Impact of magnetic resonance angiography parameters on stroke prevention therapy in pediatric patients with sickle cell anemia.

BACKGROUND: Degree of cerebrovascular stenosis in pediatric patients with sickle cell anemia (SCA) informs need for chronic transfusion therapy, which has significant risks. Flow artifact, intrinsic to magnetic resonance angiography (MRA), is dependent on technical parameters and can lead to overinterpretation of stenosis. The primary objective of this study was to document any change in stroke prevention therapy that could be attributed to the implementation of a standardized MRA scanning protocol for patients with SCA. METHODS: A standardized MRA scanning protocol with an echo time of less than 5 ms was implemented at Montefiore Medical Center (MMC), NY in May 2016. Retrospective chart review identified 21 pediatric patients with SCA, with an MRA head both pre- and post-May 2016. Arterial stenosis on MRA, machine parameters, and treatment plans were compared pre- and post-implementation. RESULTS: Ten of the 21 patients met inclusion criteria. Previously seen stenosis was re-classified to a lower degree in six of the 10 patients, leading to discontinuation of transfusions in five patients. No patients required escalation of therapy to chronic transfusions. CONCLUSION: Optimizing flow artifact by decreasing echo time to less than 5 ms can improve accurate interpretation of cerebrovascular disease, and ensure appropriate treatment plans are in place for stroke prevention. This is especially important for implementing "TCD With Transfusions Changing to Hydroxyurea (TWiTCH)" clinical trial results in the real-world setting.

Nocturnal hypertension associated with stroke and silent cerebral infarcts in children with sickle cell disease.

BACKGROUND: Strokes and silent cerebral infarcts (SCIs) lead to significant morbidity and mortality in children with sickle cell disease (SCD). Higher systolic blood pressures increase risk for stroke and SCIs; however, patients with SCD often have lower clinic blood pressures than the general population. Twenty-four-hour ambulatory blood pressure monitoring (ABPM) allows for more robust examination of blood pressures. This study evaluated associations between abnormal ABPM measurements with stroke and SCIs. PROCEDURE: A cross-sectional study was performed. Children with SCD completed 24-hour ABPMs. Children with a documented magnetic resonance imaging (MRI) brain within a year of the ABPM were included in the analysis. Bivariate analyses were performed to identify associations between ABPM parameters with cerebrovascular outcomes. RESULTS: Forty-two children with a median age of 13 years (10, 17) were included in the analysis. Seven (17%) had history of stroke and seven (17%) had SCIs. Nocturnal hypertension, elucidated via 24-hour ABPM, was noted in 25% of subjects. The presence of nocturnal hypertension was significantly higher in the SCI/stroke group (55% vs 12%, P = .01). Sensitivity analyses were performed during which stroke patients were removed from analysis. Nocturnal hypertension remained significantly associated with the presence of SCIs (P = .006). CONCLUSIONS: This study reveals an association between nocturnal hypertension and a higher prevalence of SCI and stroke in children with SCD. Larger, prospective studies are needed to confirm these findings and evaluate the contributory nature of blood pressure abnormalities to cerebrovascular events in children with SCD.

Selective Head versus Whole Body Cooling Treatment of Hypoxic-Ischemic Encephalopathy: Comparison of Electroencephalogram and Magnetic Resonance Imaging Findings.

OBJECTIVE: This study aimed to compare the utility of electroencephalogram (EEG) and brain magnetic resonance imaging (MRI) to detect brain dysfunction and injury across a cohort of newborn infants treated with selective head cooling (SHC) or whole body cooling (WBC). STUDY DESIGN: Therapeutic hypothermia (TH) is a standard neuroprotection tool for hypoxic-ischemic encephalopathy (HIE) in neonates. Sixty-six newborns, SHC (n = 22) and WBC (n = 44), were studied utilizing standardized scoring systems for interpretation of EEG and MRI based on the severity of the findings. RESULTS: SHC- and WBC-treated groups did not differ significantly amongst most of the baseline parameters. EEGs obtained postcooling were abnormal in 58 of 61 (95%) infants. The severity of the EEG background changes (depressed and undifferentiated background) was more prevalent in the SHC (8/21 [38%]) than in the WBC group (5/40 [13%]). Brain MRIs showed HIE changes in 26 of 62 (42%) newborns treated with TH. MRI abnormalities of basal ganglia, thalamic, and parenchymal lesions were more common in the SHC (5/19) versus the WBC group (3/43); p = 0.04. CONCLUSION: EEG abnormalities and MRI findings of HIE were more prevalent in the SHC than in the WBC group. WBC may offer better or at least similar neuroprotection to infants with HIE.

CT of the Neck: Image Analysis and Reporting in the Emergency Setting.

Interpreting findings seen at CT of the neck is challenging owing to the complex and nuanced anatomy of the neck, which contains multiple organ systems in a relatively small area. In the emergency department setting, CT is performed to investigate acute infectious or inflammatory symptoms and chronic processes. With few exceptions, neck CT should be performed with intravenous contrast material, which accentuates abnormally enhancing phlegmonous and neoplastic tissues and can be used to delineate any abscesses or necrotic areas. As part of the evaluation, the vascular structures and aerodigestive tract must be scrutinized, particularly for patency. Furthermore, although the patient may present because of symptoms that suggest non-life-threatening conditions involving structures such as the teeth or salivary glands, there may be serious implications for other areas, such as the orbits, brain, and spinal cord, that also may be revealed at the examination. With a focus on the emergency setting, the authors propose using an approach to interpreting neck CT findings whereby 12 areas are systematically evaluated and reported on: the cutaneous and subcutaneous soft tissues, aerodigestive tract and adjacent soft tissues, teeth and periodontal tissues, thyroid gland, salivary glands, lymph nodes, vascular structures, bony airspaces, cervical spine, orbits and imaged brain, lung apices, and superior mediastinum. The use of a systematic approach to interpreting neck CT findings is essential for identifying all salient findings, recognizing and synthesizing the implications of these findings to formulate the correct diagnosis, and reporting the findings and impressions in a complete, clear, and logical manner.Online supplemental material is available for this article.©RSNA, 2019.

Three-dimensional ultrasound of the neonatal brain: technical approach and spectrum of disease.

Brain pathology is an important cause of morbidity and mortality in neonates, especially in the premature population. While conventional two-dimensional neurosonography is traditionally used for screening, diagnosis and monitoring of brain disorders such as germinal matrix hemorrhage, periventricular leukomalacia and hydrocephalus, three-dimensional ultrasonography has gained popularity in a variety of clinical applications in recent years. Three-dimensional ultrasonography is not yet widely utilized in pediatric imaging but is a potentially powerful tool for evaluating the neonatal brain. Three-dimensional neurosonography allows imaging of the entire brain in a single volumetric sweep and offers the capability of reconstructing images in the axial plane and performing volumetric analyses that are unavailable in conventional two-dimensional neurosonography. The purpose of this article is two-fold: (1) to present the technical aspects of three-dimensional neurosonography and (2) to illustrate the potential applications of three-dimensional neurosonography in the context of commonly encountered neonatal neuropathology.

Prenatally Diagnosed Aggressive Intracranial Immature Teratoma-Clinicopathological Correlation.

OBJECTIVE: To describe clinicopathological correlation of congenital intracranial immature teratoma. METHODS: A retrospective case analysis from a tertiary medical center. RESULTS: We report a case of an intracranial immature teratoma detected prenatally at 35 weeks of gestation. The tumor showed rapid growth, causing acute hydrocephalus requiring subsequent ventriculoperitoneal shunting. Resective surgery was performed within 2 weeks after birth. The infant died at day of life 29. Histological examination revealed an immature teratoma, with high MIB1/Ki-67 proliferation index. CONCLUSION/IMPLICATIONS: Intracranial immature teratoma with high MIB1/Ki-67 proliferation index may serve as an independent poor prognostic factor.

Hippocampal sclerosis after febrile status epilepticus: the FEBSTAT study.

OBJECTIVE: Whether febrile status epilepticus (FSE) produces hippocampal sclerosis (HS) and temporal lobe epilepsy (TLE) has long been debated. Our objective is to determine whether FSE produces acute hippocampal injury that evolves to HS. METHODS: FEBSTAT and 2 affiliated studies prospectively recruited 226 children aged 1 month to 6 years with FSE and controls with simple febrile seizures. All had acute magnetic resonance imaging (MRI), and follow-up MRI was obtained approximately 1 year later in the majority. Visual interpretation by 2 neuroradiologists informed only of subject age was augmented by hippocampal volumetrics, analysis of the intrahippocampal distribution of T2 signal, and apparent diffusion coefficients. RESULTS: Hippocampal T2 hyperintensity, maximum in Sommer's sector, occurred acutely after FSE in 22 of 226 children in association with increased volume. Follow-up MRI obtained on 14 of the 22 with acute T2 hyperintensity showed HS in 10 and reduced hippocampal volume in 12. In contrast, follow-up of 116 children without acute hyperintensity showed abnormal T2 signal in only 1 (following another episode of FSE). Furthermore, compared to controls with simple febrile seizures, FSE subjects with normal acute MRI had abnormally low right to left hippocampal volume ratios, smaller hippocampi initially, and reduced hippocampal growth. INTERPRETATION: Hippocampal T2 hyperintensity after FSE represents acute injury often evolving to a radiological appearance of HS after 1 year. Furthermore, impaired growth of normal-appearing hippocampi after FSE suggests subtle injury even in the absence of T2 hyperintensity. Longer follow-up is needed to determine the relationship of these findings to TLE.

Hippocampal Malrotation Is Associated With Prolonged Febrile Seizures: Results of the FEBSTAT Study.

OBJECTIVE: Hippocampal malrotation is characterized by incomplete hippocampal inversion with a rounded shape and blurred internal architecture. There is still debate about whether hippocampal malrotation has pathologic significance. We present findings from the Consequences of Prolonged Febrile Seizures in Childhood (FEBSTAT) study on the frequency of and risk factors for hippocampal malrotation. SUBJECTS AND METHODS: FEBSTAT is a prospective multicenter study investigating the consequences of febrile status epilepticus in childhood. MRI studies of 226 patients with febrile status epilepticus were analyzed visually by two board-certified neuroradiologists blinded to clinical details and were compared with MRI studies of 96 subjects with first simple febrile seizure. Quantitative analysis of hippocampal volume was performed by two independent observers. RESULTS: Hippocampal malrotation was present in 20 of 226 (8.8%) patients with febrile status epilepticus compared with two of 96 (2.1%) control subjects (odds ratio [OR], 4.56; 95% CI, 1.05-19.92). Hippocampal malrotation was exclusively left-sided in 18 of 22 (81.8%) patients and bilateral in the remaining four patients (18.2%). There was no case of exclusively right-sided hippocampal malrotation. Hippocampal malrotation was more common in boys than in girls (OR, 6.1; 95% CI, 1.7-21.5). On quantitative volumetric MRI analysis, the left hippocampal volume was smaller in patients with hippocampal malrotation than in control subjects with simple febrile seizure (p = 0.004), and the right-to-left hippocampal volume ratio was higher in the hippocampal malrotation group than in the simple febrile seizure group (p < 0.001). CONCLUSION: Hippocampal malrotation is a developmental malformation that predominantly affects the left hippocampus in male patients and is more frequently found in children with prolonged febrile status epilepticus than in control subjects. These data provide further evidence that hippocampal malrotation represents a pathologic error in brain development rather than a normal variant.

Alexithymia and its impact on quality of life in a group of Brazilian women with migraine without aura.

BACKGROUND: Migraine is a type of primary headache widely known for its impact on quality of life of patients. Although the psychological aspects of the disease are receiving increasing attention in current research, some of them, as alexithymia, are still seldom explored. This study aimed to provide evidence on the relationships between markers of depression, anxiety, alexithymia, self-reflection, insight and quality of life in migraine. METHODS: Forty female outpatients from a Brazilian specialized headache hospital service and a paired control group were compared. RESULTS: The results revealed that women with migraine had higher levels of depression, anxiety and alexithymia, and lower levels of quality of life, self-reflection and insight, compared to controls. Quality of life in women with migraine was predicted by levels of depression and one alexithymia factor (ability to express emotions and fantasies). A binary regression analysis between clinical and control groups revealed the migraine group to comprise individuals with high anxiety, low quality of life in the physical domain and the presence of a concrete thinking style. CONCLUSIONS: The results highlight the relevance of considering psychological variables in the routine healthcare practices for migraine patients in general, while keeping steady attention to individual case features.

Self-Consciousness and Self-Awareness: Associations between Stable and Transitory Levels of Evidence.

The theory of objective self-awareness predicts the assessment of stable or dispositional self-consciousness and transitory or situational self-awareness. The aim of the present research was to investigate potential associations between patterns of experiential self-description to scores on self-report measures of dispositional self-consciousness. A total of 64 Brazilian volunteers (Mage = 29.7, SD = 8.79, 64.1% female) responded to the Revised Self-Consciousness Scale, the Philadelphia Mindfulness Scale, and the Rumination-Reflection Questionnaire before participating in an experience sampling protocol. The protocol consisted of random daily requests for up to four self-description experiences across seven consecutive days. Participants recorded audio messages on their mobile phones in reply to each request describing their current experience. Reports were analyzed through a reflexive thematic analysis that produced twenty sub-themes accounting for descriptive markers of experience. Based on those descriptive markers, the qualitative data were then transformed into quantitative data for the situational self-awareness indexes. Evidence of association between self-consciousness and self-awareness was stronger for the awareness subscale in a positive correlation with affective situational self-awareness and in a negative correlation with mental representational transitory self-awareness. Although relational evidence has been provided, the data reinforced the theoretical distinction between self-consciousness and self-awareness.

Brain MRI findings in COVID-19 patients with PRES: A systematic review.

BACKGROUND: Numerous case reports and case series have described brain Magnetic Resonance Imaging (MRI) findings in Coronavirus disease 2019 (COVID-19) patients with concurrent posterior reversible encephalopathy syndrome (PRES). PURPOSE: We aim to compile and analyze brain MRI findings in patients with COVID-19 disease and PRES. METHODS: PubMed and Embase were searched on April 5th, 2021 using the terms "COVID-19", "PRES", "SARS-CoV-2" for peer-reviewed publications describing brain MRI findings in patients 21 years of age or older with evidence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and PRES. RESULTS: Twenty manuscripts were included in the analysis, which included descriptions of 30 patients. The average age was 57 years old. Twenty-four patients (80%) required mechanical ventilation. On brain MRI examinations, 15 (50%) and 7 (23%) of patients exhibited superimposed foci of hemorrhage and restricted diffusion respectively. CONCLUSIONS: PRES is a potential neurological complication of COVID-19 related disease. COVID-19 patients with PRES may exhibit similar to mildly greater rates of superimposed hemorrhage compared to non-COVID-19 PRES patients.

Dual-layer spectral CT virtual-non-contrast images aid in parathyroid adenoma analysis and radiation dose reduction: confirmation of findings from dual-energy CT.

4D-parathyroid CT scans have become a mainstay in the evaluation and pre-surgical planning for parathyroid adenomas. Most protocols typically rely on non-contrast images, prior to the arterial and delayed phases. Previous reports with dual-energy CT imaging have highlighted the utility of virtual non-contrast images to help reduce radiation dose while maintaining diagnostic accuracy. Herein, we report two cases of surgically proven parathyroid adenomas diagnosed with 4D-parathyroid CT scans performed on dual-layer spectral scanners, and in retrospect highlight the utility of virtual non-contrast images. To our knowledge, this report provides the first description of virtual non-contrast images from dual-layer spectral CT scanners that could aid in the diagnosis of parathyroid adenomas, confirming similar findings described with dual-energy CT scanners.

Differentiation of hemorrhage from contrast enhancement using dual-layer spectral CT in patients transferred for acute stroke.

Acute stroke patients transferred to thrombectomy capable centers (TCC), undergo a CT head exam upon arrival at the TCC to evaluate for ASPECTS decay and intracranial hemorrhage. In patients who received iodinated contrast prior to transfer, parenchymal enhancement may simulate hemorrhage on this post-transfer CT. We report two cases utilizing CT spectral imaging to differentiate between parenchymal contrast enhancement and hemorrhage in this setting. TCC may consider dual-energy or dual-layer (spectral) imaging for this patient cohort.

Who is in charge when I have a headache? Brazilian version of the Headache-Specific Locus of Control Scale.

BACKGROUND: Headache-Specific Locus of Control (LOC) refers to individuals' beliefs about their control over the onset, course and consequences of headaches. LOC beliefs have been associated with depression, coping strategies, headache-related disability and treatment outcomes. OBJECTIVE: To test the cross-cultural adaptation and psychometric properties of a Brazilian version of the Headache-Specific Locus of Control Scale (HSLC). METHODS: One hundred and thirty-four migraine outpatients completed the HSLC and provided measurements of psychopathological symptoms, pain catastrophizing, depression, anxiety, quality of life and headache-related disability. RESULTS: The three-factor structure of the HSLC (LOC-P, LOC-C and LOC-I) was confirmed in the Brazilian sample. The instrument showed good internal consistency, with Cronbach's α of 0.77 for total HSLC and 0.70, 0.83 and 0.87, for LOC-P, LOC-C and LOC-I, respectively. LOC-C correlated with headache frequency and headache intensity. Along with headache intensity, depression and pain catastrophizing, LOC-I accounted for 45% of the variance (adjusted R2=0.45; F=12.97; p<0.01) in headache-related disability. CONCLUSIONS: The Brazilian version of the HSLC is a valid and reliable measure of headache-specific LOC beliefs. It is important to consider the balance between the three LOCs for each individual, instead of interpreting them separately.

Perspectiva de Segunda Pessoa em Psicoterapia: as inovações fenomenológicas de Carl Rogers / Second Person Perspective in Psychotherapy: the phenomenological innovations of Carl Rogers

O estudo aponta e analisa as inovações clínicas e científicas de Carl Rogers introduzidas à psicoterapia. O foco está no papel da intersubjetividade, aqui entendida como perspectiva de segunda pessoa, mas sem desconsiderar as contribuições advindas das perspectivas de terceira (evidência experimental) e de primeira pessoa (vivência experiencial). O estudo argumenta que a relevância dada a intersubjetividade, a não-diretividade e a abertura à experiência testifica a confluência entre Rogers e o movimento fenomenológico. Tal confluência é realçada pela atenção ao exame dos fatos e fenômenos em múltiplas perspectivas, orientadas pela ética fenomenológica. Neste sentido, o grande equívoco das comparações entre a teoria de Rogers e a fenomenologia está em tomar como ponto de partida uma dada definição de fenomenologia, e não a vivência e a descrição de eventos fenomenais. Por fim, mostra-se como os estudos científicos de Rogers encontram ressonâncias em pesquisas fenomenológicas contemporâneas aplicadas à psicologia.

The study points out and analyzes the clinical and scientific innovations that Carl Rogers introduced to psychotherapy. The focus is on the role of intersubjectivity, here understood as a second-person perspective, but without disregarding the perspectives from third-person (experimental evidence) and first-person (experiential experience). The study argues that the relevance given to intersubjectivity, non-directivity, and openness to experience testifies to the confluence between Rogers and the phenomenological movement. Such confluence is enhanced by examining facts and phenomena from multiple perspectives, guided by phenomenological ethics. In this sense, the mistake in the comparisons between Rogers' theory and phenomenology lies in taking as a starting point given definition of phenomenology, and not the experience and description of phenomenal events. Finally, it shows how Rogers' scientific studies find resonances in contemporary phenomenological research applied to psychology.

Incidence and Outcomes of Pituitary Microadenomas in Children with Short Stature/Growth Hormone Deficiency.

BACKGROUND/AIMS: Patients with short stature (SS)/growth hormone deficiency (GHD) and precocious puberty (PP) undergo brain MRI to evaluate for structural brain abnormalities or pituitary lesions, and pituitary microadenomas are a common finding. Theoretically, a mass effect from these lesions could cause GHD and growth hormone treatment could cause them to enlarge, but they should not cause PP, at least in females. METHODS: We investigated if pituitary microadenomas cause GHD by comparing their incidence in patients with SS/GHD to that in females with PP. We performed a retrospective chart review of patients with these disorders who had a brain MRI between 2000 and 2013. RESULTS: The incidence of microadenoma was high in both groups, 18.5% for SS (n = 346) and 21.1% for PP females (n = 194), but did not differ between groups (p = 0.46). In patients with microadenomas, repeat imaging showed resolution in 58% (SS, n = 33) and 67% (PP females, n = 21). Importantly, none of the lesions grew, even in patients treated with growth hormone. CONCLUSIONS: Pituitary microadenomas are common in children with GHD/SS and PP, but it does not appear that they are a cause of GHD. They appear to be of limited clinical significance and should not be considered a contraindication to growth hormone therapy.

Limitações e inconsistências das definições sintéticas para psicologia / Limitations and inconsistencies of synthetic definitions for psychology

O objetivo deste memorandumé a proposição de uma definição conceitual para a psicologia capaz de integrar desdobramentos de objetos, diferenças entre métodos, e variedades de aplicações. O argumento baseia-se no fato óbvio de que existe apenas um psiquismo, mesmo que se reconheça diferentes modos de descrevê-lo, estudá-lo, preveni-lo e tratá-lo. Desde modo, a psicologia pode ser definida como um vasto campo de manifestações impressivas e expressivas as quais podem ser sintetizadas em articulações de suas propriedades afetivas, cognitivas e conativas, podendo tais manifestações serem observáveis (perspectiva de terceira pessoa) ou não (perspectiva de primeira pessoa). Os termos do enunciado serão definidos e discutidos após análise lógica e histórica de definições apresentadas por filósofos e psicólogos, do final do século XIX ao início do século XXI. A proposição assenta-se na esclarecedora diferenciação entre pluralidade de objetos (hierarquia ontológica ou desdobramentos de objetos) e pluralismo de concepções (diversidade epistemológica).

The purpose of this memorandum is to propose a conceptual definition for psychology capable of integrating unfolding objects, methodological differences and application diversity. The argument is based on the obvious fact that there is only one psyche, even if one recognizes different ways of describing, studying, preventing and treating it. Thus, psychology can be defined as a vast field of impressive andexpressive manifestations which can be synthesized in articulations of their affective, cognitive and conative properties, and such manifestations can be observable (third-person perspective) or not (first-person perspective). The enunciation terms will be discussed after logical and historical analysis on definitions presented by philosophers and psychologists, from the end of the 19th century to the beginning of the 21th century. The proposition is based on the clarifying differentiation between plurality of objects (ontological hierarchy or unfolding of objects) and pluralism of conceptions (epistemological diversity).

Who are they, what do they talk about and who listens to the poor? / Quem são, o que falam e quem escuta os pobres?

The right to a dignified life for all requires overcoming the challenges imposed on the most vulnerable groups, and poverty is one of the oldest and most devastating phenomena. Listening to them is essential to create remediating opportunities. This study aims to identify characteristics of this listening in the context of health promotion and the Sustainable Development Goals - SDGs, an international effort to support the fight against poverty, among others. In an integrative review of literature, conducted through the search terms of Poverty, Right to the City, Equity Policy and Identification of Poverty, 86 studies that listened to vulnerable groups, such as women, children, adolescents, adults, the elderly, families and drug users, all poor and low-skilled workers were analyzed. Each strategy shown was related to one or more SDGs. The recurrent strategies in the studies analyzed were increased social protection and spaces to listen to vulnerable groups, as well as public policies that enabled the fight against poverty. Equity must be thought of in the context of comprehensive and universalizing rights policies, overcoming fragmented and focal policies that fail to address the structural causes of poverty and human exploitation.

O direito a uma vida digna para todos requer a superação de desafios impostos aos grupos mais vulneráveis, sendo a pobreza um dos fenômenos mais antigos e devastadores. Ouvi-los é essencial para criar possibilidades de superação. O estudo objetiva identificar características dessa escuta, no contexto da promoção da saúde e dos Objetivos de Desenvolvimento Sustentável-ODS, esforço internacional de apoio à superação da pobreza, dentre outros. Por meio de revisão integrativa de literatura, realizada com os termos de busca (Pobreza, Direito à Cidade, Política de Equidade e Identificação da Pobreza) foram analisados 86 estudos que escutavam os grupos vulneráveis: mulheres, crianças, adolescentes, jovens, adultos, idosos, famílias e usuários de drogas, todos pobres e trabalhadores de baixa qualificação. Cada estratégia apresentada foi relacionada a um ou mais ODS. A ampliação da proteção social e dos espaços de escuta aos grupos vulneráveis, e políticas públicas que viabilizam o combate à pobreza, foram as estratégias mais recorrentes nos estudos analisados. A equidade deve ser pensada no bojo de políticas abrangentes e universalizadoras de direitos, superando as políticas fragmentadas e focais que deixam de atacar as causas estruturais da pobreza e da exploração humana.

MRI Differences Associated with Intrauterine Growth Restriction in Preterm Infants.

BACKGROUND: Preterm infants are at risk for neurodevelopmental impairment. Intrauterine growth restriction (IUGR) further increases this risk. Brain imaging studies are often utilized at or near term-equivalent age to determine later prognosis. OBJECTIVE: To evaluate the association between intrauterine growth and regional brain volume on MRI scans performed in preterm infants at or near term-equivalent age. METHODS: This is a retrospective case-control study of 24 infants born at gestational age ≤30 weeks and cared for in a large, inner-city, academic neonatal intensive-care unit from 2012 to 2013. Each IUGR infant was matched with 1-2 appropriate for gestational age (AGA) infants who served as controls. Predischarge MRI scans routinely obtained at ≥36 weeks' adjusted age were analyzed for regional brain volumetric differences. We examined the association between IUGR and thalamic, basal ganglion, and cerebellar brain volumes in these preterm infants. RESULTS: Compared to AGA infants, IUGR infants had a smaller thalamus (7.88 vs. 5.87 mL, p = 0.001) and basal ganglion (8.87 vs. 6.92 mL, p = 0.002) volumes. There was no difference in cerebellar volumes between the two study groups. Linear regression analyses revealed similar trends in the associations between IUGR and brain volumes after adjusting for sex, gestational age at birth, and postconceptual age and weight at MRI. CONCLUSIONS: Thalamus and basal ganglion volumes are reduced in growth-restricted preterm infants. These differences may preferentially impact neurodevelopmental outcomes. Further research is needed to explore these relationships.

Nocturnal motor activity and light exposure: Objective actigraphy-based marks of melancholic and non-melancholic depressive disorder. Brief report.

Differentiation of melancholic (MEL) and non-melancholic (N-MEL) depression results from subjective assessment of psychomotor disturbance, which obscures their accurate diagnosis. CORE instrument assigned participants with severe or refractory depression to MEL or N-MEL group. Participants underwent 7 days of actigraphy. Data was fitted to a cosinusoidal curve corresponding to a 24-h rhythm. Nocturnal activity was significantly higher in N-MEL. ROC curve shows that average night activity discriminate participants with 71% sensitivity and 100% specificity (area under the curve = 0.84). Actigraphy contribute to the objective differentiation of depression subtypes, and have implications for research on their neurobiology and clinical management.