPSCC, together with the severe long-term sequela of aggressive CRT, surgery appears to be recapturing its previous role as the primary treatment modality for this disease. While a growing body of evidence suggests that TLM and TORS offer oncologic outcomes that are comparable to CRT and open surgery, many questions remain due to the lack of prospective data. In the present review, we explore the emerging range of surgical options and discuss future directions in the treatment of OPSCC, including the most relevant clinical trials currently underway.

The mechanical strength of orthodontic elastomeric memory chains and plastic chains: An in vitro study.

BACKGROUND: The loss of physical properties of orthodontic chains has been a topic of discussion among scientists and clinicians, motivating efforts to improve elastic materials and minimize the decrease of force. Orthodontic companies have introduced memory elastomers, which, according to the manufacturers, have improved mechanical properties. OBJECTIVES: The aim of the study was to evaluate the effects of stretching elastomeric chains submerged in 37°C artificial saliva. MATERIAL AND METHODS: The study assessed 2 types of chains. The first phase of the study evaluated 1) the tensile strength of the chains; and 2) elongation at the time of tearing in an environment outside of the oral cavity (without exposition). The second phase of the study evaluated 1) permanent deformation after stretching; 2) elongation at the time of tearing; and 3) the tensile strength of the chain in conditions similar to those present in the oral cavity. RESULTS: In the experiments using artificial saliva, pronounced force decay was observed in the plastic chain, in which, after just 7 days, force decreased almost by half compared to the initial value, with a continuous downward trend. The memory chain, however, showed increased elasticity, and after the first week of exposition the force decay at the time of tearing was around 20% of the initial value. Force decay at the time of tearing remained at a steady level between 14.4 and 25.4% throughout the whole period of exposition. In the plastic chain this value oscillated between 50.3 and 55.9%. In the experiments assessing permanent deformation of the chains performed after each week of exposition, the specimens prepared from the memory chain stretched from 8 cm to approximately 9.5 cm after exposition, while the specimens prepared from the plastic chain stretched to approximately 13 cm. CONCLUSIONS: Memory chains are more effective in orthodontic treatment due to diminished loss of mechanical and elastic capabilities, when compared to plastic chains.